Abstract
Despite numerous advances in the diagnosis and control of infectious diseases of nonhuman primates in the laboratory setting, a number of infectious agents continue to plague colonies. Some, such as measles virus and Mycobacterium tuberculosis, cause sporadic outbreaks despite well-established biose...
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PMID: 20472806
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Abstract
Visceral leishmaniasis (VL) is a chronic and often fatal protozoal disease that is endemic in Belo Horizonte (State of Minas Gerais, Brazil). Leishmania sp. is an intracellular obligatory parasite of macrophages that can naturally infect several mammalian species. Non-human primates (NHP) have been...
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PMID: 20056328
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Abstract
The beginning of the third millennium has been characterized by the emerging and progressive characterization of a novel malaria Plasmodium pathogen of simian origin (Plasmodium knowlesi), which now represents the fifth human malaria parasite. Evolutionary, environmental, and diagnostic-clinical fea...
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PMID: 20433003
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Abstract
Hepatitis E virus (HEV) is the most frequent pathogen of a fecal-oral transmitted hepatitis in humans in many developing countries. It is endemic in the Middle East, in India, in Southeast Asia, central Asia as well as in Central and South America. It can be predominantly found in young adults. The...
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PMID: 20496825
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Abstract
A PCR-test system for detection of primate Betaherpesvirinae viruses was developed. Using alignment of complete genome of human, chimpanzee, and macaque rhesus cytomegalovirus conserve regions of viral genes were found. The oligonucleotide primers for consensus conserve regions of CMV UL56 gene were...
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PMID: 20882773
PDF is available here.
Yasushi Itoh,
Kyoko Shinya,
Maki Kiso,
Tokiko Watanabe,
Yoshihiro Sakoda,
Masato Hatta,
Yukiko Muramoto,
Daisuke Tamura,
Yuko Sakai-Tagawa,
Takeshi Noda,
Saori Sakabe,
Masaki Imai,
Yasuko Hatta,
Shinji Watanabe,
Chengjun Li,
Shinya Yamada,
Ken Fujii,
Shin Murakami,
Hirotaka Imai,
Satoshi Kakugawa,
Mutsumi Ito,
Ryo Takano,
Kiyoko Iwatsuki-Horimoto,
Masayuki Shimojima,
Taisuke Horimoto,
Hideo Goto,
Kei Takahashi,
Akiko Makino,
Hirohito Ishigaki,
Misako Nakayama,
Masatoshi Okamatsu,
Kazuo Takahashi,
David Warshauer,
Peter A Shult,
Reiko Saito,
Hiroshi Suzuki,
Yousuke Furuta,
Makoto Yamashita,
Keiko Mitamura,
Kunio Nakano,
Morio Nakamura,
Rebecca Brockman-Schneider,
Hiroshi Mitamura,
Masahiko Yamazaki,
Norio Sugaya,
M Suresh,
Makoto Ozawa,
Gabriele Neumann,
James Gern,
Hiroshi Kida,
Kazumasa Ogasawara and
Yoshihiro Kawaoka
Abstract
We characterized one of the first US S-OIV isolates, A/California/04/09 (H1N1; hereafter referred to as CA04), as well as several other S-OIV isolates, in vitro and in vivo. In mice and ferrets, CA04 and other S-OIV isolates tested replicate more efficiently than a currently circulating human H1N1 v...
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PMID: 19672242
PDF is available here.
Abstract
We report a case of a 7-year-old girl bitten by a macaque on her forehead and discuss her postexposure management....
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PMID: 19687714
PDF is available here.
Abstract
Parasitic diseases at the wildlife/primate/human interface are of particular importance in zoological gardens. Better understanding of the types of wildlife parasites that do persist in zoological gardens, and drives that lead to increases in prevalence or impacts, can point to new strategies for li...
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PMID: 19795752
PDF is available here.
Abstract
Neoplastic diseases in prosimians have been sporadically reported in the literature. To provide a comprehensive review of prosimian neoplasia, a retrospective evaluation of neoplasia in a large captive prosimian colony and an extensive literature review were performed. Primates that belong to the Or...
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PMID: 19276064
PDF is available here.
Abstract
In Kenya, Leishmania major is responsible for human cutaneous leishmaniasis (CL). Natural infection with L. major of a vervet monkey and experimental susceptibility of some nonhuman primates (NHPs) from Kenya has been established. However, there has been no comprehensive study of the prevalence of z...
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PMID: 18983806
PDF is available here.
Abstract
Although most epidemic human infectious diseases are caused by recently introduced pathogens, cospeciation of parasite and host is commonplace for endemic infections. Occasional host infidelity, however, provides the endemic parasite with an opportunity to survive the potential extinction of its hos...
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PMID: 19232074
PDF is available here.
Abstract
More than a decade ago it was established that intact nef genes are critical for efficient viral persistence and greatly accelerate disease progression in SIVmac-infected rhesus macaques and in HIV-1-infected humans. Subsequent studies established a striking number of Nef functions that evidently co...
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PMID: 18438604
PDF is available here.
Abstract
Toxoplasma gondii infections in zoo animals are of interest because many captive animals die of clinical toxoplasmosis and because of the potential risk of exposure of children and elderly to T. gondii oocysts excreted by cats in the zoos. Seroprevalence of T. gondii antibodies in wild zoo felids, h...
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PMID: 18605803
PDF is available here.
Abstract
Asymptomatic carriage in stool was found in humans (ranging from a prevalence of 4% in the control group to 12% among a subgroup of sewer workers) but not in monkeys and apes. The T. whipplei load in stool was significantly lower in carriers than in patients with Whipple disease (P < .001). There wa...
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PMID: 18419351
PDF is available here.
Abstract
With the emergence of the AIDS epidemic over the last 2 decades and the more recent identification of Kaposi sarcoma-associated herpesvirus (KSHV, Human herpesvirus 8), the genera of rhadinoviruses have gained importance as a family of viruses with oncogenic potential. First recogniz...
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PMID: 19793454
PDF is available here.
Abstract
With the emergence of the AIDS epidemic over the last 2 decades and the more recent identification of Kaposi sarcoma-associated herpesvirus (KSHV, Human herpesvirus 8), the genera of rhadinoviruses have gained importance as a family of viruses with oncogenic potential. First recogniz...
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PMID: 19793454
PDF is available here.
Abstract
We review these technologies and approaches, including noninvasive sampling in field conditions, and we identify ways in which integrative research activities are likely to fuel future discoveries in primate disease ecology. In addition to considering applied aspects of disease research in primate h...
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PMID: 19003885
PDF is available here.
Abstract
We provide such information for two distinct wild populations of Lemur catta. Variants observed include microtia, athelia, and female virilization. Dental variants observed include individuals with supernumerary teeth, rotated teeth, maxillary incisor agenesis, and severe malocclusion. There was a s...
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PMID: 17878733
PDF is available here.
Abstract
The Neanderthals were a Eurasian human species of the genus Homo that disappeared approximately 30,000 years ago. The cause or causes of their extinction continues to intrigue specialists and non-specialists alike. Here a contributory role for Transmissible Spongiform Encephalopathies (TSEs) is sugg...
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PMID: 18280671
PDF is available here.
Abstract
Normal ovarian function is thought to protect women against coronary heart disease (CHD) and osteoporosis by delaying the pathobiological processes underlying these conditions. Supporting this proposition is the observation that, following menopause (i.e. the loss of cyclic ovarian function), these...
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PMID: 18523378
PDF is available here.
Abstract
Over the last century, only two cases of ocular oxyspirurosis were recorded in primates, both in zoos, and two species were described: in Berlin, Germany, Oxyspirura (O.) conjunctivalis from the lemurid Microcebus murinus, later also found in the lorisid Loris gracilis; in Jacksonville, Florida, O....
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PMID: 18225417
PDF is available here.
Abstract
Our results showed that natural infection by cercopithecine herpesvirus 1 in Formosan macaques was highly prevalent, and to a certain extent reflected the situation of the wild populations in Taiwan. The findings raised the issues of zoonotic public health and the occupational health of primate work...
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PMID: 17976038
PDF is available here.
Abstract
These data show that the pathogenicity of MARV-Ang infection appears to be consistent with the apparent increased human virulence attributed to this strain. The apparent reduced efficacy of rNAPc2 against MARV-Ang infection, compared with its efficacy against EBOV infection, appears to be associated...
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PMID: 17940973
PDF is available here.
Abstract
In striking contrast to HIV infection, natural SIV infection of African nonhuman primates is asymptomatic and usually does not induce significant CD4+ T cell depletion despite high levels of virus replication. Recently, significant progress has been made in understanding the mechanisms underlying th...
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PMID: 17975656
PDF is available here.
Abstract
Gastrointestinal parasites are important infectious causes of diarrhoea in captive non-human primates (NHP). However, prevalence data of gastrointestinal parasites in zoological gardens are scarce. Therefore, a cross-sectional survey was conducted to estimate the occurrence of gastrointestinal paras...
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PMID: 17656023
PDF is available here.
Patricia L PL Earl,
Jeffrey L JL Americo,
Linda S LS Wyatt,
Leigh Anne LA Eller,
David C DC Montefiori,
Russ R Byrum,
Michael M Piatak,
Jeffrey D JD Lifson,
Rama Rao RR Amara,
Harriet L HL Robinson,
John W JW Huggins and
Bernard B Moss
Abstract
We tested the ability of a recombinant MVA delivered by alternative needle-free routes (intramuscular, intradermal, or into the palatine tonsil) to protect against immunodeficiency and orthopoxvirus diseases in a non-human primate model. Rhesus macaques were immunized twice 1 month apart with MVA ex...
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PMID: 17499326
PDF is available here.
Abstract
We compare the magnitude and longevity of protective immune responses elicited by a DNA/MVA HIV-1 vaccine with those elicited by Dryvax using a monkeypox virus/macaque model. The DNA/MVA vaccine elicited similar levels of vaccinia virus (VV)-specific antibody and 5-10-fold lower levels of VV-specifi...
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PMID: 17507071
PDF is available here.
Abstract
The course of experimental infection of Swiss mice with 95 sylvatic Trypanosoma cruzi isolates included in TCI or TCII genotype was characterized. The purpose was to verify biological properties and its eventual correspondence with original host species, genotype or zymodeme. The isolates of T. cruz...
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PMID: 17274984
PDF is available here.
Abstract
We tested whether the species richness and prevalence of parasites differed between threatened and non-threatened host species. 2. We collated data on 386 species of parasites (including viruses, bacteria, protozoa, helminths and arthropods) reported to infect wild populations of 36 threatened and 8...
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PMID: 17302838
PDF is available here.
Abstract
We tested predictions involving the epidemiological correlates of spondyloarthropathy in wild mammals. Analyses revealed that 5.6% of primates and 3.6% of carnivores exhibited signs of spondyloarthropathy, with maximum incidence as high as 22% in great apes and 27% in bears. We tested whether preval...
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PMID: 17305811
PDF is available here.
Abstract
Primary renal tumors are rare neoplasms in nonhuman primates. This report describes a mixed epithelial and stromal tumor of the kidney (MESTK) in a 14.5-year-old female ringtail lemur. The well-demarcated, solid, and cystic mass was located in the pelvis of the left kidney and consisted histological...
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PMID: 17317808
PDF is available here.
Abstract
A 5-year-old, female, Japanese Macaque (Macaca fuscata) was diagnosed with round cell variant of myxoid liposarcoma. At necropsy, multifocal to coalescing, reddish tan to white nodules, ranging from 0.5 to 1 cm in diameter, were noted throughout the omentum and retroperitoneum. Similar neoplastic no...
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PMID: 17317804
PDF is available here.
Abstract
We speculate that both vertical and vector-mediated transmission play significant roles in the epidemiology of T. cruzi on the island. This also represents the first report of autochthonous infection in blue-eyed black and black-and-white ruffed lemurs....
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PMID: 17436947
PDF is available here.
Abstract
We present two different technical approaches that overcome this obstacle: (i) Pan-herpes DPOL PCR is carried out in the presence of an oligonucleotide substituted with locked nucleic acids (LNA).This suppresses the amplification of a specific herpesvirus DPOL sequence by a factor of approximately 1...
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PMID: 17822523
PDF is available here.
Abstract
The lordotic region of the lumbar spine is a significant focus of pain and dysfunction in the human body, and its susceptibility to disorders may reflect its substantial reconfiguration during the course of human evolution. The basic anatomy of the lumbar vertebra in Old World Monkeys and Early Mioc...
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PMID: 17961059
PDF is available here.
Abstract
Simian varicella virus (SVV) is closely related to varicella-zoster virus (VZV), the causative agent of chickenpox and shingles. The SVV and VZV gene 61 polypeptides are homologs of the HSV-1 ICP0, a viral transactivator which appears to play a role in viral latency and reactivation. In this study,...
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PMID: 17115302
PDF is available here.
Abstract
Adult Oesophagostomum bifurcum (Nematoda: Strongylida) from human and non-human primates from Ghana were compared in order to investigate the extent of morphological variability within the species. Using analysis of variance and principal component analysis, significant differences in morphological...
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PMID: 17125544
PDF is available here.
Abstract
In order to better comprehend the putative association between genotype Trypanosoma cruzi II and primates, an evaluation of the infection in free ranging primates and specimens born in captivity from different geographical areas, the Amazon and the Atlantic forest, was carried out. Seroprevalences o...
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PMID: 16836794
PDF is available here.
Abstract
We collected dental data on 83 living adult ring-tailed lemurs during 2003 and 2004. Among these individuals, 192 teeth were scored as absent. The most frequently missing tooth position is M1 (24%). As M1 is the first tooth to erupt, its high frequency of absence (primarily a result of wear) is not...
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PMID: 16962643
PDF is available here.
Abstract
What is the origin of HIV as the plaque of our age? What was the way of transmission? Did it just cross from the primates to the human being or has it been introduced accidentally during the polio vaccine trials period in Africa? Is there any other risks in front of the human being, originating from...
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PMID: 17205703
PDF is available here.
Abstract
Concern about emerging and re-emerging diseases plays an increasing role in conservation and management of both captive and free-ranging nonhuman primates (NHPs). Managers and policy makers must formulate conservation plans in an arena plagued by uncertainty, complexity, emotion, and politics. The r...
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PMID: 16900501
PDF is available here.
Abstract
Risk analysis is a multidisciplinary process used to evaluate existing knowledge in order to prioritize risks associated with the spread of disease. A principle aim of risk analysis is to facilitate the development of cost-effective management strategies. Risk analysis calls for a multidisciplinary...
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PMID: 16900505
PDF is available here.
Abstract
A human endogenous retrovirus (HERV-I; RTVL-I) has been located within the first intron of a haptoglobin-related gene. Two members of the HERV-I family were identified in proximal Yq11.2 and caused AZFa microdeletions as a result of intra-chromosomal recombination events in azoospermic patients. Usi...
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PMID: 16508704
PDF is available here.
Abstract
In a colony of slender lorises, 20 deaths that occurred over a period of 11 years were investigated postmortem. Juvenile/adult polycystic nephropathy was observed in one newborn and 13 adult slender lorises. Although polycystic kidney disease (PKD) in humans and other animals is known to be inherite...
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PMID: 16847971
PDF is available here.
Abstract
In a mixed sex sample of ten adult gibbon (Hylobates moloch) skulls, one cranium of a male with maxillary sinus atelectasis of the left side was identified. While external inspection revealed a slight drop of the left orbital floor, serial coronal computer tomography (CT) scans show characteristic c...
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PMID: 16091979
PDF is available here.
Abstract
We sought to determine the history, severity, and prevalence of iron storage disease within a large captive lemur population. Iron concentration and hemosiderin accumulation in a target organ, the liver, were assessed in necropsy specimens from 15 different species (n=153) of lemurs over a 12-yr per...
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PMID: 16534809
PDF is available here.
Avelin F AF Aghokeng,
Weimin W Liu,
Frederic F Bibollet-Ruche,
Severin S Loul,
Eitel E Mpoudi-Ngole,
Christian C Laurent,
Jason M JM Mwenda,
Daudi K DK Langat,
Gerald K GK Chege,
Harold M HM McClure,
Eric E Delaporte,
George M GM Shaw,
Beatrice H BH Hahn and
Martine M Peeters
Abstract
We first describe the development and validation of sensitive and specific SIV antibody detection assays representing all major known primate lentiviral lineages on a panel of 207 sera from 11 different primate species with known infection status. The newly developed assays were then used to determi...
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PMID: 16257029
PDF is available here.
Abstract
This retrospective study was performed to determine the range, occurrence and incidence of spontaneously arising histopathological findings of the cardiovascular system in purpose-bred laboratory nonhuman primates. Data were collected from 84 controlled toxicological studies with equal numbers of ma...
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PMID: 16844663
PDF is available here.
Abstract
We have developed a novel multiplex serodiagnostic system based on individually identifiable, fluorescent microbead sets, where each bead set is coated with antigens from a purified preparation of a specific virus. The coated bead sets are mixed to enable the detection of antibodies to multiple viru...
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PMID: 16425999
PDF is available here.
Abstract
Non-invasive faecal sampling in the equatorial forest in Gabon allowed the first identification of the hepatitis B virus (HBV-Ch(RC170)) genome in samples collected from wild chimpanzees (Pan troglodytes troglodytes). The HBV-Ch(RCl70)sequence clustered with 100% bootstrap support with previous vira...
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PMID: 16461230
PDF is available here.
Abstract
Few diseases generate such alarm among the general population and health professionals as viral hemorrhagic fevers (VHFs). VHFs are acute infections with high associated mortality that are difficult to clinically diagnose and differentiate. Reliable laboratory diagnosis is required for proper patien...
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PMID: 16324552
PDF is available here.
Abstract
Ternidens deminutus (Strongylida) is a parasitic nematode infecting non-human and human primates in parts of Africa, Asia and the Pacific islands. The present study genetically characterized T. deminutus and defined genetic markers in nuclear ribosomal DNA (rDNA) as a basis for developing molecular-...
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PMID: 16174419
PDF is available here.
D D Nkoghe,
P P Formenty,
E M EM Leroy,
S S Nnegue,
S Y Obame SY Edou,
J Iba JI Ba,
Y Y Allarangar,
J J Cabore,
C C Bachy,
R R Andraghetti,
A C AC de Benoist,
E E Galanis,
A A Rose,
D D Bausch,
M M Reynolds,
P P Rollin,
C C Choueibou,
R R Shongo,
B B Gergonne,
L M LM Koné,
A A Yada,
C C Roth and
M Toung MT Mve
Abstract
Outbreaks of Ebola virus haemorrhagic fever have been reported from 1994 to 1996 in the province of Ogooué Ivindo, a forest zone situated in the Northeast of Gabon. Each time, the great primates had been identified as the initial source of human infection. End of November 2001 a new alert came from...
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PMID: 16267965
PDF is available here.