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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Viral Proteins (5):
Recent article
Viral Proteins
Journal of General Virology (91)Pt 8 2010
Abstract
We observed that UL114 was much less abundant than UL44. Interaction of UL114 with UL54, independent of the UL54 carboxyl terminus, but not with UL44 was detected in vitro. Our data are consistent with a direct UL114-UL54 interaction, and suggest that UL114 and UL54 act in concert during base excisi...
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PMID: 20410316
PDF is available here.
PDF is available here.
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Journal of General Virology (91)Pt 8 2010
Abstract
Recent studies have shown that long-term persistence of human cytomegalovirus (HCMV) in mononuclear cells of myeloid lineage is dependent on the UL138 open reading frame, which promotes latent infection. Although T-cell recognition of protein antigens from all stages of lytic HCMV infection is well...
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PMID: 20375220
PDF is available here.
PDF is available here.
Journal of General Virology (91)Pt 8 2010
Abstract
We now show that HCMV targets CD112 for proteasome-mediated degradation by 48 h post-infection, thus removing both activating ligands for DNAM-1 from the cell surface during productive infection. Significantly, cell surface expression of both CD112 and CD155 was restored when UL141 was deleted from...
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PMID: 20410314
PDF is available here.
PDF is available here.
Journal of General Virology (91)Pt 8 2010
Abstract
Equine herpesvirus type 1 (EHV-1) is the causative agent of equine herpes myeloencephalopathy, of which outbreaks are reported with increasing frequency throughout North America and Europe. This has resulted in its classification as a potentially emerging disease by the US Department of Agriculture....
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PMID: 20427565
PDF is available here.
PDF is available here.
Journal of Virology (84)16 2010
Abstract
We introduced a blasticidin (Bsd) resistance gene into the virus genome and selected variants that grew at high concentrations of Bsd. The mutants grew fast and had increased rates of RNA replication and translation but did not produce significantly higher virus yields. Nucleotide sequence analysis...
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PMID: 20534860
PDF is available here.
PDF is available here.
Journal of Virology (84)16 2010
Abstract
We generated recombinant human A/Vietnam/1203/04 (VN; clade 1) and A/Turkey/15/06 (TK; clade 2.2) influenza viruses containing the H274Y neuraminidase (NA) mutation, which confers resistance to NA inhibitors, and compared the fitness levels of the wild-type (WT) and resistant virus pairs in ferrets....
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PMID: 20519385
PDF is available here.
PDF is available here.
Journal of Virology (84)16 2010
Abstract
I interferon (IFN) response plays an essential role in the control of in vivo infection by the coronavirus mouse hepatitis virus (MHV). However, in vitro, most strains of MHV are largely resistant to the action of this cytokine, suggesting that MHV encodes one or more functions that antagonize or ev...
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PMID: 20519394
PDF is available here.
PDF is available here.
Journal of Virology (84)16 2010
Abstract
Retroviral integrases associate during the early viral life cycle with preintegration complexes that catalyze the integration of reverse-transcribed viral cDNA into the host chromosomes. Several cellular and viral proteins have been reported to be incorporated in the preintegration complex. This stu...
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PMID: 20519390
PDF is available here.
PDF is available here.
Journal of Virology (84)16 2010
Abstract
We successfully generated an influenza virus that contained the genes coding for both the H1 hemagglutinin (HA) from A/PR/8/34 and the H3 HA from A/Hong Kong/1/68 (A/HK/1/68); both subtypes of HA protein were also incorporated into the viral envelope. Immunization of mice with this recombinant virus...
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PMID: 20519387
PDF is available here.
PDF is available here.
Journal of Virology (84)16 2010
Abstract
We examined here how the GII/4 virus evolves to generate and sustain new epidemics in humans, using 199 near-full-length GII/4 genome sequences and 11 genome segment clones from human stool specimens collected at 19 sites in Japan between May 2006 and February 2009. Phylogenetic studies demonstrated...
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PMID: 20534859
PDF is available here.
PDF is available here.
Journal of Virology (84)16 2010
Abstract
We investigated the role of an SH3 domain binding site centered on a PPLP motif in K15. We screened libraries of cellular SH3 domains to identify signaling molecules interacting with the KSHV PPLP motif. We found its affinities for two Src kinase family members, Lyn and Hck, to exceed those of other...
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PMID: 20534855
PDF is available here.
PDF is available here.
Journal of Virology (84)16 2010
Abstract
We report that EV71 suppresses the induction of antiviral immunity by targeting the cytosolic receptor retinoid acid-inducible gene I (RIG-I). In infected cells, EV71 inhibits the expression of IFN-beta, IFN-stimulated gene 54 (ISG54), ISG56, and tumor necrosis factor alpha. Among structural and non...
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PMID: 20519382
PDF is available here.
PDF is available here.
Journal of Virology (84)16 2010
Abstract
We employed a lentivirus-based RNA interference (RNAi) screening approach to search for possible cellular factors. By using a kinase-phosphatase RNAi library and an HCV replicon reporter system, we identified a serine-threonine kinase, Polo-like kinase 1 (Plk1), as a potential host factor regulating...
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PMID: 20534861
PDF is available here.
PDF is available here.
Cell Host & Microbe (8)1 2010
Abstract
RNA-based viral immunity (RVI) operates in fungi, plants, and invertebrates to specifically destroy viral RNAs using the cellular RNA interference machinery. Discovery of diverse viral proteins as suppressors of RNA silencing provides strong validation for the effectiveness of RVI. H...
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PMID: 20638637
PDF is available here.
PDF is available here.
Abstract
We attribute this UV(254) induced protein scission, which is nearly unprecedented in the literature, to a close association between the affected residues and viral RNA, an efficient UV(254) absorber. These results suggest that viral protein oxidation by UV(254) and (1)O(2) may play a role in virus i...
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PMID: 20553020
PDF is available here.
PDF is available here.
Abstract
Enzymatic removal of the sialic acid moiety of HPIV receptors inhibits infection with all tested HPIV strains, both in vitro and in cotton rats. Enzyme-mediated removal of sialic acid receptors represents a novel antiviral strategy for HPIV. The results of this study raise the possibility of a broad...
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PMID: 20533871
PDF is available here.
PDF is available here.
Abstract
We carried out lead optimization and structure-activity studies to provide a series of improved inhibitors that show potent PLpro inhibition and antiviral activity against SARS-CoV infected Vero E6 cells. Interestingly, the (S)-Me inhibitor 15 h (enzyme IC(50) = 0.56 microM; antiviral EC(50) = 9.1 m...
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PMID: 20527968
PDF is available here.
PDF is available here.
Scientific American (303)1 2010
Abstract
Trends in Microbiology (18)7 2010
Abstract
We focus on the importance of N-linked glycan processing in infectious virion morphogenesis.
Copyright 2010 Elsevier Ltd. All rights reserved....
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PMID: 20452219
PDF is available here.
PDF is available here.
Protein Science (19)7 2010
Abstract
We report here the gp22 structure solved by X-ray crystallography at 2.35 A resolution. We found that gp22 is a monomer in solution and possesses a significant structural similarity with lactococcal phage p2 ORF 18 N-terminal "shoulder" domain....
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PMID: 20506290
PDF is available here.
PDF is available here.
Virus Research (151)1 2010
Abstract
We focus on the function of orf390 gene. Stable expression of orf390 prevented SF9 insect cells from undergoing actinomycin D-induced apoptosis. ORF390 also rescued the replication of a p35-deficient-mutant (AcMNPVDeltap35k/pol+) in SF9 cells. In addition, ORF390 inhibits the activities of caspase-3...
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PMID: 20362018
PDF is available here.
PDF is available here.
Abstract
Previous studies suggested that helicase-primase inhibitor (HPI) resistance mutations can be selected at relatively high frequency from some isolates of herpes simplex virus type 1 (HSV-1). An intentional mismatch primer (IMP) PCR was developed to detect three known HPI resistance mu...
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PMID: 20453068
PDF is available here.
PDF is available here.
Abstract
We evaluated the effectiveness of NIs in reducing influenza complications and mortality of patients with seasonal influenza, by performing a meta-analysis of randomized controlled trials (RCTs), retrieved from PubMed, Cochrane Central Register of Controlled Trials and Scopus databases, comparing NIs...
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PMID: 20488984
PDF is available here.
PDF is available here.
Abstract
Among 489 bats of 11 species in China, three novel paramyxoviruses [Tuhokovirus 1, 2 and 3 (ThkPV-1, ThkPV-2 and ThkPV-3)] were discovered in 15 Leschenault's rousettes. Phylogenetically, the three viruses are most closely related to Menangle and Tioman virus. Genome analysis showed that their 3'-le...
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PMID: 20537670
PDF is available here.
PDF is available here.
Abstract
Peramivir is a neuraminidase (NA) inhibitor (NAI) under development that must be administered by the systemic route. The prophylactic activity of intramuscular (IM) peramivir was evaluated with mice infected with wild-type (WT) and oseltamivir-resistant (H274Y NA mutant) recombinant...
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PMID: 20404128
PDF is available here.
PDF is available here.