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All › Amino Acids, Peptides, and Proteins › Proteins › Mitochondrial Proteins

Mitochondrial Proteins (1)

    Articles on Mitochondrial Proteins

    1. A model system for mitochondrial biogenesis reveals evolutionary rewiring of protein import and membrane assembly pathways.
      Victoria L VL Hewitt, Eva E Heinz, ... Trevor T Lithgow

      Proc Natl Acad Sci U S A 109(49):E3358-66 (2012) PMID 23151513

      We present insights into the function, evolution, and regulation of mitochondrial biogenesis through the study of the protein import machinery in the human fungal pathogen, Candida albicans. Features that distinguish C. albicans from baker's yeast (Saccharomyces cerevisiae) include the stringency of...
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    2. Extended haplotype studies in South African and Dutch variegate porphyria families carrying the recurrent p.R59W mutation confirm a common a...
      A M AM van Tuyll van Serooskerken, B I BI Drögemöller, ... J J Frank

      Br J Dermatol 166(2):261-5 (2012) PMID 21910705

      Our data deliver further confirmation that the South African and Dutch VP families carrying mutation p.R59W shared a common ancestor. © 2011 The Authors. BJD © 2011 British Association of Dermatologists....
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    3. Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus.
      Sameer S SS Kulkarni, Firoozeh F Salehzadeh, ... Megan E ME Osler

      Metabolism 61(2):175-85 (2012) PMID 21816445

      We determined expression and regulation of mitochondrial enzymes including pyruvate dehydrogenase kinase (PDK) 4, PDK2, carnitine palmitoyltransferase 1b, and malonyl-coenzyme A decarboxylase in skeletal muscle from people with normal glucose tolerance (NGT) or type 2 diabetes mellitus (T2DM). Vastu...
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    4. Mutations in C12orf62, a factor that couples COX I synthesis with cytochrome c oxidase assembly, cause fatal neonatal lactic acidosis.
      Woranontee W Weraarpachai, Florin F Sasarman, ... Eric A EA Shoubridge

      Am J Hum Genet 90(1):142-51 (2012) PMID 22243966

      We investigated a family in which the index subject presented with severe congenital lactic acidosis and dysmorphic features associated with a cytochrome c oxidase (COX)-assembly defect and a specific decrease in the synthesis of COX I, the subunit that nucleates COX assembly. Using a combination of...
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    5. Crucial yet divergent roles of mitochondrial redox state in skeletal muscle vs. brown adipose tissue energetics.
      Ryan J RJ Mailloux, Cyril Nii-Klu CN Adjeitey, ... Mary-Ellen ME Harper

      FASEB J 26(1):363-75 (2012) PMID 21940996

      We show that the redox environment plays crucial, yet divergent, roles in modulating mitochondrial bioenergetics in skeletal muscle and BAT. Skeletal muscle mitochondria were found to naturally have a highly reduced environment (GSH/GSSG≈46), and this was associated with fairly high (∼40%) rates...
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    6. UCP2 inhibits ROS-mediated apoptosis in A549 under hypoxic conditions.
      Sanming S Deng, Ye Y Yang, ... Yunjie Y Wang

      PLoS One 7(1):e30714 (2012) PMID 22292025

      The Crosstalk between a tumor and its hypoxic microenvironment has become increasingly important. However, the exact role of UCP2 function in cancer cells under hypoxia remains unknown. In this study, UCP2 showed anti-apoptotic properties in A549 cells under hypoxic conditions. Over-...
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    7. BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria.
      Yasuyuki Y Nakamura, Noriaki N Kitamura, ... Hirofumi H Arakawa

      PLoS One 7(1):e30767 (2012) PMID 22292033

      We report that an additional mitochondrial outer membrane protein, BNIP3, is also involved in MALM. BNIP3 interacts with Mieap in a reactive oxygen species (ROS)-dependent manner via the BH3 domain of BNIP3 and the coiled-coil domains of Mieap. The knockdown of endogenous BNIP3 expression severely i...
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    8. The SAR11 group of alpha-proteobacteria is not related to the origin of mitochondria.
      Naiara N Rodríguez-Ezpeleta and T Martin TM Embley

      PLoS One 7(1):e30520 (2012) PMID 22291975 PMCID PMC3264578

      We have performed phylogenetic analyses on the concatenation of 24 proteins from 5 mitochondria and 71 proteobacteria. Our results support that SAR11 group is not the sistergroup of the Rickettsiales+mitochondria clade and confirm that the position of this group in the alpha-proteobacterial tree is...
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    9. Tumor strengths and frailties: Cancer SUMmOns Otto's metabolism.
      Michael M Ohh

      Nat Med 18(1):30-1 (2012) PMID 22227664

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    10. Evidence for a shift to anaerobic metabolism in adipose tissue in efavirenz-containing regimens for HIV with different nucleoside backbones.
      Kirsty C KC McGee, Mohsen M Shahmanesh, ... Jeremy W JW Tomlinson

      Antivir Ther 17(3):495-507 (2012) PMID 22300946

      We compared patterns of gene expression in the subcutaneous adipose tissue (SAT) of HIV-positive subjects before and after 18-24 months of ARV therapy with HIV-negative controls. HIV patients naive to ARV were randomized to receive zidovudine (AZT), lamivudine (3TC) with efavirenz (E...
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