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Retroviridae Proteins (7):
Recent article
Retroviridae Proteins
Plant Physiology (153)3 2010
Abstract
We have previously shown that the maize (Zea mays subsp. mays) retrotransposon Bs1 has transduced sequences from three different host genes. Here, we provide evidence that these transduction events led to the generation of a chimeric new gene that is both transcribed and translated. Expression of Bs...
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PMID: 20488894
PDF is available here.
PDF is available here.
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Molecular Cancer (9) 2010
Abstract
We have previously found that HTLV-I p30 is a negative regulator of virus expression.
In this study we show that p30 targets multiple cell cycle checkpoints resulting in a delayed entry into S phase. We found that p30 binds to cyclin E and CDK2 and prevents the formation of active cyclin E-CDK2 comp...
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PMID: 21092281
PDF is available here.
PDF is available here.
Abstract
These results were different from those for the 2 previously reported HTLV-3 strains, raising questions about serological confirmation of infection with such retroviruses....
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PMID: 19099485
PDF is available here.
PDF is available here.
EMBO Reports (10)2 2009
Abstract
I present RISF proteins from a structural perspective, describing the individual members and the common and divergent elements of their structures, as well as the mechanistic insights gained from the structures of RNase H1 enzyme complexes with RNA/DNA hybrids....
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PMID: 19165139
PDF is available here.
PDF is available here.
Abstract
We have implemented the technology by means of viral immobilization (2) on a novel surface of cluster-assembled nanostructured TiO2 (3) previously functionalized with an array of a docking protein. In this work, we present the detailed development of the "reverse infection cell-microarray based tech...
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PMID: 19649605
PDF is available here.
PDF is available here.
Abstract
We review mechanisms by which an adaptive coexistence has evolved. (Part of a multi-author review)....
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PMID: 18818872
PDF is available here.
PDF is available here.
HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
Abstract
A universal cellular defense mechanism against viral invasion is the elimination of infected cells through apoptotic cell death. To counteract host defenses many viruses have evolved complex apoptosis evasion strategies. The oncogenic human retrovirus HTLV-1 is the etiological agent of adult-T-cell...
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PMID: 18421579
PDF is available here.
PDF is available here.
Biochemical Journal (412)1 2008
Abstract
We have analysed the interactions of HIV-1 IN with HIV-1 RT and with two other related RTs: those of HIV-2 and MLV (murine-leukaemia virus). All three RTs inhibited HIV-1 IN, albeit to a different extent, suggesting a common site of binding that could be slightly modified for each one of the studied...
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PMID: 18260826
PDF is available here.
PDF is available here.
Autoimmunity (41)4 2008
Abstract
Genetic and environmental factors are believed to influence development of systemic lupus erythematosus (SLE). Endogenous retroviruses (ERV) correspond to the integrated proviral form of infectious retroviruses, which are trapped within the genome due to mutations. ERV represent a key molecular link...
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PMID: 18432409
PDF is available here.
PDF is available here.
Abstract
We designed and constructed a multigenic candidate vaccine against a recombinant C/B' subtype of HIV-1 that is dominant in southwest China. Five HIV-1 genes (gag, pol, DeltaV2env, tat, and nef) were introduced into 2 separate regions of the MVA genome using modified single- and dual-promoter inserti...
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PMID: 18209682
PDF is available here.
PDF is available here.
Abstract
We constructed a dual-promoter plasmid capable of high-level expression of 2 independent transgenes. HIV-1 gag, pol, env, nef, and tat from a primary subtype C/B' CCR5-tropic HIV-1 were "codon" optimized, modified to eliminate known functional activity, and assembled using an overlapping polymerase...
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PMID: 18209683
PDF is available here.
PDF is available here.
Journal of Virology (82)8 2008
Abstract
These results indicate that high-titer anti-SIV antibody responses and high-frequency anti-SIV cellular immune responses measurable by standard assays from the peripheral blood are not needed to achieve strong vaccine protection, even against a difficult, neutralization-resistant strain such as SIV2...
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PMID: 18272584
PDF is available here.
PDF is available here.
Arthritis & Rheumatism (58)2 2008
Abstract
Based on 4 single-nucleotide polymorphisms (SNPs) within a 935-base interval, we detected 6 HRES-1 haplotypes that were differentially segregated in unrelated Caucasian patients and control subjects (chi(2) = 16.86, P = 0.0048) and were in linkage disequilibrium (LD) with the D1S225 microsatellite (...
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PMID: 18240231
PDF is available here.
PDF is available here.
Abstract
In September 1987, in Goiânia, Brazil, one of the most serious radiological accidents occurred at a radiation therapy unit involving a source of cesium-137. The current study examined the occurrence of possible germline mutations at the AZF region of the exposed men and in their male offspring. Gen...
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PMID: 19048485
PDF is available here.
PDF is available here.
Abstract
We performed a comprehensive study of 120 non-redundant Ty3/Gypsy and Retroviridae LTR retroelements. Phylogenetic reconstruction inferred based on the concatenated analysis of the gag and pol polyproteins shows a robust phylogenetic signal regarding the clustering of OTUs. Evaluation of gag and pol...
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PMID: 18842133
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1778)7-8 2008
Abstract
Physical properties of membranes, such as fluidity, charge or curvature influence their function. Proteins and peptides can modulate those properties and conversely, the lipids can affect the activity and/or the structure of the former. Tilted peptides are short hydrophobic protein fragments charact...
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PMID: 18501700
PDF is available here.
PDF is available here.
Nucleic Acids Research (36)Database issue 2008
Abstract
We introduce the Gypsy Database (GyDB) of mobile genetic elements, an in-progress database devoted to the non-redundant analysis and evolutionary-based classification of mobile genetic elements. In this first version, we contemplate eukaryotic Ty3/Gypsy and Retroviridae long terminal repeats (LTR) r...
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PMID: 17895280
PDF is available here.
PDF is available here.
Abstract
We observed strong induction of vaccine-specific IFN-gamma-producing CD8(+) and CD4(+) effector T cells in the vaccination groups. Animals were subsequently challenged with 89.6p. The vaccine groups were protected from ongoing infection, and the IL-15 covaccinated group showed a more rapidly control...
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PMID: 18000037
PDF is available here.
PDF is available here.
Biophysical Journal (93)6 2007
Abstract
We attribute this both to electrostatic repulsion of the positively charged arginine in the FP-23 and to an increase in the repulsive fluctuation interaction brought about by the smaller K(C). Although this latter interaction works against membrane fusion, our results show that the energy that it re...
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PMID: 17526585
PDF is available here.
PDF is available here.
Abstract
Articular cartilage fragments can readily transmit infectious retrovirus, but isolated chondrocytes were likely not the source of the infectious virus because they did not harbor proviral DNA or p27 antigen....
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PMID: 17768202
PDF is available here.
PDF is available here.
Abstract
Journal of Medical Primatology (36)4-5 2007
Abstract
The current study demonstrates lymphocytes isolated and activated from the group that was immunized with DNA and pmacIL12 had a higher level of IFN-gamma producing cells. We also observed a different immunological profile when comparing the cells isolated from macaques immunized with DNA as compared...
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PMID: 17669216
PDF is available here.
PDF is available here.
Journal of Medical Primatology (36)4-5 2007
Abstract
These results underscore the potential importance of targeting transmitted viruses through judicious choice of immunogens from early isolates for vaccine development....
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PMID: 17669214
PDF is available here.
PDF is available here.
Abstract
We demonstrate that transduction of G(0)-arrested cell lines by SIVsmmPBj-derived vectors is independent of the viral accessory proteins Vif, Vpx, Vpr, or Nef. In contrast, for the transduction of primary human monocytes, the Vpx protein proved to be essential. However, trans-complementation of HIV-...
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PMID: 17418360
PDF is available here.
PDF is available here.
Abstract
The biology of foamy viruses, their mode of transmission and disease potential in their natural host and after interspecies transmission are largely unknown. To gain insights into the prevalence of bovine foamy virus (BFV) and its zoonotic potential, enzyme-linked immunosorbent assays (ELISAs) were...
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PMID: 17408715
PDF is available here.
PDF is available here.
Journal of Virology (81)13 2007
Abstract
These results reveal differences in poxvirus vector-host cell interactions that should be relevant to their use as immunization vehicles....
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PMID: 17409140
PDF is available here.
PDF is available here.
Pediatric Research (61)6 2007
Abstract
Human immunodeficiency virus-1 (HIV-1)-specific cytotoxic T-lymphocyte (CTL) responses are common in infected adults and usually exhibit rapid decay after combination antiretroviral therapy (ART). CTLs develop later in the first year of life, and the fate of HIV-1-specific responses in perinatally i...
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PMID: 17426646
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (282)19 2007
Abstract
We demonstrate that Rex and p30 form ribonucleoprotein ternary complexes onto specific viral mRNA. Our results explain the selective nuclear retention of tax/rex but not other viral mRNAs by p30. Whereas p30 suppresses Rex expression, it did not affect Rex-mediated nuclear export of RNA containing t...
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PMID: 17360706
PDF is available here.
PDF is available here.
Abstract
Retroviruses make a long and complex journey from outside the cell to the nucleus in the early stages of infection, and then an equally long journey back out again in the late stages of infection. Ongoing efforts are identifying an enormous array of cellular proteins that are used by the viruses in...
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PMID: 17325726
PDF is available here.
PDF is available here.
Abstract
Retroviruses affect a large number of species, from fish and birds to mammals and humans, with global socioeconomic negative impacts. Here the authors report and experimentally validate a novel approach for the analysis of the molecular networks that are involved in the recognition of substrates by...
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PMID: 17352531
PDF is available here.
PDF is available here.
Abstract
According to recent estimates, 39.5 million people have been infected with HIV and 2.9 million have already died. The effect of HIV infection on individuals and communities is socially and economically devastating. Although antiretroviral drugs have had a dramatically beneficial impact on HIV-infect...
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PMID: 17355212
PDF is available here.
PDF is available here.
Virus Research (124)1-2 2007
Abstract
Reticuloendotheliosis virus (REV) causes runting, high mortality, immunosuppression, and chronic neoplasia associated with T and/or B cell lymphomas in a variety of domestic and wild birds, including Attwater's prairie chickens (APC) (Tympanuchus cupido attwateri). The complete proviral sequence of...
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PMID: 17098316
PDF is available here.
PDF is available here.
Abstract
In this paper the design and use of a semi-quantitative real-time polymerase chain reaction assay (RT-PCR) for feline leukaemia virus (FeLV) provirus is described. Its performance is evaluated against established methods of FeLV diagnosis, including virus isolation and enzyme-linked immunoassay (ELI...
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PMID: 16861024
PDF is available here.
PDF is available here.
Abstract
We studied serial complete HIV-1 sequences obtained from a mother-child pair, both long-term nonprogressors. Analysis of four genomic sequences demonstrated that all viral genes were intact, lacking major deletions or premature stop codons to easily explain the slow disease progression. These data s...
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PMID: 17331038
PDF is available here.
PDF is available here.
Abstract
We studied the relative intracellular localizations of Tax, Rex and p30(II). Run-on transcription assays and immunocytochemistry at light and electron microscopy levels indicated that the Tax nuclear bodies included both de novo transcribed RNA and the RNA polymerase II form that is phosphorylated o...
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PMID: 17071021
PDF is available here.
PDF is available here.
Nucleic Acids Research (35)15 2007
Abstract
Eukaryotic genomes contain many endogenous retroviral sequences (ERVs). ERVs are often severely mutated, therefore difficult to detect. A platform independent (Java) program package, RetroTector (ReTe), was constructed. It has three basic modules: (i) detection of candidate long terminal repeats (LT...
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PMID: 17636050
PDF is available here.
PDF is available here.
Journal of General Virology (88)Pt 1 2007
Abstract
These results demonstrate that acetylation of the FV transactivator Tas may be an effective means to regulate virus transcription....
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PMID: 17170459
PDF is available here.
PDF is available here.
Journal of Molecular Biology (364)3 2006
Abstract
We present evidence for retention of a dimeric aspartyl protease in eukaryotes. The X-ray crystal structure of a domain of the Saccharomyces cerevisiae protein Ddi1 shows that it is a dimer with a fold similar to that of the retroviral proteases. Furthermore, the double Asp-Thr-Gly-Ala amino acid se...
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PMID: 17010377
PDF is available here.
PDF is available here.
Abstract
We have demonstrated that pX ORF-II mutations block virus replication in vivo and that ORF-II encoded p30II, a nuclear-localizing protein that binds with CREB-binding protein (CBP)/p300, represses CREB and Tax responsive element (TRE)-mediated transcription. Herein, we have identified p30II motifs i...
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PMID: 16890266
PDF is available here.
PDF is available here.
Infection and Immunity (74)10 2006
Abstract
We show here that proteins from the simian and human immunodeficiency viruses that are not permissive for secretion through a Salmonella enterica serovar Typhimurium type III secretion system can be modified to travel this secretion pathway by introduction of discrete mutations. Proteins optimized f...
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PMID: 16988261
PDF is available here.
PDF is available here.
Clinical Rheumatology (25)5 2006
Abstract
Since the association between human foamy virus (HFV) with rheumatic autoimmune diseases remains controversial, this study was designed to determine the relationship between HFV and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or progressive systemic sclerosis (PSS). The bel1 and P...
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PMID: 16365688
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (281)33 2006
Abstract
We report that HTLV-I has also evolved a protein that interferes with TLR4 signaling; p30 interacts with and inhibits the DNA binding and transcription activity of PU.1 resulting in the down-regulation of the TLR4 expression from the cell surface. Expression of p30 hampers the release of pro-inflamm...
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PMID: 16785240
PDF is available here.
PDF is available here.
Abstract
A modeling method is described that avoids the need to consider the domain structure of the template used for modeling, and automatically extracts compact fragments of structure that would be of a suitable size to build the model. This aids automation as the size or nature of the template structure...
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PMID: 16752419
PDF is available here.
PDF is available here.
Abstract
We identify an N-terminally truncated SIV Pr55(Gag) isoform expressed from the SIV gag gene SIV p43. We demonstrate that translation of p43 occurs independently of Pr55(Gag) translation and initiates at an in-frame AUG within the gag transcript. We test several mechanisms that could mediate translat...
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PMID: 16494914
PDF is available here.
PDF is available here.
Biochemical Journal (396)2 2006
Abstract
We report that infection of MT-2 cells with HIV-1 leads to efficient proteolysis of PABP. Analysis of PABP integrity was carried out in BHK-21 (baby-hamster kidney) and COS-7 cells upon individual expression of the protease from several members of the Retroviridae family, e.g. MoMLV (Moloney murine...
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PMID: 16594896
PDF is available here.
PDF is available here.
Journal of Virology (80)12 2006
Abstract
Human APOBEC3F (hA3F) and APOBEC3G (hA3G) are antiretroviral cytidine deaminases that can be encapsidated during virus assembly to catalyze C-->U deamination of the viral reverse transcripts in the next round of infection. Lentiviruses such as human immunodeficiency virus (HIV) and simian immunodefi...
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PMID: 16731937
PDF is available here.
PDF is available here.
Journal of Virology (80)12 2006
Abstract
We identified a survival motor neuron (SMN)-interacting protein 1 (Gemin2) that binds to HIV-1 IN. Reduction of Gemin2 with small interfering RNA duplexes (siGemin2) dramatically reduced HIV-1 infection in human primary monocyte-derived macrophages and also reduced viral cDNA synthesis. In contrast,...
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PMID: 16731905
PDF is available here.
PDF is available here.
Molecular Endocrinology (20)4 2006
Abstract
We have previously shown that ACTH evokes a rapid and transient increase in VEGF mRNA levels in primary adrenocortical cells through transcription-independent mechanisms. We further demonstrated that the zinc finger RNA-binding protein Tis11b (tetradecanoyl phorbol acetate-inducible-sequence 11b) de...
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PMID: 16306087
PDF is available here.
PDF is available here.
Abstract
We identified domains in the SIV TM cytoplasmic tail that are necessary for Env incorporation into virions and viral infectivity. In this study, we investigated the relevance to Env function of the highly conserved sequence comprising the immediate C-terminal 19 residues of TM. To this end, small in...
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PMID: 16380144
PDF is available here.
PDF is available here.
Abstract
We previously found that deletion of either one of the two Cys-His (CH) motifs in the RSV nucleocapsid (NC) protein did not abrogate Gag-Gag interactions, RNA binding, or packaging but greatly reduced virus production (E-G. Lee, A. Alidina et al., J. Virol. 77: 2010-2020, 2003). In this report, we h...
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PMID: 16406458
PDF is available here.
PDF is available here.
Abstract
We evaluated different diagnostic tests and compared them with the widely used enzyme-linked immunosorbent assay (ELISA) for the detection of p27 in the diagnosis of FeLV. Blood samples from 445 cats were tested for the presence of provirus by real-time PCR and plasma and saliva specimens from those...
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PMID: 16517876
PDF is available here.
PDF is available here.
Abstract
We established modular enzyme-linked immunosorbent assays (ELISA) suited to determine feline IgG and IgM antibody responses against structural and non-structural FFV proteins. We validated the ELISAs with standard reference sera. In 99 cats admitted to a Swiss veterinary hospital, overall FFV Gag an...
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PMID: 16297422
PDF is available here.
PDF is available here.
Abstract
We first describe the development and validation of sensitive and specific SIV antibody detection assays representing all major known primate lentiviral lineages on a panel of 207 sera from 11 different primate species with known infection status. The newly developed assays were then used to determi...
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PMID: 16257029
PDF is available here.
PDF is available here.
Abstract
Inspection of published sequences revealed a potential transcription initiator element (INR) situated downstream of, and in reverse orientation to, the usual HIV-1 promoter and transcription start site. This antisense initiator (HIVaINR) suggested the possibility of an antisense gene responsible for...
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PMID: 17090330
PDF is available here.
PDF is available here.
Abstract
The HIV and SIV gp41 ectodomains are extremely stable to chemical and thermal denaturation and the observed stability has been proposed to be an important thermodynamic driving force for gp41-mediated fusion of the viral and target cell membranes. The importance of the disulphide bond and surroundin...
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PMID: 16800801
PDF is available here.
PDF is available here.
Journal of Virology (80)1 2006
Abstract
We reported that the accessory gene products of HTLV-1 and HTLV-2 ORF II (p30II and p28II, respectively) are able to restrict viral replication. These proteins act as negative regulators of both Tax and Rex by binding to and retaining their mRNA in the nucleus, leading to reduced protein expression...
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PMID: 16352542
PDF is available here.
PDF is available here.
Abstract
Walleye dermal sarcoma virus (WDSV) is a complex retrovirus associated with seasonal dermal sarcomas. Developing tumors have low levels of accessory gene transcripts, A1 and B, and regressing tumors have high levels of full-length and spliced transcripts. Transcript A1 encodes a retroviral cyclin (r...
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PMID: 16150476
PDF is available here.
PDF is available here.
Mutation Research (579)1-2 2005
Abstract
We hypothesize that the putative HIV-1 pro-fs gene product functions by mimicry of NF-kappaB via binding to Trx. The hypothesis was tested in vitro by co-immunoprecipitation and GST-pull down assays, using a purified mutant pro-fs protein, in which the two potential selenocysteine residues were muta...
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PMID: 16054658
PDF is available here.
PDF is available here.
Journal of Infectious Diseases (192)10 2005
Abstract
Ex vivo interferon (IFN)- gamma -producing CD8 T cells specific for human immunodeficiency virus (HIV) Env, Gag, and Pol antigens were measured in the peripheral blood of 55 children not receiving highly active antiretroviral therapy (HAART) and 70 children receiving HAART. In children not receiving...
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PMID: 16235177
PDF is available here.
PDF is available here.
Abstract
I (HIAP-I) has been isolated from persons with SS. HIAP-I shares a limited number of antigenic epitopes with human immunodeficiency virus (HIV), but is distinguishable from HIV by morphological, physical, and biochemical criteria. A substantial majority of patients with SS or systemic lupus erythema...
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PMID: 16276517
PDF is available here.
PDF is available here.