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Proteins (95)


Articles on Proteins

  1. Nanotechnologies and regenerative medical approaches for space and terrestrial medicine.

    Aviat Space Environ Med 83(11):1025-36 (2012) PMID 23156089

    We now refer to as nano-medicine--and regenerative medicine have enormous untapped potential for future space and terrestrial medical applications. Novel means for drug delivery and nanoscale screening tools will one day benefit astronauts venturing to Mars and places beyond, while the space laborat...
  2. A high-throughput approach for measuring temporal changes in the interactome.

    Nat Methods 9(9):907-9 (2012) PMID 22863883

    We combine quantitative proteomics and size-exclusion chromatography to map 291 coeluting complexes. This method allows mapping of an interactome to the same depth and accuracy as AP-MS with less work and without overexpression or tagging. The use of triplex labeling enables monitoring of interactom...
  3. The use of hyaluronan to regulate protein adsorption and cell infiltration in nanofibrous scaffolds.

    Biomaterials 33(12):3428-45 (2012) PMID 22300743

    We developed a protein resistant and porous nanofibrous scaffold composed of hyaluronan (HA), silk fibroin (SF), and polycaprolactone (PCL) blends via one-step emulsion electrospinning. The scaffolds were characterized and evaluated for nanostructures, chemical composition, mechanical properties, hy...
  4. The clinical and pathological phenotype of C9ORF72 hexanucleotide repeat expansions.

    Brain 135(Pt 3):723-35 (2012) PMID 22300876

    There is increasing evidence that frontotemporal dementia and amyotrophic lateral sclerosis are part of a disease continuum. Recently, a hexanucleotide repeat expansion in C9orf72 was identified as a major cause of both sporadic and familial frontotemporal dementia and amyotrophic la...
  5. Shwachman-Diamond syndrome in India.

    Pediatr Blood Cancer 58(3):479-80 (2012) PMID 21990229

  6. Preparation of phenyl-silica hybrid monolithic column with "one-pot" process for capillary liquid chromatography.

    J Chromatogr (2012) PMID 21816404

    A phenyl-silica hybrid monolithic column for capillary liquid chromatography (cLC) was prepared through "one-pot" process by con-currently using benzyl methacrylate and alkoxysilanes. The effects of the molar ratio of tetramethoxysilane/vinyltrimethoxysilane (TMOS/VTMS), polycondensa...
  7. Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations.

    Brain 135(Pt 3):693-708 (2012) PMID 22300873

    We screened a cohort of 398 patients with frontotemporal dementia, progressive non-fluent aphasia, semantic dementia or mixture of these syndromes for mutations in the C9ORF72 gene. Motor neuron disease was present in 55 patients (14%). We identified 32 patients with C9ORF72 mutations, representing...
  8. The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis.

    Cell Death Differ 19(3):501-10 (2012) PMID 21941369

    We show that, after detachment, mouse embryonic fibroblasts (MEFs) transformed by K-Ras(V12) or ETV6-NTRK3 (EN) activate a transcriptional response overrepresented by genes related to bioenergetic stress and the AMP-activated protein kinase (AMPK) energy-sensing pathway. Accordingly, AMPK is activat...
  9. Investigation of endogenous metabolic changes in the urine of pseudo germ-free rats using a metabolomic approach

    BIOMED APPL (2012) PMID 22300547

    We prepared pseudo germ-free rats by antibiotic treatment, and we investigated urinary metabolite profiles of pseudo germ-free rats using UPLC-QTOF-MS based on metabolomics. The repeatability and stability of the analysis were evaluated using QC samples and testmixes in both positive and negative io...
  10. Genetics. Gene losses in the human genome.

    Science 335(6070):806-7 (2012) PMID 22344433