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Wasting Disease, Chronic (0):
Recent article
Wasting Disease, Chronic
Abstract
We studied how prion infection influenced the number of offspring raised to weaning per adult (≥2 yr old) female mule deer and subsequently the estimated growth rate (λ) of an infected deer herd. Infected and presumably uninfected radio-collared female deer were observed with their fawns in late...
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PMID: 20966260
PDF is available here.
PDF is available here.
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Journal of Virology (84)16 2010
Abstract
We describe a modification of the scrapie cell assay allowing evaluation of prions causing chronic wasting disease, a naturally occurring transmissible spongiform encephalopathy. We compare this cervid prion cell assay to bioassays in transgenic mice, the only other existing method for quantificatio...
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PMID: 20519392
PDF is available here.
PDF is available here.
Abstract
We measured liver tissue concentrations of copper, manganese, and molybdenum in samples from 447 apparently healthy, adult (> or = 2 yr old) mule deer (Odocoileus hemionus) culled or vehicle killed from free-ranging populations in north-central Colorado, United States, where CWD occurs naturally; we...
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PMID: 20688718
PDF is available here.
PDF is available here.
Abstract
We hypothesized that binding to soil enhances prion resistance to enzymatic digestion, thereby facilitating prion longevity in the environment and providing protection from host degradation. We characterized the performance of a commercially available subtilisin enzyme, Prionzyme, to degrade soil-bo...
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PMID: 20450190
PDF is available here.
PDF is available here.
Journal of General Virology (91)Pt 6 2010
Abstract
These results demonstrate that CWD can be transmitted by aerosol (as well as nasal) exposure and suggest that exposure via the respiratory system merits consideration for prion disease transmission and biosafety....
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PMID: 20164261
PDF is available here.
PDF is available here.
Veterinary Pathology (47)3 2010
Abstract
Eyes and nuclei of the visual pathways in the brain were examined in 30 Rocky Mountain elk (Cervus elaphus nelsoni) representing 3 genotypes of the prion protein gene PRNP (codon 132: MM, ML, or LL). Tissues were examined for the presence of the abnormal isoform of the prion protein associated with...
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PMID: 20382822
PDF is available here.
PDF is available here.
Abstract
We examined whether mountain lions (Puma concolor) selectively prey upon mule deer (Odocoileus hemionus) infected with chronic wasting disease, a prion disease. We located kill sites of mountain lions in the northern Front Range of Colorado, USA, and compared disease prevalence among lion-killed adu...
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PMID: 19864271
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
We examined whether mountain lions (Puma concolor) selectively prey upon mule deer (Odocoileus hemionus) infected with chronic wasting disease, a prion disease. We located kill sites of mountain lions in the northern Front Range of Colorado, USA, and compared disease prevalence among lion-killed adu...
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PMID: 19864271
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
We examined whether mountain lions (Puma concolor) selectively prey upon mule deer (Odocoileus hemionus) infected with chronic wasting disease, a prion disease. We located kill sites of mountain lions in the northern Front Range of Colorado, USA, and compared disease prevalence among lion-killed adu...
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PMID: 19864271
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
We examined whether mountain lions (Puma concolor) selectively prey upon mule deer (Odocoileus hemionus) infected with chronic wasting disease, a prion disease. We located kill sites of mountain lions in the northern Front Range of Colorado, USA, and compared disease prevalence among lion-killed adu...
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PMID: 19864271
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
We examined whether mountain lions (Puma concolor) selectively prey upon mule deer (Odocoileus hemionus) infected with chronic wasting disease, a prion disease. We located kill sites of mountain lions in the northern Front Range of Colorado, USA, and compared disease prevalence among lion-killed adu...
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PMID: 19864271
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
We examined whether mountain lions (Puma concolor) selectively prey upon mule deer (Odocoileus hemionus) infected with chronic wasting disease, a prion disease. We located kill sites of mountain lions in the northern Front Range of Colorado, USA, and compared disease prevalence among lion-killed adu...
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PMID: 19864271
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
We examined whether mountain lions (Puma concolor) selectively prey upon mule deer (Odocoileus hemionus) infected with chronic wasting disease, a prion disease. We located kill sites of mountain lions in the northern Front Range of Colorado, USA, and compared disease prevalence among lion-killed adu...
|
PMID: 19864271
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
We examined whether mountain lions (Puma concolor) selectively prey upon mule deer (Odocoileus hemionus) infected with chronic wasting disease, a prion disease. We located kill sites of mountain lions in the northern Front Range of Colorado, USA, and compared disease prevalence among lion-killed adu...
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PMID: 19864271
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
We examined whether mountain lions (Puma concolor) selectively prey upon mule deer (Odocoileus hemionus) infected with chronic wasting disease, a prion disease. We located kill sites of mountain lions in the northern Front Range of Colorado, USA, and compared disease prevalence among lion-killed adu...
|
PMID: 19864271
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
We examined whether mountain lions (Puma concolor) selectively prey upon mule deer (Odocoileus hemionus) infected with chronic wasting disease, a prion disease. We located kill sites of mountain lions in the northern Front Range of Colorado, USA, and compared disease prevalence among lion-killed adu...
|
PMID: 19864271
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
We examined whether mountain lions (Puma concolor) selectively prey upon mule deer (Odocoileus hemionus) infected with chronic wasting disease, a prion disease. We located kill sites of mountain lions in the northern Front Range of Colorado, USA, and compared disease prevalence among lion-killed adu...
|
PMID: 19864271
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
We examined whether mountain lions (Puma concolor) selectively prey upon mule deer (Odocoileus hemionus) infected with chronic wasting disease, a prion disease. We located kill sites of mountain lions in the northern Front Range of Colorado, USA, and compared disease prevalence among lion-killed adu...
|
PMID: 19864271
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
We examined whether mountain lions (Puma concolor) selectively prey upon mule deer (Odocoileus hemionus) infected with chronic wasting disease, a prion disease. We located kill sites of mountain lions in the northern Front Range of Colorado, USA, and compared disease prevalence among lion-killed adu...
|
PMID: 19864271
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
We examined whether mountain lions (Puma concolor) selectively prey upon mule deer (Odocoileus hemionus) infected with chronic wasting disease, a prion disease. We located kill sites of mountain lions in the northern Front Range of Colorado, USA, and compared disease prevalence among lion-killed adu...
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PMID: 19864271
PDF is available here.
PDF is available here.
Abstract
Molecular genetic data provide powerful tools for genealogy reconstruction to reveal mechanisms underlying disease ecology. White-tailed deer (Odocoileus virginianus) congregate in matriarchal groups; kin-related close social spacing may be a factor in the spread of infectious diseases. Spread of ch...
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PMID: 20592847
PDF is available here.
PDF is available here.
New Microbiologica (33)2 2010
Abstract
Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE)--or prion disease (PD)--that has become of increasing concern throughout years among different captive and free-living deer species and populations in North America. Starting from the recent pre-clinical evidence of pri...
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PMID: 20518283
PDF is available here.
PDF is available here.
Abstract
Chronic wasting disease (CWD), an important emerging prion disease of cervids, is readily transmitted by intracerebral or oral inoculation from deer-to-deer and elk-to-elk, suggesting the latter is a natural route of exposure. Studies of host range susceptibility to oral infection, particularly of t...
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PMID: 20436863
PDF is available here.
PDF is available here.
Abstract
Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) of Rocky Mountain elk in North America. Recent studies suggest that tissue and blood mineral levels may be valuable in assessing TSE infection in sheep and cattle. The objectives of this study were to examine baseline l...
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PMID: 20357959
PDF is available here.
PDF is available here.
Journal of Virology (84)1 2010
Abstract
We intracerebrally inoculated four species of epidemic-sympatric rodents with CWD. Transmission was efficient in all species; the onset of disease was faster in the two vole species than the two Peromyscus spp. The results for inocula prepared from CWD-positive deer with or without CWD-resistant gen...
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PMID: 19828611
PDF is available here.
PDF is available here.
Molecular Brain (3)1 2010
Abstract
We have used a combination of in vitro and in vivo models of intestinal epithelial cell barrier to understand the role of ferritin in mediating PrPSc uptake and transport. In this report, we demonstrate that PrPSc and ferritin from CWD affected deer and elk brains and scrapie from sheep resist degra...
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PMID: 20429907
PDF is available here.
PDF is available here.
Abstract
To determine if the number of rectal lymphoid follicles decreases with respect to age and sex relative to diagnosis of chronic wasting disease (CWD), rectal biopsies (n = 1,361) were taken from captive Rocky Mountain elk (Cervus elaphus nelsoni) at 4 ranches in the western United States between 2005...
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PMID: 19901292
PDF is available here.
PDF is available here.
Abstract
We propose a Bayesian hierarchical survival model where latent parameters capture temporal and spatial trends in disease incidence, incorporating several individual covariates and random effects. The model is applied to a data set which consists of 65085 harvested deer in Wisconsin from 2002 to 2006...
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PMID: 19552977
PDF is available here.
PDF is available here.
Abstract
We show the ability of serial protein misfolding cyclic amplification (sPMCA) to amplify a 1.3 x 10(-7) dilution of CWD-infected brain homogenate spiked into water samples, equivalent to approximately 5 x 10(7) protease resistant cervid prion protein (PrP(CWD)) monomers. We also detected PrP(CWD) in...
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PMID: 19823039
PDF is available here.
PDF is available here.
Ecological Applications (19)5 2009
Abstract
We applied hierarchical Bayesian disease mapping methods to account for risk factors and to estimate spatial and temporal patterns of infection by chronic wasting disease (CWD) in white-tailed deer (Odocoileus virginianus) of Wisconsin, U.S.A. We found significant heterogeneities for infection due t...
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PMID: 19688937
PDF is available here.
PDF is available here.
Abstract
We have examined potential motifs within the kringle region that may be responsible for binding to PrP. We synthesized 12-15-mer peptides that contain small, repetitive stretches of amino acid residues found within the kringle domains of plasminogen. These synthetic peptides were found to capture Pr...
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PMID: 19221431
PDF is available here.
PDF is available here.
Abstract
Antemortem biopsy of the rectal mucosa was evaluated as a method for the preclinical diagnosis of chronic wasting disease (CWD) in a herd of ranch-raised Rocky Mountain elk (Cervus elaphus nelsoni) quarantined because of exposure to CWD. Biopsy samples were obtained from 41 elk during the winter of...
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PMID: 19139496
PDF is available here.
PDF is available here.
Abstract
A captive adult male white-tailed deer (Odocoileus virginianus) with wasting and neurologic signs similar to chronic wasting disease (CWD) was evaluated by histopathology, histochemistry, and immunohistochemistry (IHC) for disease-associated prion protein (PrP(d)). On histologic examination, the bra...
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PMID: 18957666
PDF is available here.
PDF is available here.
Abstract
In September 2002, chronic wasting disease (CWD), a prion disorder of captive and wild cervids, was diagnosed in a white-tailed deer (Odocoileus virginianus) from a captive farm in Wisconsin. The facility was subsequently quarantined, and in January 2006 the remaining 76 deer were depopulated. Sixty...
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PMID: 18776116
PDF is available here.
PDF is available here.
Abstract
Chronic wasting disease (CWD), a prion disease of North American deer, elk and moose, affects both free-ranging and captive cervids. The potential host range for CWD remains uncertain. The susceptibility of the ferret to CWD was examined experimentally by administering infectious brain material by t...
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PMID: 18387626
PDF is available here.
PDF is available here.
Veterinary Pathology (45)3 2008
Abstract
To compare clinical and pathologic findings of chronic wasting disease (CWD) in a natural host, 3 groups (n = 5) of white-tailed deer (WTD) fawns were intracerebrally inoculated with a CWD prion of WTD, mule deer, or elk origin. Three other uninoculated fawns served as controls. Approximately 10 mon...
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PMID: 18487485
PDF is available here.
PDF is available here.
Journal of General Virology (89)Pt 5 2008
Abstract
We genotyped 171 samples, collected between 2002 and 2005 from CWD-infected and uninfected wapiti from three free-ranging populations in Colorado, USA, to study influences of PrP polymorphisms on CWD susceptibility further. Overall genotype frequencies for 124 apparently uninfected animals were 65.3...
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PMID: 18420812
PDF is available here.
PDF is available here.
Abstract
We show that the DY TME agent can block hamster-adapted chronic wasting disease (HaCWD) and the 263K scrapie agent from causing disease following sciatic nerve inoculation. Additionally, per os inoculation of DY TME agent slightly extends the incubation period of per os superinfected HY TME agent. T...
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PMID: 19098442
PDF is available here.
PDF is available here.
Journal of General Virology (89)Pt 4 2008
Abstract
We investigated whether mink have a species barrier to chronic wasting disease (CWD) by performing primary intracerebral (IC) and primary oral challenge with CWD-positive elk brain. Primary IC challenge resulted in clinical disease in two of eight mink at 31-33 months incubation. Affected mink had s...
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PMID: 18343853
PDF is available here.
PDF is available here.
Journal of General Virology (89)Pt 2 2008
Abstract
We created transgenic (Tg) mice expressing cervid PrPC with L at residue 132, referred to as CerPrPC-L132, and compared the transmissibility of CWD prions from elk of defined PRNP genotypes, namely homozygous M/M or L/L or heterozygous M/L, in these Tg mice with previously described Tg mice expressi...
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PMID: 18198392
PDF is available here.
PDF is available here.
Veterinary Research (39)4 2008
Abstract
Chronic wasting disease (CWD) is a prion disease of deer, elk, and moose, initially recognized in Colorado mule deer. The discovery of CWD beyond the borders of Colorado and Wyoming, in Canada and as far east as New York, has led to its emergence as a prion disease of international importance. Epide...
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PMID: 18381058
PDF is available here.
PDF is available here.
Journal of Comparative Pathology (138)2-3 2008
Abstract
To determine the transmissibility of chronic wasting disease (CWD) to fallow deer (Dama dama) and to provide information about clinical course, lesions and suitability of currently used diagnostic procedures for detection of CWD in this species, 13 fawns were inoculated intracerebrally with CWD brai...
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PMID: 18336829
PDF is available here.
PDF is available here.
Environmental Health (7)1 2008
Abstract
Our results indicate two types of risks for those who attended the feast, a Feast Risk and a General Risk. The larger the number of risk factors, the greater the risk to human health if CWD is transmissible to humans. Long-term surveillance of feast participants exposed to CWD is ongoing. CONCLUSION...
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PMID: 18577220
PDF is available here.
PDF is available here.
Abstract
We focus this chapter on three diseases that are of major management concern and the center of most disease research for cervids in North America: bovine tuberculosis, chronic wasting disease, and brucellosis. We discuss the available data and recent advances in modeling and management of these dise...
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PMID: 18566093
PDF is available here.
PDF is available here.
Abstract
Chronic wasting disease (CWD) in Wisconsin was first identified in February 2002. By April 2005, medial retropharyngeal lymph node (RLN) tissues had been examined from over 75,000 white-tailed deer for the presence of CWD by either immunohistochemical (IHC) staining for the prion protein associated...
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PMID: 18182509
PDF is available here.
PDF is available here.
Neuroscience Letters (429)2-3 2007
Abstract
We have used a mouse model system and the Rocky Mountain Laboratory (RML) mouse-adapted scrapie prion strain to screen efficacy of potential vaccine candidates. Three peptides derived from the primary amino acid sequence of the prion protein were conjugated to blue carrier protein (BCP) and formulat...
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PMID: 18023980
PDF is available here.
PDF is available here.
Neuroreport (18)18 2007
Abstract
We now report that elk lacking the predisposing 132-methionine allele develop chronic wasting disease after a long incubation period and display a novel PrP folding pattern....
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PMID: 18007190
PDF is available here.
PDF is available here.
Canadian Veterinary Journal (48)12 2007
Abstract
An outbreak of chronic wasting disease (CWD) in farmed elk in Saskatchewan from 1996 to 2002 was reviewed to 1, determine the progression of CWD from infection to death in farmed elk; 2, assess animal risk factors for CWD infection in farmed elk; 3, assess farm management and exposure risk factors f...
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PMID: 18189044
PDF is available here.
PDF is available here.
Abstract
This communication documents age-associated pathologic changes and final observations on experimental transmission of chronic wasting disease (CWD) by the intracerebral route to raccoons (Procyon lotor). Four kits were inoculated intracerebrally with a brain suspension from mule deer with CWD. Two u...
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PMID: 17998557
PDF is available here.
PDF is available here.
Abstract
We evaluated the role that wallow use by elk (Cervus elaphus) may play in CWD transmission by monitoring wallows with animal-activated cameras throughout their period of use. We monitored 39 wallows from 5 August 2005 to 14 October 2005. Elk visited 20 sites; we recorded 22 events when only male elk...
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PMID: 17984281
PDF is available here.
PDF is available here.
Journal of Virology (81)17 2007
Abstract
We report the use of both nondenaturing amplification and protein-misfolding cyclic amplification (PMCA) to amplify PrP(CWD) in vitro. Normal brains from deer, transgenic mice expressing cervid PrP(C) [Tg(cerPrP)1536 mice], and ferrets supported amplification. PMCA using normal Tg(cerPrP)1536 brains...
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PMID: 17553879
PDF is available here.
PDF is available here.
Abstract
To study the pathogenesis of chronic wasting disease (CWD) in deer and elk, transgenic (tg) mice were generated that expressed the prion protein (PrP) of deer containing a glycine at amino acid (aa) 96 and a serine at aa 225 under transcriptional control of the murine PrP promoter. This construct wa...
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PMID: 17451773
PDF is available here.
PDF is available here.
Veterinary Pathology (44)4 2007
Abstract
Fourteen, 3-month-old calves were intracerebrally inoculated with the agent of chronic wasting disease (CWD) from white-tailed deer (CWDwtd) to compare the clinical signs and neuropathologic findings with those of certain other transmissible spongiform encephalopathies (TSE, prion diseases) that hav...
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PMID: 17606510
PDF is available here.
PDF is available here.
Journal of General Virology (88)Pt 7 2007
Abstract
The utility of rectal lymphoid tissue sampling for the diagnosis of chronic wasting disease (CWD) infections in mule deer (Odocoileus hemionus) and white-tailed deer (Odocoileus virginianus) was evaluated. CWD-associated prion protein (PrP(CWD)) deposits were observed in the rectal mucosa from 19 or...
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PMID: 17554043
PDF is available here.
PDF is available here.
Abstract
These results indicate that decontamination methods and tissue disposal systems maintaining elevated temperatures for long periods of time could interfere with immunodetection, and the reliability of assays for PrPres detection could be compromised when applied to tissues exposed to heat with time....
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PMID: 17609348
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1772)6 2007
Abstract
Until recently, chronic wasting disease of cervids, the only prion disease affecting wildlife, was believed to be geographically concentrated to Colorado and Wyoming within the United States. However, increased surveillance has unveiled several additional pockets of CWD-infected deer and elk in 12 a...
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PMID: 17223321
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1772)6 2007
Abstract
Abstract
We investigated whether CWD-affected elk and deer differ in distribution or quantity of disease-associated prion protein (PrPres) in lymphoid tissues. Immunoblot quantification of PrPres from tonsil and retropharyngeal lymph nodes showed much higher levels of PrPres in deer than in elk. This differe...
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PMID: 17553219
PDF is available here.
PDF is available here.
Journal of Virology (81)9 2007
Abstract
These results demonstrate the importance of deer PrP polymorphisms in susceptibility to CWD infection. Furthermore, this deer PrP transgenic model is the first to demonstrate extraneural accumulation of PrPres in spleen and intestinal tissue and thus may prove useful in studies of CWD pathogenesis a...
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PMID: 17314157
PDF is available here.
PDF is available here.
Journal of Virology (81)8 2007
Abstract
These results show that CWD can be transmitted and adapted to some species of rodents and suggest that the cervid-derived CWD inocula may have contained or diverged into at least two distinct transmissible spongiform encephalopathy strains....
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PMID: 17287284
PDF is available here.
PDF is available here.