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Foot Rot (0):
Recent article
Foot Rot
Preventive Veterinary Medicine (95)1-2 2010
Abstract
Dichelobacter nodosus is a slow-growing anaerobic bacterium that is the causative agent of virulent ovine footrot. Vaccination targeted at up to two specific serogroups can eliminate those serogroups from infected flocks, but requires identification of serogroups present in infected flocks. Serogrou...
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PMID: 20303191
PDF is available here.
PDF is available here.
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Abstract
The ovine foot rot is a severe infectious disease of sheep. Dichelobacter nodosus is an essential pathogen of this disease. An obligatory anaerobic gram-negative rod-shaped microorganism has slow rate of accumulating bacterial density and fastidious growth requirements. This causes obstacles to vacc...
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PMID: 20050159
PDF is available here.
PDF is available here.
Veterinary Microbiology (132)3-4 2008
Abstract
Footrot is a contagious disease of ruminants requiring strains of Dichelobacter nodosus that possess virulence factors including proteases and fimbriae. Sheep can be immunised against footrot using vaccine-containing fimbriae, either native or recombinant. The fimbriae are responsible for the serolo...
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PMID: 18621488
PDF is available here.
PDF is available here.
Journal of Bacteriology (190)9 2008
Abstract
We showed that mutation of either the pilT or pilU gene eliminated the ability to carry out twitching motility. However, the pilT mutants displayed decreased adhesion to epithelial cells and reduced protease secretion, whereas the pilU mutants had wild-type levels of extracellular protease secretion...
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PMID: 18310333
PDF is available here.
PDF is available here.
Veterinary Journal (175)2 2008
Abstract
A brief summary of the currently accepted aetiology and pathogenesis of footrot and interdigital dermatitis in sheep in Great Britain is presented together with a description of the transmission dynamics of Dichelobacter nodosus. Approaches that may be successful for control or elimination of the di...
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PMID: 17418598
PDF is available here.
PDF is available here.
Veterinary Journal (175)2 2008
Abstract
Abstract
A study was conducted in a feedlot in Alberta, Canada, to compare the clinical efficacy of a single injection of ceftiofur crystalline free acid sterile injectable suspension with three daily treatments of ceftiofur sodium sterile powder for the treatment of footrot. Use of a long-ac...
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PMID: 18597254
PDF is available here.
PDF is available here.
Abstract
Footrot is a highly contagious and economically important disease of sheep and goats, caused by Dichelobacter nodosus, a slow growing anaerobic Gram-negative rod. The current Australian antigenic classification system, based on variation in the fimbriae, classifies D. nodosus into at least 10 serogr...
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PMID: 17250860
PDF is available here.
PDF is available here.
Nature Biotechnology (25)5 2007
Abstract
We sequenced its 1.4-Mb genome, the smallest known genome of an anaerobe. It differs markedly from small genomes of intracellular bacteria, retaining greater biosynthetic capabilities and lacking any evidence of extensive ongoing genome reduction. Comparative genomic microarray studies and bioinform...
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PMID: 17468768
PDF is available here.
PDF is available here.
Abstract
The in vitro antimicrobial susceptibility of Gram-negative anaerobic bacilli commonly isolated from footrot in goats was studied. A total of 97 isolates belonging to the genera Dichelobacter, Fusobacterium, Prevotella, Porphyromonas and Bacteroides, obtained from clinical cases of footrot in south-w...
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PMID: 17385552
PDF is available here.
PDF is available here.
Abstract
These results provide two hypotheses: one that 'footrot and interdigital dermatitis are infectious diseases that can be controlled, in part, through the use of antibiotic therapy, which acts to reduce the infectious period of diseased sheep' and two, that 'routine trimming of diseased and healthy fe...
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PMID: 17092589
PDF is available here.
PDF is available here.
Abstract
Major parts of the virulence-associated vrl locus known from the gammaproteobacterium Dichelobacter nodosus, the causative agent of ovine footrot, were analyzed in the genome of the sulfate-reducing deltaproteobacterium Desulfococcus multivorans. In the genome of D. multivorans 13 of the 19 vrl gene...
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PMID: 17693723
PDF is available here.
PDF is available here.
Abstract
We developed a nested polymerase chain reaction that allowed detection of D. nodosus without culture. Using this assay, we were able to diagnose D. nodosus infections of ibex, mouflon, and domestic sheep in natural outbreaks. From these results we conclude that D. nodosus plays an etiological role i...
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PMID: 17347396
PDF is available here.
PDF is available here.
Abstract
The spirochaete isolate was identified as a Treponema species closely related to some isolates from the United States (by 16S rDNA) and to T. phagedenis (by flagellin gene sequence) and is associated with bacteriophage particles. SIGNIFICANCE AND IMPACT OF THE STUDY: The fact that the isolates with...
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PMID: 16968306
PDF is available here.
PDF is available here.
Veterinary Journal (172)2 2006
Abstract
An outbreak of virulent footrot was investigated in a flock of 605 Merino cross-bred sheep in Bhutan. Conventional control methods in the preceding eight years had reduced its prevalence from 36-79% in different components of the flock to about 15% overall. Only one serogroup (B) of Dichelobacter no...
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PMID: 16019243
PDF is available here.
PDF is available here.
Abstract
The present study reports on the location of major foci of footrot in goats in the Extremadura region of Spain by the determination of locally occurring strictly anaerobic microorganisms involved in the pathogenesis and development of this disease. The most commonly isolated microorganisms belonged...
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PMID: 17020135
PDF is available here.
PDF is available here.
Veterinary Journal (171)3 2006
Abstract
Footrot is a highly contagious disease of the feet of ruminants caused by the synergistic action of certain bacterial species of which Dichelobacter nodosus (D. nodosus) is the main transmitting agent. The infection is specific to sheep and goats, although it has also been reported in cattle, horses...
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PMID: 16624707
PDF is available here.
PDF is available here.
Veterinary Journal (171)2 2006
Abstract
The first cases of footrot in Bhutan were reported in sheep in 1990 at the National Sheep Breeding Centre (NSBC), which supplies breeding animals to village sheep flocks throughout Bhutan. Despite the presence of footrot at the Centre the distribution of apparently disease-free sheep continued. Case...
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PMID: 16490719
PDF is available here.
PDF is available here.
Veterinary Record (158)2 2006
Abstract
Abstract
European mouflon are in the focus of research since they were brought from the Tyrrhenic islands to the European mainland a hundred years ago. From the beginning many populations on European mainland suffer from different claw diseases which are unknown in their original habitats. Foot rot, the ovin...
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PMID: 17007468
PDF is available here.
PDF is available here.
Veterinary Microbiology (111)3-4 2005
Abstract
Contagious ovine digital dermatitis (CODD) is a recently recorded, apparently new infection of the ovine hoof, which differs clinically from footrot caused by Dichelobacter nodosus and which fails to respond well to accepted treatment practices for footrot. Despite the welfare implications of such a...
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PMID: 16280206
PDF is available here.
PDF is available here.
Veterinary Microbiology (111)3-4 2005
Abstract
We aimed to isolate, identify, and characterize as many D. nodosus strains as possible from NZ farms by using polymerase chain reaction (PCR)-based technology. Understanding the virulence of this bacterium and showing extensive genomic variation in the fimbrial subunit gene (fimA) in different D. no...
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PMID: 16280202
PDF is available here.
PDF is available here.
Veterinary Record (157)24 2005
Abstract
In 1999, a study was initiated to improve the treatment and control of footrot and interdigital dermatitis in sheep flocks in England and Wales. In November 2000, a retrospective cross-sectional study was conducted in which 392 sheep farmers were asked to estimate the prevalence of footrot and inter...
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PMID: 16339978
PDF is available here.
PDF is available here.
Abstract
An outbreak of footrot has occurred in Debrezeit swine farm that is located 44 km south east of the capital. Among 24 pigs, 75% showed lameness, hot, painful and swollen feet, hemorrhagic bruising of the coronary band, heel erosion, sole ulcers and separation of skin from hoof on hind limbs. Bacteri...
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PMID: 16294005
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of subcutaneous slow-release melatonin implants in the humoral response after a vaccination. We reported here a new feature of melatonin as an adjuvant-like system towards Dichelobacter nodosus (A1 and C serotypes)--the bacterium which cause ovine footrot--the most importa...
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PMID: 16055232
PDF is available here.
PDF is available here.
Canadian Veterinary Journal (46)11 2005
Abstract
A randomized and blinded field trial was carried out to evaluate the efficacy of a Fusobacterium necrophorum bacterin for control of liver abscesses and footrot under commercial feedlot conditions in western Canada. Half of the vaccinated and half of the unvaccinated control animals had ad libitum a...
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PMID: 16363327
PDF is available here.
PDF is available here.
Veterinary Journal (170)1 2005
Abstract
Veterinary Microbiology (108)1-2 2005
Abstract
Footrot, caused by the strictly anaerobic bacterium Dichelobacter nodosus, is the most common cause of lameness in sheep in Great Britain but problems exist in association with its diagnosis and control. The fastidious nature of D. nodosus means that complex media and several weeks are required for...
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PMID: 15917134
PDF is available here.
PDF is available here.
Veterinary Journal (169)2 2005
Abstract
We have investigated the hypothesis that the two diseases may have a shared (common) spirochaetal aetiology. Experiments were designed to identify serological similarities and differences between the two spirochaetes; an enzyme-linked immunosorbent assay (ELISA) was developed to detect anti-treponem...
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PMID: 15727915
PDF is available here.
PDF is available here.
Veterinary Journal (169)1 2005
Abstract
Ovine footrot remains the most important cause of lameness in sheep flocks in the UK, despite the existence of proven methods for the control of the disease. Recent research suggests that sheep farmers may be unaware of these methods and may allocate greater resources to treatment of footrot rather...
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PMID: 15683762
PDF is available here.
PDF is available here.
Abstract
An outbreak of footrot occurred in a flock of Corriedale sheep; 27 animals were treated with antibiotic and footbathed in a 5% copper sulfate solution. Being deprived of water for > 17 h, many sheep drank the footbath solution. After 6 h 16 sheep became ill with acute copper poisoning, 10 animals di...
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PMID: 15587248
PDF is available here.
PDF is available here.
Abstract
Dichelobacter nodosus was detected in three clinical cases of ovine footrot in Kashmir, India. The detection was done by PCR in three clinical specimens directly, without isolating the organism, using species-specific 16S rDNA primers. Positive results were indicated by amplification of a 783 bp pro...
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PMID: 15294315
PDF is available here.
PDF is available here.
Abstract
I and II showed only signs of vegetative interdigital pododermatitis. The lesions were surgically removed and either protected with bandages (in Group I) or cauterized with incandescent iron (Group II). The animals in Groups III, IV, and V, showed signs of necrotic pododermatitis. These were treated...
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PMID: 15604479
PDF is available here.
PDF is available here.
Veterinary Record (154)24 2004
Abstract
Abstract
The agar dilution method was used to determine the inhibitory activity of 25 antimicrobial agents against 69 strains of Dichelobacter nodosus and 108 strains of the genus Fusobacterium, all of which were isolated from 90 clinical cases of ovine footrot between October 1998 and November 2000. In the...
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PMID: 15330985
PDF is available here.
PDF is available here.
Veterinary Record (154)18 2004
Abstract
As part of an investigation into improving the treatment and control of lameness in sheep flocks in England and Wales, a postal survey was conducted in November 2000. Farmers were asked to estimate the prevalence of footrot and interdigital dermatitis in their flocks. In the ewes the prevalence of i...
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PMID: 15143999
PDF is available here.
PDF is available here.
Veterinary Record (154)2 2004
Abstract
Abstract
We propose a simple, rapid and effective way to achieve this task. Our flowchart will provide the means to identify this microorganism in any laboratory of general microbiology without having to use any specialised equipment....
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PMID: 15379442
PDF is available here.
PDF is available here.
Abstract
When a flock infected with IFR was moved to a region where climatic conditions were more favourable for footrot transmission, the clinical classification of the disease remained the same in both the original flock and in sheep exposed to the infection for the first time....
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PMID: 15080488
PDF is available here.
PDF is available here.
Abstract
IFR can be eradicated by inspection and culling but latent infections, which may persist undetected for at least 34 weeks, require surveillance inspections to be repeated during the non-transmission phase of the program. The use of parenteral antibiotics as an aid to the eradication of IFR is contra...
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PMID: 15086111
PDF is available here.
PDF is available here.
Abstract
We found it appropriate to carry out a study directed towards isolating and identifying the entailed microorganisms which trigger off footrot in sheep, placing special emphasis on the serotipification of the different Dichelobacter nodosus species. With this goal in mind four flocks from the Portugu...
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PMID: 12667188
PDF is available here.
PDF is available here.
Veterinary Microbiology (92)1-2 2003
Abstract
I strain to serogroup G. The resultant mutants were shown by Western blotting and slide agglutination to produce serogroup G fimbriae, but by two independent methods to still have the genotype of the parent type I strain. These data have significant implications for the use of fimbrial vaccines for...
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PMID: 12488080
PDF is available here.
PDF is available here.
Veterinary Record (152)12 2003
Abstract
A postal survey of the techniques being used for the treatment and control of footrot in sheep flocks between November 1999 and October 2000 was conducted in England and Wales in November 2000. Of the 392 questionnaires circulated, 251 (64 per cent) were returned, and 209 of these were usable. Negat...
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PMID: 12678258
PDF is available here.
PDF is available here.
Abstract
The introduction of the first part deals with immunogenetic investigations on the field of life-stock. The main chapter is outlined as a tabular overview of current opportunities of the application of indicator traits as well as marker and causal genes in breeding for disease resistance in cattle, s...
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PMID: 12596663
PDF is available here.
PDF is available here.
Australian Veterinary Journal (81)1-2 2003
Abstract
Repeated daily footbathing did not eradicate virulent ovine footrot because strain A198 produced deep, covert lesions that facilitated the survival of D. nodosus....
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PMID: 15084013
PDF is available here.
PDF is available here.
Veterinary Record (151)10 2002
Abstract
Programmes based on the identification and treatment of cases and the culling of animals refractory to treatment had failed to eradicate virulent footrot from two districts in the western region of Nepal. From 1993 to 1996 vaccination against two endemic virulent strains of Dichelobacter nodosus was...
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PMID: 12243270
PDF is available here.
PDF is available here.
Abstract
The identification of Dichelobacter nodosus present in a flock is a prerequisite to specific (autogenous) vaccination. Current methods of identification of the serogroup present in a population requires that the organisms be isolated, identified visually in mixed culture on streak plates, subculture...
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PMID: 12270270
PDF is available here.
PDF is available here.
Veterinary Microbiology (87)3 2002
Abstract
We investigated the primary immune response of goats to experimental and natural infection, the memory response in recovered animals, and the transfer and persistence of colostral antibodies in kids. Footrot stimulated the goat's immune system and, as in sheep, under-running lesions were the primary...
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PMID: 12052334
PDF is available here.
PDF is available here.
Abstract
Chemotaxis toward P. levii was not significantly different from control values at any of the tested bacterial concentrations. Phagocytosis of P. levii was approximately 10% at a 10:1 bacterium to macrophage ratio and did not change significantly over time. When higher proportions of P. levii were te...
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PMID: 12013480
PDF is available here.
PDF is available here.
Abstract
A novel spirochaete was isolated from a case of severe virulent ovine foot rot (SVOFR) by immunomagnetic separation with beads coated with polyclonal anti-treponemal antisera and prolonged anaerobic broth culture. The as yet unnamed treponeme differs considerably from the only other spirochaete isol...
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PMID: 11761190
PDF is available here.
PDF is available here.
Veterinary Record (149)16 2001
Abstract
Abstract
After footbathing, there were no lesions in any treatment sheep at any inspection to week 52. The percentage of feet of control sheep with lesions increased from 9% (391 of 4,284) between weeks 20 and 36, to 14% (593 of 4,284) between weeks 36 and 52. Ninety-five of 96 control sheep with no lesions...
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PMID: 11491224
PDF is available here.
PDF is available here.
Veterinary Microbiology (80)2 2001
Abstract
We describe an approach to genotyping D. nodosus, based on variation in the fimbrial subunit gene (fimA), which uses polymerase chain reaction (PCR) amplification and hybridisation to immobilised oligonucleotides (PCR/oligotyping).The variable region of D. nodosus fimA, amplified and labelled with d...
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PMID: 11295335
PDF is available here.
PDF is available here.
Veterinary Microbiology (79)1 2001
Abstract
The immunological memory (anamnestic) responses in sheep recovered from virulent footrot (VFR) can be aroused by subcutaneous injection of outer membrane protein (OMP) antigens of Dichelobacter nodosus. The magnitude of this response is directly correlated to the highest antibody response attained d...
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PMID: 11230927
PDF is available here.
PDF is available here.
FEMS Microbiology Letters (194)2 2001
Abstract
A strain of Corynebacterium pseudotuberculosis, designated Toxminus, that has been rationally attenuated by deletion of the phospholipase D gene, is being developed as a live vaccine vector for the delivery of veterinary vaccine antigens. In the present study a recombinant form of the basic protease...
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PMID: 11164307
PDF is available here.
PDF is available here.
Abstract
A microbiological study of 25 cases of ovine footrot was performed. Cultures belonging to Dichelobacter nodosus were isolated in 48% of the sampled animals. The sensitivity of the 99 strict anaerobic bacterial isolates to 5 antibiotics (penicillin G, amoxycillin, spiramycin, erythromycin and oxytetr...
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PMID: 11402641
PDF is available here.
PDF is available here.
Veterinary Microbiology (76)2 2000
Abstract
Polymerase chain reaction (PCR) was used to amplify the variable region of the fimbrial subunit encoding gene (fimA) of Dichelobacter nodosus from sheep and goats infected with footrot. Two amplimers (designated X and Y) generated single-strand conformation polymorphism (SSCP) patterns different to...
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PMID: 10946146
PDF is available here.
PDF is available here.
Veterinary Microbiology (74)3 2000
Abstract
We describe the preliminary classification of this spirochete based on nucleotide sequence analysis of the PCR-amplified 16S rRNA gene. Phylogenetic analysis of this sequence in comparison with other previously reported 16S rRNA gene sequences showed that the spirochete belonged to the treponemal ph...
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PMID: 10808093
PDF is available here.
PDF is available here.