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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Proteins (95):
- Ubiquitins
- Thymosin
- Proteome
- Apoproteins
- Algal Proteins
- Proteinase Inhibitory Proteins, Secretory
- Mutant Proteins
- Transcription Factors
- Salivary Proteins and Peptides
- Receptors, Drug
- Protein Precursors
- Amyloid
- GTP-Binding Protein Regulators
- Fungal Proteins
- Hemeproteins
- Cell Cycle Proteins
- Lithostathine
- Aprotinin
- Phosphoproteins
- Amphibian Proteins
- Fish Proteins
- Polyproteins
- Iron-Regulatory Proteins
- Colipases
- Thioredoxins
- Protein Subunits
- Cerebrospinal Fluid Proteins
- Photosynthetic Reaction Center Complex Proteins
- Intracellular Signaling Peptides and Proteins
- Mitochondrial Proteins
- Silk
- Pregnancy Proteins
- Eye Proteins
- Selenium-Binding Proteins
- Recombinant Proteins
- Receptors, Cytoplasmic and Nuclear
- Lectins
- Nerve Tissue Proteins
- Intercellular Signaling Peptides and Proteins
- Albumins
- Glycoproteins
- Seminal Plasma Proteins
- Blood Proteins
- Immediate-Early Proteins
- Oxidative Phosphorylation Coupling Factors
- Photoreceptors, Microbial
- Iodoproteins
- Proteolipids
- Flavoproteins
- Selenoproteins
- Prions
- Archaeal Proteins
- Lipoproteins
- Antifreeze Proteins
- Egg Proteins
- Protozoan Proteins
- Fanconi Anemia Complementation Group Proteins
- Helminth Proteins
- Molecular Chaperones
- Peptones
- Serpins
- Dental Enamel Proteins
- Nucleoproteins
- Plant Proteins
- Dynein ATPase
- DNA-Binding Proteins
- Avian Proteins
- Ribosomal Proteins
- Nuclear Proteins
- Cytoskeletal Proteins
- Protein Hydrolysates
- Globulins
- Contractile Proteins
- Cystatins
- Viral Proteins
- Scleroproteins
- Pulmonary Surfactant-Associated Proteins
- Protein Isoforms
- Insect Proteins
- Luminescent Proteins
- Neoplasm Proteins
- Fetal Proteins
- Dietary Proteins
- Bacterial Proteins
- Membrane Proteins
- Tissue Inhibitor of Metalloproteinases
- Epididymal Secretory Proteins
- LDL-Receptor Related Proteins
- Metalloproteins
- Immobilized Proteins
- Silver Proteins
- Reptilian Proteins
- Carrier Proteins
- Heat-Shock Proteins
- Armadillo Domain Proteins
Recent article
Proteins
Abstract
| < More recent | Older article > |
Abstract
We show that RegIIIγ, a secreted antibacterial lectin, is essential for maintaining a ~50-micrometer zone that physically separates the microbiota from the small intestinal epithelial surface. Loss of host-bacterial segregation in RegIIIγ(-/-) mice was coupled to increased bacterial colonization o...
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PMID: 21998396
PDF is available here.
PDF is available here.
Developmental Cell (21)3 2011
Abstract
We report a role of Lgl1, the mammalian homolog of Drosophila tumor suppressor Lethal giant larvae, in controlling membrane trafficking underlying axonal growth. We find that Lgl1 is associated with plasmalemmal precursor vesicles and enriched in developing axons. Lgl1 upregulation promoted axonal g...
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PMID: 21856246
PDF is available here.
PDF is available here.
Abstract
We present a data mining approach that enables the identification of alternative analog series with different core structures, corresponding substitution patterns, and comparable potency progression. Scaffolds can be exchanged between these series and new analogs suggested that incorporate preferred...
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PMID: 21774471
PDF is available here.
PDF is available here.
Abstract
A large-scale similarity search investigation has been carried out on 266 well-defined compound activity classes extracted from the ChEMBL database. The analysis was performed using two widely applied two-dimensional (2D) fingerprints that mark opposite ends of the current performanc...
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PMID: 21728295
PDF is available here.
PDF is available here.
Circulation Research (109)4 2011
Abstract
We focus on emerging techniques that may form a coherently integrated pipeline to overcome present limitations to both the discovery and validation processes....
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PMID: 21817166
PDF is available here.
PDF is available here.
Abstract
The C57BL/6 mice were subjected to a chronic combined stress which resulted in the induction of a depressive-like state. The occurrence of a depressive-like state was defined by a decrease in sensitivity to the reward determined by the diminished preference of sweetened solutions ove...
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PMID: 21961309
PDF is available here.
PDF is available here.
Abstract
Abstract
We used large-scale quantitative phosphoproteomics experiments to define the signaling networks downstream of mTORC1 and mTORC2. Characterization of one mTORC1 substrate, the growth factor receptor-bound protein 10 (Grb10), showed that mTORC1-mediated phosphorylation stabilized Grb10, leading to fee...
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PMID: 21659605
PDF is available here.
PDF is available here.
Biomacromolecules (12)6 2011
Abstract
This Review is focused on the growing interest brought to phosphorus-containing organic materials for applications in the biomedical field, mainly because of their properties such as biocompatibility, hemocompatibility, and protein adsorption resistance. It mainly describes relevant...
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PMID: 21553908
PDF is available here.
PDF is available here.
Kidney International (80)4 2011
Abstract
Abstract
Integration of cellular and extracellular signals maintains tissue homeostasis under conditions of normal proliferation and stress. A central player in regulating responses to stress is the serine/threonine kinase mammalian target of rapamycin (mTOR). In many cancers, mTOR complex 1...
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PMID: 21499767
PDF is available here.
PDF is available here.
Abstract
We bring this 'bottom-up' approach alongside the current NGS-driven genetic study of genetic variations and disease aetiology. We describe experimental and computational techniques for assessing genetic variants and their deleterious effects on protein structure and function....
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PMID: 21350909
PDF is available here.
PDF is available here.
Abstract
We discuss the various modes of intramembrane protein-lipid interactions in cellular membranes, including examples for both annular and nonannular bound lipids. Furthermore, we will discuss possible functional roles of such specific protein-lipid interactions as well as roles of lipids as chaperones...
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PMID: 21536707
PDF is available here.
PDF is available here.
Proteomics (11)11 2011
Abstract
We utilize multidimensional protein identification technology to characterize the murine left ventricle (LV), right ventricle (RV), and atria (A) proteomes, identifying thousands of distinct proteins. Moreover, using multidimensional algorithm protein map tool, relative abundances of proteins among...
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PMID: 21598388
PDF is available here.
PDF is available here.
Abstract
In the cell, protein folding into stable globular conformations is in competition with aggregation into non-functional and usually toxic structures, since the biophysical properties that promote folding also tend to favor intermolecular contacts, leading to the formation of β-sheet-...
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PMID: 21538897
PDF is available here.
PDF is available here.
Abstract
We present the proteome of metaphase II mouse oocytes to a depth of 3699 proteins, which substantially extends the number of proteins identified until now in mouse oocytes and is comparable by size to the proteome of undifferentiated mouse ES cells. Twenty-eight oocyte proteins, also detected in ES...
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PMID: 21344949
PDF is available here.
PDF is available here.
Abstract
We performed comparative proteome analysis of lung tissue from patients with sporadic IPF (n = 14) and human donor lungs (controls, n = 10) using two-dimensional gel electrophoresis and MALDI-TOF-MS. Eighty-nine differentially expressed proteins were identified, from which 51 were up-regulated and 3...
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PMID: 21319792
PDF is available here.
PDF is available here.
Cold Spring Harbor Protocols (2011)5 2011
Abstract
Protein-DNA interactions (PDIs) are critical for many cellular processes. We present here a protocol for the identification of PDIs in vitro using protein microarray technology. The procedure involves double-stranding synthesized DNA oligonucleotides with a fluorescent-labeled primer, binding the la...
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PMID: 21536762
PDF is available here.
PDF is available here.
Abstract
We propose that establishing the natural variation in urinary protein expression among a healthy population can serve as a reference to help identify protein abundance changes that are caused by disease, not by individual variations or physiological changes. We also discuss that comparing protein ex...
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PMID: 21455690
PDF is available here.
PDF is available here.
Abstract
Aging cells accumulate damaged and misfolded proteins through a functional decline in their protein homeostasis (proteostasis) machinery, leading to reduced cellular viability and the development of protein misfolding diseases such as Alzheimer's and Huntington's. Metabolic signaling...
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PMID: 21441594
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Gas-phase fractionation (GPF), defined as iterative mass spectrometric interrogations of a sample over multiple smaller mass-to-charge (m/z) ranges, enables the ions selected for collision-induced dissociation to come from a greater number of unique peptides compared to the ions selected from the wi...
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PMID: 18370021
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Phase II of the Protein Structure Initiative, funded by the NIH NIGMS (National Institute of General Medical Sciences), is a 5-year effort to determine thousands of protein structures. The New York SGX Research Center for Structural Genomics (NYSGXRC) is one of the four large-scale production center...
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PMID: 18542890
PDF is available here.
PDF is available here.
Cell Host & Microbe (9)4 2011
Abstract
We show that the Leishmania protease GP63 cleaves the mammalian/mechanistic target of rapamycin (mTOR), a serine/threonine kinase that regulates the translational repressor 4E-BP1. mTOR cleavage results in the inhibition of mTOR complex 1 (mTORC1) and concomitant activation of 4E-BP1 to promote Leis...
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PMID: 21501832
PDF is available here.
PDF is available here.
Abstract
In recent developments in chemistry and genetic engineering, the humble researcher dealing with the origin of life finds her(him)self in a grey area of tackling something that even does not yet have a clear definition agreed upon. A series of chemical steps is described to be conside...
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PMID: 21641557
PDF is available here.
PDF is available here.
Journal of Proteomics (74)4 2011
Abstract
A large series of protein pathway components have been shown to be dysregulated in Down syndrome (DS) brain. No information about pathomechanisms linked to the trisomic state can be obtained from adult DS brain, however, as neurodegeneration occurs from the fourth decade. The aim of...
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PMID: 21262400
PDF is available here.
PDF is available here.
Nature Immunology (12)4 2011
Abstract
We demonstrate that differentiation into the T(H)1 and T(H)17 subsets of helper T cells was selectively regulated by signaling from mTOR complex 1 (mTORC1) that was dependent on the small GTPase Rheb. Rheb-deficient T cells failed to generate T(H)1 and T(H)17 responses in vitro and in vivo and did n...
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PMID: 21358638
PDF is available here.
PDF is available here.
Journal of Immunotherapy (34)3 2011
Abstract
We investigated the effects of murine Trop2 (mTrop2) VLP immunization in a pancreatic cancer syngeneic murine model. VLPs incorporating mTrop2 were used to immunize C57BL/6 tumor-bearing mice. Immunization with mTrop2 VLPs led to a significant reduction in tumor growth accompanied by a broad activat...
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PMID: 21389873
PDF is available here.
PDF is available here.
Proteomics (11)7 2011
Abstract
We describe the first proteomic characterization of the radial nerve cord (RNC) of an echinoderm, the sea star Marthasterias glacialis. The combination of 2-DE with MS (MALDI-TOF/TOF) resulted in the identification of 286 proteins in the RNC. Additionally, 158 proteins were identified in the synapto...
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PMID: 21365759
PDF is available here.
PDF is available here.
Proteomics (11)7 2011
Abstract
We established a 2-DE reference map for INS-1E cells. Using MALDI-TOF/TOF-MS/MS, we identified 546 spots. These included various proteins with an important role in β-cell physiology and with known roles as crucial proteins for diabetes development. We believe that the availability of this reference...
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PMID: 21365744
PDF is available here.
PDF is available here.
Abstract
Urinary peptidome changes and discrimination for potential renal glomerular and tubular damage after 6 wk of fenofibrate treatment were evaluated in 26 healthy subjects.
Peptide profiling was performed in urine samples before and after treatment using high-resolution...
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PMID: 21360683
PDF is available here.
PDF is available here.
Abstract
We describe a strategy that circumvents problems related to the biochemical complexity of this sample and the presence of high concentrations of interfering substances. Bile collected from a patient suffering from a biliary stenosis caused by a pancreatic adenocarcinoma was fractionated by a differe...
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PMID: 21314112
PDF is available here.
PDF is available here.
Ageing Research Reviews (10)2 2011
Abstract
All cells count on precise mechanisms that regulate protein homeostasis to maintain a stable and functional proteome. A progressive deterioration in the ability of cells to preserve the stability of their proteome occurs with age and contributes to the functional loss characteristic...
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PMID: 20152936
PDF is available here.
PDF is available here.
Analytical Biochemistry (411)1 2011
Abstract
Guanidinium thiocyanate-phenol-chloroform extraction (GTPC extraction) is widely used in molecular biology for isolating DNA, RNA, and proteins. Protein isolation by commercially available GTPC solutions is time consuming and the resulting pellets are only incompletely soluble. In th...
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PMID: 21094121
PDF is available here.
PDF is available here.
Abstract
To increase our current understanding of cellular processes, such as cell signaling and division, knowledge is needed about the spatial and temporal organization of the proteome at different organizational levels. These levels cover a wide range of length and time scales: from the at...
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PMID: 21094684
PDF is available here.
PDF is available here.
Abstract
We provide a proof of principle for such an approach. Using a set of protein complexes representing known interactors in their unbound form, we show that a standard docking program can distinguish the true interactors from a background of 922 non-redundant potential interactors. We additionally show...
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PMID: 21326236
PDF is available here.
PDF is available here.
Abstract
The biosyntheses of oligosaccharides and glycoconjugates are conducted by glycosyltransferases. These extraordinarily diverse and widespread enzymes catalyze the formation of glycosidic bonds through the transfer of a monosaccharide from a donor molecule to an acceptor molecule, with the stereochemi...
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PMID: 21301100
PDF is available here.
PDF is available here.
Abstract
Proteomics (11)3 2011
Abstract
We performed the first high-throughput and comprehensive proteomic profiling of the rat hippocampal proteome. Using a combination of 2-D LC-MS and data analysis with the Rosetta Elucidator(®) system, we identified 1340 unique proteins. Functional classification showed that most of these were associ...
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PMID: 21268280
PDF is available here.
PDF is available here.
Proteomics (11)3 2011
Abstract
We have shown previously that the scaffold protein MEK1 partner (MP1) is localized to late endosomes by the adaptor protein p14. Using conditional gene disruption of p14 in livers of mice (p14(Δhep) ) we analyzed protein and transcript signatures in tissue samples. Further biological network analys...
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PMID: 21268275
PDF is available here.
PDF is available here.
Proteomics (11)4 2011
Abstract
The ability to sequence DNA rapidly, inexpensively and in a high-throughput fashion provides a unique opportunity to sequence whole genomes of a large number of species. The cataloging of protein-coding genes from these species, however, remains a non-trivial task with the majority o...
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PMID: 21246734
PDF is available here.
PDF is available here.
Proteomics (11)4 2011
Abstract
We review several emerging targeted technologies to chart both N-terminal acetylation as well as acetylation at the lysine side chain, on a proteome-wide scale, highlighting in particular studies that have expanded the biological knowledge on the appearance and function of these common but functiona...
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PMID: 21246731
PDF is available here.
PDF is available here.
Proteomics (11)4 2011
Abstract
Within a mammalian organism, the interaction among cells both at short and long distances is mediated by soluble factors released by cells into the extracellular environment. The secreted proteins may involve extracellular matrix proteins, proteinases, growth factors, protein hormone...
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PMID: 21241017
PDF is available here.
PDF is available here.
Proteomics (11)4 2011
Abstract
The identification, quantitation and global characterisation of all proteins within a given proteome are extremely challenging. This is due to the absolute detection limits of technology as well as the dynamic range in expression of proteins; and the extreme diversity and heterogenei...
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PMID: 21241016
PDF is available here.
PDF is available here.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] (Chapter 11) 2011
Abstract
Two enzymatic methods commonly used in N-terminal sequence analysis of blocked proteins are presented: one uses pyroglutamate aminopeptidase for N(α)-pyrrolidone carboxyl-proteins in solution or blotted onto a membrane, and the other uses acylaminoacyl-peptide hydrolase for N(α)-ac...
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PMID: 21400688
PDF is available here.
PDF is available here.
Abstract
Spinosad bait is used to control western cherry fruit fly, Rhagoletis indifferens Curran (Diptera: Tephritidae), by killing flies before they oviposit. However, effects of different insecticide baits on management of reproductively mature flies are largely unknown. Objectives here were to determine m...
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PMID: 21404858
PDF is available here.
PDF is available here.
Abstract
We now show that AKT inhibition induces the expression and phosphorylation of multiple receptor tyrosine kinases (RTKs). In a wide spectrum of tumor types, inhibition of AKT induces a conserved set of RTKs, including HER3, IGF-1R, and insulin receptor. This is in part due to mTORC1 inhibition and in...
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PMID: 21215704
PDF is available here.
PDF is available here.
Abstract
We introduce several PRNP gene mutations (such as, PrP-KDEL, PrP-3AV, PrP-A117V, PrP-G114V, PrP-P102L and PrP-E200K) into the cultured cells in order to explore the pathogenic mechanism of familial prion disease....
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PMID: 21298055
PDF is available here.
PDF is available here.
Abstract
The hexosamine biosynthesis pathway (HBP) flux and protein O-linked N-acetyl-glucosamine (O-GlcNAc) levels have been implicated in mediating the adverse effects of diabetes in the cardiovascular system. Activation of these pathways with glucosamine has been shown to mimic some of the...
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PMID: 21494549
PDF is available here.
PDF is available here.
Abstract
We describe a workflow for proteomic semi-quantitative expression profiling of liver from rats treated with a known hepatotoxicant using a multiplexed isobaric labeling strategy and multi-dimensional liquid chromatography....
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PMID: 20972766
PDF is available here.
PDF is available here.
Abstract
In recent years, several global omics technologies have been increasingly used to better understand the molecular mechanisms of drug toxicity. Two-dimensional difference gel electrophoresis (2D-DIGE) is a large-scale proteomics high-resolution gel-based quantitative method widely used to detect prot...
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PMID: 20972754
PDF is available here.
PDF is available here.
Abstract
Xenobiotics, including therapeutic agents, can produce a variety of beneficial, as well as adverse, effects in mammals. One potential source of drug-mediated toxicity stems from metabolic activation of the parent compound, typically catalyzed by one or more members of the cytochrome P450 family of e...
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PMID: 20972760
PDF is available here.
PDF is available here.
Abstract
We have utilized a model protein, cytochrome c, to guide us in identifying 1,4-BQ- and 1,4-BQ-thioether derived site-specific protein modifications. LC-MS/MS analyses reveals that these modifications occur selectively on lysine and glutamic acid residues of the target protein, and that these modific...
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PMID: 20972762
PDF is available here.
PDF is available here.
Abstract
We have used cytochrome c and model peptides to view adduction profiles of quinone-thioether metabolites, and have determined by MALDI-TOF analysis that these electrophiles target specific residues within these model systems....
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PMID: 20972761
PDF is available here.
PDF is available here.
Abstract
The isolation of a given protein, free of all other biomolecules, is the primary objective of any protein purification scheme. Classical chromatographic procedures have been designed to exploit particular distinguishing features of individual target proteins, such as size, physico-chemical propertie...
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PMID: 20978957
PDF is available here.
PDF is available here.
Abstract
Fast protein liquid chromatography (FPLC) is a form of high-performance chromatography that takes advantage of high resolution made possible by small-diameter stationary phases. It was originally developed for proteins and features high loading capacity, biocompatible aqueous buffer systems, fast fl...
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PMID: 20978981
PDF is available here.
PDF is available here.
Abstract
We show how UPLC/MS can be used to separate and identify intact proteins....
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PMID: 20978979
PDF is available here.
PDF is available here.
Abstract
Blood handling routines have been worked out that result in consistent protein analytic results in clinical practice. It would seem reasonable to build on this experience when devising handling routines for new protein biomarker discovery. Consequently, normal blood sample handling precautions apply...
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PMID: 20949401
PDF is available here.
PDF is available here.
Abstract
We find useful for Biacore-based studies. Many kinetic-based screening assays require rigorous sample preparation and purification prior to analysis. To highlight these procedures, this protocol describes the kinetic characterisation of single chain Fv (scFv) antibody fragments from crude bacterial...
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PMID: 20978978
PDF is available here.
PDF is available here.
Abstract
We describe simple protocols for protein digestion and the analysis of digested peptides produced both by one-dimensional reversed-phase liquid chromatography and two-dimensional liquid chromatography (i.e. strong cation exchange chromatography followed by reversed-phase chromatography), coupled wit...
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PMID: 20978984
PDF is available here.
PDF is available here.