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Venereal Tumors, Veterinary (0):
Recent article
Venereal Tumors, Veterinary
Abstract
Therapeutic efficacy and histological changes after bacillus Calmette-Guerin (BCG), vincristine and BCG/vincristine combination therapy of canine transmissible venereal tumours (CTVT) were studied. Twenty dogs with naturally occurring CTVT in the progression stage were divided into 4 groups and trea...
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PMID: 19831270
PDF is available here.
PDF is available here.
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Abstract
We previously reported that tumor infiltrating lymphocyte (TIL)-derived IL-6 inhibits TGF-beta1 and restores natural killing (NK) activity. Using an in vivo canine-transmissible venereal tumor (CTVT) tumor model, we presently assessed IL-6 and TGF-beta involvement associated with the MHC antigen exp...
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PMID: 18259750
PDF is available here.
PDF is available here.
Abstract
We compared the expression of surface molecules on monocyte-derived DCs between normal dogs and dogs with CTVT. These markers were CD1a, CD83, costimulatory factors (CD40, CD80, and CD86), and major histocompatability complex classes I and II. In immature DCs (iDCs) and lipopolysaccharide-treated ma...
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PMID: 17710396
PDF is available here.
PDF is available here.
Abstract
We have considered it important to identify the role of the T963C mutation of the TP53 gene in the clonal origin of CTVT in dogs.Consequently the region which includes the mutation of the TP53 gene in twenty samples of CTVT obtained from various canine breeds was PCR amplified and afterwards its seq...
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PMID: 17668284
PDF is available here.
PDF is available here.
Abstract
Gaceta medica de Mexico (143)4 2007
Abstract
A direct, horizontal and natural transmission of neoplasic cells has only recently been accepted by the biomedical community. There are three known examples in mammals: the Tasmanian Devil Tumor Disease, the Canine Transmissible Venereal Tumor and a similar disease in Sirian Hamsters. These diseases...
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PMID: 17969847
PDF is available here.
PDF is available here.
Medical Hypotheses (68)5 2007
Abstract
Theriogenology (66)6-7 2006
Abstract
One of the most frequent canine neoplasms is the transmissible venereal tumor (TVT), which affects the male and the female genital tract. The objective of this study was to determine (immunohistochemically) estrogen receptor (ER-alpha) expression in vaginal tissue of healthy bitches and in the vagin...
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PMID: 16483645
PDF is available here.
PDF is available here.
Abstract
Abstract
In this issue of Cell, Murgia et al. (2006) confirm that the infectious agent of canine transmissible venereal tumor is the cancer cell itself and that the tumor is clonal in origin. Their findings have implications for understanding the relationship between genome instability and transmissible canc...
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PMID: 16901777
PDF is available here.
PDF is available here.
Abstract
We analyzed genetic markers including major histocompatibility (MHC) genes, microsatellites, and mitochondrial DNA (mtDNA) in naturally occurring tumors and matched blood samples. In each case, the tumor is genetically distinct from its host. Moreover, tumors collected from 40 dogs in 5 continents a...
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PMID: 16901782
PDF is available here.
PDF is available here.
Abstract
We assessed the presence of mast cell numbers and microvessel density during the progression and regression stages of natural spontaneous canine transmissible venereal tumours (CTVT). Mast cells were demonstrated by histochemical staining with toluidine blue, alcian blue and safranin O. Microvessel...
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PMID: 16838203
PDF is available here.
PDF is available here.
Abstract
We speculate that transmission of neoplastic cells occurred during cohabitation and social/mothering behavior between the dogs. Despite the atypical clinical presentation, response to chemotherapy with vincristine was excellent, leading to complete regression of the neoplasm without relapse after 6...
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PMID: 16511800
PDF is available here.
PDF is available here.
Chemical tumor ablation with use of a novel multiple-tine infusion system in a canine sarcoma model.
Abstract
Chemical ablation with 15% acetic acid with use of a multiple-tine infusion device resulted in larger diameters of contiguous tumor coagulation and enabled greater volumes of infusion than standard needle infusion or ethanol ablation. This suggests that chemical ablation with acetic acid infused wit...
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PMID: 16517782
PDF is available here.
PDF is available here.
Abstract
Transmissible venereal tumor (TVT) is a well-documented transplantable tumor in dogs, with no breed or sex predilection and a low metastatic rate. In this report, a 2-year-old intact female Mastiff that had numerous, rapidly growing masses throughout the subcutis mainly at the dorsal body plane, the...
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PMID: 16566273
PDF is available here.
PDF is available here.
Abstract
Our results indicate that Doxil is effective against CTVT in mouse xenograft models....
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PMID: 16327225
PDF is available here.
PDF is available here.
Abstract
We investigated the clinical and cytological changes after weekly vincristine sulphate administration in 38 cases of naturally occurring TVT. Tumours totally regressed in 31 dogs after two to seven doses (mean 3.54 +/- 1.01) of vincristine. One dog died after the fifth dose of vincristine, and in si...
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PMID: 16109105
PDF is available here.
PDF is available here.
Abstract
We characterize the experimental transplantation of the canine transmissible venereal tumor in the brain, skin, muscle, prostate, lung, liver, and bone of dogs and provide X-ray computed tomographic and magnetic resonance imaging characteristics of the tumors in the brain, muscle, lung, and prostate...
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PMID: 16158909
PDF is available here.
PDF is available here.
Abstract
These results suggest that the modulation of stromal cells that occurs during the regression of CTVT is similar to that occurring during wound healing. Tenascin-C was weakly expressed in the stroma of tumours in the progressive stage and in regions of the regressing tumours with tumour infiltrating...
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PMID: 15375754
PDF is available here.
PDF is available here.
Abstract
Increasing linear correlation was observed between tumor coagulation diameter and overall baseline system impedance (R(2) = 0.65). RF ablation of lung tumors resulted in the greatest coagulation diameter (13.0 mm +/- 3.5) compared with that in the other groups (P <.01). The smallest coagulation diam...
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PMID: 14990840
PDF is available here.
PDF is available here.
Journal of Immunology (172)3 2004
Abstract
We used canine transmissible venereal tumor (CTVT), which produces TGF-beta1, as a model to determine whether IL-6 restores lymphokine-activated killer (LAK) activity. During the progression phase, CTVT cells stop expressing MHC molecules. During the regression phase, the number of surface MHC molec...
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PMID: 14734728
PDF is available here.
PDF is available here.
Abstract
The aim was to determine if water-cooled diffusing tips could produce larger and safer (better controlled) thermal lesions than non-cooled diffusing tips at 980 nm. Thermal lesions were induced in beef myocardium in vitro with and without water cooling using a 980 nm diode laser at various power lev...
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PMID: 14612313
PDF is available here.
PDF is available here.
Abstract
Veterinary Quarterly (25)3 2003
Abstract
Canine transmissible venereal tumour (CTVT) is the only known naturally occurring tumour that can be transplanted as an allograft across major histocompatibility (MHC) barriers within the same species, and even to other members of the canine family, such as foxes, coyotes and wolves. The progression...
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PMID: 14535580
PDF is available here.
PDF is available here.
Abstract
Increasing coagulation was observed with increasing acetic acid concentrations (1.7 cm +/- 0.4, 2.8 cm +/- 0.6, and 3.5 cm +/- 0.3 for 10%, 15%, and 50% acetic acid alone, respectively; P <.01). The combination of RF ablation with acetic acid resulted in greater coagulation than with either therapy...
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PMID: 12902563
PDF is available here.
PDF is available here.
Abstract
Canine transmissible venereal tumor (CTVT) is an excellent model for investigating the interaction between host immunity and tumor growth. Although CTVT is an allograft, initially the host immune system is unable to destroy the tumor cells, and the tumor grows progressively for about 4-6 months (P p...
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PMID: 12730015
PDF is available here.
PDF is available here.
Abstract
We analysed the ORF2 located in the 5' region to the first exon of oncogene c-myc in canine transmissible venereal tumor (TVT) cell. We also showed the transcription activation was induced by this TVT-LINE sequence using CAT assay. To identify the mutation of tumor suppressor gene, sequence analysis...
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PMID: 12825561
PDF is available here.
PDF is available here.
Veterinary Dermatology (13)5 2002
Abstract
The clinical signs and histopathological features of a primary extragenital canine transmissible venereal tumour (TVT) are described. Three subcutaneous round alopecic nodules were located on the anterior and caudal dorsal region and in the ventral area of the neck. Cytologically, tumour cells were...
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PMID: 12358607
PDF is available here.
PDF is available here.
Abstract
The effect of vincristine treatment on semen parameters in a male boxer with a genital transmissible venereal tumour are described. The dog was treated with vincristine intravenously at 0.5 to 0.7 mg/m2 body surface area per week for six weeks until complete regression of the tumour occurred. Semen...
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PMID: 12238508
PDF is available here.
PDF is available here.
Abstract
Percutaneous inoculation and intraarterial transplantation of cTVT fragments in the canine lung result in predictable patterns of tumor growth resembling the solitary pulmonary nodules and metastatic disease found in humans. In addition, cyclosporin administration may be necessary to promote growth...
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PMID: 12354827
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of tumor infiltrating lymphocytes (TIL) on the expression of MHC molecules of CTVT cells. Isolated, viable CTVT cells were inoculated at each of 12 sites (1 x 10(8) CTVT cells per site) on the back of six, mixed-breed dogs. Tumor masses were collected every 2-3 weeks and...
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PMID: 12052339
PDF is available here.
PDF is available here.
Abstract
Pretreatment with intratumoral injection of small volumes of highly concentrated NaCl markedly increases RF heating and coagulation in a large animal tumor model. The complete destruction of tumors 5 cm in diameter or larger suggests that this substantial increase may be achieved for tumor ablation...
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PMID: 12119331
PDF is available here.
PDF is available here.
Abstract
We recently reported a xenograft model of CTVT (XTVT) in NOD/SCID mice. XTVT cells retain cytological and histological features of CTVT as well as characteristic rearranged LINE/c-MYC junction [Am. J. Vet. Res. 62 (2001) 907]. In this paper, we demonstrate that XTVT cells maintain ultrastructural ch...
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PMID: 12007890
PDF is available here.
PDF is available here.
Abstract
Cell proliferation and apoptosis in canine cutaneous histiocytomas and transmissible venereal tumours were examined in twenty cases. The Ki-67 immunohistochemistry and Tunel methods were used to detect mitotic activity and apoptosis, respectively. The number of Ki-67 immunoreactive cells was 11.65 (...
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PMID: 12237973
PDF is available here.
PDF is available here.
Abstract
The medical records of six dogs with primary intranasal transmissible venereal tumour (TVT) were reviewed. Epistaxis (4/6), serosangineous nasal discharge (2/6), oronasal fistulae (2/6), facial swelling (1/6) and submandibular lymphadenopathy (3/6) due to reactive hyperplasia (2/3) and metastasis (1...
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PMID: 11599677
PDF is available here.
PDF is available here.
Abstract
8 of 10 NOD/SCID mice that were inoculated with CTVT developed tumors 3 to 10 weeks after inoculation. In the second-generation xenograft, all mice developed tumors by postinoculation day 47; 1 X 10(6) of XTVT cells were enough to create a xenograft. Metastases developed in 4 of 20 mice. Xenografted...
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PMID: 11400849
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Eleven dogs with canine transmissible venereal tumour (CTVT) were given vincristine sulphate chemotherapy to induce tumour regression. Biopsy specimens were collected from tumours during the growth phase, before chemotherapy, and again from the same dogs during the regression induced by chemotherapy...
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PMID: 10805977
PDF is available here.
PDF is available here.
Abstract
A five-year-old crossbred dog was referred with rapidly growing masses over its penis and right popliteal lymph node. The dog had severe blepharospasm, congestion of episcleral vessels and rubeosis iridis of the left eye. A presumptive diagnosis of transmissible venereal tumour (TVT) and iridocyclit...
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PMID: 10812546
PDF is available here.
PDF is available here.
Theriogenology (53)5 2000
Abstract
We examined the semen of 17 dogs suffering from TVT during vincristine treatment. Each animal received 0.6 mg, i.v. vincristine sulphate per square meter of body surface, per week for 4 wk until complete regression of the tumor. The following semen parameters were evaluated: semen volume (second fra...
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PMID: 10798495
PDF is available here.
PDF is available here.
Abstract
Mice with a severe metastasized tumour burden can be cured with a single local injection of interleukin-2. Such a treatment can also be effective against ocular squamous cell carcinoma in cows and transmissible venereal tumours in dogs. We did not notice any toxic effects of this treatment.
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PMID: 10501856
PDF is available here.
PDF is available here.
Animal Genetics (30)1 1999
Abstract
We determined the 4251-bp sequence of open reading frame 2 (ORF2) of canine LINE-1 retroposon that encodes 1275 amino acids. The truncated LINE-1 inserts associated with transmissible venereal tumor (TVT) of dogs contained the 1378-bp LINE-1 insert (TVT-LINE) flanked by 10-bp direct repeats upstream...
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PMID: 10050284
PDF is available here.
PDF is available here.
Abstract
Abstract
In this study, the immunohistochemical distribution of CD3 (T lymphocytes), CD79 (B lymphocytes and plasma cells), IgG, IgM, IgA, IgG subclasses (IgG2, IgG3 and IgG4) L1 (macrophages) and MHC Class II antigen was analysed in the inflammatory infiltrates associated with spontaneous canine transmissib...
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PMID: 9661263
PDF is available here.
PDF is available here.
Abstract
Twenty-nine cases of naturally occurring, transmissible venereal tumor were studied retrospectively. The external genitalia was the primary site of tumor involvement in 27 dogs, with the remaining two dogs having primary intranasal involvement. Extragenital tumor involvement was identified in six ca...
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PMID: 9826280
PDF is available here.
PDF is available here.
Abstract
Abstract
The canine transmissible venereal tumour is a naturally occurring contagious round-cell neoplasia which is primarily located in the mucous membrane of the external genitalia in dogs of either sex. In order to specify the controversial cytogenetic origin of this round-cell tumour, 14 cases of canine...
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PMID: 9239833
PDF is available here.
PDF is available here.
Abstract
Density gradient centrifugation using Ficoll-Conray solution was attempted to isolate viable canine transmissible sarcoma (CTS) cells. The viability of isolated tumor cells increased from about 50% to > 90%, and the yield of CTS cells was > 50% with over 99% purity, in when an isolation solution den...
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PMID: 8959669
PDF is available here.
PDF is available here.
Abstract
The role of transmissible venereal tumours in the pathogenesis of urinary tract infection in dogs was investigated in 86 dogs. Fifty-five had transmissible venereal tumours, and the remaining 31 animals were used as controls. A thorough clinical examination of the external genitalia was carried out...
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PMID: 8805098
PDF is available here.
PDF is available here.
Veterinary Pathology (33)3 1996
Abstract
Our findings support the hypothesis of a histiocytic immunophenotype for CTVT, and these staining techniques could be used in the differential diagnosis with lymphomas....
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PMID: 8740698
PDF is available here.
PDF is available here.
Abstract
Ten canine transmissible venereal tumour (TVT) cases were studied by digital image analysis quantification on sections stained with silver to demonstrate nucleolar organizer regions (Ag-NORs). In each animal, 100 neoplastic cells were randomly selected for evaluation. The following parameters were m...
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PMID: 7593765
PDF is available here.
PDF is available here.
Veterinary Record (136)9 1995
Abstract
Abstract
Abstract
We found that the c-MYC oncogene was rearranged in this tumor by the insertion of a transposable genetic element sequence (known as LINE, long interspersed element) 5' to the first exon. The amplification of a DNA segment located in the junction of the LINE genome and c-MYC upstream sequences enable...
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PMID: 1654559
PDF is available here.
PDF is available here.
Veterinary Record (129)25 1991
Abstract
Abstract
Tumor antigen (TA) associated with the canine transmissible venereal sarcoma (CTVS) was detected in the sera of dogs bearing the tumor. Rabbit antisera specific for tumor antigen and 3 M KCl extracts of CTVS cells were used in both a competitive enzyme-linked immunosorbent assay (ELISA) and antigen-...
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PMID: 2059969
PDF is available here.
PDF is available here.
Abstract
I consisted of four dogs that received oral cyclophosphamide (50 mg/M2 body surface area [BSA]) on the first four days for six weeks. No therapeutic response was noted in any of the four dogs. Group II consisted of ten dogs that received intravenous (IV) cyclophosphamide (50 mg/M2 BSA) for four cons...
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PMID: 2366223
PDF is available here.
PDF is available here.
Abstract
Our findings suggest that self-regulating thermoseeds offer the possibility of predictable heat delivery to defined tissue volumes, and may be useful in the treatment of human tumours which are amenable to implantation. Until migration can be controlled, clinical trials should be limited to removabl...
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PMID: 2299225
PDF is available here.
PDF is available here.
Abstract
We compared temperature distributions and biologic effects in canine muscle and transmissible venereal tumors for bare thermoseeds and thermoseeds contained within catheters. We found no significant difference in the heating patterns and similar tissue changes when all implants were removed immediat...
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PMID: 2599914
PDF is available here.
PDF is available here.