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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Viral Regulatory and Accessory Proteins (5):
Recent article
Viral Regulatory and Accessory Proteins
Journal of Virology (82)15 2008
Abstract
We generated a series of site-specific point mutants of vpx and examined their phenotypes. The resultant five mutants, with no infectivity for MDMs, showed, without exception, the same defect as the vpx-defective mutant. Our results here clearly demonstrated that the entire Vpx protein is critical f...
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PMID: 18495778
PDF is available here.
PDF is available here.
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Abstract
The NF-kappaB signaling pathway of L02-HBx cells was activated after transfection with HBx gene as compared to the control L02 cells without treatment. The mRNA and protein levels of VEGF in L02-HBx cells increased 4.07 +/- 0.31 and 4.34 +/- 0.64 times respectively. The difference was of statistical...
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PMID: 19094539
PDF is available here.
PDF is available here.
Abstract
We cloned nef alleles from 11 SIVsmm-infected SMs with high (>500) and 15 animals with low (<500) CD4+ T-cells/microl in bulk into proviral HIV-1 IRES/eGFP constructs and analyzed their effects on the phenotype, activation, and apoptosis of primary T cells. We found that not only efficient Nef-media...
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PMID: 18636106
PDF is available here.
PDF is available here.
Microbes and Infection (10)9 2008
Abstract
Vpu is an accessory viral protein almost unique to HIV-1 among primate immunodeficiency viruses, and has two major functions: degradation of the CD4 molecule in endoplasmic reticulum and enhancement of virion release from cells. Recent identification of a novel host restriction factor, tetherin, as...
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PMID: 18672082
PDF is available here.
PDF is available here.
Abstract
We investigated structural consequences of phosphorylation of the two serines using nuclear magnetic resonance spectroscopy. A uniformly 15N and 13C stable isotope-labeled 45-residue peptide comprising the cytoplasmic domain of VpU (VpUcyt) was recombinantly produced in E .coli. The peptide forms tw...
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PMID: 18186541
PDF is available here.
PDF is available here.
Journal of Bacteriology (190)13 2008
Abstract
We produced E. coli K-12 strains carrying either one Stx2 prophage or two different Stx2 prophages. We used recombinant phages in which an antibiotic resistance gene (aph, cat, or tet) was incorporated in the middle of the Shiga toxin operon. Shiga toxin was quantified by immunoassay and by cytotoxi...
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PMID: 18469095
PDF is available here.
PDF is available here.
Journal of Virology (82)13 2008
Abstract
We show that two domains of this protein determine this aberrant migration and that this region mediates its incorporation into virions. These regions, amino acids 439 to 492 and amino acids 589 to 739, alter the mobility of Ebola virus NP by sodium dodecyl sulfate-polyacrylamide gel electrophoresis...
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PMID: 18417588
PDF is available here.
PDF is available here.
Abstract
Abstract
We have now investigated whether agnoprotein phosphorylation is regulated by PP2A, a serine/threonine-specific protein phosphatase and whether JCV small t antigen (Sm t-Ag) is involved in this regulation. Protein-protein interaction studies demonstrated that PP2A associates with agnoprotein and deph...
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PMID: 18353419
PDF is available here.
PDF is available here.
HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
Abstract
A universal cellular defense mechanism against viral invasion is the elimination of infected cells through apoptotic cell death. To counteract host defenses many viruses have evolved complex apoptosis evasion strategies. The oncogenic human retrovirus HTLV-1 is the etiological agent of adult-T-cell...
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PMID: 18421579
PDF is available here.
PDF is available here.
Nature Medicine (14)6 2008
Abstract
We identify calcium-modulating cyclophilin ligand (CAML) as a Vpu-interacting host factor that restricts HIV-1 release. Expression of human CAML (encoded by CAMLG) in AGM cells conferred a strong restriction of virus release that was reversed by Vpu and HIV-2 Env, suggesting that CAML is the mechani...
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PMID: 18500349
PDF is available here.
PDF is available here.
Abstract
The X gene of HBV encodes a 17-kD protein, termed HBx, which has been shown to function as a transcriptional trans-activator of a variety of viral and cellular promoter/enhancer elements. The aim of this study was to investigate the effect of HBx on gene expression of interleukin (IL)-1 and IL-6, an...
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PMID: 18563316
PDF is available here.
PDF is available here.
Neuropathology (28)3 2008
Abstract
We have tried to create an animal model that replaces an in vivo JCV infection. As a result, we have obtained a stable persistence of JCV-infected human cells in the mouse brain by inoculating the virus-infected cells into the nude mice brains. In this model, the JCV-infected cells were well preserv...
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PMID: 18179406
PDF is available here.
PDF is available here.
Abstract
We present evidence that accessory proteins are subjected to positive selective forces exclusively in HIV. This scenario suggests that accessory protein genes are under adaptive evolution in HIV clades, while in SIVcpz such a phenomenon could not be detected. As a result, we show that comparative st...
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PMID: 18465165
PDF is available here.
PDF is available here.
Journal of General Virology (89)Pt 6 2008
Abstract
The Borna disease virus (BDV) proteins X and P are translated from a bicistronic viral mRNA. Here, it was shown that the rescue of recombinant BDV from cDNA was enhanced approximately eightfold if reconstitution of the viral polymerase complex was performed with an expression vector encoding X and P...
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PMID: 18474560
PDF is available here.
PDF is available here.
Journal of Virology (82)11 2008
Abstract
We used two precisely defined reverse genetics-generated Ebola viruses to investigate global host cell responses resulting from the inhibition of IRF-3 phosphorylation. The two viruses encoded either wild-type (WT) VP35 protein (recEbo-VP35/WT) or VP35 with an arginine (R)-to-alanine (A) amino acid...
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PMID: 18353943
PDF is available here.
PDF is available here.
Journal of Virology (82)11 2008
Abstract
We serendipitously observed that standard intracellular cytokine assays on fresh whole blood from a cohort of 26 HIV-infected subjects identified non-T lymphocytes expressing gamma interferon (IFN-gamma) in response to overlapping linear peptides spanning HIV-1 proteins. The effector cells were CD3(...
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PMID: 18353957
PDF is available here.
PDF is available here.
Abstract
We found that synthetic peptides containing mutations in SIV Gag CM9 and Tat SL8 were no longer recognized by the respective CTL. On the other hand, the described I-to-T replacement at the N-terminal amino acid residue of the SIV Nef IW9 epitope only moderately affected CTL recognition of the varian...
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PMID: 18328525
PDF is available here.
PDF is available here.
Journal of the Neurological Sciences (268)1-2 2008
Abstract
We report progressive multifocal leukoencephalopathy (PML) and CD4+ T-lymphocytopenia in a 71-year-old man with Sjögren syndrome (SjS). The patient was admitted to our hospital because of progressive dementia and gait disturbance. T2-weighted MR images showed high-intensity lesions in his left fr...
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PMID: 18234228
PDF is available here.
PDF is available here.
Cellular Microbiology (10)5 2008
Abstract
We investigated whether Vpu affects the subcellular distribution of Env as well as Gag. Env and Vpu colocalized with each other, in part within the trans-Golgi network. In the absence of Vpu, Env accumulated more extensively within clathrin-coated endosomal structures. These structures had several f...
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PMID: 18076669
PDF is available here.
PDF is available here.
PLoS Pathogens (4)5 2008
Abstract
We have found that Vpx protein of the pathogenic SIVmac 239 strain associates with a ternary protein complex comprising DDB1 and VprBP subunits of Cullin 4-based E3 ubiquitin ligase, and DDA1, which has been implicated in the regulation of E3 catalytic activity, and that Vpx participates in the Cull...
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PMID: 18464893
PDF is available here.
PDF is available here.
Protein Science (17)5 2008
Abstract
We report the structure of the Cro protein from Enterobacteria phage N15 at 1.05 A resolution. The subunit fold contains five alpha-helices and is closely similar to the structure of P22 Cro (1.3 A backbone room mean square difference over 52 residues), but quite different from that of lambda Cro, a...
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PMID: 18369196
PDF is available here.
PDF is available here.
Biophysical Journal (94)9 2008
Abstract
We show that these two modes of upregulation have very different effects on the promoter function. We predict that if CI(2) bound to O(R)2 produced equal increase in RNAP-DNA binding constant (compared to wild-type increase in the closed-open transition probability), the lysogen would be significant...
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PMID: 18400951
PDF is available here.
PDF is available here.
Journal of Virology (82)9 2008
Abstract
We show that in infected cells, ICP22 and U(S)3 protein kinase mediate the phosphorylation of cdc25C at its C-terminal domain. In in vitro assays with purified components, both U(L)13 and U(S)3 viral kinases phosphorylate cdc25C and ICP22. cdc25C also interacts with cdc2. However, in infected cells,...
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PMID: 18272572
PDF is available here.
PDF is available here.
Journal of Virology (82)9 2008
Abstract
We probed some features of the ICP22-dependent pathway of upregulation of gamma(2) genes in cdc25C(-/-) cells and in cdc25C(+/+) cells derived from sibling mice. We report that cyclin B1 turned over in cdc25C(+/+) or cdc25C(-/-) cells at the same rate, that cdc2 increased in amount, and that U(S)11...
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PMID: 18272575
PDF is available here.
PDF is available here.