Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Pseudorabies (0):
Recent article
Pseudorabies
Abstract
A loop-mediated isothermal amplification (LAMP) assay was developed specifically for detection and differentiation of pseudorabies virus (PRV). One group of primers was designed to detect wild-type strains (i.e., strains with the gE gene) and the other group of primers was designed to detect both PR...
|
PMID: 20691214
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We constructed and characterized a mutant virus (Δ41). In the absence of vhs activity, Δ41 mutant is highly attenuated in mice model and the lethality is correlated with the virus dissemination in neural tissues. As with herpes simplex virus type 1 (HSV-1), the prototype virus of alphaherpesvirus,...
|
PMID: 20448414
PDF is available here.
PDF is available here.
Journal of Neurotrauma (27)8 2010
Abstract
We recently reported a significant attenuation of PRV-152 labeling of the intermediolateral cell column (IML) and celiac ganglia after complete T4 spinal cord transection versus sham injury in rats at 96 h after PRV-152 inoculation of the left kidney. Here we found a significant increase in noxious...
|
PMID: 20528165
PDF is available here.
PDF is available here.
Veterinary Microbiology (143)1 2010
Abstract
In the United States of America, Aujeszky's disease (pseudorabies) has been eradicated from all domestic swine. Some re-emergence of infection occurred as vaccine use diminished. Sporadic outbreaks have also occurred because of the reservoir of infection in feral swine that have spread across the so...
|
PMID: 20444559
PDF is available here.
PDF is available here.
Veterinary Microbiology (143)1 2010
Abstract
Infection of target cells by alphaherpesviruses leads to extensive modulation of host cell gene expression. To gain detailed information on the molecular pathways affected by infection of Madin-Darby bovine kidney (MDBK) cells with PrV, transcript analysis was combined with a stable isotope-based qu...
|
PMID: 20233642
PDF is available here.
PDF is available here.
Abstract
Pseudorabies virus (PRV) is a neurotropic alphaherpesvirus that produces fatal encephalitis in newborn pigs, respiratory disorders in fattening pigs, and reproductive failure in sows. Following primary infection of the respiratory tract, PRV can develop into a systemic infection with dispersion of t...
|
PMID: 20219878
PDF is available here.
PDF is available here.
Abstract
Viral infections of CNS are difficult to diagnose, especially in an early phase. In diagnosis, beside the examination of the cerebrospinal fluid, many other diagnostic tools are used, such a serological tests (in cases with TBE suspicion), PCR (in cases with CMV, VZV, HSV, WNV, enteroviruses infecti...
|
PMID: 20976946
PDF is available here.
PDF is available here.
Abstract
In this report two cases of spontaneous Aujeszky's disease (AD, syn. pseudorabies) in European wild boars (Sus scrofa), in the federal state of Brandenburg, Germany, are described. Both animals displayed severe central nervous disturbances, including loss of fear of humans, disorientation, and tremo...
|
PMID: 21038806
PDF is available here.
PDF is available here.
Abstract
We tested the role of several spatial variables on the risk of a sow herd being Aujeszky's disease virus (ADV) seropositive in certain areas of North Eastern Spain and during different periods of the eradication programme. Distance to the nearest slaughterhouse, distance to the nearest conventional...
|
PMID: 19631999
PDF is available here.
PDF is available here.
Abstract
Our results provide a clear example of how diseases can spread because of anthropogenic activities and highlight the need for disease surveillance and monitoring in the import of invasive species....
|
PMID: 19617504
PDF is available here.
PDF is available here.
Abstract
The CC chemokine receptor 7 (CCR7) and cognate CCR7 ligands, CCL19 and CCL21, help establish microenvironments in lymphoid tissue that can facilitate encounters between naive T cells and mature dendritic cells (DCs). This study was conducted to determine if CCR7 ligands can augment the immunogenicit...
|
PMID: 18794906
PDF is available here.
PDF is available here.
Abstract
These results suggest that administration of replication-incompetent adenoviruses can induce different types of immunity depending on the expressed antigen and that recombinant adenoviruses expressing gB induced the most potent Th1-biased humoral and cellular immunity and provided effective protecti...
|
PMID: 19116444
PDF is available here.
PDF is available here.
Microbes and Infection (10)12-13 2008
Abstract
We developed a recombinant pseudorabies virus (PRV) expressing TgSAG1 (rPRV/SAG1) based on the PRV vaccine strain Bartha K-61 by homologous recombination, in which partial PK and gG genes were deleted. The growth assay of rPRV/SAG1 showed that the recombinant virus can replicate in vitro as efficien...
|
PMID: 18761418
PDF is available here.
PDF is available here.
Journal of Virology (82)20 2008
Abstract
We constructed a pseudorabies virus strain that expressed Us9-GFP and tested its spread capabilities in the rat visual system and in primary neuronal cultures. We report that Us9-EGFP does not promote anterograde spread of infection and may disrupt packing of viral membrane proteins in lipid rafts,...
|
PMID: 18684822
PDF is available here.
PDF is available here.
Journal of Virology (82)19 2008
Abstract
A quantitative proteome study using the stable isotope labeling with amino acids in cell culture technique was performed on bovine kidney cells after infection with the alphaherpesvirus pseudorabies virus (PrV), the etiological agent of Aujeszky's disease. To enhance yields of proteins to be identif...
|
PMID: 18653448
PDF is available here.
PDF is available here.
Abstract
Commercial vaccines against Aujeszky's disease are mainly formulated using deleted versions of attenuated or inactivated Pseudorabies virus (PRV) particles lacking of the structural glycoprotein E (gE). Complementary diagnostic assays used to differentiate infected from vaccinated animals (DIVAs), a...
|
PMID: 18638504
PDF is available here.
PDF is available here.
Abstract
We aimed to investigate the underlying pathogenic mechanism(s) of PRV infection in mink by using immunohistochemistry and laser capture microdissection (LCM) on material from naturally and experimentally infected animals. The inflammatory reaction induced by PRV was minimal or absent not only in the...
|
PMID: 18490062
PDF is available here.
PDF is available here.
Preventive Veterinary Medicine (86)1-2 2008
Abstract
We explored for areas where more negative sow farms became infected and areas where more sow farms eliminated the infection. These analyses demonstrated areas with significantly higher proportions of sow farms that became negative, which indicates that the eradication of the disease had a spatial co...
|
PMID: 18562026
PDF is available here.
PDF is available here.
Abstract
These results demonstrated the potential application of the developed real-time PCR assays as a differential test for rapid and specific detection of PRV in domestic and feral swine, as well as nonporcine species that can be infected with PRV and serve as carriers....
|
PMID: 18599848
PDF is available here.
PDF is available here.
Abstract
We compared the protective immunities induced by multiple alternating immunizations with DNA vaccine (pCIgB) and replication-incompetent adenovirus (Ad-gB) expressing glycoprotein gB of pseudorabies virus (PrV). The platform of pCIgB-prime and Ad-gB-boost induced the most effective immune responses...
|
PMID: 18667863
PDF is available here.
PDF is available here.
Abstract
We designed two pairs of primers and their corresponding TaqMan probes according to gH, gE gene of PRV. By optimizing the probe's concentration, Mg2+ concentration, primers concentration and sample DNA extraction, real-time fluorescent quantitative PCR (FQ-PCR) which can quickly identity field virus...
|
PMID: 18837387
PDF is available here.
PDF is available here.
Abstract
A rapid, convenient and reliable pseudorabies virus (PRV) detection system was developed by using the loop-mediated isothermal amplification (LAMP) method. Six special primers were designed successfully based on the PRV DNA-binding protein (DBP) gene. The assay was optimized to amplify PRV DNA by in...
|
PMID: 18468699
PDF is available here.
PDF is available here.
Abstract
Blood samples were collected from wild boar (Sus scrofa) shot during the hunting season from 1999 to 2005 in the Czech Republic. Sera were tested by enzyme-linked immunosorbent assay for the presence of antibodies against classical swine fever virus (CSFV), swine vesicular disease virus (SVDV), Auje...
|
PMID: 18689671
PDF is available here.
PDF is available here.
Abstract
We directly show that depletion of cholesterol from the plasma membrane of host cells significantly reduces PRV entry. Cholesterol depletion did not reduce PRV attachment, but stalled virus particles at the plasma membrane before penetration of the cell. Cholesterol depletion results in destabilizat...
|
PMID: 18471850
PDF is available here.
PDF is available here.
Zhen ci yan jiu = Acupuncture research / [Zhongguo yi xue ke xue yuan Yi xue qing bao yan jiu suo bian ji] (33)3 2008
Abstract
1) After injection of PRV, PRV-IR positive cells widely distributed in the spinal cord (cervical, thoracic and lumbar segments), brain stem (nucleus of solitary tract, cuneate nucleus, gigantocellular reticular nucleus, nucleus of spinal tract of trigeminal nerve, nucleus raphe magnus, locus caerule...
|
PMID: 18807714
PDF is available here.
PDF is available here.
Journal of General Virology (89)Pt 6 2008
Abstract
We generated PrV mutants either lacking the 12 kDa UL35 gene product, or expressing GFP fused to the N terminus of pUL35. Remarkably, both mutants exhibited significant replication defects in rabbit kidney cells, which could be corrected in pUL35-expressing cells. After intranasal infection of mice...
|
PMID: 18474549
PDF is available here.
PDF is available here.
Veterinary Record (162)15 2008
Abstract
Experimental Animals (57)2 2008
Abstract
In this study, the influence of pregnancy and parturition on mice in a mouse model of latent infection with Pseudorabies virus (PrV) was analyzed. Latently infected (LI) female mice were paired with mature uninfected males. The mating produced progeny without any clinical signs of Aujeszky's Disease...
|
PMID: 18421179
PDF is available here.
PDF is available here.
Virus Genes (36)2 2008
Abstract
Our previous studies demonstrated that TK(-)/gG(-)/P1(+), a recombinant expressing the FMDV capsid precursor protein (P1) based on attenuated pseudorabies virus (PRV) TK(-)/gG(-), could be used as a recombinant vaccine to protect pigs against both pseudorabies and FMD. However, because the P1 expres...
|
PMID: 18246420
PDF is available here.
PDF is available here.
Abstract
We have used it to construct a recombinant virus, rPRV/eGFP/rgp, expressing the rabies virus glycoprotein. This recombinant virus has been shown to be safe for dogs by oral and intramuscular routes of inoculation and was demonstrated to induce immune responses against both pseudorabies and rabies in...
|
PMID: 18262313
PDF is available here.
PDF is available here.
Abstract
A murine model immunized by systemic and mucosal delivery of plasmid DNA vaccine expressing glycoprotein B (pCIgB) of pseudorabies virus (PrV) was used to evaluate both the nature of the induced immunity and protection against a virulent virus. With regard to systemic delivery, the intramuscular (i....
|
PMID: 18388482
PDF is available here.
PDF is available here.
Journal of General Virology (89)Pt 3 2008
Abstract
We elucidated that PCV2 downregulates in vitro the immune cell functions during recall antigen responses. We showed that PCV2, but not the non-pathogenic porcine circovirus type 1, induces interleukin (IL)-10 secretion by monocytic cells. Notably, PCV2-induced IL-10 led to effective repression of IL...
|
PMID: 18272768
PDF is available here.
PDF is available here.
Abstract
We have previously demonstrated that human-specific CpG ODN is a potent adjuvant to pseudorabies live attenuated virus (PRV) vaccine when administered subcutaneously (SC) or ocularly in piglets. In this study, we screened and evaluated the optimal CpG sequences (porcine-specific, human-specific, mou...
|
PMID: 18063448
PDF is available here.
PDF is available here.
Abstract
Aujeszky's disease (AD), Porcine reproductive and respiratory syndrome (PRRS) and Swine influenza (SI) are among the principal agents of respiratory diseases of pigs. The aim of the study was to determine the prevalence of antibodies to SHV-1, PRRSV and SIV in pigs reared in Sicily. An Enzyme Linked...
|
PMID: 19227130
PDF is available here.
PDF is available here.
BMC Genomics (9)1 2008
Abstract
An increase in the number of differentially expressed cellular genes and PrV genes especially from 4 h post-infection (pi) was observed concomitantly with the onset of viral progeny while no early global cellular shutoff was recorded. Many cellular genes were down-regulated from 4 h pi and their num...
|
PMID: 18331636
PDF is available here.
PDF is available here.
Veterinary Microbiology (125)3-4 2007
Abstract
We examined the kinetics and distribution of nitric oxide synthase (NOS) expression during the early steps of infection of the porcine nervous system by the alphaherpesvirus pseudorabies virus (PRV). To this end, we examined changes in the expression of the three major NOS isoforms, neuronal NOS (nN...
|
PMID: 17614218
PDF is available here.
PDF is available here.
Journal of Neurovirology (13)6 2007
Abstract
We assess the authors assess PrV-Kaplan for transsynaptic anterograde "live-cell"-tracing. Following intranasal application in mice, labelled trigeminal and brainstem neurons could be identified in vitro. Detailed electrophysiological analysis indicated that viral infection did not affect neuronal p...
|
PMID: 18097889
PDF is available here.
PDF is available here.
Journal of Virology (81)24 2007
Abstract
We deleted several predicted functional and structural motifs within PrV pUL36 and analyzed the resulting phenotypes in cell culture and a mouse infection model. Extension of the internal deletion to encompass aa 2087 to 2981 exerted only minor effects on virus replication but resulted in prolonged...
|
PMID: 17928337
PDF is available here.
PDF is available here.
Biotechnology Letters (29)11 2007
Abstract
Pseudorabies (PR), foot-and-mouth disease (FMD), and porcine parvovirus disease are three important infectious diseases in swine worldwide. The gene-deleted pseudorabies virus (PRV) has been used as a live-viral vector to develop multivalent genetic engineering vaccine. In this study, a recombinant...
|
PMID: 17628752
PDF is available here.
PDF is available here.
Journal of Virology (81)19 2007
Abstract
We discovered that PRV infection could spread efficiently from neurons to cells and back to neurons in the absence of gD, the viral ligand required for entry of extracellular particles. Unexpectedly, PRV infection can also spread transneuronally via axo-axonal contacts. We show that this form of int...
|
PMID: 17652377
PDF is available here.
PDF is available here.
Abstract
Previous biodistribution studies of plasmids following intramuscular or intradermal injections of DNA vaccines have been performed in mice, rats or rabbits, but not in large mammals. The aim of the present study was to determine the biodistribution of plasmids in swine using the PRV-specific DNA vac...
|
PMID: 17728026
PDF is available here.
PDF is available here.
Abstract
We used a murine neurogenic cystitis model to investigate the development of pelvic pain behavior. Neurogenic cystitis was induced by the injection of Bartha's strain of pseudorabies virus (PRV) into the abductor caudalis dorsalis tail base muscle of female C57BL/6J mice. Infectious PRV virions were...
|
PMID: 17626130
PDF is available here.
PDF is available here.
Abstract
We used a murine model immunized with different immunogens, the PrV modified live vaccine (MLV), inactivated vaccine (IAV), and commercial oil-adjuvant subunit vaccine (OSV), via either intranasal (i.n.) or intramuscular (i.m.) route. Both MLV and IAV induced a different nature of immunity biased to...
|
PMID: 17196231
PDF is available here.
PDF is available here.
Journal of Comparative Pathology (137 Suppl 1) 2007
Abstract
DNA vaccination represents a unique opportunity to overcome the limitations of conventional early life vaccine strategy which is restricted by the effects of maternally derived immunity. The pseudorabies virus (PRV) infection model in neonatal piglets was employed to demonstrate that a single DNA va...
|
PMID: 17553517
PDF is available here.
PDF is available here.
Abstract
We compared the capacity of porcine IFN-alpha, -beta and -gamma, or a combination of them, to protect IBRS-2 cells (porcine kidney cells) from infection with pseudorabies virus (PRV). The results demonstrated that porcine IFN-beta (PoIFN-beta) was the most efficient of the three IFNs in conferring r...
|
PMID: 17594939
PDF is available here.
PDF is available here.
Abstract
Specific oligonucleotide primers were selected and combined in a multiplex arrangement, in order to detect simultaneously three economically important porcine viruses by polymerase chain reaction (PCR). The pathogen panel was comprised of viruses that cause reproductive failure in infected herds: Au...
|
PMID: 17555292
PDF is available here.
PDF is available here.
Ideggyogyaszati szemle (60)3-4 2007
Abstract
Viral infection of brain nuclei (dorsal vagal nucleus, nucleus of the solitary tract, caudal raphe nuclei, A5 cell group, hypothalamic paraventricular nucleus) from the left adrenal was more severe than that from the right organ. Dual-infected neurons from the two adrenals were also detected both in...
|
PMID: 17451059
PDF is available here.
PDF is available here.
Veterinary Record (160)11 2007
Abstract
During two survey rounds of a national surveillance system for infectious diseases in wild boar in Switzerland, each lasting four months from November to February, between 2001 and 2003, 1949 blood samples and 62 tissue samples from the spleen and 50 from the reproductive organs were collected from...
|
PMID: 17369476
PDF is available here.
PDF is available here.
Veterinary Microbiology (120)3-4 2007
Abstract
Our results provide evidence for latency of ADV in wild boars and stress the fact that antibody detection based tests may fail to detect a proportion of recently infected animals. This is of great concern since current management schemes in our study promote animal translocation for hunting purposes...
|
PMID: 17169510
PDF is available here.
PDF is available here.
Biology of Reproduction (76)3 2007
Abstract
We conclude that the use of protease to investigate the virus embryo interaction can lead to misinterpretation of results. Results also show that blastomeres of five-cell embryos up to the hatched blastocysts can become infected with PRV, but there is no risk of a PRRSV infection....
|
PMID: 17123941
PDF is available here.
PDF is available here.
Immunology (120)2 2007
Abstract
These results suggest that co-injection of a chemokine, in the form of an adjuvant preparation, causes a rebalancing of the immunity, which subsequently affects the protective efficacy against a virulent virus infection....
|
PMID: 17116174
PDF is available here.
PDF is available here.
Veterinary Microbiology (119)2-4 2007
Abstract
We suggest that PCV2 is possibly the main contributor to PNP cases in Europe while PRRSV could play a similar role in North America....
|
PMID: 17070659
PDF is available here.
PDF is available here.
Abstract
Despite recent technological advances in vaccine production, most the vaccines depend on the association with adjuvant substances. This work evaluated the adjuvant capacity of an ethanol extract of green propolis associated to inactivated Suid herpesvirus type 1 (SuHV-1) vaccine preparations. Mice i...
|
PMID: 17084001
PDF is available here.
PDF is available here.
Acta Virologica (51)3 2007
Abstract
The immune efficacy of DNA vaccines containing three plasmids encoding gB, gC, and gD glycoproteins (Mix DNA) of Pseudorabies virus (PRV) or the plasmid for gC only (gC DNA), killed virus (KV) vaccine or combination of gC DNA, Mix DNA and KV vaccines was evaluated in mice using primeboost strategy....
|
PMID: 18076306
PDF is available here.
PDF is available here.
Acta Virologica (51)1 2007
Abstract
We found that the fusion of ubiquitin to viral glycoproteins increased their degradation in proteasomes in vitro, in which ubiquitin plays a key role. In the animals immunized with the plasmids encoding PRV ubi-glycoproteins and then challenged with PRV, we detected a slightly decreased cellular imm...
|
PMID: 17432942
PDF is available here.
PDF is available here.
Veterinary Research (38)5 2007
Abstract
We studied the acute phase protein response after experimental virus infection in pigs. The animals were experimentally infected with African Swine Fever (ASF) or Aujeszky's disease (AD) viruses. The clinical course of ASF infection correlated with increasingly high levels of pig Major Acute-phase P...
|
PMID: 17637332
PDF is available here.
PDF is available here.
Veterinary Research (38)2 2007
Abstract
In the present review, several cell biological and molecular aspects of virus-cell and virus-host (pig) interactions are reviewed for pseudorabies (Aujeszky's disease) virus. Concerning the virus-cell interactions, the complex cascade of events in the virus replication cycle is given together with t...
|
PMID: 17257571
PDF is available here.
PDF is available here.
Voprosy Virusologii (52)3 2007
Abstract
A panel of monoclonal antibodies (MAbs) specific to glycoprotein D (gD) of Aujeszky's disease virus (ADV, Suid herpesvirus 1) was produced and characterized. MAbs were used to identify 9 topologically different epitopes and epitopic groups on gD. The majority of the identified epitopes were conforma...
|
PMID: 17601050
PDF is available here.
PDF is available here.
Journal of Virology (81)2 2007
Abstract
We show here that deletion of the tegument protein pUL21 resulted in a drastic decrease in the incorporation of the pUL46, pUL49, and pUS3 tegument components into mature virions. Moreover, the attenuated PrV strain Bartha (PrV-Ba), which, among other defects, carries mutations in pUL21, also fails...
|
PMID: 17079290
PDF is available here.
PDF is available here.
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) infection still remains today as the most significant health threat to swine and poses a challenge to current vaccination strategies. To develop a new generation of vaccine against PRRSV, a live attenuated pseudorabies virus (PRV) was used...
|
PMID: 16920232
PDF is available here.
PDF is available here.