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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Viral Regulatory and Accessory Proteins (5):
Recent article
Viral Regulatory and Accessory Proteins
Abstract
We describe KIR-associated amino-acid polymorphisms in the HIV-1 sequence of chronically infected individuals, on a population level. We show that these KIR-associated HIV-1 sequence polymorphisms can enhance the binding of inhibitory KIRs to HIV-1-infected CD4(+) T cells, and reduce the antiviral a...
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PMID: 21814282
PDF is available here.
PDF is available here.
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Trends in Microbiology (18)9 2010
Abstract
We review this new host-pathogen relationship and discuss its impact on the evolution of primate lentiviruses and the origins of the HIV pandemic.
Published by Elsevier Ltd....
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PMID: 20688520
PDF is available here.
PDF is available here.
Abstract
Primate immunodeficiency viruses encode viral proteins that are uniquely auxiliary to their growth in host cells. Of these accessory proteins, those designated Vpr and Vpx are least well understood with respect to their functions in the viral replication cycle. Moreover, their assign...
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PMID: 20069611
PDF is available here.
PDF is available here.
Journal of Virology (84)6 2010
Abstract
Ebola virus (EBOV) protein VP35 is a double-stranded RNA (dsRNA) binding inhibitor of host interferon (IFN)-alpha/beta responses that also functions as a viral polymerase cofactor. Recent structural studies identified key features, including a central basic patch, required for VP35 dsRNA binding act...
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PMID: 20071589
PDF is available here.
PDF is available here.
Avian Pathology (39)1 2010
Abstract
The present study was undertaken to detect and characterize enteric viruses (rotavirus, astrovirus, reovirus, and coronavirus) in breeder poults. Five turkey breeder flocks were selected. Faecal samples were collected from all flocks at 1 week of age and then every other week until the poults reache...
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PMID: 20390537
PDF is available here.
PDF is available here.
Abstract
We define the antiretroviral efficacy of BIT225 activity in macrophages, which are important drug targets because cells of the monocyte lineage are key reservoirs of HIV-1, disseminating virus to the peripheral tissues as they differentiate into macrophages. In assays with acutely and chronically HI...
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PMID: 19995924
PDF is available here.
PDF is available here.
Journal of General Virology (91)Pt 2 2010
Abstract
We report that Ebola virus VP35 impairs the maturation of mouse DCs. When expressed in mouse immature DCs, Ebola virus VP35 prevents virus-stimulated expression of CD40, CD80, CD86 and major histocompatibility complex class II. Further, it suppresses the induction of cytokines such as interleukin (I...
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PMID: 19828757
PDF is available here.
PDF is available here.
Journal of Virology (84)3 2010
Abstract
We confirm the ability of Vpx to enhance simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) infection of macrophages up to 100-fold by using single-cycle reporter viruses and by pretreatment of the cells with Vpx-containing viruslike particles. Vpx was also active in...
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PMID: 19923175
PDF is available here.
PDF is available here.
Veterinary Research (41)3 2010
Abstract
We used an attenuated Salmonella choleraesuis (C500) vaccine strain, to carry the plasmid that expresses siRNA directed against the polymerase gene 3D (p3D-NT56) of FMDV. We used guinea pigs to evaluate the inhibitory effects of recombinant S. cho (p3D-NT56/S. cho) on FMDV infection. The results sho...
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PMID: 20167192
PDF is available here.
PDF is available here.
Bing du xue bao = Chinese journal of virology / [bian ji, Bing du xue bao bian ji wei yuan hui] (26)1 2010
Abstract
Abstract
We present unbound and dsRNA-bound crystal structures of the dsRNA-binding domain of Reston ebolavirus VP35. The structures show that VP35 forms an unusual, asymmetric dimer on dsRNA binding, with each of the monomers binding dsRNA in a different way: one binds the backbone whereas the other caps th...
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PMID: 20018665
PDF is available here.
PDF is available here.
Abstract
The lambda cI repressor is found to be cleaved in the presence of activated RecA in its DNA-bound dimeric form at a rate similar to that in the absence of operator DNA in contrast to previous studies inferring repressor monomer as a preferred substrate. Though activated RecA does not possess any mea...
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PMID: 19583447
PDF is available here.
PDF is available here.
Abstract
The filoviruses, Ebola virus (EBOV) and Marburg virus (MARV), cause frequently lethal viral hemorrhagic fever. These infections induce potent cytokine production, yet these host responses fail to prevent systemic virus replication. Consistent with this, filoviruses have been found to encode proteins...
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PMID: 19694547
PDF is available here.
PDF is available here.
Abstract
I integral membrane protein. Vpu forms ion conducting homooligomeric assemblies. To assess the energy landscape of an ion traversing the channel or pore single ion potentials of mean force (PMF) are reconstructed from short (1.2 ns) steered molecular dynamics (SMD) simulations using the Langevin equ...
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PMID: 19492858
PDF is available here.
PDF is available here.
Biophysical Journal (97)1 2009
Abstract
We slow down its folding in a cryogenic water-ethylene-glycol solvent (-18 to -28 degrees C). The refolding kinetics are probed by small-angle x-ray scattering, circular dichroism, and fluorescence to measure the radius of gyration, the average secondary structure content, and the native packing aro...
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PMID: 19580767
PDF is available here.
PDF is available here.
Abstract
Virus/Uirusu (59)1 2009
Abstract
We summarize the current knowledge of HIV accessory proteins and their cellular targets, and discuss the functional roles of these biologically unique and important viral proteins for virus replication in vitro and in vivo....
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PMID: 19927991
PDF is available here.
PDF is available here.
Abstract
We characterized the molecular features of pathogenesis associated with HBx in a human liver cell model.
We examined gene expression profiles in L-O2-X cells, an engineered L-O2 cell line that constitutively expresses HBx, relative to L-O2 cells using an Agilent 22 K human 70-mer oli...
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PMID: 19343061
PDF is available here.
PDF is available here.
Abstract
We developed a cell-based assay with a western equine encephalitis virus replicon that expresses a luciferase reporter gene and screened a small molecule diversity library of 51,028 compounds. We identified and validated a thieno[3,2-b]pyrrole compound with a half maximal inhibitory concentration of...
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PMID: 19239364
PDF is available here.
PDF is available here.
Abstract
I propose that the acquisition of vpu may have allowed the viral lineage that gave rise to HIV-1 to evolve towards greater pathogenicity by removing the selective pressure for a protective Nef function that prevents damagingly high levels of immune activation....
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PMID: 19305418
PDF is available here.
PDF is available here.
Abstract
LC-PUFAs are bioactive molecules capable of activating the cellular protective machinery via modulation of endogenous background K+ or KCNK channels. KCNK channel expression contributes significantly to the stability of the cell membrane potential. During HIV-1 infection, degradation of the KCNK cha...
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PMID: 19346195
PDF is available here.
PDF is available here.
Avian Diseases (53)1 2009
Abstract
The effects of chicken anemia virus (CAV) and infectious bursal disease virus (IBDV) coinfection in commercial layer-type and meat-type (broiler) chickens with specific maternal immunity were evaluated. In addition, the broiler progeny used had been vaccinated in ovo against IBDV. Layer chickens wer...
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PMID: 19432010
PDF is available here.
PDF is available here.
Chinese Medical Journal (122)4 2009
Abstract
The peptide derived from Kunitz domain of HBx protein induces HepG2 cell growth arrest and apoptosis, which may result from down-regulation of p97 expression, and decrease of both the ATPase and chymotryptic activities of proteasomes....
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PMID: 19302755
PDF is available here.
PDF is available here.
PLoS Pathogens (5)2 2009
Abstract
We show that positive selection is evident in primate tetherin sequences and that HIV-1 Vpu appears to have specifically adapted to antagonize variants of tetherin found in humans and chimpanzees. Tetherin variants found in rhesus macaques (rh), African green monkeys (agm) and mice were able to inhi...
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PMID: 19214216
PDF is available here.
PDF is available here.
Abstract
3H-TdR incorporation increased significantly in LX-2 cells co-cultured with QSG7701-HBx cells compared to those cultured with QSG7701-pcDNA3 and QSG7701 (non-tumorigenic human liver cell line). Cell cycle results revealed that HBx accelerated the progression of G1 to S in LX-2 cells. The expressions...
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PMID: 19208517
PDF is available here.
PDF is available here.
Abstract
We observed a growth arrest at G1/S-phase that was mediated by destabilization of cyclin D1. The growth arrest was independent of the stability of cdc25A and preceded transcriptional up-regulation of p21(waf1). Cyclin D1 destabilization involved its phosphorylation by GSK-3beta at threonine-286, sin...
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PMID: 19374252
PDF is available here.
PDF is available here.
Xenobiotica (39)2 2009
Abstract
These results demonstrate that HBx inhibits the induction of phase II detoxifying enzymes, which is mediated by its interaction with C/EBPbeta, but not Nrf2, substantiating the specific role of HBx in phase II detoxifying capacity....
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PMID: 19255944
PDF is available here.
PDF is available here.
Abstract
KIPyV and WUPyV show reactivation frequencies comparable to those of BKV and JCV during immunosuppression. TCR changes that potentially lead to transcriptional dysregulation may have pathogenic consequences equivalent in severity to those observed for JCV and BKV....
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PMID: 19090778
PDF is available here.
PDF is available here.
Abstract
A total of 322 SIV nef SIV sequences, collected during the first 3 weeks following experimental infection of two rhesus macaques with the SIVmac239 clone, were analyzed and found to display a comparable level of genetic diversity, 0.015% to 0.052%, with that of env sequences from acute HIV-1 infecti...
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PMID: 19505314
PDF is available here.
PDF is available here.
Abstract
We found that the requirements for the boxB stem length and N peptide linker length were optimized and strict. In contrast, when the boxB/N interaction was replaced by heterologous RNA/peptide interactions, the strict requirement for the length of the peptide linker and the RNA stem was relaxed, pre...
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PMID: 19749275
PDF is available here.
PDF is available here.
Abstract
Out of 22 patients, 4 had desmoplastic tumors while the rest had classical tumors. All children were below the age of 10. Results indicate that while PML tissues showed consistent immunostaining both with antibody to T antigen and agnoprotein antibody, none of the tumors showed any positive staining...
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PMID: 19136778
PDF is available here.
PDF is available here.
Chinese Medical Journal (122)1 2009
Abstract
Numerous effectors of HBx that may promote the development of HCC are identified, of which 7 are newly noted in HepG2 cells. Several of these effectors of HBx may help in elucidating the roles of HBx in hepatocarcinogenesis and diagnostics or targets for therapeutic intervention....
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PMID: 19187611
PDF is available here.
PDF is available here.
Frontiers in Bioscience (Volume)14 2009
Abstract
The CD4+ T-cell malignancy induced by human T-cell leukemia virus type 1 (HTLV-I) infection and termed; Adult T-cell Leukemia lymphoma (ATLL), is caused by defects in the mechanisms underlying cell proliferation and cell death. In the CD4+ T-cells, calcium ions are central for both phenomena. ATLL i...
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PMID: 19273323
PDF is available here.
PDF is available here.
Abstract
We present the state of the art of compounds that target HIV accessory proteins. Most of the research has focused on the inhibition of specific accessory proteins/host cell partner interactions. Promising compounds have been found within different classes of molecules: small natural and synthetic mo...
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PMID: 19149577
PDF is available here.
PDF is available here.
Protein Science (12)5 2009
Abstract
The thermodynamic stabilities of three monomeric variants of the bacteriophage &lgr; Cro repressor that differ only in the sequence of two amino acids at the apex of an engineered &bgr;-hairpin have been determined. The sequences of the turns are EVK-XX-EVK, where the two central residues are DG, GG,...
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PMID: 12717034
PDF is available here.
PDF is available here.
Biophysical Journal (96)2 2009
Abstract
We investigated the binding interaction between the bacteriophage lambda-repressor CI and its target DNA using total internal reflection fluorescence microscopy. Large stepwise changes in the intensity of the red fluorescent protein fused to CI were observed as it associated with and dissociated fro...
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PMID: 19167308
PDF is available here.
PDF is available here.
Abstract
We studied the dynamic features of DNA in vitro evolution in the presence of the Mnt repressor under sequential constant selection pressure. When evolving under a constant pressure from an initial random pool of DNA, our system showed a clear, sharp, and reproducible crossover from a random populati...
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PMID: 19037577
PDF is available here.
PDF is available here.
Cancer Research (68)24 2008
Abstract
Our data are consistent with a model in which HBx expression contributes to liver disease and cancer formation by affecting early steps in liver regeneration....
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PMID: 19074903
PDF is available here.
PDF is available here.
Antiviral Research (80)3 2008
Abstract
There are currently 25 drugs belonging to 6 different inhibitor classes approved for the treatment of human immunodeficiency virus (HIV) infection. However, new anti-HIV agents are still needed to confront the emergence of drug resistance and various adverse effects associated with long-term use of...
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PMID: 18789977
PDF is available here.
PDF is available here.
Abstract
We found that HSP72 formed complex with HBx in human hepatocellular carcinoma cells. The association between HSP72 and HBx in human hepatocellular carcinoma cells may contribute to study the pathogenesis and immunotherapy of hepatocellular carcinoma....
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PMID: 19367718
PDF is available here.
PDF is available here.
Abstract
Partial proteolysis of the lambda cI repressor has been carried out systematically with trypsin, chymotrypsin, elastase, endoproteinase Glu-C, kallikrein, and thrombin. The cleavage sites have been determined by (i) comparison of fragments produced and observed in SDS-polyacrylamide gel with known f...
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PMID: 18808200
PDF is available here.
PDF is available here.
Journal of Bacteriology (190)23 2008
Abstract
We screened libraries in which each nonconserved residue in the RNA-binding domain of P22 N was randomized. Mutants were assayed for the ability to complement N-deficient virus and for antitermination with P22 boxB(left) and boxB(right) reporters. Single amino acid substitutions complementing P22 N(...
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PMID: 18820025
PDF is available here.
PDF is available here.
Journal of Molecular Biology (384)1 2008
Abstract
We test an RNA looping model for this N-dependent "action at a distance" by cleaving the nascent transcript between boxB and RNAP during transcript elongation. Cleavage decreases antitermination, showing that an intact RNA transcript is required to stabilize the interaction of boxB-bound N with RNAP...
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PMID: 18922547
PDF is available here.
PDF is available here.
Journal of Virology (82)24 2008
Abstract
We recently reported that Vpx promoted the accumulation of full-length viral DNA following the infection of human monocyte-derived dendritic cells (DCs). This positive effect was exerted following the infection of DCs with cognate viruses and with retroviruses as divergent as HIV-1, feline immunodef...
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PMID: 18829761
PDF is available here.
PDF is available here.
Veterinary Microbiology (132)1-2 2008
Abstract
Hepatitis E virus (HEV) causes acute hepatitis in humans, and infects several animal species, mostly asymptomatically. Swine and human HEV strains are genetically related suggesting both a zoonotic and a possible foodborne transmission. The prevalence of swine HEV was investigated in 274 randomly se...
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PMID: 18538512
PDF is available here.
PDF is available here.
Journal of Hepatology (49)5 2008
Abstract
The complex mutation involving T1766/A1768 was closely related to HCC. The enhanced risk of HCC caused by BCP variants could be attributable partially to the aberrant activity of HBx....
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PMID: 18801591
PDF is available here.
PDF is available here.
Molecular Microbiology (70)3 2008
Abstract
We found that, unlike these repressors, inactivation of ImmR requires an ICEBs1-encoded anti-repressor ImmA (YdcM). ImmA was needed for the degradation of ImmR in B. subtilis. Coexpression of ImmA and ImmR in Escherichia coli or co-incubation of purified ImmA and ImmR resulted in site-specific cleav...
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PMID: 18761623
PDF is available here.
PDF is available here.
Journal of Medical Virology (80)10 2008
Abstract
I Dun sequence for assay design. Despite the known polymorphism of this gene, 484 VP-1 sequences with conserved areas potentially suitable for PCR assay design are available. Assay targets in the Large T-antigen and agnogene are less subject to genetic variation, but sequence information correspondi...
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PMID: 18712842
PDF is available here.
PDF is available here.
Microbes and Infection (10)12-13 2008
Abstract
We analyzed a series of site-specific vpx-mutants for their growth potentials in lymphocytic cells and compared the results with those in macrophages. We found that amino acid residues important for virus growth in lymphocytic cells, in macrophages, and in both are clustered separately in Vpx. Throu...
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PMID: 18771746
PDF is available here.
PDF is available here.
Journal of Virology (82)19 2008
Abstract
We investigated the mechanism by which the cholesterol-binding compound amphotericin B methyl ester (AME) inhibits human immunodeficiency virus type 1 (HIV-1) particle production. We observed no significant effect of AME on Gag binding to the plasma membrane, Gag association with lipid rafts, or Gag...
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PMID: 18653459
PDF is available here.
PDF is available here.
Biochemistry (Washington) (47)38 2008
Abstract
We present the crystal structure of the TPR domain of human SGT (SGT-TPR), which shows that it contains typical features found in the structures of other TPR domains. Previous studies show that full-length SGT can bind to both Vpu and Gag of human immunodeficiency virus type 1 (HIV-1) and the overex...
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PMID: 18759457
PDF is available here.
PDF is available here.
Journal of Molecular Biology (382)1 2008
Abstract
We report that Id-1 interacts with the Hepatitis-B virus (HBV)-encoded protein HBX and regulates its stability in hepatocellular carcinoma (HCC) cells. We found that in HCC cells, ectopic Id-1 expression significantly decreased the half-life of the HBX protein, indicating that HBX is destabilized by...
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PMID: 18674781
PDF is available here.
PDF is available here.
Abstract
MTT showed that the Ad-XC group cells grew faster than the other group cells. Colony-forming experiment showed that the colony-forming rate for the Ad-XC group cells was significantly higher than that for the other group cells. FCM analysis showed that Ad-XC/Ad-X/Ad-C infection enhanced the progress...
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PMID: 18803352
PDF is available here.
PDF is available here.
Abstract
We show that protein kinase C phosphorylates BKV agnoprotein at serine-11. Replacing serine-11 by either non-phosphorylable alanine or phospho-mimicking aspartic acid reduced the ability of these mutants to propagate compared to wildtype virus. Moreover, both these mutants displayed altered expressi...
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PMID: 18635245
PDF is available here.
PDF is available here.
Journal of General Virology (89)Pt 9 2008
Abstract
Vaccination with live attenuated simian immunodeficiency virus (SIVmacC8) confers potent, reproducible protection against homologous wild-type virus challenge (SIVmacJ5). The ability of SIVmacC8 to confer resistance to superinfection with an uncloned ex vivo derivative of SIVmac251 (SIVmac32H/L28) w...
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PMID: 18753233
PDF is available here.
PDF is available here.
Mutation Research (643)1-2 2008
Abstract
These results support a two-tiered model where RecQ facilitates fork progression through triplex-forming tracts and, failing processivity, RecG is critical for replication fork restart....
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PMID: 18582477
PDF is available here.
PDF is available here.
Abstract
We showed that the Vpu protein from HIV-1 subtype C is more efficiently transported to the cell surface than the well studied subtype B Vpu (Pacyniak et al., 2005) and that a SHIV expressing the subtype C Vpu exhibited a decreased rate of CD4+ T cell loss following inoculation in macaques (Hill et a...
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PMID: 18579178
PDF is available here.
PDF is available here.
Abstract
TAT-HBX-EGFP was highly expression in E. coli; HBX could be induced into mouse liver by TAT. CONCLUSION: HBX protein could be induced into mouse liver by TAT induced peptide....
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PMID: 19105346
PDF is available here.
PDF is available here.
Gene Therapy (16)1 2008
Abstract
We have previously described that the transduction of DCs with wild-type HIV-1-derived vectors can be considerably improved by providing DCs with noninfectious virion-like particles (VLPs) carrying Vpx (Vpx-VLPs), a nonstructural protein coded by members of the SIV(SM)/HIV-2 lineage that removes a s...
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PMID: 18668143
PDF is available here.
PDF is available here.
Abstract
We discuss the mechanisms involved in JCV oncogenesis, briefly review studies that do and do not support a causative role for this virus in human CNS tumors, and identify key issues for future research....
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PMID: 18648329
PDF is available here.
PDF is available here.