Abstract
Prolonged hypotensive resuscitation is not compatible with survival after primary blast. Casualties most likely to be in this category are those injured by blast in confined spaces or by enhanced blast weapons. The risk of rebleeding associated with normotensive resuscitation needs to be balanced wi...
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PMID: 20485127
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Abstract
These results suggest that sodium nitroprusside is a safe and effective drug for induced hypotension in pediatric patients....
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PMID: 19227170
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Abstract
The results of the study using Repeated Measures Test statistical analysis showed that there were no significant differences between the 2 groups in respect to physiologic responses or surgery time. CONCLUSION: Both protocols tried in this study proved to be effective and safe, and they seem to be i...
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PMID: 18940490
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Abstract
Baseline rSO(2) values were similar in the 2 groups. There were no significant differences in rSO(2) values between the 2 groups. Cerebral desaturation was not observed in any of the patients. Both nitroglycerin and nicardipine reduced MAP and increased HR during induced hypotension as compared with...
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PMID: 18848109
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Abstract
Controlled hypotension is sometimes necessary for accurate endograft deployment and adjunctive ballooning and stenting near the arch and proximal descending thoracic aorta. This article describes a technique in which a compliant occlusion balloon inflated in the right atrium is used to occlude the i...
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PMID: 18644496
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Abstract
In patients without any renal disease, hypotensive anesthesia with propofol and remifentanil results in a transient tubular dysfunction, which appears to be minimized by the preoperative administration of alpha-tocopherol....
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PMID: 18502357
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Abstract
Infusion of dexmedetomidine, at the doses used in this study, was less effective than remifentanil in achieving controlled hypotension, good surgical field exposure condition and surgeons' satisfaction during tympanoplasty....
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PMID: 18294411
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Abstract
We compared the values obtained using the T-Line values to simultaneous arterial line measurements in patients undergoing general anaesthesia with induced hypotension. Twenty-five patients, aged 18-70 years, were studied. The T-Line and arterial line were positioned on the contralateral wrists. Intr...
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PMID: 18289239
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Abstract
We report the absence of complications (with calculated upper limit 95% confidence interval of approximately 13.6%) when hypotensive epidural anesthesia was performed in 22 patients with noncritical asymptomatic aortic stenosis....
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PMID: 18299093
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Abstract
Controlled hypotension was achieved within a shorter period using laryngeal mask using lower rates of remifentanil infusion and lower total dose of remifentanil. CONCLUSION: In summary, our results indicate that airway management using FRLMA during controlled hypotension anesthesia provided better s...
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PMID: 19178808
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Abstract
The serum S100B concentration increased significantly in the Hct 20% + CH and Hct 15% + CH groups. However, there were no significant differences in the serum levels of NSE between the groups. In the CA1 region of the rat hippocampus, marked ultrastructural alterations, such as mitochondrial denatur...
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PMID: 17944636
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Abstract
Seventeen articles met the inclusion criteria. The surgeries studied included total hip arthroplasty (seven), orthognathic surgery (eight), total knee arthroplasty (one) and spinal fusion (one). A total of 636 patients were randomized across all studies. For blood loss, the overall weighted mean dif...
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PMID: 17934161
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Abstract
Patient demographics were similar in both groups. Sustained controlled hypotension was sufficient in all of the groups throughout surgery. Surgical field scores were lower in group R (p<0.05), although the scores were =2 in both groups, which was regarded as adequate for tympanoplasty. Four patien...
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PMID: 17768460
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Abstract
Controlled hypotension decreases the release of natriuretic peptides in cardiovascular healthy patients. This effect may be contributed to by changes in cardiac filling pressure due to lower systemic resistance and diminished perfusion pressure....
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PMID: 17241506
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Abstract
CBF was significantly higher in the cortex during normotensive (control) settings, MAP approximately 100 mmHg, compared with during hypotension (MAP 40-60 mmHg). Neither different anesthetic nor MAC or local measurement sites were found to influence CBF at any perfusion pressure. CONCLUSION: In this...
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PMID: 17430324
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Abstract
Blood pressure and heart rate was not different between the two groups. Dryness of the operating site was rated significantly better (p < 0.0001) in the DARS-group (median; 25th/75th-percentile: 2.0; 1.5-3.5 vs. RADS-group: 2.6; 2.0-4.0) but the overall rating of the surgical conditions did not diff...
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PMID: 17432075
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Abstract
Controlled hypotension was achieved at a target mean arterial pressure of 60+/-5 mmHg in both groups. Compared to the baseline levels, heart rate values were lower in the remifentanil group (p<0.05), and similar in the sodium nitroprusside group (p>0.05). The amount of bleeding and the dryness of th...
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PMID: 18187995
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Abstract
For half a century, controlled hypotension has been used to reduce bleeding and the need for blood transfusions, and provide a satisfactory bloodless surgical field. It has been indicated in oromaxillofacial surgery (mandibular osteotomy, facial repair), endoscopic sinus or middle ear microsurgery,...
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PMID: 17488147
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Abstract
Operative blood loss in the epidural group was significantly less than that in the control group (955 +/- 517 mL vs 1477 +/- 823 mL respectively, P < 0.001). The percentage of patients who reached the threshold trigger for allogenic transfusion was significantly less in the epidural group (8% vs 26%...
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PMID: 16960264
PDF is available here.
Abstract
The value of rSO(2) was the same in both groups in the absence of CH (at baseline: group A, 70.1 +/- 6.0%; group CH, 69.9 +/- 6.7%; after surgery: group A, 64.5 +/- 4.9%; group CH, 64.3 +/- 5.8%). However, in the presence of CH, rSO(2) values were significantly lower in group CH than in group A (at...
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PMID: 16879470
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Abstract
In the magnesium group, there was a reduction in surgical time [68.1 (15.6) min vs 88.1 (10.7) min], although the anaesthetic time was 10 min longer and thus presuming a prolongation in anaesthetic emergence. There was a significant reduction of blood loss [165 (19) ml vs 257 (21) ml]. The anaesthet...
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PMID: 16670112
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Abstract
The mean duration of hypotension (MAP<55 mm Hg) was 94 min (range 35-305 min). The mean age was 71 yr. All patients with a creatinine level of 124 micromol litre(-1) had a creatinine clearance of <40 ml min(-1) 1.73 m(-2) (range: 13-56). Patients with CRD received more crystalloid during surgery (17...
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PMID: 16377652
PDF is available here.
Abstract
For many years deliberate hypotension was used to prevent intraoperative bleeding. The intentional reduction of systolic blood pressure to 50-60 mm Hg was achieved by the use of Sodium Nitroprusside alone or in combination with other vasoactive agents. However, intraoperative bleeding is not affecte...
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PMID: 16444651
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Abstract
In spite the similar mean arterial pressure levels noted between groups, HEA results in less intraoperative blood loss than HTIVA during primary total hip replacement. This outcome may be associated with non-positive pressure ventilation, distribution of blood flow, and lower mean intraoperative cen...
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PMID: 16171661
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Abstract
Lowering mean arterial blood pressure decreased GFR and ERPF in both groups. During hypotension ERPF was lower in Group S (n = 5) than Group V (n = 6). Renal function was normalized postoperatively. We found a positive but non-significant correlation between the relative GFR change and the duration...
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PMID: 16045658
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Abstract
I or II patients, 18 to 32 years old, and undergoing maxillary and mandibular osteotomies were randomly assigned to receive anesthesia with propofol-remifentanil (group P), desflurane-remifentanil (group D), or sevoflurane-remifentanil (group S). All patients were given premedication: midazolam 0.03...
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PMID: 16077295
PDF is available here.
Abstract
Tourniquets commonly are used during total knee arthroplasties to reduce intraoperative blood loss, despite their various side effects. The goal of this study was to determine whether tourniquet use could be avoided using epinephrine-augmented hypotensive epidural anesthesia during a total knee arth...
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PMID: 15995439
PDF is available here.
Abstract
Our preliminary data with a measurement of cerebral oxygenation demonstrates the safety of CH within the accepted mean blood pressure recommendations of 55-65 mmHg....
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PMID: 15910352
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Abstract
Vmca and blood gas were measured before hemodilution, after hemodilution, 80 minutes after starting hypotension, and 60 minutes after recovery from hypotension. Vmca significantly increased in group A (+122%) and group B (+156%) after each hemodilution. In group B, Vmca was significantly greater tha...
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PMID: 15896583
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Abstract
In our cohort of 167 patients with colorectal liver metastases, 73 fulfilled the optimal acceptance criteria (5 or fewer tumors that were =5 cm). The median survival periods were 38 months, with a 5-year survival rate of 30%, after the diagnosis of liver metastases and 31 months, with a 5-year sur...
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PMID: 15759208
PDF is available here.
Abstract
This study compared the efficacy of isoflurane, sevoflurane, and desflurane in achieving hemodynamic stability in spinal procedures using moderate levels of controlled hypotension. After obtaining ethics committee approval and written informed consent, 32 American Surgical Association I-II patients...
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PMID: 16236684
PDF is available here.
Abstract
An induced and controlled steady hypotension under general anaesthesia did not affect the hearing function of any of the patients. It may be supposed, therefore, that an adverse effect on the cochlear oxygenation is more likely to be caused by the sympathetic changes induced by a consistent decrease...
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PMID: 15667680
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Abstract
The problems linked to blood loss and blood-sparing techniques in spine surgery have been less studied than in other fields of orthopedics, such as joint-replacement procedures. Decreasing bleeding is not only important for keeping the patient's hemodynamic equilibrium but also for allowing a better...
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PMID: 15480823
PDF is available here.
Abstract
Controlled, deliberate hypotension during anesthesia for major spinal surgery reduces intraoperative blood loss and transfusion requirement. Hypotension may be achieved with increased doses of volatile anesthetic agents or by continuous infusion of vasodilating drugs. Safe application of this techni...
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PMID: 15197633
PDF is available here.
Abstract
Although a state of mild hypotension may be beneficial to limit blood loss during spinal deformity corrective surgery, acute and/or prolonged hypotension may jeopardize spinal cord vascularity and should be avoided especially during surgical treatment of high-risk deformities such as kyphosis. Early...
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PMID: 15187651
PDF is available here.
Abstract
Ephedrine restored BP more easily in those patients who had received trimethaphan compared with those who had received nitroglycerin for deliberate hypotension....
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PMID: 15261317
PDF is available here.
Abstract
We reviewed the records of 115 consecutive cases of simultaneous bimaxillary osteotomies at Morriston Hospital over a 5-year period (January 1996 to December 2000). Ordering and use of blood were investigated and the cost analysed. Blood loss was minimised using a strategy of controlled moderate hyp...
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PMID: 15121269
PDF is available here.
Abstract
This study shows that blood loss during orthognathic surgery under hypotensive anesthesia can be significantly reduced when a combination of tranexamic acid and desmopressin is added....
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PMID: 15170275
PDF is available here.
Abstract
PGE(1)-induced hypotension has an effect on IL-6 response to oral and maxillofacial surgery....
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PMID: 15217654
PDF is available here.
Abstract
Surgical correction of kyphoscoliosis may result in spinal cord injury and neurologic deficits. Monitoring somatosensory evoked potentials (SSEPs) and transcranial motor evoked potentials (MEPs) intraoperatively may allow for early detection and reversal of spinal cord injury. Controlled hypotension...
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PMID: 15021289
PDF is available here.
Abstract
These results suggest that hypotensive anesthesia with PGE1 maintains autoregulation of the dynamic cerebral blood flow, but NTG impairs the autoregulation in the low frequency range....
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PMID: 15160662
PDF is available here.
Abstract
Low ABP during reperfusion increases the size of myocardial infarction and decreases CBF....
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PMID: 15078763
PDF is available here.
Abstract
Nitroprusside's effect on platelet aggregation produces no increase in blood loss compared with nicardipine. Nicardipine causes less transient severe hypotension than nitroprusside, although both drugs are acceptable choices for obtaining the goals of deliberate hypotension....
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PMID: 14984856
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Abstract
We sought to determine if subarachnoid block, induced by combined spinal-epidural (CSE) using loss-of-resistance to air could render higher sensory anesthesia than single-shot spinal (SSS) when an identical mass of intrathecal anesthetic was injected. Sixty patients, scheduled for minor gynecologica...
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PMID: 14742393
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Abstract
The average intra-operative blood loss was 534+/-198 ml in the group T and 1287+/-380 ml in the group K (p<0.001). Post-operative blood loss was the same in both groups. The average operation time was 10% shorter in the group T (p=0.078). Fentanyl use in the T group was 203+/-91 microg and 1266+/-60...
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PMID: 15630346
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Abstract
The intra-operative blood loss was less for 45.7% in group T than in group K but post-operative blood loss was the same in groups. The mean operation time was 14.2% shorter in group T. We used 80% less fentanyl and 43% less inhaled anesthetics in group T. The stay in intensive care unit was 2.6 days...
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PMID: 15079132
PDF is available here.
Abstract
Several major orthopedic surgical procedures including hip arthroplasty, femoral osteotomy, and spinal fusion may result in significant blood loss and the need for allogeneic blood transfusions. Due to the heightened awareness of the potential deleterious effects of allogeneic blood product administ...
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PMID: 14872436
PDF is available here.
Abstract
alpha-GST concentrations were significantly higher in patients receiving CH (SN: 5.9 +/- 3.4; Esmolol: 6.5 +/- 2.8 microg/L) in comparison with controls (2.5 +/- 1.4 microg/L) at T1. Already at T2 there were no significant differences between the three groups. Standard liver enzymes showed a similar...
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PMID: 14666441
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Abstract
Isoflurane resulted in improved neurologic function and reduced histologic damage regardless of the presence or absence of systemic hypotension during the ischemic insult. This indicates that beneficial effects of isoflurane are most likely attributable to direct effects at the neuronal level as opp...
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PMID: 14576552
PDF is available here.
Abstract
We applied controlled hypotension and a minimal inflation pressure (CHAMIP) technique to provide a bloodless surgical field. Thirty-six patients scheduled for upper extremity surgery were randomized equally to receive either normotensive anesthesia and conventional inflation pressures or controlled...
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PMID: 14570681
PDF is available here.