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Viral Proteins (5):
Recent article
Viral Proteins
Cancer Cell (19)6 2011
Abstract
We explored whether KSHV oncogenes deploy cell type-specific signaling pathways activating mTOR, which could be exploited to halt KS development while minimizing immune suppressive effects. We found that PI3Kγ, a PI3K isoform exhibiting restricted tissue distribution, is strictly required for signa...
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PMID: 21665152
PDF is available here.
PDF is available here.
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Abstract
We report here the first comprehensive HCV customized biomedical text-mining based online web resource, dragon exploratory system on hepatitis C virus (DESHCV), a biomedical text-mining and relationship exploring knowledge base was developed by exploring literature on HCV. The pre-compiled dictionar...
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PMID: 21194573
PDF is available here.
PDF is available here.
Abstract
We were not able to determine serum stability; the peptide consisting of 36 amino acid residues is subject to cleavage by endopetidases. Three of the homologated compounds, 2b, 2c, and 5c, were shown to be agonists (Fig. 7 and 11). A comparison of terminal homologation with other stability-increas...
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PMID: 21560227
PDF is available here.
PDF is available here.
Metallomics (3)5 2011
Abstract
Although the proteome and genome of bacteriophages are well developed, there is little knowledge about metals and their interactions with the phages, even though metals have been observed in stabilizing phage particles. With expanding studies of phage display and its promising applic...
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PMID: 21423961
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
We recently showed that isolated replication complexes are able to synthesize two species of nascent viral RNA, one double stranded and the other single stranded. NS5B nucleoside inhibitors block synthesis of both species, whereas nonnucleoside inhibitors inhibit mostly single- tranded RNA synthesis...
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PMID: 19009261
PDF is available here.
PDF is available here.
Poultry Science (90)5 2011
Abstract
Effect of dietary lutein supplementation on turkey production parameters, cytokine production, and oxidative status during an acute phase response following lipopolysaccharide (LPS) injection was studied. One-day-old chicks were fed a basal diet supplemented with 3 levels (0, 25, or 50 mg/kg of feed)...
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PMID: 21489941
PDF is available here.
PDF is available here.
Virology Journal (8)1 2011
Abstract
Our results demonstrated that siRNAs directed against HCV core gene showed 70% reduction in viral titer in HCV infected liver cells. Moreover, siRNAs against E1 and E2 envelop genes showed a dramatic reduction in HCV viral RNA, E2si 86 exhibited 93% inhibition, while E1si 192, E2si 493 and E1si 52 s...
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PMID: 21535893
PDF is available here.
PDF is available here.
Abstract
We tested whether, during different phases of HBV infection, virus-specific T cells can acquire specific proinflammatory functions that could drive granulocyte/mononuclear cell liver infiltration. Multifunctional analysis of HBV-specific T cells during acute and chronic HBV infection revealed that H...
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PMID: 21876747
PDF is available here.
PDF is available here.
Virology Journal (8)1 2011
Abstract
We found that siRNAs against HCV NS2- NS5B efficiently inhibit HCV replication in Huh-7 cells. Our results demonstrated that siRNAs directed against HCV NS3 (NS3si-229 and NS3si-858) showed 58% and 88% reduction in viral titer respectively. Moreover, NS4Bsi-166 and NS5Bsi-1064 exhibited a dramatic r...
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PMID: 21388559
PDF is available here.
PDF is available here.
Virology Journal (8)1 2011
Abstract
We studied the relationship between V protein variants and IFN-α2b-induced apoptosis. V proteins decrease activation of the extrinsic IFN-α2b-induced apoptotic pathway monitored by the caspase 8 activity, being the effect greater with the VWT protein. Both V proteins decrease the activity of caspa...
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PMID: 21569530
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)52 2010
Abstract
We obtained new results, which led us to propose a novel model for the initiation of viral RNA (vRNA) replication. In our study, we analyzed the initiation mechanisms of influenza virus vRNA and complementary RNA (cRNA) synthesis in vitro, using purified RNA polymerase (RdRp) and 84-nt model RNA tem...
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PMID: 20858902
PDF is available here.
PDF is available here.
Abstract
We validated the availability of this system using a known anti-flavivirus gene, mouse oligoadenylate synthetase 1b (Oas1b). The Oas1b-transfected cells were more resistant to repWNV/SEAP replication than the original cells. Thus, this system not only affords a useful tool for identification/evaluat...
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PMID: 21187681
PDF is available here.
PDF is available here.
Abstract
We have shown previously that immunoglobulin fragment-fused GLP-1 (GLP-1/Fc) is a structurally stable GLP-1 analog. Here, we report a non-viral GLP-1/Fc gene therapy strategy utilizing a REP78-in-trans and REB-in-cis element system to achieve a site-specific genomic integration. For this purpose, th...
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PMID: 21070745
PDF is available here.
PDF is available here.
Abstract
Abstract
Influenza surveillance was implemented in Kolkata, eastern India in 2005 to identify the circulating subtypes and characterize their genetic diversity. Throat and nasal swabs were collected from outpatients with influenza-like illness (ILI). Of 2844 ILI cases identified at two referr...
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PMID: 20678590
PDF is available here.
PDF is available here.
Amplification of unknown RNAs and RNA mixtures based on unique restriction enzyme cleavage in vitro.
Abstract
We have developed a novel method to amplify target RNA. The amplification procedure was carried out by sequential RT-PCR, effective separation, restriction enzymatic cleavage of cDNA strand, and run-off transcription in vitro of target RNA from its cDNA. Introduction of a unique stem-loop linker int...
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PMID: 21106769
PDF is available here.
PDF is available here.
Abstract
We developed a candidate orthopoxvirus DNA-based vaccine, termed 4pox, which targets four viral structural components, A33, B5, A27, and L1. While this vaccine protects mice and nonhuman primates from lethal infections, we are interested in further enhancing its potency. One approach to enhance pote...
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PMID: 20844086
PDF is available here.
PDF is available here.
Abstract
We developed a candidate orthopoxvirus DNA-based vaccine, termed 4pox, which targets four viral structural components, A33, B5, A27, and L1. While this vaccine protects mice and nonhuman primates from lethal infections, we are interested in further enhancing its potency. One approach to enhance pote...
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PMID: 20844086
PDF is available here.
PDF is available here.
Abstract
These results illustrate the great progress that has been made in the HCV field and how this knowledge can be used to devise innovative strategies to counteract this pathogen.
© Thieme Medical Publishers....
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PMID: 20960374
PDF is available here.
PDF is available here.
Hepatology (52)5 2010
Abstract
We therefore analyzed the relationship between NS3/4A and TNFα. Wild-type and NS3/4A-transgenic (Tg) mice were treated with TNFα/D-galactosamine (D-galN), acting through the TNF receptor 1 on hepatocytes and macrophages, or lipopolysaccharide (LPS)/D-galN, acting through Toll-like receptor 4 on si...
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PMID: 20886569
PDF is available here.
PDF is available here.
Abstract
We created transgenic mice (VS28 mice) in which US28 expression was targeted to IECs. Expression of US28 was detected in all IECs of the small and large intestine, including in cells expressing leucine rich repeat containing GPCR5 (Lgr5), a marker gene of intestinal epithelial stem cells. US28 expre...
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PMID: 20978345
PDF is available here.
PDF is available here.
Abstract
We use a method called discrete chemical master equation (dCME) to compute directly the full steady-state probability landscape of the lysogeny maintenance network in phage lambda from its CME. Results show that wild-type phage lambda can maintain a constant level of repressor over a wide range of r...
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PMID: 20937911
PDF is available here.
PDF is available here.
Abstract
We demonstrate that dimeric vSET operates with negative cooperativity between the two active sites and engages in H3K27 methylation one site at a time. New atomic structures of vSET in the free form and a ternary complex with S-adenosyl homocysteine and a histone H3 peptide and biochemical analyses...
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PMID: 20937900
PDF is available here.
PDF is available here.
Abstract
β-Turns are secondary structure elements not only exposed on protein surfaces, but also frequently found to be buried in protein-protein interfaces. Protein engineering so far considered mainly the backbone-constraining properties of synthetic β-turn mimics as parts of surface-exposed loops. A β-...
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PMID: 20937907
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)43 2010
Abstract
We present here the first structural study of the Cpl-7 endolysin, encoded by pneumococcal bacteriophage Cp-7. It contains an N-terminal catalytic module (CM) belonging to the GH25 family of glycosyl hydrolases and a C-terminal region encompassing three identical repeats of 42 amino acids (CW_7 repe...
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PMID: 20720016
PDF is available here.
PDF is available here.
Abstract
Little is known about whether neuraminidase inhibitors are effective for children infected with oseltamivir-resistant influenza A(H1N1) viruses.
Children aged 15 years and younger having influenza-like illness and who visited outpatient clinics within 48 hours of fever onset were enrolled from 2006-...
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PMID: 20442686
PDF is available here.
PDF is available here.
Abstract
We showed that MDV pUL49.5 down-regulates MHC class I directly and identified its cytoplasmic tail as essential for this function. In vivo, viruses lacking the cytoplasmic tail of pUL49.5 showed no differences in MD pathogenesis compared to revertant viruses in highly susceptible chickens of the B(1...
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PMID: 20637486
PDF is available here.
PDF is available here.
Abstract
We evaluated the role of gE-2 in the virus lifecycle by deleting amino acids 124-495 (gE2-del virus). In the mouse retina infection model, gE2-del virus does not spread to nuclei in the brain, indicating a defect in anterograde (pre-synaptic to post-synaptic neurons) and retrograde (post-synaptic to...
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PMID: 20598729
PDF is available here.
PDF is available here.
Abstract
We show that the replication-associated proteins (Rep: a rolling-circle replication initiator protein) encoded by these alphasatellites interact with the Rep and C4 proteins encoded by their helper begomovirus, Cotton leaf curl Rajasthan virus (CLCuRaV), in a yeast two-hybrid assay. Both the alphasa...
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PMID: 20598726
PDF is available here.
PDF is available here.
Abstract
We characterized the functional domains of BFV BTas. BTas contains two major functional domains: the N-terminal DNA-binding domain (residues 1-133) and the C-terminal activation domain (residues 198-249). The complete BTas responsive regions were mapped to the positions -380/-140 of LTR and 9205/927...
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PMID: 20615521
PDF is available here.
PDF is available here.
Abstract
We analyzed four amino acid residues within domain VI of the Sendai virus L protein and our data indicated that there could be differences in L protein sequence requirements for cap methylation in two different families of Mononegavirales - rhabdoviruses and paramyxoviruses. In this study, we conduc...
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PMID: 20609457
PDF is available here.
PDF is available here.
Abstract
We investigated the importance of the YLDL motif for SeV budding. Virus budding of an M-deficient SeV was not rescued by transient expression of motif mutants, M-A2 (ALDA) and M-A4 (AAAA), and viruses possessing those mutations hardly propagated in cultured cells. However, a budding-competent revert...
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PMID: 20605035
PDF is available here.
PDF is available here.
Abstract
We report the second identification of SRV-4 and its complete genome from infected cynomolgus macaques with Indochinese and Indonesian/Indochinese mixed ancestry. Phylogenetic analysis demonstrated that SRV-4 was distantly related to SRV-1, 2, 3, 5, 6 and 7. SRV/D-T, a new SRV/D recovered in 2005 fr...
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PMID: 20615522
PDF is available here.
PDF is available here.
Biochemical Journal (431)2 2010
Abstract
These results reiterate the unique features of this group of kinases and present an opportunity for designing more specific antiviral compounds....
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PMID: 20704565
PDF is available here.
PDF is available here.
Abstract
To determine the genetic diversity of group A rotaviruses in bovine calves in Kashmir, India.
Of 200 diarrhoeic faecal samples collected from calves, aged between 0 and 6 months and screened by polyacrylamide gel electrophoresis (PAGE), 31 were detected positive for group A rotaviruses. On G and P g...
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PMID: 20875036
PDF is available here.
PDF is available here.
Kidney International (78)10 2010
Abstract
Mucosal Immunology (3)5 2010
Abstract
We produced mucosal vaccine vectors by HPV PsV encapsidation of DNA plasmids expressing an experimental antigen derived from the M and M2 proteins of respiratory syncytial virus (RSV). Intravaginal (IVag) delivery elicited local and systemic M-M2-specific CD8+ T-cell and antibody responses in mice t...
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PMID: 20555315
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to evaluate a fast and simple bead-based method using paramagnetic beads covered with recombinant Listeria phage endolysin-derived cell-wall-binding domain proteins specific for Listeria spp. for separation of the foodborne pathogen Listeria monocytogenes fr...
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PMID: 20500083
PDF is available here.
PDF is available here.
ISME Journal (4)9 2010
Abstract
We show that in cyanophage S-PM2, this intron is spliced during the entire infection cycle. Furthermore, we report the widespread occurrence of psbA introns in marine metagenomic libraries, and with psbA often adjacent to a homing endonuclease (HE). Bioinformatic analysis of the intergenic region be...
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PMID: 20410936
PDF is available here.
PDF is available here.
Abstract
We constructed and characterized a mutant virus (Δ41). In the absence of vhs activity, Δ41 mutant is highly attenuated in mice model and the lethality is correlated with the virus dissemination in neural tissues. As with herpes simplex virus type 1 (HSV-1), the prototype virus of alphaherpesvirus,...
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PMID: 20448414
PDF is available here.
PDF is available here.
Abstract
Our long-term goal is to develop a vaccine/therapy to induce highly crossreactive anti-influenza immunity, which may lead to the establishment of an ultimate strategy for the control of influenza....
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PMID: 20845738
PDF is available here.
PDF is available here.
Abstract
Abstract
We review our current molecular knowledge of transmissibility and pathogenicity of influenza viruses and discuss the future aspects of the pandemic virus....
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PMID: 20845737
PDF is available here.
PDF is available here.
Abstract
We designed three different expression plasmids encoding the HN protein targeted to different subcellular compartments: cytoplasmic (Cy-HN), secreted (Sc-HN) and membrane-anchored (M-HN). On the basis of antitumor effect in vitro, the aim of this study is to investigate the anti-tumor immunity effec...
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PMID: 20704816
PDF is available here.
PDF is available here.
Genes & Development (24)16 2010
Abstract
We report the identification of related proteins that individually (Ligatin) or together (the oncogene MCT-1 and DENR, which are homologous to N-terminal and C-terminal regions of Ligatin, respectively) promote efficient eIF2-independent recruitment of Met-tRNA(Met)(i) to 40S/mRNA complexes, if atta...
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PMID: 20713520
PDF is available here.
PDF is available here.
Abstract
We report molecular dynamics (MD) simulations of calcium-bound and calcium-free N1 complexes with the inhibitor oseltamivir (marketed as the drug Tamiflu), independently using both the AMBER FF99SB and GROMOS96 force fields, to give structural insight into calcium stabilization of key framework resi...
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PMID: 20602360
PDF is available here.
PDF is available here.
Abstract
We investigated the role of autophagy on hepatitis C virus (HCV) RNA replication and demonstrated anti-HCV effects of an autophagic proteolysis inhibitor, chloroquine.
Induction of autophagy was evaluated following the transfection of HCV replicon to Huh-7 cells. Next, we investigate...
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PMID: 19760134
PDF is available here.
PDF is available here.
Abstract
A proteomic approach was used to investigate the dynamic cellular host cell response induced by influenza virus infection in two different vaccine production cell lines, MDCK and Vero. For identification of proteins possibly involved in global host cell response mechanisms and virus-host cell intera...
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PMID: 20435171
PDF is available here.
PDF is available here.
Abstract
Epstein-Barr virus (EBV) open reading frame BILF1 encodes a seven trans-membrane (TM) G protein-coupled receptor that signals with high constitutive activity through Galpha(i) (Beisser et al., 2005; Paulsen et al., 2005). In this paper, the transforming potential of BILF1 is investigated in vitro in...
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PMID: 20543866
PDF is available here.
PDF is available here.
Biophysical Journal (99)4 2010
Abstract
We hypothesize that tightly looping DNA is alone sufficient to repress transcription. To test this hypothesis, we have developed an assay to quantify transcription elongation by bacteriophage T7 RNAP on small, circular DNA templates approximately 100 bp in size. From these highly bent transcription...
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PMID: 20712997
PDF is available here.
PDF is available here.
Abstract
We verified the importance of pseudoknot base pairings for IRES-mediated translation and, using 35 mutants, conducted a comprehensive study of the structural tolerance and functional contributions of the pseudoknot. Ribosomal toeprinting experiments show that the entirety of the pseudoknot element p...
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PMID: 20584896
PDF is available here.
PDF is available here.
Abstract
We previously confirmed that they conferred GCV resistance to recombinant baculoviruses (Nakano et al., J. Virol. Methods 161:223-230, 2009). Six characterized mutations, including a previously reported one that encodes a GCV-sensitive kinase-activity mutant (Isegawa et al., J. Clin. Virol. 44:15-19...
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PMID: 20083192
PDF is available here.
PDF is available here.
Virus Research (151)2 2010
Abstract
We report the newly characterized molecular properties of WhNV subgenomic RNA3 and its encoded protein B2. We have successfully multiplied WhNV in the natural host Pieris rapae larvae under laboratory conditions. WhNV replication in the host cells resulted in the expression of viral proteins, ProA,...
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PMID: 20441781
PDF is available here.
PDF is available here.
Virus Research (151)2 2010
Abstract
We performed a yeast-2-hybrid screen to identify cellular proteins that interact with EIAV S2. The screen identified two human cellular proteins, amplified in osteosarcoma (OS-9) and proteasome 26S ATPase subunit 3 (PSMC3) that interact with S2. The equine homologues of these proteins were cloned an...
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PMID: 20417672
PDF is available here.
PDF is available here.
Virus Research (151)2 2010
Abstract
I and some group II NPVs. bm60 encodes a late expressed protein that localizes to both the cytoplasm and nucleus of infected cells. This paper describes the characterization of a BmNPV mutant (vbm60-Null) lacking functional bm60. It was observed that the production of budded virus (BV) was reduced b...
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PMID: 20576538
PDF is available here.
PDF is available here.
Virus Research (151)2 2010
Abstract
Hantaviral N and Gn proteins were shown to interact, thus providing the long-awaited evidence for one of the crucial steps in the virus replication at which RNPs are directed to the site of the virus assembly. Using pull-down assay and point mutagenesis it was demonstrated that intact, properly fold...
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PMID: 20566401
PDF is available here.
PDF is available here.
Virus Research (151)2 2010
Abstract
Grapevine leafroll-associated virus 3 (GLRaV-3) is a positive sense, single stranded RNA virus that has a detrimental effect on wine and table grapes worldwide. Previous studies have shown that GLRaV-3, like other closteroviruses produces subgenomic (sg) RNAs during replication and that these sgRNAs...
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PMID: 20561952
PDF is available here.
PDF is available here.
Abstract
Wild type T4 bacteriophage and recombinant T4 bacteriophages displaying biotin binding peptide (BCCP) and cellulose binding module (CBM) on their heads were immobilized on nano-aluminum fiber-based filter (Disruptor), streptavidin magnetic beads and microcrystalline cellulose, respectively. Infectiv...
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PMID: 20561957
PDF is available here.
PDF is available here.
Journal of General Virology (91)Pt 8 2010
Abstract
We undertook a high-resolution analysis of the reassortment of internal genes and evolution of HA of 651 avian H5N1 viruses from 2000 to 2008. Our analysis suggested: (i) all current H5N1 genotypes were derived from a single, clearly defined sequence of initial reassortment events; (ii) reassortment...
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PMID: 20392897
PDF is available here.
PDF is available here.
Journal of General Virology (91)Pt 8 2010
Abstract
We further examined the death mechanisms induced in epithelial cell lines following rotavirus infection or inactivated rotavirus exposure. Monolayer integrity changes in MA104, HT-29 and partially differentiated Caco-2 cells following inactivated rotavirus exposure or RRV or CRW-8 rotavirus infectio...
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PMID: 20392902
PDF is available here.
PDF is available here.