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Myxomatosis, Infectious (0):
Recent article
Myxomatosis, Infectious
Abstract
The European rabbit was brought to Australia as a companion animal by early settlers. It sometimes escaped, but failed to survive in the Australian bush. In 1879 wild rabbits were deliberately sent to Victoria to provide game for wealthy settlers to shoot. They soon spread all over Australia, except...
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PMID: 20617651
PDF is available here.
PDF is available here.
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Abstract
Vaccination is the best way to control myxomatosis in both pet and production rabbits. Two types of myxomatosis vaccines are commercially available, namely, a vaccine prepared from the Shope fibroma virus (SFV) and one prepared from an attenuated myxoma virus (MV) strain, e.g., SG33....
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PMID: 20334023
PDF is available here.
PDF is available here.
Abstract
A cross-sectional study was carried out in natural wild rabbit (Oryctolagus cuniculus) populations from southern Spain to identify risk factors associated to myxoma virus infection. Blood samples from 619 wild rabbits were collected, and questionnaires which included variables related to host, disea...
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PMID: 19818517
PDF is available here.
PDF is available here.
Abstract
A long-range PCR method directed at the Myxoma virus (MV) left hand and right hand terminal inverted repeats (TIRs) for rapid amplification of genomic DNA and MV isolate differentiation by restriction fragment length polymorphism (RFLP) analysis is described. The efficacy of this method was tested b...
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PMID: 19591871
PDF is available here.
PDF is available here.
Parasitology (85 (Pt 2))02 2009
Abstract
Veterinary Research (40)1 2009
Abstract
Myxoma virus (MYXV), a member of the Poxviridae family, is the agent responsible for myxomatosis, a fatal disease in the European rabbit (Oryctolagus cuniculus). MYXV has a linear double-stranded DNA genome that encodes several factors important for evasion from the host immune system. Among them, f...
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PMID: 19019281
PDF is available here.
PDF is available here.
Veterinary Microbiology (129)1-2 2008
Abstract
Myxoma virus (MXV) causes the systemic disease myxomatosis in the European rabbit. Despite many in vitro studies on the function of MXV immunomodulatory proteins and detailed molecular knowledge of virus, little is known about the dynamics of interaction of the virus with the integrated host-immune...
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PMID: 18222052
PDF is available here.
PDF is available here.
Preventive Veterinary Medicine (84)1-2 2008
Abstract
We analyzed the capture-mark-recapture data obtained in a 4-year field experiment (1991-1994) in a park near Paris, France wherein 300 out of 565 seronegative juvenile rabbits were vaccinated at first capture against myxomatosis with the nontransmissible Dervaximyxo SG33 vaccine. After accounting fo...
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PMID: 18045714
PDF is available here.
PDF is available here.
Abstract
We examined the hypothesis that the interaction between concomitant infecting parasites modifies host susceptibility, parasite intensity and the pattern of parasite distribution within the host population. We used a 26 year time series of three common parasites in a natural population of rabbits: tw...
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PMID: 17936286
PDF is available here.
PDF is available here.
Abstract
We have built a stochastic model of a rabbit metapopulation infected by myxomatosis. We show that the impact of the pathogen agent can be reduced by early infections only when the agent has a long local persistence time and/or when the host subpopulations are highly connected. The length of the repr...
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PMID: 18068733
PDF is available here.
PDF is available here.
Abstract
The myxoma virus M063R gene product exhibits some sequence similarity to the poxvirus host range gene, C7L, of vaccinia virus. To address the potential host range function of the M063R gene product in rabbits, a deletion mutant of myxoma virus (vMyx63KO) was generated and characterized. vMyx63KO rep...
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PMID: 17184804
PDF is available here.
PDF is available here.
Veterinary Research (38)2 2007
Abstract
Myxoma virus (MV) is a poxvirus that evolved in Sylvilagus lagomorphs, and is the causative agent of myxomatosis in European rabbits (Oryctolagus cuniculus). This virus is not a natural pathogen of O. cuniculus, yet is able to subvert the host rabbit immune system defenses and cause a highly lethal...
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PMID: 17296158
PDF is available here.
PDF is available here.
Journal of Virology (81)1 2007
Abstract
We propose that M135R is an important immunomodulatory virulence factor for myxomatosis but that the target immune ligand is not from the predicted type I interferon family and remains to be identified....
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PMID: 17065210
PDF is available here.
PDF is available here.
Abstract
We show that this phenomenon may lead to a difference of impact of myxomatosis according to its transmission rate. Young are exposed when they still carry maternal antibodies and develop a mild disease in high transmission populations. Our results show that the impact of myxomatosis is generally hig...
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PMID: 16580697
PDF is available here.
PDF is available here.
Immunogenetics (58)5-6 2006
Abstract
We have characterized and compared CCR5 genes of leporid species with different susceptibility levels to myxomatosis. The CCR5 protein of O. cuniculus differs markedly from all those known from other species. The most striking was the replacement of a specific peptide motif of the second extracellul...
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PMID: 16596402
PDF is available here.
PDF is available here.
Abstract
Myxoma virus (MYX) prevents apoptosis in RK-13 cells and forms thick dermal lesions with 100% mortality in rabbits. MYX encodes the virulence factor SERP2, a serine proteinase inhibitor (serpin). SERP2 was mutated to evaluate SERP2 function during MYX infection. MYXDeltaSERP2::lacZ (deleted for SERP...
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PMID: 16959285
PDF is available here.
PDF is available here.
Abstract
We performed a functional mapping of MV-LAP and showed that not only the C(4)HC(3) motif is necessary for a marked downregulation of MHC-I but also a conserved region in the C-terminal part of the protein. We also showed that the putative transmembrane domains are responsible for a specific subcellu...
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PMID: 16185739
PDF is available here.
PDF is available here.
Abstract
We assessed the effect of two pathogens (myxoma virus and Eimeria stiedae) and five macroparasites (gastrointestinal helminth species) of the wild rabbit (Oryctolagus cuniculus) upon total host body mass and abdominal fat level. Additionally, we assessed the effects of these organisms on the number...
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PMID: 16051247
PDF is available here.
PDF is available here.
Veterinary Record (155)19 2004
Abstract
Serological data on myxoma virus, rabbit haemorrhagic disease (RHD) virus and RHD-like viruses in juvenile rabbits (Oryctolagus cuniculus) trapped in 1995, 1996 and 1997 in two areas of France were analysed. For each disease, the effects of bodyweight, year, month and seropositivity for the other di...
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PMID: 15573951
PDF is available here.
PDF is available here.
Veterinary Record (155)13 2004
Abstract
The effects of vaccination against myxomatosis and viral haemorrhagic disease (VHD) on long-term mortality rates in European rabbits (Oryctolagus cuniculus) were studied from 1993 to 1996 by radiotracking a free-living population of wild rabbits. During the three months after immunisation, unvaccina...
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PMID: 15499810
PDF is available here.
PDF is available here.
Abstract
Myxomatous stromal changes and bone marrow necrosis (BMN) are uncommon histologic findings. These changes have been found in various conditions like disseminated carcinomatosis, postchemotherapy cases, chronic infections, infiltrative disorders of the marrow etc. The present study is a retrospective...
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PMID: 16295422
PDF is available here.
PDF is available here.
Abstract
Rabbit IL-4 was expressed in the virulent standard laboratory strain (SLS) and the attenuated Uriarra (Ur) strain of myxoma virus with the aim of creating a Th2 cytokine environment and inhibiting the development of an antiviral cell-mediated response to myxomatosis in infected rabbits. This allowed...
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PMID: 15183059
PDF is available here.
PDF is available here.
Archives of Virology (149)3 2004
Abstract
Partial sequence mapping of the MSW Californian strain of Myxoma virus was performed by cloning EcoRI and SalI restriction fragments of viral DNA and sequencing the ends of these. In this way, regions of 74 MSW open reading frames were sequenced and mapped onto the complete genome sequences of the r...
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PMID: 14991443
PDF is available here.
PDF is available here.
Veterinary Record (153)14 2003
Abstract
Abstract
Atypical form of myxomatosis, which caused non-lethal and clinically mild disease in domestic rabbits 1 month after immunization with a commercially available vaccine MXT, is described. The isolated myxoma virus designated as Litovel 2 (Li-2) did not induce systemic disease following subcutaneous an...
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PMID: 14628995
PDF is available here.
PDF is available here.
Abstract
I discuss the biochemical properties of the characterized immunomodulatory proteins of myxoma virus, and their pathogenic effects in laboratory rabbits. Disruption of any one myxoma immunomodulatory gene diminishes the severity of the infection without compromising infectivity. Thus, the characteriz...
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PMID: 12734406
PDF is available here.
PDF is available here.
Veterinary Record (152)10 2003
Abstract
Epidemiology and Infection (130)1 2003
Abstract
An identifiable strain of myxoma virus was introduced into four local populations of wild rabbits Oryctolagus cuniculus on the southern tablelands of New South Wales (NSW) and its spread in the presence of other field strains was monitored for 6 months. The main vector in this region was considered...
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PMID: 12613755
PDF is available here.
PDF is available here.
Epidemiology and Infection (130)1 2003
Abstract
A survey of rabbit populations in the southern tablelands of New South Wales, Australia, was carried out to establish the pattern of occurrence of myxomatosis in preparation for a deliberate release of myxoma virus. Myxomatosis was first detected in December and cases were found on most sites throug...
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PMID: 12613753
PDF is available here.
PDF is available here.
Epidemiology and Infection (130)1 2003
Abstract
To be able to study the dynamics of myxoma virus spread following a release in the field, a strain of virus is required that is both highly transmissible and readily differentiated from other field strains. Eight strains of virus of known virulence for laboratory rabbits and with previously mapped a...
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PMID: 12613754
PDF is available here.
PDF is available here.
Medical Journal of Australia (178)2 2003
Abstract
Abstract
An outbreak of the atypical form of myxomatosis struck a rabbit farm in Hungary. The animals had previously been vaccinated with a vaccine containing Shope rabbit fibroma virus strain. The disease appeared in winter when the presence of mosquitoes and fleas is not common. The virus was isolated from...
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PMID: 14680061
PDF is available here.
PDF is available here.
Virus Research (88)1-2 2002
Abstract
I discuss the characterized immunomodulatory proteins of myxoma virus, their biochemical properties, their pathogenic effects in laboratory rabbits, the role of the host immune system in the susceptibility or resistance to myxomatosis, and the evidence that immunomodulatory genes may have been atten...
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PMID: 12297325
PDF is available here.
PDF is available here.
Veterinary Record (150)25 2002
Abstract
From January 1993 to June 1996, the epidemiology of myxomatosis and viral haemorrhagic disease (VHD) was studied in a free-living population of wild rabbits (Oryctolagus cuniculus) in Spain by means of serological surveys and radiotracking. Myxomatosis was endemic and associated with the breeding pe...
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PMID: 12135072
PDF is available here.
PDF is available here.
Journal of Virology (76)6 2002
Abstract
We cloned and characterized a gene coding for an endoplasmic reticulum (ER)-resident protein containing an atypical zinc finger and two transmembrane domains, which we called myxoma virus leukemia-associated protein (MV-LAP). MV-LAP down-regulated surface MHC-I and Fas-CD95 molecules upon transfecti...
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PMID: 11861858
PDF is available here.
PDF is available here.
Viral Immunology (15)2 2002
Abstract
Myxoma virus causes the systemic disease myxomatosis in the European rabbit (Oryctolagus cuniculus). Originating in the South American rabbit Sylvilagus brasiliensis, where it causes a relatively localized fibroma, myxoma virus is a classic example of a virus that has jumped species to produce an ex...
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PMID: 12081009
PDF is available here.
PDF is available here.
Abstract
Abstract
Understanding the factors controlling the distribution of parasites within their host population is fundamental to the wider understanding of parasite epidemiology and ecology. To explore changes in parasite aggregation, Taylor's power law was used to examine the distributions of five gut helminths...
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PMID: 11595228
PDF is available here.
PDF is available here.
Abstract
We look at these events and examine what insights can be gained from this history....
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PMID: 11553459
PDF is available here.
PDF is available here.
Abstract
We have recently developed a transmissible vaccine against myxomatosis and rabbit hemorrhagic disease (RHD) based on a recombinant myxoma virus (MV) expressing the RHDV capsid protein [J. Virol. 74 (2000) 1114]. The efficacy and safety of the vaccine have been extensively evaluated under laboratory...
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PMID: 11483281
PDF is available here.
PDF is available here.
Journal of General Virology (82)Pt 6 2001
Abstract
Myxoma virus (MV), a member of the family Poxviridae, is the causative agent of myxomatosis, a fatal disease of the European rabbit. The MV genome is a linear, double-stranded DNA molecule that encodes several factors important for evasion of the host immune system. Sequencing the right-end region o...
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PMID: 11369885
PDF is available here.
PDF is available here.
Seminars in Immunology (13)1 2001
Abstract
We draw attention to some of the new open reading frames (ORFs) discovered during the sequencing of the myxoma virus DNA genome [Cameron C, Hota-Mitchell S, Chen L, Barrett J, Cao J-X, Macaulay C, Willer D, Evans D, McFadden G (1999) The complete DNA sequence of myxoma virus. Virology 264:298-318] t...
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PMID: 11289802
PDF is available here.
PDF is available here.
Abstract
Myxomatosis is a major viral disease of the European rabbit (Oryctolagus cuniculus). Two forms of the disease (nodular and amyxomatous) exist. The clinical diagnosis of the nodular form is easily performed on the basis of typical skin lesions whereas that of amyxomatous forms must be based on virus...
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PMID: 11150634
PDF is available here.
PDF is available here.
Abstract
We have recently developed a transmissible vaccine to immunize rabbits against myxomatosis and rabbit haemorrhagic disease based on a recombinant myxoma virus (MV) expressing the rabbit haemorrhagic disease virus (RHDV) capsid protein [Bárcena et al. Horizontal transmissible protection against my...
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PMID: 10930670
PDF is available here.
PDF is available here.
Molecular Ecology (9)9 2000
Abstract
These results suggest that, contrary to what is usually thought and in spite of the subsequent high mortality rates, past epizootics (especially myxomatosis) may have had little effect on the genetic diversity of wild rabbit populations in Europe....
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PMID: 10972766
PDF is available here.
PDF is available here.
Abstract
The myxoma virus (MYX) serpin SERP1 is a secreted glycoprotein with anti-inflammatory activity that is required for full MYX virulence in vivo. The cowpox virus (CPV) serpin SPI-3 (vaccinia virus ORF K2L) is a nonsecreted glycoprotein that blocks cell-cell fusion, independent of serpin activity, and...
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PMID: 10873771
PDF is available here.
PDF is available here.
Abstract
An outbreak of myxomatosis occurred between September and October 1993 on a rabbit farm in Punta Colnett (Ensenada, Baja California in northwestern Mexico, Transpeninsular Highway, km 128) and was confirmed by the Mexico-USA Commission for Prevention of Foreign Diseases of Animals (CPA). This repres...
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PMID: 10941750
PDF is available here.
PDF is available here.
Veterinary Journal (159)2 2000
Abstract
Sixty-six rabbits, with no history of vaccination against myxomatosis and which had died of pulmonary lesions, were submitted for virological and serological tests for Myxoma virus (MV) infection and for bacteriological examinations. At post mortem, the diagnoses based on observed lesions were as fo...
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PMID: 10712805
PDF is available here.
PDF is available here.
Abstract
We have compared the pathogensis of the virulent strain of myxoma virus originally released into Australia and an attenuated, naturally derived field strain of myxoma virus. This was done in laboratory rabbits, which have not been selected for resistance, and in wild rabbits that have developed sign...
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PMID: 10648181
PDF is available here.
PDF is available here.
Journal of Virology (74)3 2000
Abstract
We have developed a new strategy for immunization of wild rabbit populations against myxomatosis and rabbit hemorrhagic disease (RHD) that uses recombinant viruses based on a naturally attenuated field strain of myxoma virus (MV). The recombinant viruses expressed the RHDV major capsid protein (VP60...
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PMID: 10627521
PDF is available here.
PDF is available here.
Journal of Comparative Pathology (122)2-3 2000
Abstract
The virulence of five amyxomatous myxoma virus (MV) strains, the clinical and pathogenetic effects of which had been studied previously in specific pathogen-free (SPF) rabbits, was determined by inoculation of five groups of 10 crossbred New Zealand White/Californian conventional rabbits. A much mor...
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PMID: 10684679
PDF is available here.
PDF is available here.
Journal of Comparative Pathology (122)2-3 2000
Abstract
Two types of myxomatosis vaccine are available commercially, namely, vaccine prepared from the Shope fibroma virus (SFV) and that prepared from an attenuated myxoma virus (MV) strain, e.gSG33. An experiment was designed to compare two vaccination schemes for their ability to protect rabbits against...
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PMID: 10684680
PDF is available here.
PDF is available here.
Abstract
Myxomatosis is a specific disease of the European rabbit (Oryctolagus cuniculus) due to a virus belonging to the genus Leporipoxvirus. Forty-seven years after its deliberate introduction into Europe, the clinical aspects and the epizootiology of myxomatosis have changed. Two forms (nodular and amyxo...
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PMID: 10542126
PDF is available here.
PDF is available here.
Abstract
We hypothesized that removal of the RDEL motif from M-T4 would alter the subcellular localization of the protein and provide insight into its antiapoptotic role. Surprisingly, removal of the RDEL motif from M-T4 did not affect localization of the protein within the endoplasmic reticulum (ER), but it...
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PMID: 10544103
PDF is available here.
PDF is available here.
Abstract
An enzyme-linked immunosorbent assay (ELISA) was developed and compared with 2 reference diagnostic tests (indirect immunofluorescence [IF] and complement fixation) to detect myxoma virus-specific antibodies in sera from 50 rabbits experimentally vaccinated with an attenuated strain of myxoma virus...
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PMID: 10353355
PDF is available here.
PDF is available here.
Abstract
We constructed a recombinant M-T1-deletion mutant virus that was defective in M-T1 expression. Here, we demonstrate that M-T1 is expressed continuously during the course of myxoma virus infection as a highly stable 43-kDa glycoprotein and is dispensable for virus replication in vitro. Deletion of M-...
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PMID: 10191189
PDF is available here.
PDF is available here.
Immunological Reviews (168) 1999
Abstract
We describe two distinct viral strategies carried out by viral proteins with which myxoma virus subverts the host immune response. The first strategy is the production of virus-encoded proteins known as viroceptors or virokines that mimic host receptors or cytokines. These seek to actively block ext...
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PMID: 10399068
PDF is available here.
PDF is available here.
Journal of Virology (72)10 1998
Abstract
We address the role of Serp2 in the development of myxomatosis, a lethal infectious disease of the European rabbit. A Serp2 mutant myxoma virus was constructed by disruption of the single-copy serp2 gene and insertion of the Escherichia coli gpt gene serving as the selectable marker. A revertant vir...
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PMID: 9733819
PDF is available here.
PDF is available here.
Abstract
An outbreak of rabbit viral hemorrhagic disease (RVHD) and of myxomatosis occurred in a free-living population of rabbits (Oryctolagus cuniculus) near Paris (France) in 1995. Annual mortality rates were 88% in adults and 99% in juveniles. There was no difference in mortality rates between males and...
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PMID: 9706551
PDF is available here.
PDF is available here.
Abstract
Myxoma virus in European rabbits (Oryctolagus cuniculus) is one of the best documented examples of host-virus co-evolution. In the natural hosts (Sylvilagus brasiliensis or S. bachmani rabbits in the Americas), myxoma virus causes a benign cutaneous fibroma. In European rabbits, however, myxoma viru...
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PMID: 9638815
PDF is available here.
PDF is available here.