Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Paratuberculosis (0):
Recent article
Paratuberculosis
Tijdschrift voor diergeneeskunde (135)23 2010
Abstract
Paratuberculosis is a chronic disease in ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP). Most economic losses due to MAP occur in the dairy industry. However, the infection is not restricted to cattle, but also occurs in other ruminants, such as sheep, goat, and deer. Although...
|
PMID: 21207913
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Journal of Dairy Science (93)10 2010
Abstract
We describe available models' structure and examine them in the context of current knowledge about host infection and pathogen transmission pathways. We investigate how population structure and herd management are modeled with regard to their influence on contact structure and pathogen transmission....
|
PMID: 20854979
PDF is available here.
PDF is available here.
Abstract
Paratuberculosis (Johne's disease) has emerged as one of the most important diseases in cattle. The role of infected bull semen in the spread of infection remains unclear, as the correlation between the amount of excreted Mycobacterium avium subsp. paratuberculosis (semen and feces) and the infectio...
|
PMID: 20460836
PDF is available here.
PDF is available here.
Abstract
To study the association of polymorphisms at five microsatellite loci with immune responses to a killed Mycobacterium avium subsp. paratuberculosis (Map) vaccine.
Merino sheep (504 vaccinates and 430 unvaccinated controls) from a long-term Johne's vaccine trial undertaken on three different properti...
|
PMID: 20927174
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)8 2010
Abstract
Among the costs attributed to Mycobacterium avium ssp. paratuberculosis (MAP) infection in dairy cattle, the effects on reproduction and culling are the least documented. To estimate the cost of MAP infections and Johne's disease in a dairy herd, the rates of calving and culling were calculated for...
|
PMID: 20655419
PDF is available here.
PDF is available here.
Assessment of food as a source of exposure to Mycobacterium avium subspecies paratuberculosis (MAP).
Abstract
current methods for detection of MAP have significant limitations, and a standard method for the detection of viable MAP cells is needed. Aside from MAP-infected domestic ruminant animals, the organism is found infrequently. If MAP in cattle is controlled, the source of MAP in other animals, food, a...
|
PMID: 20615354
PDF is available here.
PDF is available here.
Abstract
Paratuberculosis is a chronic enteropathy of ruminants caused by Mycobacterium avium subspecies paratuberculosis (MAP); infection of sheep results in two disease forms - paucibacillary (tuberculoid) and multibacillary (lepromatous) associated with the differential polarization of the immune response...
|
PMID: 20053460
PDF is available here.
PDF is available here.
Preventive Veterinary Medicine (95)1-2 2010
Abstract
Genetic association studies are a means to elucidate underlying genetic regulation of host-pathogen interaction, immune response, and the fate of infection. Diseases such as paratuberculosis in cattle lack definitive diagnostic criteria, thereby complicating the definition of infection status as an...
|
PMID: 20363040
PDF is available here.
PDF is available here.
Microbial Pathogenesis (48)5 2010
Abstract
We hypothesized that host and pathogen behavior to vary considerably in comparison to 37 degrees C. Our MAP-macrophage interaction studies show striking differences in regards to velocity of cell invasion of MAP as well as bacterial and host gene regulation at 39 degrees C compared with 37 degrees C...
|
PMID: 20188816
PDF is available here.
PDF is available here.
Abstract
A survey was conducted to assess the beliefs of veterinarians on Johne's disease (JD) and their attitudes towards the Canadian, risk assessment based, JD prevention program. The veterinarians surveyed believed Mycobacterium avium subsp. paratuberculosis may have zoonotic potential, liked the risk as...
|
PMID: 20592831
PDF is available here.
PDF is available here.
Abstract
A diagnostic assay using immunomagnetic separation was developed to capture Mycobacterium avium subsp. paratuberculosis (MAP) from bovine feces by means of IgY derived from chicken eggs. The antibody was coupled directly onto the surface of MagaCell cellulose/iron oxide beads or indirectly by being...
|
PMID: 20592839
PDF is available here.
PDF is available here.
Abstract
The severity score provides an objective measure of the severity of Johne's disease, and is useful for comparing individuals and groups of deer in studies involving experimental or natural infection with MAP. In mild disease, lesions were more evident in mesenteric lymph nodes than in jejunum and il...
|
PMID: 20383243
PDF is available here.
PDF is available here.
Abstract
A dynamic, deterministic, economic simulation model was developed to estimate the costs and benefits of controlling Mycobacterium avium subsp. paratuberculosis (Johne's disease) in a suckler beef herd. The model is intended as a demonstration tool for veterinarians to use with farmers. The model des...
|
PMID: 20004032
PDF is available here.
PDF is available here.
Abstract
This study investigated the susceptibility of 1- to 2-year-old cattle to Mycobacterium avium subsp. paratuberculosis (MAP) on pasture previously grazed by infected cattle. The exposure of yearling cattle to pastures contaminated with MAP resulted in infection with MAP, showing that age resistance to...
|
PMID: 20436867
PDF is available here.
PDF is available here.
Preventive Veterinary Medicine (93)2-3 2010
Abstract
The objective was to detect presence of calves excreting Mycobacterium avium subsp. paratuberculosis (MAP) in their feces as a consequence of being born to MAP fecal culture positive (vs. negative) dams. For each cow that was about to calf, approximately 10g of feces was collected manually by the he...
|
PMID: 20015557
PDF is available here.
PDF is available here.
Abstract
Abstract
We investigated the antibody seroprevalence against Pestivirus, Herpesvirus, Bluetongue (BT) virus, M. avium paratuberculosis (MAP), and Brucella sp. in 519 roe deer from different regions in Spain, south-western Europe.
No antibodies were detected against BT and Brucella sp. However, antibodies wer...
|
PMID: 21078207
PDF is available here.
PDF is available here.
Abstract
Mycobacterium avium subspecies paratuberculosis (MAP), is the etiological agent of Johne's disease (or paratuberculosis) in animals and has also been linked with Crohn's disease of human beings. Extreme fastidious nature of the organism (MAP) has hampered studies on diversity within the organism. St...
|
PMID: 20358861
PDF is available here.
PDF is available here.
Abstract
Conventional and real-time polymerase chain reaction (PCR) assays were used to measure the recovery of DNA from Mycobacterium avium subspecies paratuberculosis (MAP) extracted with 3 different methods (MagMAX, DNeasy(R), and phenol-chloroform) after growth in a broth-based culture system. Of the 304...
|
PMID: 20093685
PDF is available here.
PDF is available here.
Abstract
Critical, systematic reviews of available diagnostic test evaluations are a meticulous approach to synthesize evidence about a diagnostic test. However, often the review finds that data quality is poor due to deficiencies in design and reporting of the test evaluations and formal statistical compari...
|
PMID: 19747743
PDF is available here.
PDF is available here.
Abstract
We conclude that the ELISA is preferred to the ZN-test to confirm the presumptive diagnosis of clinical paratuberculosis in the Netherlands. Little diagnostic information can be gained by performing the ZN-test in addition to the ELISA....
|
PMID: 19762098
PDF is available here.
PDF is available here.
Canadian Veterinary Journal (50)10 2009
Abstract
The objective of this study was to describe the distribution of Mycobacterium avium subsp. paratuberculosis (MAP) in the environment of infected dairy farms over time. Johne's disease (JD) prevalence was monitored annually in 7 Michigan dairy herds. Environmental samples were collected bi-annually a...
|
PMID: 20046602
PDF is available here.
PDF is available here.
Preventive Veterinary Medicine (91)2-4 2009
Abstract
The US Voluntary Bovine Johne's Disease Control Program (VBJDCP) stipulates the national standards for Johne's disease (JD) control, and herds classified as test-negative at Level 4 of the VBJDCP have the greatest likelihood of being non-infected. A questionnaire survey of owners of VBJDCP test-nega...
|
PMID: 19625094
PDF is available here.
PDF is available here.
Preventive Veterinary Medicine (91)2-4 2009
Abstract
Paratuberculosis (Johne's disease) imposes a significant problem to the world dairy and beef industries and today is considered a potential zoonosis. The disease is caused by Mycobacterium avium subsp. paratuberculosis and is characterized by progressive weight loss and profuse diarrhoea. Susceptibi...
|
PMID: 19525022
PDF is available here.
PDF is available here.
Preventive Veterinary Medicine (91)2-4 2009
Abstract
One thousand three hundred and twenty-four adult beef cattle were tested for paratuberculosis using 2 antibody enzyme-linked immunosorbent assays (ELISA), an interferon-gamma (INF-gamma) ELISA, and radiometric bacterial culture of feces from 5 populations. Two populations of cattle (n=226) had data...
|
PMID: 19577813
PDF is available here.
PDF is available here.
Abstract
We reviewed the latest advances in the development of DNA vaccines against TB, Buruli ulcer and Johne's disease. Current understanding of the immunity to the respective causative pathogens indicates that the use of DNA vaccines encoding mycobacterial antigens could lead to efficient vaccination stra...
|
PMID: 19722896
PDF is available here.
PDF is available here.
Veterinary Pathology (46)4 2009
Abstract
We have established and utilized the neonatal calf ligated ileal loop model to study the early temporal host changes during MAP infection. After inoculation of ligated ileal loop with MAP, samples were analyzed for bacterial invasion, histologic and ultrastructural morphologic changes, and gene expr...
|
PMID: 19276052
PDF is available here.
PDF is available here.
Abstract
Calves fed CR at birth were less likely (hazard ratio = 0.559) to become infected with MAP (as determined by use of an ELISA, bacterial culture, or both diagnostic tests), compared with the likelihood for calves fed MC at birth. CONCLUSIONS AND CLINICAL RELEVANCE: This study revealed that feeding CR...
|
PMID: 19405889
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE-To evaluate the effect of vaccination of calves with a killed Mycobacterium avium subsp paratuberculosis (MAP) vaccine on colonization of tissues following oral MAP exposure. ANIMALS-12 healthy Holstein calves. PROCEDURES-At 14 days after birth, calves received the MAP vaccine (1.0 mL, SC)...
|
PMID: 19335105
PDF is available here.
PDF is available here.
Veterinary Record (164)9 2009
Abstract
Veterinary Record (164)9 2009
Abstract
Veterinary Record (164)9 2009
Abstract
Abstract
We have found that MAP actively invades the human gut epithelial goblet cells of the small intestine, inducing severe tissue damage and inflammation. These observations indicate that MAP can specifically colonize the normal human small intestine and can elicit inflammation and severe mucosal damage....
|
PMID: 19133807
PDF is available here.
PDF is available here.
Mammalian Genome (20)2 2009
Abstract
Paratuberculosis (Johne's disease), caused by Mycobacterium avium subsp. paratuberculosis, is an important disease for bovines, although its genetic basis is poorly understood. In this study, three candidate genes were typed to study the associations between single nucleotide polymorphisms (SNPs) an...
|
PMID: 19145459
PDF is available here.
PDF is available here.
Abstract
The hypothesis postulating that Mycobacterium avium paratuberculosis (MAP) is the cause of Crohn's disease (CD) has been circulating for many years. Advances in molecular techniques, such as polymerase chain reaction and culture methods, have enabled researchers to demonstrate that there is an assoc...
|
PMID: 19152445
PDF is available here.
PDF is available here.
Abstract
Of the 427 responding farmers, 201 (47%) had suspected clinical cases of JD in their herd in the preceding 5 years. Only 56/427 (13%) farmers observed an average annual incidence of >0.5 cases/100 cows during this period. Ninety percent (203/225) of farmers that had not observed clinical cases and 2...
|
PMID: 19252541
PDF is available here.
PDF is available here.
Journal of Dairy Science (92)1 2009
Abstract
A0) repeated ELISA negative; A1) ELISA negative, but only once; A2) ELISA negative on the last 3 tests, but with 1 previous positive result; A3) ELISA negative on the last test, but with 1 or more previous positive results; A4) last sample was ELISA positive, but all previous were negative; and A5)...
|
PMID: 19109273
PDF is available here.
PDF is available here.
Deutsche Medizinische Wochenschrift (134)1-2 2009
Abstract
Abstract
Paratuberculosis (Johne's disease) is a chronic, infectious enteritis of both domestic and wild ruminants. Unfortunately, the problem of MAP infections is not linked only with the health status of animals and potential direct and indirect economic losses in bovine herds (of dairy cattle in particula...
|
PMID: 19886260
PDF is available here.
PDF is available here.
Abstract
BACKGROUND: Mycobacterium avium ssp. paratuberculosis is the causative agent of Johen's disease. This infection of the small intestine is a global problem in the livestock industry. Bacterial shedding by infected but subclinical animals, and transmission via the fecal or intrauterine route and throu...
|
PMID: 19441901
PDF is available here.
PDF is available here.
Abstract
MAP-specific IS900 DNA and RNA could not be detected by nested PCR in the intestinal tissues of any patient with CD. CONCLUSION: Our results do not support the etiological role of MAP in the pathogenesis of CD in Indian patients....
|
PMID: 20107965
PDF is available here.
PDF is available here.
Abstract
The objective of the present study was to determine whether offspring of dams infected with Mycobacterium avium subsp. paratuberculosis (Map) have an increased risk for Map infection. Antemortem and postmortem disease surveillance data were used to identify positive and test-negative ruminants born...
|
PMID: 19139499
PDF is available here.
PDF is available here.
Abstract
Johne's disease (paratuberculosis) was diagnosed in a 2-yr-old, male, free-ranging white-tailed deer (Odocoileus virginianus) from Fauquier County, Virginia, USA, based on histopathology and culture for Mycobacterium avium subspecies paratuberculosis. Clinical and pathologic findings included emacia...
|
PMID: 19204350
PDF is available here.
PDF is available here.
Abstract
We used a zero-inflated negative-binomial (ZINB) multivariable model to determine simultaneously the risk factors associated with the count of MAP-seropositive cows in a herd, and the odds of herds having no MAP-seropositive cows as compared to having one or more MAP seropositive cows in a herd. The...
|
PMID: 18692926
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To evaluate farm-level economic costs and benefits related to control of paratuberculosis (Johne's disease) in dairy herds in the National Johne's Disease Demonstration Herd Project (NJDDHP). DESIGN: Economic analysis. SAMPLE POPULATION: 40 dairy herds enrolled in the NJDDHP. PROCEDURES:...
|
PMID: 19072597
PDF is available here.
PDF is available here.
Abstract
Results revealed steady increases in program participation by cattle producers in Minnesota over time, with > 30% of dairy producers and 2% of beef producers in the state participating by the end of 2006. Despite risk of introduction of Johne's disease to cattle herds through continued introduction...
|
PMID: 19072610
PDF is available here.
PDF is available here.
Veterinary Microbiology (132)3-4 2008
Abstract
Diagnosis of infections with Mycobacterium avium subsp. paratuberculosis (MAP) is difficult due to a long incubation period and lack of tests which can accurately predict the future status of animals. Early detection of infectious animals is necessary to reduce transmission of MAP. The objective of...
|
PMID: 18599225
PDF is available here.
PDF is available here.
Journal of Dairy Science (91)12 2008
Abstract
Mycobacterium avium ssp. paratuberculosis (MAP) infections cause major losses to the dairy industry. Transmission of MAP occurs primarily via feces and in utero, but MAP can also be excreted in colostrum and milk. The objective of this study was to determine whether colostrum and milk fed to calves...
|
PMID: 19038936
PDF is available here.
PDF is available here.
Journal of Dairy Science (91)12 2008
Abstract
Long-term effects of paratuberculosis on within-herd prevalence and on-farm economy of implementing risk-based control strategies were compared with alternative strategies by using a herd-simulation model. Closing transmission routes is essential for effective control of paratuberculosis. However, m...
|
PMID: 19038935
PDF is available here.
PDF is available here.
Abstract
The etiology of chronic inflammatory bowel diseases (IBD) remains unknown. Understanding IBD epidemiology helps to identify at-risk individuals, to appreciate the changing demographic profile of IBD, and to interpret theories of IBD pathogenesis. This article reviews recent advances in epidemiology...
|
PMID: 19006614
PDF is available here.
PDF is available here.
Inflammatory Bowel Diseases (14)12 2008
Abstract
Abstract
Osteopontin (Opn), a highly acidic glycoprotein, promotes cellular adhesion and recruitment and has been shown to be upregulated in the granulomas of mycobacterial infections. Johne's disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), is associated with granulomatous enteritis. Th...
|
PMID: 18620757
PDF is available here.
PDF is available here.
Microbes and Infection (10)12-13 2008
Abstract
We analyzed the macrophage-induced gene expression of three diverse genotypes of Mycobacterium avium subsp. paratuberculosis (MAP). Using selective capture of transcribed sequences (SCOTS) on three genotypically diverse MAP isolates from cattle, human, and sheep exposed to primary bovine monocyte de...
|
PMID: 18692151
PDF is available here.
PDF is available here.
Abstract
The objective of this study was to determine if viable Mycobacterium avium subsp. paratuberculosis (MAP) was present in waste milk delivered and fed to calves on California calf ranches. Four calf-raising facilities in the Central Valley of California that fed pasteurized waste milk to calves were e...
|
PMID: 18681799
PDF is available here.
PDF is available here.
Abstract
We quantified the effects of MAP control in US dairy herds, using the basic reproduction ratio R(0). The effectiveness of culling strategies was evaluated for good and poor herd management (low- and high-transmission rates, respectively) by a phase diagram approach. To establish a quantitative relat...
|
PMID: 18573505
PDF is available here.
PDF is available here.
Abstract
We have evaluated the vaccine potential of two MAP proteins, i.e. MAP0586c and MAP4308c, previously identified by postgenomic and immunoproteomic analysis of MAP secretome as novel serodiagnostic antigens. Immunizations of BALB/c and C57BL/6 mice with plasmid DNA encoding MAP0586c and MAP4308c induc...
|
PMID: 18652866
PDF is available here.
PDF is available here.
Abstract
Present pilot study is the first attempt in the country to estimate sero-prevalence of Bovine Johne's disease (BJD) by screening cattle and buffaloes representing large population belonging to farmer's and farm herds in the home tracts (Uttar Pradesh (UP) and Punjab) of Hariana cattle and Murrah buf...
|
PMID: 17854892
PDF is available here.
PDF is available here.
Abstract
Johne's disease is a slowly developing intestinal disease, primarily of ruminants, caused by Mycobacterium avium subspecies paratuberculosis. The disease contributes to significant economic losses worldwide in agricultural industry. Analysis of bacterial proteomes isolated directly from infected ani...
|
PMID: 18547663
PDF is available here.
PDF is available here.
Abstract
We reported that 85 antigen complex (85A, 85B, and 85C), superoxide dismutase (SOD), and 35kDa protein could induce significant lymphocyte proliferation as well as the elaboration of Th1-associated cytokines including interferon gamma (IFN-gamma), interleukin-2 (IL-2), IL-12 and tumor necrosis facto...
|
PMID: 18582521
PDF is available here.
PDF is available here.
Preventive Veterinary Medicine (86)1-2 2008
Abstract
Surveillance and monitoring are important for measuring the level of disease in a population, documenting changes in prevalence over time, determining high-risk areas for implementation of control measures, eradicating disease, and documenting freedom from disease. The documentation of freedom from...
|
PMID: 18406483
PDF is available here.
PDF is available here.