Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
beta Catenin (0):
Recent article
beta Catenin
Biochemical Pharmacology (82)11 2011
Abstract
We analyzed the effects of IFN-α2b and TGF-β1 treatments on Wnt/β-catenin pathway, Smads proteins levels, β-catenin/TCF4/Smads interaction and proliferation and apoptotic death in HepG2/C3A and Huh7 cell lines. IFN-α2b and TGF-β1 attenuated Wnt/β-catenin signal by decreasing β-catenin and Fr...
|
PMID: 21843516
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Transplantation (92)9 2011
Abstract
We hypothesized that CsA is able to trigger these EPCs in tubular cells in vivo.
We studied the kinetics of the EMT markers β-catenin, snail, vimentin, collagen III, and HSP47 at the messenger RNA and protein levels in the kidneys from rats injected with 15 mg/kg/day of CsA or its v...
|
PMID: 21909056
PDF is available here.
PDF is available here.
Transplantation (92)9 2011
Abstract
We hypothesized that CsA is able to trigger these EPCs in tubular cells in vivo.
We studied the kinetics of the EMT markers β-catenin, snail, vimentin, collagen III, and HSP47 at the messenger RNA and protein levels in the kidneys from rats injected with 15 mg/kg/day of CsA or its v...
|
PMID: 21909056
PDF is available here.
PDF is available here.
Transplantation (92)9 2011
Abstract
We hypothesized that CsA is able to trigger these EPCs in tubular cells in vivo.
We studied the kinetics of the EMT markers β-catenin, snail, vimentin, collagen III, and HSP47 at the messenger RNA and protein levels in the kidneys from rats injected with 15 mg/kg/day of CsA or its v...
|
PMID: 21909056
PDF is available here.
PDF is available here.
Abstract
We show that homozygous disruption of PHD-1 (PHD-1(-/-)) could facilitate HIF-1α-mediated cardioprotection in ischemia/reperfused (I/R) myocardium. Wild-type (WT) and PHD-1(-/-) mice were randomized into WT time-matched control (TMC), PHD-1(-/-) TMC (PHD1TMC), WT I/R, and PHD-1(-/-) I/R (PHD1IR). I...
|
PMID: 21083501
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)37 2011
Abstract
We found that many Wnt-signaling genes were dynamically regulated, with an immediate decrease, followed by an eventual normalization during memory consolidation. This rapid decrease in Wnt mRNA was confirmed with individual quantitative PCR and in situ hybridization. We then manipulated Wnt signalin...
|
PMID: 21917789
PDF is available here.
PDF is available here.
Rinsho Ketsueki (52)7 2011
Abstract
Kidney International (79)9 2011
Abstract
We studied the orientation of cell division and proliferation in the kidneys of inv mutant mice, as its loss is thought to maintain activation of the canonical Wnt signaling. To establish if canonical signaling was involved in this process, we mated inv mutant with BATlacZ mice to measure canonical...
|
PMID: 21248711
PDF is available here.
PDF is available here.
Kidney International (79)9 2011
Abstract
We studied the orientation of cell division and proliferation in the kidneys of inv mutant mice, as its loss is thought to maintain activation of the canonical Wnt signaling. To establish if canonical signaling was involved in this process, we mated inv mutant with BATlacZ mice to measure canonical...
|
PMID: 21248711
PDF is available here.
PDF is available here.
Abstract
We show that SAMe supplementation in cultured hepatocytes every 12h, leads to an up-regulation of Cx26 and 32 mRNA and protein levels and blocks culture-induced Cx43 expression, although it failed to increase Cx26 and 32 membrane localization and GAP junction intracellular communication. SAMe reduce...
|
PMID: 21093098
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)5 2011
Abstract
I interferon, type 2 immune responses and mechanical stress as extracellular cues that modulate fibroblast function and differentiation, and as potential targets for therapy. Moreover, fibrillin-1 has a major role in storing and regulating the bioavailability of TGF-ß and other cytokines, and fibri...
|
PMID: 20863909
PDF is available here.
PDF is available here.
Abstract
We show that stem cells in the bulge deposit nephronectin into the underlying basement membrane, thus regulating the adhesion of mesenchymal cells expressing the nephronectin receptor, α8β1 integrin, to the bulge. Nephronectin induces α8 integrin-positive mesenchymal cells to upregulate smooth mu...
|
PMID: 21335239
PDF is available here.
PDF is available here.
Abstract
We identify a mechanism in which EZH2 expression-mediated downregulation of DNA damage repair leads to accumulation of recurrent RAF1 gene amplification in BTICs, which activates p-ERK-β-catenin signaling to promote BTIC expansion. We further reveal that AZD6244, a clinical trial drug that inhibits...
|
PMID: 21215703
PDF is available here.
PDF is available here.
Abstract
We compared the clinicopathologic characteristics, including survival data and immunohistochemical profiles of cell adhesion molecules (E-cadherin, β-catenin, IQGAP-1, and CD44v6), of MPCs with those of adenocarcinomas lacking MPC components (non-MPC) in the stomach. We compared 72 MPC cases with 1...
|
PMID: 21164291
PDF is available here.
PDF is available here.
Innate Immunity (17)3 2011
Abstract
Dendritic cells (DCs) serve as a link between the innate and adaptive immune systems. The activation state of DCs is crucial in this role. However, when DCs are isolated from lymphoid tissues, purified and placed in culture they undergo 'spontaneous' activation. The basis of this was...
|
PMID: 20501515
PDF is available here.
PDF is available here.
Abstract
We provide evidence that a discrete subtype of medulloblastoma that contains activating mutations in the WNT pathway effector CTNNB1 (hereafter, WNT subtype) arises outside the cerebellum from cells of the dorsal brainstem. We found that genes marking human WNT-subtype medulloblastomas are more freq...
|
PMID: 21150899
PDF is available here.
PDF is available here.
Abstract
We show that reducing TRPM4 expression decreases proliferation of HeLa cells, a cervical cancer-derived cell line. In this cell line, constitutive TRPM4 silencing promoted GSK-3β-dependent degradation of β-catenin and reduced β-catenin/Tcf/Lef-dependent transcription. Conversely, overexpression o...
|
PMID: 20625999
PDF is available here.
PDF is available here.
Abstract
Signaling crosstalk between the β-catenin and NF-κB pathways represents a functional network. To test whether the crosstalk also occurs on their common target genes, the cyclin D1 promoter was used as a model because it contains binding sites for both proteins. β-catenin activated transcription f...
|
PMID: 21056029
PDF is available here.
PDF is available here.
Lab On a Chip (10)23 2010
Abstract
We developed a microfluidic device designed to generate stable concentration gradients at low hydrodynamic shear and allowing long term culture of adhering cells. The gradient forms in a culture space between two parallel laminar flow streams of culture medium at two different concentrations of a gi...
|
PMID: 20936235
PDF is available here.
PDF is available here.
Abstract
β-Catenin is a multifunctional protein stimulating as oncogenic transcription factor several genes important for cell proliferation. β-Catenin-regulated genes include the serum- and glucocorticoid-inducible kinase SGK1, which is known to stimulate a variety of transport systems. The present study...
|
PMID: 20951116
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We identified the cytoskeleton-associated α-N/E-catenins as novel nesprin-2-binding partners. The association involves the C termini of nesprin-2 giant and α-N/E-catenins. α-E/T/N-catenins are known primarily for their roles in cadherin-mediated cell-cell adhesion. Here, we show that, in addition...
|
PMID: 20801886
PDF is available here.
PDF is available here.
Abstract
We sought to determine if differences might exist between osteocytic and osteoblastic cell models relative to the activation of β-catenin signaling in MLO-Y4 osteocytic, 2T3 osteoblastic and primary neonatal calvarial cells (NCCs) in response to pulsatile fluid flow shear stress (PFFSS). β-catenin...
|
PMID: 20713195
PDF is available here.
PDF is available here.
Abstract
We identified an FDA-approved drug, pyrvinium, as a potent inhibitor of Wnt signaling (EC(50) of ∼10 nM). We show pyrvinium binds all casein kinase 1 (CK1) family members in vitro at low nanomolar concentrations and pyrvinium selectively potentiates casein kinase 1α (CK1α) kinase activity. CK1α...
|
PMID: 20890287
PDF is available here.
PDF is available here.
Bulletin du cancer (97)11 2010
Abstract
Recent progress in the field of molecular biology has allowed us to identify at least two different molecular mechanisms implicated in colorectal carcinogenesis (CRC): chromosomal instability (CIN) and genetic instability. Even though the two molecular mechanisms differ, their signalling pathways, i...
|
PMID: 21115420
PDF is available here.
PDF is available here.
Biochemical Journal (432)1 2010
Abstract
We hypothesized that a mitochondria-targeted antioxidant would prevent kidney damage in the Ins2(+/)⁻(AkitaJ) mouse model (Akita mice) of Type 1 diabetes. To test this we orally administered a mitochondria-targeted ubiquinone (MitoQ) over a 12-week period and assessed tubular and glomerular functi...
|
PMID: 20825366
PDF is available here.
PDF is available here.
Abstract
Radiation induced a biphasic stress response in the lung, as shown by the induction of heme oxygenase 1 at 1-3 days and at 6-8 weeks after irradiation. At 6-8 weeks after irradiation, the down-regulation of proteins involved in cytoskeletal architecture (filamin A and talin), antioxidant defense (bi...
|
PMID: 20584581
PDF is available here.
PDF is available here.
Abstract
The Modern Challenges in Therapeutic Protein Production conference hosted 44 delegates from the UK and Germany and was organized by EuroSciCon. The aim of the meeting was to look at the challenges that currently face the production of therapeutic proteins and to attempt to demystify some of the nove...
|
PMID: 20973635
PDF is available here.
PDF is available here.
Cell Research (20)10 2010
Abstract
We reported that Dvl also functions in the nucleus by stabilizing the β-catenin/TCFs transcriptional complex. Here we describe that Dvl may function as a repressor of NF-κB. Our data show that Dvl directly binds to p65 and their interaction occurs in the nucleus. Dvl expression inhibits p65-mediat...
|
PMID: 20628365
PDF is available here.
PDF is available here.
Clinical calcium (20)10 2010
Abstract
Wnt signaling system plays essential roles in development, cancer and bone metabolism. Canonical wnt signaling, which involves wnt ligands, receptor named frizzled and co-receptors LRP5/6, beta-catenin and transcription factors named LEF/TCF is well characterized and its defect causes bone abnormali...
|
PMID: 20890034
PDF is available here.
PDF is available here.
Clinical calcium (20)10 2010
Abstract
Parathyroid hormone (PTH) has clinically appeared as a bone anabolic reagent in Japan. Local or systemic factors produced by various cells are involved in the bone anabolic action of PTH. Insulin-like growth factor-1 and fibroblast growth factor 2 are included in them. Although the significance of c...
|
PMID: 20890039
PDF is available here.
PDF is available here.
Abstract
We investigated the role of Notch signaling in the osteoblastic differentiation of both MC3T3E-1 cells and primary mouse bone marrow stromal cells (BMSCs). P-LPS stimulation activated the Notch1 signaling cascade and increased expression of the Notch target genes HES1 and HEY1. P-LPS can also act as...
|
PMID: 20648628
PDF is available here.
PDF is available here.
Abstract
We investigated DAB2 expression and function during in vitro mesoderm differentiation of murine embryonic stem cells (ESCs). We found that DAB2 was up-regulated when ESCs were co-cultured with OP9 stromal cells for mesoderm differentiation. DAB2 was also up-regulated when ESCs were induced for embry...
|
PMID: 20648627
PDF is available here.
PDF is available here.
Abstract
We describe a rapid yeast bioassay for androgenic and anti-androgenic compounds based on androgen-dependent β-catenin-enhanced N-C interaction. The bioassay was also effective at detecting compounds that inhibit the N-C interaction in ways that do not involve binding to the ligand-binding domain....
|
PMID: 20834141
PDF is available here.
PDF is available here.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology (21)3 2010
Abstract
We analyzed the expressions of Wnt5a, MMP-7 and β-catenin genes in 40 primary gastric normal and tumor biopsies by RT-PCR and the subcellular localization of β-catenin by immunohistochemistry.
Our results showed a specific combination of genes expressed significantly in the gastric tumor tissues:...
|
PMID: 20931424
PDF is available here.
PDF is available here.
Abstract
We have identified key machinery of the Wnt-β-catenin (canonical)-signalling pathway that is encoded in the Amphimedon queenslandica (Demospongiae; Porifera) genome, namely Wnt, Fzd, SFRP, Lrp5/6, Dvl, Axin, APC, GSK3, β-catenin, Tcf, and Groucho. Most of these genes are not detected in the choano...
|
PMID: 20883218
PDF is available here.
PDF is available here.
Abstract
We showed that TCF-1 deficiency limited proliferation of CD8(+) effector T cells and impaired their differentiation toward a central memory phenotype. Moreover, TCF-1-deficient memory CD8(+) T cells were progressively lost over time, exhibiting reduced expression of the antiapoptotic molecule Bcl-2...
|
PMID: 20727791
PDF is available here.
PDF is available here.
Oncology Reports (24)3 2010
Abstract
To understand the role of cyclooxygenase (COX)-2 in metastatic potential of oral cancer, COX-2 overexpressing KB/COX-2 cells were inoculated orthotopically into the masseter muscle or injected into the left cardiac ventricle of nude mice. KB/COX-2 showed about 4-fold increase of COX-2 protein expres...
|
PMID: 20664981
PDF is available here.
PDF is available here.
Current Oncology Reports (12)5 2010
Abstract
We emphasize that the cellular homeostasis of Wnt/beta-catenin signaling may represent a more appropriate concept than the simplified view of the Wnt/beta-catenin pathway as either oncogenic or tumor-suppressing. Ultimately, a more refined understanding of the contextual regulation of Wnt/beta-caten...
|
PMID: 20603725
PDF is available here.
PDF is available here.
Abstract
We report here that the Wnt-beta-catenin signaling in intestinal dendritic cells regulates the balance between inflammatory versus regulatory responses in the gut. beta-catenin in intestinal dendritic cells was required for the expression of anti-inflammatory mediators such as retinoic acid-metaboli...
|
PMID: 20705860
PDF is available here.
PDF is available here.
Abstract
Rat mesenchymal stem cells (rMSCs) and salidroside have been applied in the treatment of hepatic fibrosis. The present study aimed to investigate the mechanism of hepatic differentiation of rMSCs in vitro and synergistic effects of rMSCs and salidroside on the experimental hepatic fibrosis in rats....
|
PMID: 20824962
PDF is available here.
PDF is available here.
Abstract
Accumulating lines of experimental evidence have revealed that the malignant transformation of multipotent tissue-resident adult stem/progenitor cells into cancer stem/progenitor cells endowed with a high self-renewal capacity and aberrant multilineage differentiation potential may be at origin of t...
|
PMID: 20552555
PDF is available here.
PDF is available here.
Abstract
We previously showed that divalent cations regulate alpha2beta1 integrin-mediated pancreatic cancer cell interactions with type I collagen in 2 dimensions (2D), including cell adhesion, migration, and proliferation. Presently, we examined divalent cation-dependent alpha2beta1 integrin-mediated pancr...
|
PMID: 20182393
PDF is available here.
PDF is available here.
Abstract
We summarize how proline-directed kinases (Gsk3, PKA, Pftk1, Grk5/6) and non-proline-directed kinases (CK1 family) act upon Lrp6, how the phosphorylation is regulated by ligand binding and mitosis, and how Lrp6 phosphorylation leads to beta-catenin stabilization....
|
PMID: 20229235
PDF is available here.
PDF is available here.
Oncology Reports (24)2 2010
Abstract
Our research results showed that CPP caused a dose- and time-dependent inhibition of cell growth as assessed by MTT assay and an induction in apoptosis as measured by flow cytometry and transmission electron microscopy. Furthermore, the CPP- treated cells were characterized by a decreased expression...
|
PMID: 20596624
PDF is available here.
PDF is available here.
Developmental Biology (344)1 2010
Abstract
We report that Cav-1 is required for proper dorsoventral patterning in zebrafish. Both Wnt and BMP signals act coordinately to negatively control transcriptional expression of cav-1 during embryonic development. Ectopic expression of Cav-1alpha or -1beta resulted in formation of typical ventralized...
|
PMID: 20452340
PDF is available here.
PDF is available here.
Molecular Carcinogenesis (49)8 2010
Abstract
We used immunohistochemistry to assess the presence of Dvl-1, Dvl-3, beta-catenin, and p120ctn, and compared their expression to the prognosis in 102 specimens from NSCLC patients. We also examined the effect of Dvl-1 and Dvl-3 on Tcf-dependent transcriptional activity, as well as on the invasivenes...
|
PMID: 20572159
PDF is available here.
PDF is available here.
Abstract
We focus on the new hemimetabolous paradigm. We highlight how hemimetabolous short-germ or intermediate-germ embryos establish the anterior/posterior (A/P) pattern and the importance of dynamic cell movement during germband formation. In hemimetabolous insects, orthodenticle, encoding a homeodomain-...
|
PMID: 20462751
PDF is available here.
PDF is available here.
Carcinogenesis (31)7 2010
Abstract
FHL2 was highly expressed in primary and metastatic colon cancer but not in normal tissues. FHL2 was critical for cancer cell adhesion to extracellular matrix, migration and invasion. FHL2 expression was stimulated by transforming growth factor (TGF)-beta1. Moreover, FHL2 acted as a potent EMT induc...
|
PMID: 20460358
PDF is available here.
PDF is available here.
Carcinogenesis (31)7 2010
Abstract
We reported earlier that pterostilbene (trans-3,5-dimethoxy-4'-hydroxystilbene), a structurally related stilbene found in blueberries, was effective in reducing the incidence and multiplicity of aberrant crypt foci formation in the colon of rats injected with azoxymethane (AOM). Our present study wa...
|
PMID: 20061362
PDF is available here.
PDF is available here.
Gastroenterology (139)1 2010
Abstract
Klf4 is essential for squamous epithelial differentiation in vivo and interacts with Klf5 to maintain normal epithelial homeostasis.
Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved....
|
PMID: 20347813
PDF is available here.
PDF is available here.
Abstract
90K, a tumour-associated glycoprotein, interacts with galectins and has roles in host defence by augmenting the immune response, but the serum 90K level was suggested to indicate poor prognosis in several cancers. The cellular mechanisms of 90K action on colorectal cancer (CRC) cell...
|
PMID: 20581239
PDF is available here.
PDF is available here.
Abstract
90K, a tumour-associated glycoprotein, interacts with galectins and has roles in host defence by augmenting the immune response, but the serum 90K level was suggested to indicate poor prognosis in several cancers. The cellular mechanisms of 90K action on colorectal cancer (CRC) cell...
|
PMID: 20581239
PDF is available here.
PDF is available here.
Abstract
90K, a tumour-associated glycoprotein, interacts with galectins and has roles in host defence by augmenting the immune response, but the serum 90K level was suggested to indicate poor prognosis in several cancers. The cellular mechanisms of 90K action on colorectal cancer (CRC) cell...
|
PMID: 20581239
PDF is available here.
PDF is available here.
Abstract
90K, a tumour-associated glycoprotein, interacts with galectins and has roles in host defence by augmenting the immune response, but the serum 90K level was suggested to indicate poor prognosis in several cancers. The cellular mechanisms of 90K action on colorectal cancer (CRC) cell...
|
PMID: 20581239
PDF is available here.
PDF is available here.
Abstract
90K, a tumour-associated glycoprotein, interacts with galectins and has roles in host defence by augmenting the immune response, but the serum 90K level was suggested to indicate poor prognosis in several cancers. The cellular mechanisms of 90K action on colorectal cancer (CRC) cell...
|
PMID: 20581239
PDF is available here.
PDF is available here.
Abstract
90K, a tumour-associated glycoprotein, interacts with galectins and has roles in host defence by augmenting the immune response, but the serum 90K level was suggested to indicate poor prognosis in several cancers. The cellular mechanisms of 90K action on colorectal cancer (CRC) cell...
|
PMID: 20581239
PDF is available here.
PDF is available here.
Abstract
90K, a tumour-associated glycoprotein, interacts with galectins and has roles in host defence by augmenting the immune response, but the serum 90K level was suggested to indicate poor prognosis in several cancers. The cellular mechanisms of 90K action on colorectal cancer (CRC) cell...
|
PMID: 20581239
PDF is available here.
PDF is available here.
Abstract
90K, a tumour-associated glycoprotein, interacts with galectins and has roles in host defence by augmenting the immune response, but the serum 90K level was suggested to indicate poor prognosis in several cancers. The cellular mechanisms of 90K action on colorectal cancer (CRC) cell...
|
PMID: 20581239
PDF is available here.
PDF is available here.
Abstract
90K, a tumour-associated glycoprotein, interacts with galectins and has roles in host defence by augmenting the immune response, but the serum 90K level was suggested to indicate poor prognosis in several cancers. The cellular mechanisms of 90K action on colorectal cancer (CRC) cell...
|
PMID: 20581239
PDF is available here.
PDF is available here.
Abstract
90K, a tumour-associated glycoprotein, interacts with galectins and has roles in host defence by augmenting the immune response, but the serum 90K level was suggested to indicate poor prognosis in several cancers. The cellular mechanisms of 90K action on colorectal cancer (CRC) cell...
|
PMID: 20581239
PDF is available here.
PDF is available here.