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Aleutian Mink Disease (0):
Recent article
Aleutian Mink Disease
Abstract
A neuropathologic survey was conducted on mink brains from the 5 licensed mink farms in Ireland. The survey was part of a transmissible spongiform encephalopathy surveillance study. Aleutian disease (AD) was present on 4 of the 5 farms (80%). Neuropathologic features of nonsuppurative meningoencepha...
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PMID: 20093694
PDF is available here.
PDF is available here.
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Abstract
Spleen samples from 14 mink that were trapped in 4 counties of Nova Scotia were tested for the presence of the Aleutian mink disease virus (AMDV) by polymerase chain reaction. Viral DNA was not detected in samples from Kings County (n = 2), but was detected in all the mink sampled from Colchester (n...
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PMID: 20357945
PDF is available here.
PDF is available here.
Abstract
The European mink, Mustela lutreola, has suffered a dramatic decline in Europe during the 20th century and is one of the most endangered carnivores in the world. The subpopulation of European mink from Navarra, Spain, estimated to number approximately 420, represents approximately two thirds of the...
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PMID: 18816991
PDF is available here.
PDF is available here.
Abstract
Antemortem diagnostic tests revealed renal disease but failed to identify an etiologic agent. A diagnosis of severe nonsuppurative interstitial nephritis was made on the basis of results of histologic examination of renal biopsy specimens. TREATMENT AND OUTCOME: The skunk was administered isotonic f...
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PMID: 18312184
PDF is available here.
PDF is available here.
Abstract
Clinical reports of Chediak-Higashi syndrome have identified mutations throughout the CHS1/LYST gene. The nature of the mutation can be a predictor of the severity of the disease. Over the past decade the CHS1/LYST family of proteins has been analyzed using model organisms, two-hybrid analysis, over...
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PMID: 18043242
PDF is available here.
PDF is available here.
Abstract
To research safer diagnosis antigen for ADV, the main antigenic region VP2a and VP2b gene of ADV were obtained by restriction digestion of the recombinant plasmids pMD-VP2a and pMD-VP2b. Then the genes were respectively cloned into pMAL-c2 to get two prokaryotic recombinant plasmids pMAL-VPa and pMA...
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PMID: 18271270
PDF is available here.
PDF is available here.
Veterinary Pathology (44)5 2007
Abstract
This report describes the use of polymerase chain reaction and DNA in situ hybridization to diagnose Aleutian mink disease parvovirus DNA in various tissue specimens from 2 companion striped skunks. Clinical, laboratory, and microscopic findings also support a clinical diagnosis of Aleutian disease...
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PMID: 17846242
PDF is available here.
PDF is available here.
Journal of Virology (81)13 2007
Abstract
The abundant R2 mRNA encoded by the single left-end promoter of Aleutian mink disease parvovirus is tricistronic; it not only expresses the capsid proteins VP1 and VP2 but is also the major source for the nonstructural protein NS2. A cis-acting sequence within the NS2 gene was shown to be required f...
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PMID: 17428872
PDF is available here.
PDF is available here.
Voprosy Virusologii (52)3 2007
Abstract
The nucleotide sequence of the VP2 gene for Aleutian mink disease virus isolated in the fur farms in the Primorye Territory (Russia) was determined. The isolated strain was shown to be genetically close to highly pathogenetic American strains of the Utah group. An intraspecific classification of ADV...
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PMID: 17601051
PDF is available here.
PDF is available here.
Abstract
These results suggest that IHC demonstration of viral antigen allows rapid and reliable diagnosis of the 3 viral infections in mink and is a potential supplement to histologic diagnostic procedures. The TMA technique proved useful for screening large numbers of samples for expression of specific vir...
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PMID: 17193876
PDF is available here.
PDF is available here.
Abstract
A 2-year-old domestic ferret that appeared clinically healthy was repeatedly seropositive for Aleutian mink disease parvovirus (ADV) over a 2-year observation period. Antibody titers, determined by counter-immunoelectrophoresis, ranged from 1024 to 4096. Viral DNA also was identified in serum, urine...
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PMID: 16475522
PDF is available here.
PDF is available here.
Tijdschrift voor diergeneeskunde (130)13 2005
Abstract
Abstract
We believe, indicate a memory CTL response created by the vaccination. Most CD8+ cells were found to contain interferon gamma as measured by FACS intracellular staining. Severity of Aleutian disease was judged by quantification of plasma gammaglobulin levels and mink death statistics. The findings l...
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PMID: 15652664
PDF is available here.
PDF is available here.
Abstract
Aleutian mink disease parvovirus (ADV) is an unusual member of the autonomous parvoviruses in both its replication and pathogenesis. Infection of newborn mink kits results in an acute disease typified by virus replication in type II pneumocytes in the lung. This replication is permissive and cytopat...
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PMID: 16316395
PDF is available here.
PDF is available here.
Abstract
Owing to the rapid decline of the European mink (Mustela lutreola) in France, a national conservation action plan has been initiated, in which scientific research to improve understanding of the causes of the decline is one of the primary objectives. In order to investigate the possible role of Aleu...
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PMID: 15465705
PDF is available here.
PDF is available here.
Journal of Virology (77)13 2003
Abstract
We quantified the percentages of IFN-gamma- and IL-4-positive lymphocytes and IL-8-positive monocytes up to week 38 after virus challenge. The results clearly indicated marked increases in the percentages of IFN-gamma- and IL-4-producing lymphocytes during ADV infection. The total number of IL-8-pro...
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PMID: 12805443
PDF is available here.
PDF is available here.
Veterinary Record (150)6 2002
Abstract
Abstract
Aleutian mink disease parvovirus (ADV) is distinct among the parvoviruses as infection in vivo is persistent, restricted, and noncytopathic. In contrast, infections with other more prototypic parvoviruses, like mink enteritis virus (MEV), are acute, cytopathic, and characterized by permissive replic...
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PMID: 11878925
PDF is available here.
PDF is available here.
Abstract
Information on the development of the infectious process in the Aleutian disease of minks (ADM) on the molecular level, are updated. In particular, the decisive role played by the ABM virus infection of the cells of the immune system (B lymphocytes, macrophages, follicular dendritic cells) and the p...
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PMID: 12506642
PDF is available here.
PDF is available here.
Veterinary Record (149)23 2001
Abstract
Journal of Virology (75)22 2001
Abstract
We studied heterologous antibodies against several peptides present in the major capsid protein, VP2. Of these antibodies, a polyclonal rabbit antibody to peptide VP2:428-446 was the most interesting. The anti-VP2:428-446 antibody aggregated virus particles into immune complexes, mediated ADE, and n...
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PMID: 11602751
PDF is available here.
PDF is available here.
Veterinary Record (149)16 2001
Abstract
Fourteen of 27 American mink (Mustela vison) trapped in the upper Thames region were positive for anti-Aleutian disease antibodies. This demonstration of the occurrence of this viral disease in a feral American mink population suggests that it could threaten populations of at least two protected mus...
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PMID: 11700927
PDF is available here.
PDF is available here.
Abstract
A chimera containing only the 3 amino acid substitutions in NS1 did not elicit measurable responses indicative of replication or pathogenicity in inoculated mink. Serum antiviral antibody responses, frequency of detection of viral nucleic acid in serum, gamma globulin response, and histologic change...
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PMID: 11592336
PDF is available here.
PDF is available here.
Abstract
These results indicated that the 2 isolates found in Japan were new DNA types of FADV and could have been derived from FADV(s). A restriction fragment length polymorphism (RFLP) method to distinguish the ferret types of ADV from the mink types of ADV was developed on the basis of differences in thei...
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PMID: 11478607
PDF is available here.
PDF is available here.
Voprosy Virusologii (46)2 2001
Abstract
Studies of reactions in animals with hereditary diseases (Sapphire minks highly sensitive to Aleutian disease virus, ADV; CBA mice with 60-70% incidence of tumors; AKR mice with 90% incidence of leukemia) showed that serum DNAse activity in these animals dropped after injection of a foreign heteroge...
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PMID: 11392967
PDF is available here.
PDF is available here.
Abstract
We surveyed native riparian carnivores and feral American mink. When serum samples from 12 free-ranging European and 16 feral American mink were tested, antibodies to ADV were detected from three of nine European mink. ADV DNA was detected by polymerase chain reaction in whole cell DNA from four of...
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PMID: 11272488
PDF is available here.
PDF is available here.
Abstract
We detected a single band of about 400 bp, specific to the AD virus....
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PMID: 10852410
PDF is available here.
PDF is available here.
Abstract
Severe nonsuppurative meningoencephalitis associated with Aleutian mink disease parvovirus (ADV) infection was observed in adult ranch mink. Brain lesions included severe, locally extensive to coalescing lymphoplasmacytic meningoencephalitis with accompanying gliosis, satellitosis, and mild extensio...
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PMID: 10730948
PDF is available here.
PDF is available here.
Journal of General Virology (81)Pt 2 2000
Abstract
We studied replication of ADV in gel-supported histocultures prepared from adult mink mesenteric lymph node (MLN). Evidence of virus replication in the histocultures was first observed by indirect immunofluorescence 72 h after incubation with virus. Cells resembling lymphocytes and macrophages conta...
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PMID: 10644831
PDF is available here.
PDF is available here.
Abstract
The genetic diversity of Aleutian mink disease virus (AMDV) was examined. Sequences obtained from 35 clinical samples were compared with five published sequences. An unusual, high genetic variability was revealed. Three phylogenetic subgroups of AMDV were identified, and the presence of more than on...
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PMID: 10565948
PDF is available here.
PDF is available here.
Journal of Virology (73)10 1999
Abstract
Aleutian mink disease parvovirus (ADV) is the etiological agent of Aleutian disease of mink. Several ADV isolates have been identified which vary in the severity of the disease they elicit. The isolate ADV-Utah replicates to high levels in mink, causing severe Aleutian disease that results in death...
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PMID: 10482625
PDF is available here.
PDF is available here.
Journal of Virology (73)8 1999
Abstract
The three-dimensional structure of expressed VP2 capsids of Aleutian mink disease parvovirus strain G (ADVG-VP2) has been determined to 22 A resolution by cryo-electron microscopy and image reconstruction techniques. A structure-based sequence alignment of the VP2 capsid protein of canine parvovirus...
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PMID: 10400786
PDF is available here.
PDF is available here.
Abstract
Six overlapping fragments of the Aleutian Mink Disease parvoVirus (AMDV) virion protein VP1 and 2 (VP1/2) gene were inserted into the expression vector pMAL-c2. Four of the clones carried large overlapping fragments covering the entire VP1/2 gene. The remaining two clones covered specifically chosen...
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PMID: 10219758
PDF is available here.
PDF is available here.
Voprosy Virusologii (44)1 1999
Abstract
Addition of mutilus hydrolysate MIGI-K to rations of minks with virus plasmacytosis involving grave immunological disorders led to changes in the ratio of serum protein fractions and in the differential blood count. Normalization of the protein spectrum of minks with Aleutian disease apparently inhi...
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PMID: 10190240
PDF is available here.
PDF is available here.
Abstract
Mink were infected with Aleutian Mink Disease Parvovirus (AMDV) and sacrificed at monthly intervals after infection. During this time humoral immune responses and leucocyte numbers in blood, mesenteric lymph node, spleen and thymus were monitored. Serum hypergammaglobulinaemia was observed together...
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PMID: 9656422
PDF is available here.
PDF is available here.
Journal of Virology (71)2 1997
Abstract
We examined replication of the autonomous parvovirus Aleutian mink disease parvovirus (ADV) in relation to cell cycle progression of permissive Crandell feline kidney (CRFK) cells. Flow cytometric analysis showed that ADV caused a composite, binary pattern of cell cycle arrest. ADV-induced cell cycl...
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PMID: 8995664
PDF is available here.
PDF is available here.
Archives of Virology (142)2 1997
Abstract
We reported infection to be antibody-dependent [22,23]. Recently, we learned that the U937 cells were contaminated with the human cell line, K562 [12]. To clarify which cell line actually supported ADV infection, we studied the antibody-dependent enhancement (ADE) of ADV infection in pure lines of U...
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PMID: 9125049
PDF is available here.
PDF is available here.
Abstract
Infected black dams were more likely to produce infected kits than were uninfected dams. In contrast, infected black sires were less likely to produce infected kits than were uninfected sires. In brown mink, in which prevalence of Aleutian disease was lower, transmission from infected dams and sires...
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PMID: 8950422
PDF is available here.
PDF is available here.
Abstract
After infection, leukocyte viral DNA is initially present in large amounts, but, in most mink, decreases markedly in association with the appearance of antibody. There is no difference in the progression and severity of the disease between black mink infected experimentally or naturally. Transmissio...
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PMID: 8950430
PDF is available here.
PDF is available here.
Abstract
Aleutian disease (AD) results from a persistent parvoviral infection that results in marked hypergammaglobulinemia and immune complex mediated lesions of the kidney, liver, lungs and, arteries. Melatonin protected both a wild type or demi strain and a demi/dark crossed strain of mink from AD. The bi...
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PMID: 8989719
PDF is available here.
PDF is available here.
Journal of Virology (70)3 1996
Abstract
The transplacental transmission of Aleutian mink disease parvovirus (ADV) was studied in experimental infection of 1-year-old female non-Aleutian mink. The ADV-seronegative female mink were inoculated with ADV prior to mating or after the expected implantation of the embryos during pregnancy. A grou...
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PMID: 8627663
PDF is available here.
PDF is available here.
Journal of Virology (70)2 1996
Abstract
We decided to examine the relationship between the capsid protein sequences and pathogenicity of ADV. Comparison of the ADV-TR hypervariable region sequence with sequences of other isolates of ADV revealed that ADV-TR was 94 to 100% related to the nonpathogenic type 1 ADV-G at both the DNA and amino...
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PMID: 8551624
PDF is available here.
PDF is available here.
Veterinary Research (27)6 1996
Abstract
Bacterial and fungi were isolated from different tissues (brain, liver, heart) taken from 81 dead newborn mink originating from Aleutian disease (AD) infected and AD-non-infected farms. Of the 123 isolates obtained, 96% were bacterial isolates (predominantly Gram-negative) and 4% were fungi. The pre...
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PMID: 8956475
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Aleutian mink disease (AD) is a naturally occurring persistent virus infection of mink caused by the Aleutian mink disease parvovirus (ADV). The classical form of AD, which occurs in adult mink, is notable for high titers of antiviral antibodies, hypergammaglobulinemia, plasmacytosis, and immune com...
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PMID: 7889316
PDF is available here.
PDF is available here.
Abstract
Aleutian mink disease (AD) has been characterized by immune complex glomerulonephritis associated with persistent infection of Aleutian mink disease parvovirus (ADV). Histopathological examination of kidneys from ADV-infected mink in this study revealed that interstitial nephritis characterized by p...
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PMID: 8203470
PDF is available here.
PDF is available here.
Journal of Virology (68)4 1994
Abstract
We have previously suggested that ADV replicates in the alveolar type II epithelial cells of the lung. By using double in situ hybridization, with the simultaneous use of a probe to detect ADV replication and a probe to demonstrate alveolar type II cells, we now confirm this hypothesis. Furthermore,...
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PMID: 8139047
PDF is available here.
PDF is available here.
Journal of Virology (68)2 1994
Abstract
We suppressed the B-cell development and antibody response in mink by using treatment with polyclonal anti-immunoglobulin M (anti-IgM) to study the effects of antiviral antibodies on development of Aleutian mink disease parvovirus (ADV)-induced disease in more detail. Newborn mink kits were injected...
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PMID: 8289377
PDF is available here.
PDF is available here.
Veterinary Record (134)4 1994
Abstract
Abstract
These results suggest that baculovirus recombinant ADV capsid proteins may be useful as diagnostic antigens....
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PMID: 8011776
PDF is available here.
PDF is available here.
Veterinary Record (133)7 1993
Abstract
Veterinary Record (132)19 1993
Abstract
Aleutian disease was diagnosed as the cause of posterior ataxia and paresis in domestic ferrets. Six serologically positive animals (four clinically affected and two unaffected) were investigated in detail and seven other clinically affected ferrets were also identified. The diagnostic findings incl...
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PMID: 7685128
PDF is available here.
PDF is available here.
Journal of Virology (67)4 1993
Abstract
We have previously shown that it is the level of viral gene expression that determines the disease pattern. To study the gene regulation of ADV, we have cloned the P3 ADV and P36 ADV promoters in front of a reporter gene, the chloramphenicol acetyltransferase (CAT) gene, and analyzed these construct...
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PMID: 8383215
PDF is available here.
PDF is available here.
Journal of Virology (67)4 1993
Abstract
We are currently investigating the regulation of transcription of the Aleutian mink disease parvovirus (ADV). ADV causes a chronic immune complex-mediated condition known as classical Aleutian disease, characterized by slow viral replication. This slow replication is an intrinsic property of ADV and...
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PMID: 8383216
PDF is available here.
PDF is available here.
Veterinary Record (131)13 1992
Abstract
Journal of Virology (66)9 1992
Abstract
We examined Aleutian mink disease parvovirus (ADV) mRNA expression in lymph nodes of adult mink infected with ADV by Northern (RNA) blot and in situ hybridization. In Northern blot analysis, ADV transcripts were detected in the poly(A) RNA fraction extracted from mesenteric lymph nodes of two of fiv...
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PMID: 1323697
PDF is available here.
PDF is available here.
Abstract
We present the clinical and laboratory findings associated with Aleutian disease in 2 domestic ferrets, one with the chronic wasting form of the disease and one with the central nervous system form....
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PMID: 1644626
PDF is available here.
PDF is available here.
Journal of Virology (66)5 1992
Abstract
These results suggested, therefore, that both VP1 and VP2 were synthesized from a single cloned transcript. CsCl density gradient centrifugation of partially purified VV:ADSP-infected cell lysates indicated that the majority of the antigen was located in a fraction with a density near 1.33 g/ml, ind...
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PMID: 1313919
PDF is available here.
PDF is available here.
Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society (3)2 1992
Abstract
In order to distinguish true positive results in counterimmunoelectrophoresis from false positive ones an additive counterimmunoelectrophoresis was developed. The method was tested on selected mink serum samples as part of a routine testing for antibodies towards Aleutian disease virus on 3 million...
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PMID: 1335756
PDF is available here.
PDF is available here.