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Pancreatic Polypeptide (0)
Articles on Pancreatic Polypeptide
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Long-acting lipidated analogue of human pancreatic polypeptide is slowly released into circulation.
J Med Chem 54(8):2658-67 (2011) PMID 21410292
We describe the modification of a human pancreatic polypeptide analogue specific for the human (h)Y(2) and hY(4) receptor with PEGs of different size and palmitic acid. Receptor specificity was demonstrated by competitive binding studies. Modifications had only a small influence on binding affinitie... -
[Endocrine glands of pancreas].
Nihon Rinsho (2011) PMID 21830527
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Quantitative assessment of β-cell apoptosis and cell composition of isolated, undisrupted human islets by laser scanning cytometry.
Transplantation 90(8):836-42 (2010) PMID 20697327
We have developed fluorescence-based assays using laser scanning cytometry for assessing beta-cell apoptosis and islet cell composition on serial sections of intact isolated islets. METHODS.: Isolated human islets were fixed in formalin and embedded in paraffin. Serial sections were immunostained fo... -
Y4 receptors and pancreatic polypeptide regulate food intake via hypothalamic orexin and brain-derived neurotropic factor dependent pathways
Neuropeptides 44(3):8 (2010) PMID 20116098
We show that peripherally administered pancreatic polypeptide (PP) stimulates neurons in key nuclei of the hypothalamus critical for appetite and satiety regulation. In the lateral hypothalamic area (LHA), also known as the feeding center, neurons expressing the orexigenic neuropeptide orexin co-loc... -
Expression of Pancreatic Endocrine Markers by Prolactin-Treated Rat Bone Marrow Mesenchymal Stem Cells
Transplant Proc 42(2):4 (2010) PMID 20304194
Isolated cells were mostly MSCs, as confirmed at fluorescent-activated cell sorting and cytochemistry. Pax6, Ngn-3, Isl1, NeuroD1, Nkx2.2, and Nkx6.1 exhibited varied expression during culture stages. The long form of the prolactin receptor messenger RNA was induced in prolactin-treated cultures (P... -
Changes of dipeptidyl peptidase IV (DPP-IV) in obese children with weight loss: relationships to peptide YY, pancreatic peptide, and insulin...
J Pediatr Endocrinol Metab 23(1-2):101-8 (2010) PMID 20432813
These findings suggest that the increase of fasting PP and PYY in weight loss is influenced at least in part by a decrease of their cleavage enzyme DPP-IV. Further research is necessary to evaluate the mechanisms in weight loss leading to a decrease of DPP-IV activity and consequently to an improvem... -
Tissue-specific pattern of angiotensin-converting enzyme 2 expression in rat pancreas.
J Int Med Res 38(2):558-69 (2010) PMID 20515569
Angiotensin-converting enzyme 2 (ACE2), a carboxypeptidase that is highly homologous to ACE, acts as a negative regulator for the renin-angiotensin system (RAS). Pancreatic RAS is thought to play important endocrine and exocrine roles in hormone secretion. Further exploration of this system is likel... -
Changes of dipeptidyl peptidase IV (DPP-IV) in obese children with weight loss: relationships to peptide YY, pancreatic peptide, and insulin...
J Pediatr Endocrinol Metab 23(1-2):101-8 (2010) PMID 20432813
We analyzed changes of DPP-IV after weight loss in obese children and its relationships to the GI hormones pancreatic peptide (PP), peptide YY (PYY), and insulin sensitivity. We measured at baseline and one year later anthropometrics, percentage body fat based on skinfold thickness,... -
Perioperative intensive insulin therapy using artificial endocrine pancreas in patients undergoing pancreatectomy.
World J Gastroenterol 15(33):4111-5 (2009) PMID 19725142
We have demonstrated the reliability of the artificial pancreas in dogs with total pancreatectomy, and its postoperative clinical use has been shown to be effective and safe, without the occurrence of hypoglycemic episodes, even in patients after total pancreatectomy. Considering the increasing requ... -
The effect of a high-MUFA, low-glycaemic index diet and a low-fat diet on appetite and glucose metabolism during a 6-month weight maintenanc...
Br J Nutr 101(12):1846 (2009) PMID 19079942
We aimed to test the effects of three different weight maintenance diets on appetite, glucose and fat metabolism following an initial low-energy diet (LED) induced body weight loss. Following an 8-week LED and a 2-3-week refeeding period, 131 subjects were randomized to three diets for 6 months: MUF...