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Adipokines (3)


Articles on Adipokines

  1. Role of adipokines in cardiovascular disease.

    J Endocrinol 216(1):T17-36 (2013) PMID 23160967

    The discovery of leptin in 1994 sparked dramatic new interest in the study of white adipose tissue. It is now recognised to be a metabolically active endocrine organ, producing important chemical messengers - adipokines and cytokines (adipocytokines). The search for new adipocytokine...
  2. Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin.

    J Endocrinol 216(1):T1-T15 (2013) PMID 23160966

    Adipose tissue is an active endocrine organ, and our knowledge of this secretory tissue, in recent years, has led us to completely rethink how our body functions and becomes dysregulated with weight gain. Human adipose tissue appears to act as a multifunctional secretory organ with t...
  3. Weight loss due to a very low calorie diet differentially affects insulin sensitivity and interleukin-6 serum levels in nondiabetic obese hu...

    Horm Metab Res 44(6):465-70 (2012) PMID 22438213

    We aimed to investigate the effect of weight loss due to a very low calorie diet (VLCD) on insulin sensitivity and IL-6 serum levels in nondiabetic obese human individuals. 10 patients with obesity were examined during 12 weeks of a VLCD (800 kcal/d). Body composition was measured by impedance analy...
  4. Weight loss due to a very low calorie diet differentially affects insulin sensitivity and interleukin-6 serum levels in nondiabetic obese hu...

    Horm Metab Res 44(6):465-70 (2012) PMID 22438213

    We aimed to investigate the effect of weight loss due to a very low calorie diet (VLCD) on insulin sensitivity and IL-6 serum levels in nondiabetic obese human individuals. 10 patients with obesity were examined during 12 weeks of a VLCD (800 kcal/d). Body composition was measured by impedance analy...
  5. Acute testosterone deprivation reduces insulin sensitivity in men.

    Clin Endocrinol (Oxf) 76(2):281-8 (2012) PMID 21797916

    We employed a model of experimental hypogonadism with or without hormone replacement. Placebo-controlled, randomized trial. Twenty-two healthy male volunteers, 18-55 years old. Following screening, subjects received the gonadotrophin-releasing hormone...
  6. Acute testosterone deprivation reduces insulin sensitivity in men.

    Clin Endocrinol (Oxf) 76(2):281-8 (2012) PMID 21797916

    We employed a model of experimental hypogonadism with or without hormone replacement. Placebo-controlled, randomized trial. Twenty-two healthy male volunteers, 18-55 years old. Following screening, subjects received the gonadotrophin-releasing hormone...
  7. Hepatitis C virus induced insulin resistance impairs response to anti viral therapy.

    World J Gastroenterol 18(3):212-24 (2012) PMID 22294824

    Hepatitis C virus (HCV) infection is an important risk factor for insulin resistance (IR). The latter is the pathogenic foundation underlying metabolic syndrome, steatosis and cirrhosis, and possibly hepatocellular carcinoma (HCC). The interplay between genetic and environmental risk...
  8. Study of biomaterial-induced macrophage activation, cell-mediated immune response and molecular oxidative damage in patients with dermal bio...

    Immunobiology 217(1):44-53 (2012) PMID 21903293

    We analysed plasma concentrations of myeloperoxidase (MPO), the chitinase-like proteins chitotriosidase and YKL-40 and molecular oxidative damage. The present study shows, for the first time, that the components of innate immunity: chitotriosidase and YKL-40, are significantly higher in patients wit...
  9. Identification and validation of novel adipokines released from primary human adipocytes.

    Mol Cell Proteomics 11(1):M111.010504 (2012) PMID 21947364

    We conducted a complementary protein profiling on concentrated conditioned medium derived from primary human adipocytes. SDS-PAGE/liquid chromatography-electrospray ionization tandem MS and two-dimensional SDS-PAGE/matrix-assisted laser desorption ionization/time of flight MS identified 347 proteins...
  10. Blood profiling of proteins and steroids during weight maintenance with manipulation of dietary protein level and glycaemic index.

    Br J Nutr 107(1):106-19 (2012) PMID 21733334

    Weight regain after weight loss is common. In the Diogenes dietary intervention study, a high-protein and low-glycaemic index (GI) diet improved weight maintenance. The objective of the present study was to identify (1) blood profiles associated with continued weight loss and weight...