Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Transcription Factors (66):
- Receptors, Steroid
- Immunoglobulin J Recombination Signal Sequence-Binding Protein
- I-kappa B Proteins
- GATA Transcription Factors
- Early Growth Response Transcription Factors
- Cyclic AMP Receptor Protein
- Trans-Activators
- Repressor Proteins
- Receptors, Aryl Hydrocarbon
- Onecut Transcription Factors
- NFI Transcription Factors
- NF-kappa B
- MSX1 Transcription Factor
- Kruppel-Like Transcription Factors
- Host Cell Factor C1
- Hepatocyte Nuclear Factors
- T-Box Domain Proteins
- Proto-Oncogene Proteins c-ets
- Interferon Regulatory Factors
- Inhibitor of Differentiation Proteins
- G-Box Binding Factors
- Adenovirus E1A Proteins
- Transcription Factors, General
- SOX Transcription Factors
- Receptors, Thyroid Hormone
- Receptors, Notch
- Proto-Oncogene Proteins c-rel
- POU Domain Factors
- Adenovirus E1B Proteins
- Steroidogenic Factor 1
- Smad Proteins
- Sigma Factor
- Rho Factor
- Receptors, Retinoic Acid
- Otx Transcription Factors
- Transcription Factor DP1
- Paired Box Transcription Factors
- NFATC Transcription Factors
- Myeloid-Lymphoid Leukemia Protein
- Winged-Helix Transcription Factors
- Transcriptional Elongation Factors
- STAT Transcription Factors
- Proto-Oncogene Proteins c-myb
- Nuclear Receptor Coactivator 2
- MADS Domain Proteins
- Basic-Leucine Zipper Transcription Factors
- TCF Transcription Factors
- Receptors, Calcitriol
- p300-CBP Transcription Factors
- Fushi Tarazu Transcription Factors
- Basic Helix-Loop-Helix Transcription Factors
- Tristetraprolin
- Nuclear Factor 90 Proteins
- Leucine-Responsive Regulatory Protein
- Goosecoid Protein
- beta Catenin
- Antennapedia Homeodomain Protein
- Transcription Factor AP-2
- Erythroid-Specific DNA-Binding Factors
- Proto-Oncogene Proteins c-bcl-6
- Peroxisome Proliferator-Activated Receptors
- Nuclear Respiratory Factors
- Interferon-Stimulated Gene Factor 3
- E2F Transcription Factors
- Core Binding Factors
- BRCA1 Protein
Recent article
Transcription Factors
Abstract
Cancer stem cells (CSCs) can proliferate and self-renew extensively due to their ability to express anti-apoptotic and drug resistant proteins, thus sustaining tumor growth. Therefore, the strategy to eradicate CSCs might have significant clinical implications. The objectives of this study were to ex...
|
PMID: 21304978
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
The NTERA2 cl D1 (NT2) cell line, derived from human teratocarcinoma, exhibits similar properties as embryonic stem (ES) cells or very early neuroepithelial progenitors. NT2 cells can be induced to become postmitotic central nervous system neurons (NT2N) with retinoic acid. Although neurons derived f...
|
PMID: 21283767
PDF is available here.
PDF is available here.
Abstract
We also demonstrate that two key transcription factor genes known to be regulated by Wnt signaling and to be vital for the generation and function of dopaminergic neurons; i.e., Lmx1a and Engrailed 1, are down-regulated in the HPRT knockdown SH-SY5Y cells. In addition to the Wnt signaling aberration...
|
PMID: 21305049
PDF is available here.
PDF is available here.
Abstract
We quantified and enriched ALDH1(+) cells within HNSCC cell lines and subsequently characterized their phenotypical and functional properties like invasion capacity and epithelial-mesenchymal transition (EMT). Spheroid culture enriched CSC from five HNSCC cell lines by up to 5-fold. In spheroid-deri...
|
PMID: 21304586
PDF is available here.
PDF is available here.
Abstract
We address these issues by studying five populations: the popular Sprague-Dawley strain, sub-strains of Long-Evans and Wistar rats, and two lines derived from crosses between the Long-Evans and Wistar sub-strains. Using three independent techniques - variance analysis, linear modelling, and unsuperv...
|
PMID: 21760882
PDF is available here.
PDF is available here.
Abstract
We report the regulatory response of C. crescentus to carbon starvation, based on combined high-throughput proteome and transcriptome analyses. Our results identify cell cycle changes in gene expression in response to carbon starvation that involve the prominent role of the FixK FNR/CAP family trans...
|
PMID: 21494595
PDF is available here.
PDF is available here.
Fortschritte der Arzneimittelforschung. Progress in drug research. Progres des recherches pharmaceutiques (67) 2011
Abstract
We discuss three mechanisms through which histone methylation can be removed from the chromatin template. We describe how these "erasure" mechanisms are linked to pathways that are known to be misregulated in diseases, such as cancer. We further describe how errors in the removal of histone methylat...
|
PMID: 21141725
PDF is available here.
PDF is available here.
Abstract
We have used pathway-restricted gene expression profiles derived from RAS oncogene-transformed cells and from RAS-expressing cancer cells to identify regulators downstream of the MAPK pathway.We describe the role of epigenetic regulation exemplified by the control of several immune genes in generic...
|
PMID: 21094659
PDF is available here.
PDF is available here.
Abstract
Glial cells missing 2 (Gcm2) is a master regulatory gene of parathyroid gland development, and it is exclusively expressed in the parathyroid gland. Diagnostic application of anti-Gcm2 antibody has not been reported yet. In this study, a total of 58 cases of parathyroid lesions including 40 adenomas...
|
PMID: 21164298
PDF is available here.
PDF is available here.
Epigenetics (6)1 2011
Abstract
We compared two commonly used approaches to enrich for methylated DNA regions of the genome, namely methyl-DNA immunoprecipitation (MeDIP) that is based on enrichment with antibodies specific for 5'-methylcytosine (5MeC), and capture of methylated DNA using a methyl-CpG binding domain-based (MBD) pr...
|
PMID: 20818161
PDF is available here.
PDF is available here.
Epigenetics (6)1 2011
Abstract
We compared two commonly used approaches to enrich for methylated DNA regions of the genome, namely methyl-DNA immunoprecipitation (MeDIP) that is based on enrichment with antibodies specific for 5'-methylcytosine (5MeC), and capture of methylated DNA using a methyl-CpG binding domain-based (MBD) pr...
|
PMID: 20818161
PDF is available here.
PDF is available here.
Abstract
We present an introduction to the structure and function of nuclear receptors, specifically the estrogen, androgen, glucorticoid, peroxisome proliferator, steroid, thyroid and vitamin D receptors, and a discussion of the state-of-the-art of induced fit approaches for the nuclear receptor family....
|
PMID: 20939793
PDF is available here.
PDF is available here.
Abstract
Four and a half LIM domains protein 1 (FHL1) and FHL2, as the name suggests, contain four and a half LIM domain binding proteins. Proteins in this family capable of interacting with many types of proteins, including structural proteins, kinases, and several classes of transcription f...
|
PMID: 21539754
PDF is available here.
PDF is available here.
Abstract
We used bioinformatic analysis of publicly available data in order to systematically identify the genes involved in resistance to cytotoxic effects of these two drugs in the NCI60 cell line panel. We used the pharmacological data available for all the NCI60 cell lines to classify simvastatin or lova...
|
PMID: 21483694
PDF is available here.
PDF is available here.
Abstract
Copy number variations (CNV) within the genome are extremely abundant. In this closeup, Canales and Walz discuss how CNV are associated with normal variation, genomic disorders, genome evolution, adaptive traits and how the use of a novel screen described by Ermakova et al in this is...
|
PMID: 21204264
PDF is available here.
PDF is available here.
Gene Expression Patterns (11)1-2 2011
Abstract
We used in situ hybridization to screen numerous expression patterns of the TFs involved in the development of the mouse thymus. More than 400 members, including unique TFs and some transcription co-factors, were tested. Among the screened TFs, 160 were found to be expressed in the thymus after E15....
|
PMID: 20932939
PDF is available here.
PDF is available here.
Abstract
Recent advances in pancreas organogenesis have greatly improved the understanding of cell lineage from inner cell mass to fully differentiated β-cells. Based upon such knowledge, insulin-producing cells similar to β-cells to a certain extent have been generated from various cell so...
|
PMID: 20589399
PDF is available here.
PDF is available here.
Abstract
We develop a novel computational method that combines accurate quantification of 2D limb bud morphologies and growth modeling to analyze mouse clonal data of early limb development. Firstly, we explore various tissue movements that match experimental limb bud shape changes. Secondly, by comparing co...
|
PMID: 21347315
PDF is available here.
PDF is available here.
Abstract
Hypospadias is a common congenital anomalies, yet its molecular basis remains unknown. Recent studies have linked perturbations in the Hedgehog signaling pathway to hypospadias. However, the expression of Sonic hedgehog (Shh) has not been reported during genital development. Immunohi...
|
PMID: 21434830
PDF is available here.
PDF is available here.
Abstract
We investigated possible cooperative deregulation of microRNAs (miRNAs) and transcription factors (TFs) in glioblastoma, under the hypothesis that miRNAs and TFs might have a combinational regulatory effect on glioblastoma genes. We searched glioblastoma-specific regulatory networks by integrating g...
|
PMID: 21712563
PDF is available here.
PDF is available here.
Abstract
We show sheep fibroblasts can be reprogrammed to pluripotency by defined factors using a drug-inducible system. Sheep iPSCs derived in this fashion have a normal karyotype, exhibit morphological features similar to those of human ESCs and express AP, Oct4, Sox2, Nanog and the cell surface marker SSE...
|
PMID: 21253598
PDF is available here.
PDF is available here.
Abstract
We found that expression of MAGE I proteins, MAGE-A3 or MAGE-C2, relieved repression of a reporter gene by ZNF382, a KZNF with tumor suppressor activity. ChIP of MAGE I (-) HEK293T cells showed KAP1 and H3me3K9 are normally bound to the ID1 gene, a target of ZNF382, but that binding is greatly reduc...
|
PMID: 21876767
PDF is available here.
PDF is available here.
Abstract
We have employed a novel approach for the identification of functionally important microRNA (miRNA)-target interactions, integrating miRNA, transcriptome and proteome profiles and advanced in silico analysis using the FAME algorithm. Since miRNAs play a crucial role in the inner ear, demonstrated by...
|
PMID: 21483685
PDF is available here.
PDF is available here.
Abstract
We systematically queried the Saccharomyces cerevisiae proteome for Prp19 WD40 domain interaction partners by two-hybrid analysis. We report that in addition to S. cerevisiae Cwc2, the splicing factor Prp17 binds directly to the Prp19 WD40 domain in a 1:1 ratio. Prp17 binds simultaneously with Cwc2...
|
PMID: 21386897
PDF is available here.
PDF is available here.
PLoS Genetics (7)1 2011
H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases.
Abstract
We report that silencing of the fission yeast mating-type cassettes, which are located in a well-characterized heterochromatic region, is hardly affected in cells lacking the H3K9 methyltransferase Clr4. We document the existence of a pathway parallel to H3K9me ensuring gene repression in the absenc...
|
PMID: 21253571
PDF is available here.
PDF is available here.