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Steroidogenic Factor 1 (0):
Recent article
Steroidogenic Factor 1
Molecular Endocrinology (24)7 2010
Abstract
The orphan nuclear receptor steroidogenic factor 1 (SF-1, also called Ad4BP, encoded by the NR5A1 gene) is an essential regulator of endocrine development and function. Initially identified as a tissue-specific transcriptional regulator of cytochrome P450 steroid hydroxylases, studie...
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PMID: 20203099
PDF is available here.
PDF is available here.
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Abstract
Steroidogenic factor-1 (SF-1), a major protein regulating the complex cascade of steroidogenis, has been postulated to play a role in ovarian endometriosis. However, the expression in situ of SF-1 in ovarian endometriosis is unknown. To shed light on its presence, the expression of SF-1 was studied...
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PMID: 19875956
PDF is available here.
PDF is available here.
Abstract
We have encountered an increasing number of image-guided adrenal mass biopsies in which the differential diagnosis is adrenal cortical lesion versus pheochromocytoma. This distinction is sometimes difficult because of confounding clinical presentations, overlapping morphologies, and some degree of i...
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PMID: 20154585
PDF is available here.
PDF is available here.
Cell Stem Cell (6)2 2010
Abstract
We show that the orphan nuclear receptor Nr5a2 (also known as Lrh-1) can replace Oct4 in the derivation of iPSCs from mouse somatic cells, and it can also enhance reprogramming efficiency. Sumoylation mutants of Nr5a2 with enhanced transcriptional activity can further increase reprogramming efficien...
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PMID: 20096661
PDF is available here.
PDF is available here.
Molecular and Cellular Endocrinology (315)1-2 2010
Abstract
We discuss the current understanding on SF-1 with focus on the parameters that control the transcriptional capacity of SF-1 and the mechanisms that ensure proper stage- and tissue-specific expression of the gene encoding SF-1.
2009 Elsevier Ireland Ltd. All rights reserved....
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PMID: 19616058
PDF is available here.
PDF is available here.
Abstract
We identified IFN-lambda genes from the genome sequences of the human, chimpanzee, macaque, orangutan, mouse, rat and dog, and found that the locations and copy of a specific IFN-lambda varied in different genomes, not just the copy of IFN-lambdas. We found human IFN-lambdas were expressed in fetal...
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PMID: 20043142
PDF is available here.
PDF is available here.
Growth Factors (28)1 2010
Abstract
Both fibroblast growth factor 2 (FGF2) and luteinizing hormone (LH) have been reported to regulate androgen production in Leydig cells in progenitor Leydig cells. The objective of the present study is to examine the regulation of androgen production in rat immature Leydig cells (ILCs). ILCs were iso...
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PMID: 19814654
PDF is available here.
PDF is available here.
Abstract
We demonstrate that Pin1 is required for both basal and GnRH-induced gonadotropin beta-subunit gene transcription, through interactions with the transcription factors SF-1, Pitx1, and Egr-1. Pin1 activates transcription of the gonadotropin beta-subunit genes synergistically with these transcription...
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PMID: 19995909
PDF is available here.
PDF is available here.
Abstract
In reptiles with temperature-dependent sexual determination, the thermosensitive period (TSP) is the interval in which the sex is defined during gonadal morphogenesis. One-shift experiments in a group of eggs define the onset and the end of the TSP as all and none responses, respectively. Timing for...
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PMID: 20090307
PDF is available here.
PDF is available here.
Abstract
We have used the reduced levels of Sf1 expression in Cited2(-/-) mice as a hypomorphic model to gain insight into the sex-specific roles of SF1 function in gonadal development. In XY mutant mice, we found that testis development was delayed in Cited2(-/-) gonads, and that testis structure was perman...
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PMID: 19757380
PDF is available here.
PDF is available here.
Abstract
We describe a case of XY complete gonadal dysgenesis due to a p.D293N homozygous mutation in the NR5A1 gene, with normal SRY and no adrenal failure....
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PMID: 20453312
PDF is available here.
PDF is available here.
Abstract
Dicer1 is dispensable for formation and differentiation of fetal tissues derived from the SF1-positive adrenogonadal primordium. Dicer1 is essential for maintaining cell survival in adrenal and testis; however, development of the ovary from fetal stages to postnatal day 5 does not require the presen...
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PMID: 20540774
PDF is available here.
PDF is available here.
médecine/sciences (25)10 2009
Abstract
We have identified NR5A1 mutations associated with POI, including familial cases with affected 46,XY individuals. This demonstrates that NR5A1 plays an important role in ovarian development and function. However several questions remain. What is the incidence of NR5A1 mutations in POI? Is there a ge...
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PMID: 19849982
PDF is available here.
PDF is available here.
Cancer Research (69)13 2009
Abstract
We report that primary human endometriotic H-38 cells express high levels of GPR30 with no detectable ERalpha or ERbeta. Using a novel tamoxifen analogue, STX, which activates GPR30 but not ERs, significant stimulation of the phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase...
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PMID: 19549922
PDF is available here.
PDF is available here.
Abstract
Cryptorchidism, the most common congenital abnormality in newborn boys, is a major risk factor for male infertility and testicular malignancy in adulthood. This disorder appears as an isolated form or as part of impaired male sex development or a congenital malformation syndrome. Based mainly on the...
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PMID: 19550383
PDF is available here.
PDF is available here.
Chinese Medical Journal (122)8 2009
Abstract
DES can inhibit transabdominal testicular descent in a dose-dependent manner via down-regulating the expression of INSL3, which is induced by down-regulating the expression of SF-1. HOXA10 may not be involved in DES induced intra-abdominal cryptorchidism at 2.5 mg/kg, but is involved at 5, 10 and 20...
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PMID: 19493424
PDF is available here.
PDF is available here.
Abstract
Ad4BP/SF-1 (adrenal4 binding protein/steroidogenic factor-1[NR5A1]) is an essential nuclear receptor required for animal reproduction and endocrine regulation. The present study reports on monoclonal antibodies (MAbs) directed against mouse Ad4BP/SF-1, which were produced by the hybr...
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PMID: 19382844
PDF is available here.
PDF is available here.
Molecular and Cellular Endocrinology (300)1-2 2009
Abstract
Endometriosis is a common and chronic disease characterized by persistent pelvic pain and infertility. Estradiol is essential for growth and inflammation in endometriotic tissue. The complete cascade of steroidogenic proteins/enzymes including aromatase is present in endometriosis le...
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PMID: 19150483
PDF is available here.
PDF is available here.
Cancer Letters (275)1 2009
Abstract
We used RT-PCR and Western blot to show that the nuclear receptors SF1 and LRH1, two well-known regulators of steroidogenic gene expression in gonadal and adrenal cells, are also expressed in endometrial cancer cell lines. By transient transfections, we found that SF1 and LRH1, but not the related n...
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PMID: 19022561
PDF is available here.
PDF is available here.
Abstract
We report that NUR77 and c-JUN have additive effects on the Star promoter. These effects were abolished only when both elements, NUR77 at -95 bp and AP-1 at -78 bp, were mutated. Consistent with this, in vitro co-immunoprecipitation revealed that NUR77 and c-JUN interact and that this interaction is...
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PMID: 18987158
PDF is available here.
PDF is available here.
Abstract
We hypothesized that this might be due to the differential transcriptional properties of the mutant proteins on heart versus gonadal target genes. Five mutations (S52F, E215D, G295S, V266M, and E359X) were recreated in the rat GATA4 protein. Several parameters were used to analyze the transcriptiona...
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PMID: 19008335
PDF is available here.
PDF is available here.
Abstract
We found that SF-1 is selectively SUMOylated at K194 in Y1 adrenocarcinoma cells and that although SUMOylation does not alter the subcellular localization of SF-1, the modification inhibits the ability of SF-1 to activate target genes. Notably, whereas SF-1 SUMOylation is independent of S203 phospho...
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PMID: 19015234
PDF is available here.
PDF is available here.
Abstract
These results indicate that r RFX1 specifically bind to promoter region and negatively regulate the transcription of the human PNRC gene....
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PMID: 19334528
PDF is available here.
PDF is available here.
Abstract
We used ciglitazone to selectively activate PPARgamma and examine its role in STAR-mediated steroidogenesis in immortalised KK1 mouse granulosa cells and MA-10 mouse Leydig tumour cells. Cotreatment with both dibutyryl-cAMP and ciglitazone revealed a dose-dependent, significant increase in progester...
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PMID: 19698295
PDF is available here.
PDF is available here.
Abstract
We previously identified a fetal adrenal-specific enhancer (FAdE) in the Ad4BP/SF-1 locus that directs transgene expression to the fetal adrenal cortex and demonstrated that this enhancer is autoregulated by Ad4BP/SF-1. We now combine the FAdE with the Cre/loxP system to trace cell lineages in which...
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PMID: 18809574
PDF is available here.
PDF is available here.
Biology of Reproduction (79)6 2008
Abstract
We have extended our analyses of knockout (KO) mice with markedly decreased SF-1 expression in granulosa cells. As described, these SF-1 KO mice had hypoplastic ovaries that contained a decreased number of follicles and lacked corpora lutea. In the present study, we showed that SF-1 KO mice exhibite...
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PMID: 18703422
PDF is available here.
PDF is available here.
Abstract
We examined the functional and structural consequences of SF-1 sumoylation at two conserved lysines (Lys119 and Lys194) that reside adjacent to the DNA-binding domain (DBD) and ligand-binding domain (LBD), respectively. Surprisingly, while previous loss-of-function studies predicted that sumoylation...
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PMID: 18838537
PDF is available here.
PDF is available here.
Endocrinology (149)11 2008
Abstract
We present evidence to support that methylation of CpG sites located in the proximal promoter of the gene encoding SF1 contributes to the restricted expression pattern of this nuclear receptor. DNA methylation analyses revealed a nearly perfect correlation between the methylation status of the proxi...
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PMID: 18653709
PDF is available here.
PDF is available here.
Endocrinology (149)11 2008
Abstract
We generated mice lacking Socs3 specifically in neurons positive for steroidogenic factor 1 (SF1), which is expressed abundantly in the VMH. These mice had increased phosphorylation of signal transducer and activator of transcription-3 in VMH neurons, suggesting improved leptin signaling, and consis...
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PMID: 18669597
PDF is available here.
PDF is available here.
Endocrinology (149)9 2008
Abstract
We have previously clarified that adenovirus-mediated forced expression of SF-1 can transform long-term cultured mouse bone marrow mesenchymal cells (BMCs) into ACTH-responsive steroidogenic cells. In the present study, we extended this work to adipose tissue-derived mesenchymal cells (AMCs) and com...
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PMID: 18566117
PDF is available here.
PDF is available here.
Abstract
Exposure of endometrial cells to A4 may enhance CYP19 gene expression through its aromatization to estrogens....
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PMID: 18559914
PDF is available here.
PDF is available here.
Development (135)15 2008
Abstract
We used two Sf1/Cre transgenes to inactivate conditional beta-catenin alleles. Inactivation of beta-catenin mediated by Sf1/Cre(high), a transgene expressed at high levels, caused adrenal aplasia in newborn mice. Analysis of fetal adrenal development with Sf1/Cre(high)-mediated beta-catenin inactiva...
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PMID: 18599507
PDF is available here.
PDF is available here.
Endocrinology (149)8 2008
Abstract
To study the effects of gestational exposure to estrogen on early gonadal differentiation, pregnant mice were treated by sc injection of diethylstilbestrol (DES) or vehicle from embryonic day (E) 8.5 to E14.5, and gonads at E11.5, E12.5, and E14.5 were examined. Quantitative real-time RT-PCR and in...
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PMID: 18436715
PDF is available here.
PDF is available here.
Molecular Endocrinology (22)8 2008
Abstract
We demonstrate that SF-1 colocalizes in VMH neurons with the cannabinoid receptor 1 (CB1R) and that a specific CB1R agonist modulates electrical activity of SF-1 neurons in hypothalamic slice preparations. We further show that SF-1 directly regulates CB1R gene expression via a SF-1-responsive elemen...
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PMID: 18511494
PDF is available here.
PDF is available here.
Behavioral Neuroscience (122)4 2008
Abstract
Sex hormones are a major factor responsible for the development of sex differences. Steroidogenic factor 1 (SF-1) is a key regulator of gonadal and adrenal development, and SF-1 knockout mice (SF-1 KO) are born without gonads and adrenal glands. Consequently, these mice are not exposed to gonadal se...
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PMID: 18729641
PDF is available here.
PDF is available here.
Abstract
Normal human pancreas expresses 4 gene transcripts involved in steroid synthesis similarly to steroidogenic organs. A distinctive characteristic is the sexually dimorphic expression of these factors. These data provide further evidence to support that the pancreas is a truly steroidogenic tissue, hi...
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PMID: 18665078
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (314)1-2 2008
Abstract
We analyzed the expression of genes associated with steroid production using simple culture system with serum medium. In addition, we examined the involvement of DAX-1, COUP-TFII, and Ad4BP/SF-1 transcription factors on the steroid production in theca cells. Theca cells begin to display an elongated...
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PMID: 18409030
PDF is available here.
PDF is available here.
Endocrinology (149)7 2008
Abstract
The type 4 adenylyl cyclase, Adcy4, is the least abundant of five different adenylyl cyclase isoforms expressed in the Y1 mouse adrenocortical cell line and is deficient in a Y1 mutant with impaired steroidogenic factor 1 (SF1) activity. This study examines the contributions of SF1 and other DNA pro...
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PMID: 18388192
PDF is available here.
PDF is available here.
Abstract
We show that SRY binds to multiple elements within a Sox9 gonad-specific enhancer in mice, and that it does so along with steroidogenic factor 1 (SF1, encoded by the gene Nr5a1 (Sf1)), an orphan nuclear receptor. Mutation, co-transfection and sex-reversal studies all point to a feedforward, self-rei...
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PMID: 18454134
PDF is available here.
PDF is available here.
Molecular Pharmacology (73)6 2008
Abstract
The steroidogenic factor 1 (SF-1, also known as NR5A1) is a transcription factor belonging to the nuclear receptor superfamily. Whereas most of the members of this family have been extensively characterized, the therapeutic potential and pharmacology of SF-1 still remains elusive. Described here is...
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PMID: 18334597
PDF is available here.
PDF is available here.
Molecular Endocrinology (22)6 2008
Abstract
We propose that these interactions with beta-catenin define a multicomponent transcriptional network required for regulated expression of the four signature genes of the gonadotrope, Cga, Lhb, Fshb, and Gnrhr....
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PMID: 18218726
PDF is available here.
PDF is available here.
Abstract
We have demonstrated that dehydroepiandrosterone (DHEA) acts directly on rat zona fasciculata-reticularis (ZFR) cells to diminish corticosterone secretion by an inhibition of post-cAMP pathway, and decreases functions of steroidogenic enzymes after P450(scc) as well as steroidogenic acute regulatory...
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PMID: 18004794
PDF is available here.
PDF is available here.
Abstract
We examined whether the methylation status of a large CpG island in the first intron of mouse SF-1 gene is associated with the expression level of SF-1 in cultured cells and in tissues. The island consists of three small islands (ICI-1, ICI-2, and ICI-3). In cultured adrenocortical Y-1 cells and in...
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PMID: 18325326
PDF is available here.
PDF is available here.
Biology of Reproduction (78)5 2008
Abstract
We postulated that the differences were the result of organizational changes derived from embryonic exposure to environmental contaminants and are related to the poor reproductive success reported in alligators from Lake Apopka. In this study we examine differences in alligators collected as eggs fr...
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PMID: 18172066
PDF is available here.
PDF is available here.
Abstract
Three synthetic routes were developed for structure-activity relationship (SAR) studies of HTS-derived isoquinolinone inhibitor probes for the orphan nuclear receptor steroidogenic factor-1 (NR5A1). Among the new analogs reported herein, 31 and 32 have improved potency, lower cellular toxicity, and...
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PMID: 18374567
PDF is available here.
PDF is available here.
Molecular Endocrinology (22)4 2008
Abstract
We used Cre-LoxP and gene targeting technology to mutate the binding sequence for SF-1 (SF-1 response element) on the promoter of the mouse Cyp11a1 gene, which encodes a critical enzyme for steroid biosynthesis. The resulting Cyp11a1 L/L mice expressed about 7-fold less cytochrome P450 side-chain cl...
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PMID: 18174359
PDF is available here.
PDF is available here.
Molecular Endocrinology (22)4 2008
Abstract
We investigated differences in SF-1 expression in endometriotic tissue and normally located endometrium to elucidate the mechanism underlying increased StAR and aromatase activities in endometriosis. Serial deletion and site-directed mutants of the SF-1 promoter showed that an E-box sequence was cri...
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PMID: 18165439
PDF is available here.
PDF is available here.
Molecular Pharmacology (73)3 2008
Abstract
Steroidogenic factor SF-1, a constitutively active nuclear hormone receptor, is essential to the development of adrenal and gonadal glands and acts as a shaping factor of sexual determination and differentiation. Its effects are exerted primarily through the control of the synthesis of steroid hormo...
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PMID: 18055761
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To explore the mechanism of inhibitory effect of SLW on estrogen production by endometrial cells of endometriosis. METHOD: After the model of eutopic primary cultured endometrial cells of endometiosis and hysteromyoma in vitro was successfully established, the changes of steroidgenic fact...
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PMID: 18590202
PDF is available here.
PDF is available here.
Abstract
We first examined CXorf6 protein structure, identifying homology to mastermind-like 2 (MAML2) protein, which functions as a co-activator in canonical Notch signaling. Transactivation analysis for wild-type CXorf6 protein by luciferase assays showed that CXorf6 significantly transactivated the promot...
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PMID: 18162467
PDF is available here.
PDF is available here.
Development (135)4 2008
Abstract
We identify the molecular mechanism responsible for this ovarian asymmetry. Asymmetric PITX2 expression in the left presumptive gonad leads to the asymmetric expression of the retinoic-acid (RA)-synthesizing enzyme, RALDH2, in the right presumptive gonad. Subsequently, RA suppresses expression of th...
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PMID: 18199582
PDF is available here.
PDF is available here.
Abstract
We focus on studies that have begun to define the mechanisms regulating the transcription of these genes. Understanding the mechanisms controlling differential expression of these proteins should provide novel information about the human adrenal reticularis and its production of DHEA and DHEA-S....
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PMID: 17945481
PDF is available here.
PDF is available here.
Abstract
We report here that BMP-4 is also expressed by adrenal cortical cells throughout chick embryonic development, suggesting a putative role in chromaffin cell development. Moreover, bone morphogenetic protein receptor IA is expressed by both cortical and chromaffin cells. Inhibiting BMP-4 with noggin p...
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PMID: 18945349
PDF is available here.
PDF is available here.
Human Mutation (29)1 2008
Abstract
We have analyzed the gene encoding SF1 (NR5A1) in a cohort of 27 patients with 46,XY disorders of sex development (DSD) from the German network of DSD. Heterozygous SF1 mutations were found in 5 out of 27 (18.5%) of cases. Four patients with SF1 mutations presented with the similar phenotype of mild...
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PMID: 17694559
PDF is available here.
PDF is available here.
Sexual Development (2)4-5 2008
Abstract
Steroidogenic factor-1 (SF-1) (Ad4BP, NR5A1) is a nuclear receptor that regulates many aspects of adrenal and reproductive development and function. Consequently, deletion of the gene (Nr5a1) encoding Sf-1 in XY mice results in impaired adrenal development, complete testicular dysgen...
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PMID: 18987494
PDF is available here.
PDF is available here.
Hormone Research (70)5 2008
Abstract
Immunoreactivity for Ad4BP/SF-1 and DAX-1 indicated that it was localized exclusively in the nuclei. Ad4BP/SF-1 immunoreactivity was observed in the carcinoma cells of 2 patients, but not in the others, whereas DAX-1 immunoreactivity was observed in the carcinoma cells of all 4 patients. CONCLUSION:...
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PMID: 18824868
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (307)1-2 2008
Abstract
We investigated an inhibitory effect of TGF-beta on CYP17 expression in H295R cells using constructs containing the CYP17 promoter region fused with the luciferase gene. In the H295R cells, TGF-beta decreased endogenous SF-1 level and inhibited activity of the 300 bp fragment of CYP17 promoter, whic...
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PMID: 17786540
PDF is available here.
PDF is available here.
Molecular Endocrinology (22)1 2008
Abstract
We report that serine 203 is phosphorylated by a cyclin-dependent kinase 7 (CDK7)-mediated process. As part of the CDK-activating kinase complex, CDK7 is a component of the basal transcription factor TFIIH, and phosphorylation of SF1 as well as SF1-dependent transcription was clearly reduced in cell...
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PMID: 17901130
PDF is available here.
PDF is available here.
Molecules and Cells (24)3 2007
Abstract
We found that a previously unidentified repressor, EID-1, is an SF-1-interacting protein that inhibits the transactivation of SF-1. A transient transfection assay revealed that EID-1 inhibits SF-1, but not LRH-1, ERRgamma, or mCAR. Using the yeast two hybrid and GST pull-down assays, we determined t...
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PMID: 18182853
PDF is available here.
PDF is available here.
Journal of Neuroscience (27)50 2007
Abstract
We now identify approximately 200 genes highly enriched in neonatal (postnatal day 0) mouse VMH tissue. Analyses of these VMH markers by real or virtual (Allen Brain Atlas; http://www.brain-map.org) experiments revealed distinct regional patterning within the newly formed VMH. Top neonatal markers i...
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PMID: 18077674
PDF is available here.
PDF is available here.