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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Embryo, Nonmammalian (2):
Recent article
Embryo, Nonmammalian
Abstract
We examine the distribution, interactions and functions of the maternal planar cell polarity core protein Vangl2 and the apical-basal complex component aPKC. We show that Vangl2 is distributed in animally enriched islands in the subcortical cytoplasm in full-grown oocytes, where it interacts with a...
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PMID: 21813572
PDF is available here.
PDF is available here.
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Abstract
We now show that Fgf signalling is both necessary and sufficient for anterior otic specification during a similar period, a function that is completely separable from its earlier role in otic placode induction. In lia(-/-) (fgf3(-/-)) mutants, anterior otic character is reduced, but not lost altoget...
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PMID: 21831919
PDF is available here.
PDF is available here.
Abstract
We report that one of the spectraplakin isoforms, VAB-10B1, plays an essential role in cell and nuclear migration of DTCs by regulating the actin and microtubule (MT) cytoskeleton. In the vab-10(tk27) mutant, which lacks VAB-10B1, alignment of filamentous (F)-actin and MTs was weakly and severely di...
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PMID: 21831923
PDF is available here.
PDF is available here.
Abstract
We examined two CRMs from the Drosophila snail gene locus, which are both active in the ventral region of pre-gastrulation embryos. By performing a deletion series in a ∼25 kb DNA rescue construct using BAC recombineering and site-directed transgenesis, we demonstrate that the two CRMs are not red...
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PMID: 21813571
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1810)9 2011
Abstract
Our aim was to set up a method to examine the behavior of these vesicles in vivo....
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PMID: 21609754
PDF is available here.
PDF is available here.
Abstract
Abstract
We show here that establishment of select CNS longitudinal tracts and formation of precise mechanosensory afferent innervation to the same CNS region are coordinately regulated by the secreted semaphorins Sema-2a and Sema-2b. Both Sema-2a and Sema-2b utilize the same neuronal receptor, plexin B (Ple...
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PMID: 21521614
PDF is available here.
PDF is available here.
Lymphology (44)1 2011
Abstract
We experimentally validate the utility of these two marker lines as potential tools for establishing lymphatic vascular identity and visualizing developmental lymphangiogenesis. We introduced twenty nanometer red florescent microspheres into the blood vasculature of flil:GFP zebrafish and collected...
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PMID: 21667817
PDF is available here.
PDF is available here.
Development (138)6 2011
Abstract
We show that, when grown at high temperature, a majority of synMuv B mutants irreversibly arrest at the L1 stage. High temperature arrest (HTA) is accompanied by upregulation of many genes characteristic of germ line, including genes encoding components of the synaptonemal complex and other meiosis...
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PMID: 21343362
PDF is available here.
PDF is available here.
Abstract
We report that Yki/Sd synergizes with and requires the transcription factor dE2F1 to induce a specific transcriptional program necessary to bypass the cell cycle exit. We show that Yki/Sd and dE2F1 bind directly to the promoters of the Yki/Sd-dE2F1 shared target genes and activate their expression i...
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PMID: 21325133
PDF is available here.
PDF is available here.
Abstract
We identified and characterized the role of Drosophila Sponge (Spg), the vertebrate DOCK3/DOCK4 counterpart as an ELMO-interacting protein. Our analysis shows Spg mRNA and protein is expressed in the visceral musculature and developing nervous system, suggesting a role for Spg in later embryogenesis...
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PMID: 21283588
PDF is available here.
PDF is available here.
Abstract
We discovered that a 255 bp cis-regulatory module, the promoter tethering element (PTE), located 5' of the Abd-B transcriptional start site is able to tether IAB5 to the Abd-B promoter in transgenic embryo assays. In this study we examine the functional role of the PTE at the endogenous BX-C using t...
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PMID: 21283702
PDF is available here.
PDF is available here.
Abstract
These results may guide development of novel therapeutic strategies to selectively eliminate tumors or minimize the size of tissue injury in degenerative or traumatic cell death....
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PMID: 21224042
PDF is available here.
PDF is available here.
Abstract
We have compared the gene regulatory network implicated in dorsoventral patterning of the basal chordate amphioxus and vertebrates. We found that Bmp but not canonical Wnt signaling regulates promoters of genes encoding homeodomain proteins AmphiVent1 and AmphiVent2. Furthermore, AmphiVent1 and Amph...
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PMID: 21304903
PDF is available here.
PDF is available here.
médecine/sciences (27)6-7 2011
Abstract
Abstract
The Frog Embryo Teratogenesis Assay Xenopus (FETAX) test is a development toxicity screening test. Due to the small amount of compound needed and the capability to study organogenesis in a short period of time (96 h), FETAX test constitutes an efficient development toxicity alert test when performed...
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PMID: 20972758
PDF is available here.
PDF is available here.
Abstract
The embryonic zebrafish model offers the power of whole-animal investigations (e.g., intact organism, functional homeostatic feedback mechanisms, and intercellular signaling) with the convenience of cell culture (e.g., cost- and time-efficient, minimal infrastructure, small quantities of nanomateria...
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PMID: 20972759
PDF is available here.
PDF is available here.
Abstract
We review the protocols for a yeast-based assay to detect effective ZFNs. Additionally, we detail the procedures for synthesis and injection of ZFN-encoding mRNA into zebrafish embryos, screening of injected embryos for induced mutations in the soma, and recovery of germline mutations....
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PMID: 21805278
PDF is available here.
PDF is available here.
Chemosphere (82)3 2011
Abstract
This work investigates the ecotoxicological evaluation of contaminated dredged sediments from French Mediterranean navy harbour (A), commercial port (B) and two composite specimens (C) and (D) coming from the mixture of A and B with other port sediments. The toxicity of elutriates from these sedimen...
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PMID: 21035165
PDF is available here.
PDF is available here.
Chemosphere (82)3 2011
Abstract
The effects of bisphenol A (BPA) on abalone (Haliotis diversicolor supertexta) embryonic development were investigated by exposing the fertilized eggs to four different concentrations of BPA (0.05, 0.2, 2 and 10 μg mL(-1)). Toxicity endpoints including the embryo development parameters, the physiol...
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PMID: 20970156
PDF is available here.
PDF is available here.
Abstract
We have generated a zebrafish line carrying a stop mutation in the kinase domain of the Tie-2 receptor. Mutant embryos lack Tie-2 protein, but do not display any defect in heart and vessel development. Simultaneous loss of Tie-1 and Tie-2, however, leads to a cardiac phenotype. Our study shows that...
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PMID: 21045210
PDF is available here.
PDF is available here.
Abstract
We have determined the oxidative stress and the mRNA content of four antioxidant enzymes (catalase, glutathione reductase, glutathione-S-transferase, and superoxide dismutase) during Japanese rice fish embryogenesis (from 0 day post-fertilization to hatching) and after exposing the embryos to ethano...
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PMID: 20965276
PDF is available here.
PDF is available here.
Abstract
We analyze the effects of loss of Heart adaptor protein 1 (Hadp1), which we show is required for normal function and morphogenesis of the embryonic zebrafish heart. Hadp1 is a pleckstrin homology (PH)-domain-containing protein whose expression is enriched in embryonic cardiomyocytes. Knockdown of ha...
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PMID: 21628396
PDF is available here.
PDF is available here.
Abstract
We manipulated levels of Ena, the Drosophila homologue of Mena, in migrating embryonic macrophages (haemocytes). Consistent with data from fibroblasts in vitro, Ena localises to regions of actin dynamics within migrating haemocytes, stimulates lamellipodial dynamics and positively regulates the numb...
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PMID: 21045209
PDF is available here.
PDF is available here.
Abstract
We present a method for predicting the developmental stage of zebrafish embryos using novel metabolomic non-target fingerprints of "single-embryos". With this method, we observed the rate of development at different temperatures. Our results suggest that this method allows us to analyse the conditio...
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PMID: 21630594
PDF is available here.
PDF is available here.
Abstract
We showed that C/EBPβ was downregulated with exercise, whereas the expression of CITED4 was increased. Reduction of C/EBPβ in vitro and in vivo resulted in a phenocopy of endurance exercise with cardiomyocyte hypertrophy and proliferation. This proliferation was mediated, at least in part, by the...
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PMID: 21183071
PDF is available here.
PDF is available here.
Abstract
We investigate how cell deformations emerge from the interplay between force generation and cortical force transmission during this remodelling in Drosophila melanogaster. The shrinkage of dorsal-ventral-oriented ('vertical') junctions during this process is known to require planar polarized junctio...
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PMID: 21068726
PDF is available here.
PDF is available here.
Abstract
We have identified one sox11 homologue, sox11b, from the ovary of the orange-spotted grouper. In the present study, another sox11 homologue, sox11a, was cloned from the brain. The orange-spotted grouper Sox11a contained the signature features of mammalian SOX11 homologues except the Pro-Glu rich reg...
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PMID: 20851206
PDF is available here.
PDF is available here.
Abstract
In the present study, a full-length cDNA encoding the insulin-like growth factor binding protein-2 (IGFBP-2) was cloned from the liver of orange-spotted grouper (Epinephelus coioides) by rapid amplification of cDNA ends technique. The IGFBP-2 cDNA sequence was 1413 bp long and had an open reading fr...
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PMID: 20708707
PDF is available here.
PDF is available here.
Abstract
Abstract
We isolated a SET domain-containing gene from the zebrafish (Danio rerio). The gene has the highest sequence similarity to human NSD2, also known as Wolf-Hirschhorn syndrome candidate 1 or WHSC1, and therefore, was named DrWhsc1. DrWhsc1 mRNA is expressed in various tissues with the highest level in...
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PMID: 20946879
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We report novel functions of B56ε in regulating apoptosis. We provide evidence that B56ε has both anti- and pro-apoptotic functions. B56ε suppresses p53-independent apoptosis during neural development, but triggers p53-dependent apoptosis. Mechanistically, B56ε regulates the p53-dependent apopto...
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PMID: 20807766
PDF is available here.
PDF is available here.
Abstract
Epigenetic modifications of the genome are generally stable in somatic cells of multicellular organisms. In germ cells and early embryos, however, epigenetic reprogramming occurs on a genome-wide scale, which includes demethylation of DNA and remodeling of histones and their modifications. The mecha...
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PMID: 21030646
PDF is available here.
PDF is available here.
Abstract
We have carried out two cDNA sequencing projects to characterize the mRNA transcripts that are present during development of this embryo. These efforts have generated 480 megabases of new sequence, which have been assembled into transcript contigs and represent thousands of newly identified Ilyanass...
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PMID: 21558239
PDF is available here.
PDF is available here.
EMBO Journal (29)21 2010
Abstract
We show that zebrafish hen1 is specifically expressed in germ cells and is essential for maintaining a female germ line, whereas it is dispensable in the testis. Hen1 protein localizes to nuage through its C-terminal domain, but is not required for nuage formation. In hen1 mutant testes, piRNAs beco...
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PMID: 20859253
PDF is available here.
PDF is available here.
Development (137)22 2010
Abstract
We report that although Nv nanos (Nv-nos) has a conserved function in embryonic patterning through translational repression of hb, the timing and mechanisms of this repression are significantly delayed in the wasp compared with the fly. This delay in Nv-nos function appears to be related to the dyna...
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PMID: 20929949
PDF is available here.
PDF is available here.
Developmental Cell (19)4 2010
Abstract
We report a cell-intrinsic mode of BMP response control executed by the membrane protein Jiraiya. In the Xenopus embryo, zygotic Jiraiya, expressed exclusively in the neuroectoderm, is essential and sufficient for limiting dorsal neural development, which is dependent on BMP signals. In animal cap a...
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PMID: 20951346
PDF is available here.
PDF is available here.
Abstract
Blood-feeding mosquitoes, including the dengue and yellow fever vector Aedes aegypti, transmit many of the world's deadliest diseases. Such diseases have resurged in developing countries and pose clear threats for epidemic outbreaks in developed countries. Recent mosquito genome projects have stimul...
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PMID: 20889708
PDF is available here.
PDF is available here.
Abstract
In the present study, two conventional (with and without sand filter) and four additional (moving bed biofilm reactor, ozone, moving bed biofilm reactor combined with ozone and a membrane bio reactor) treatment technologies were operated in small-scale at Hammarby Sjöstad sewage treatment plant, St...
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PMID: 20570351
PDF is available here.
PDF is available here.
Tissue & Cell (42)5 2010
Abstract
We detected the localization of the three proteases at the protein level between one-cell stage and adult age. Their expression was weak at early stages, then increased at tadpole stage and decreased through metamorphosis and adult life. The calpain's expression was maximal during the period charact...
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PMID: 20828774
PDF is available here.
PDF is available here.
American Naturalist (176)4 2010
Abstract
We examined embryonic development of fence lizards (Sceloporus undulatus) from three populations (Indiana, Mississippi, and Florida) that occur at different latitudes and therefore experience different temperatures and season lengths. These data reveal countergradient variation: at identical tempera...
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PMID: 20718676
PDF is available here.
PDF is available here.
Abstract
We report eight homologs of mical family genes in zebrafish and their expression profiles during embryonic development. Consistent with the findings in Drosophila and mammals, most zebrafish mical family genes display expression in neural and musculature systems. In addition, five mical homologs are...
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PMID: 21035094
PDF is available here.
PDF is available here.
Abstract
We have recently found that Rem2 GTPase, highly expressed in human embryonic stem cells (hESC), maintains the cell cycle and controls proper differentiation towards ectoderm, suggesting a role in neuronal development. We describe here the use of the zebrafish (Danio rerio) model to determine the phy...
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PMID: 20729629
PDF is available here.
PDF is available here.
Abstract
We have identified key machinery of the Wnt-β-catenin (canonical)-signalling pathway that is encoded in the Amphimedon queenslandica (Demospongiae; Porifera) genome, namely Wnt, Fzd, SFRP, Lrp5/6, Dvl, Axin, APC, GSK3, β-catenin, Tcf, and Groucho. Most of these genes are not detected in the choano...
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PMID: 20883218
PDF is available here.
PDF is available here.
Abstract
We tested the TH requirement for gut development in E. coqui. Inhibition of TH synthesis with methimazole arrested gut development in its embryonic form. Embryos treated with methimazole failed to utilize the yolk in their nutritional endoderm, and survived for weeks without further development. Con...
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PMID: 20883213
PDF is available here.
PDF is available here.
Abstract
We show that short-term exposure to platinum during development uncouples at least two of the processes associated with torsion of the freshwater snail Marisa cornuarietis. That is, the anus of the treated snails is located anteriorly, but the gill and the designated mantle tissue remains in a poste...
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PMID: 20883216
PDF is available here.
PDF is available here.
Abstract
We have searched the genome and expressed sequence tags of the demosponge Amphimedon queenslandica for molecules involved in TLR and IL1R signaling. Although we did not identify a conventional TLR or ILR, the Amphimedon genome encodes two related receptors, AmqIgTIRs, which are comprised of at least...
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PMID: 20883219
PDF is available here.
PDF is available here.
Aquatic Toxicology (99)3 2010
Abstract
We found no evidence of adverse effects on zebrafish reproductive health following exposure to the concentrations occurring in most aquatic systems, indicating that DEHP alone may not be a causative agent of the reproductive abnormalities seen in wildlife, at least as a result of short-term exposure...
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PMID: 20561692
PDF is available here.
PDF is available here.
Abstract
Levels of juvenile hormone III (JH), FGLamide allatostatin peptides (ASTs), ASTs precursor (preproAST) mRNA and methyl farnesoate epoxidase (CYP15A1) mRNA were measured in embryos of the cockroach Blattella germanica. JH starts to rise just after dorsal closure, reaches maximal levels between 60% an...
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PMID: 20542115
PDF is available here.
PDF is available here.
Abstract
We designed a framework for imaging and reconstructing unstained whole zebrafish embryos for their first 10 cell division cycles and report measurements along the cell lineage with micrometer spatial resolution and minute temporal accuracy. Point-scanning multiphoton excitation optimized to preferen...
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PMID: 20724640
PDF is available here.
PDF is available here.
Abstract
These results indicate that interactions involving distinct cis-elements contribute to the proper integration of pair-rule regulatory information. A model fully accounting for these results proposes that metameric slp1 expression is achieved through the Runt-dependent regulation of interactions betw...
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PMID: 20435028
PDF is available here.
PDF is available here.
Developmental Cell (19)2 2010
Abstract
We show that stereotypic positioning of outgrowing Drosophila renal tubules depends on signaling in a subset of tubule cells and results from enhanced sensitivity to guidance signals by targeted matrix deposition. VEGF/PDGF ligands from the tubules attract hemocytes, which secrete components of the...
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PMID: 20708591
PDF is available here.
PDF is available here.
Developmental Cell (19)2 2010
Abstract
We report that the metalloproteinase activity of ADAM13 is required for early induction of CNC in Xenopus. In both cultured cells and X. tropicalis embryos, membrane-bound Ephrins (Efns) B1 and B2 were identified as substrates for ADAM13. ADAM13 upregulates canonical Wnt signaling and early expressi...
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PMID: 20708595
PDF is available here.
PDF is available here.
Developmental Biology (344)2 2010
Abstract
We have rescued the developmental defect of a strong toy mutant allele and analyzed so expression in the ocelli primordium of toy loss-of-function eye-antennal discs during third instar larva. The results show that so expression is only marginally affected in the absence of Toy transcriptional activ...
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PMID: 20580700
PDF is available here.
PDF is available here.
Developmental Biology (344)2 2010
Abstract
We identified zipper (zip), encoding a Drosophila non-muscle myosin II (myosin II) heavy chain, as a gene required for LR asymmetric development of the embryonic anterior midgut (AMG). Myosin II is known to directly generate mechanical force in various types of cells during morphogenesis and cell mi...
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PMID: 20553709
PDF is available here.
PDF is available here.
Abstract
Control of mRNA translation and degradation has been shown to be key in the development of complex organisms. The core mRNA degradation machinery is highly conserved in eukaryotes and relies on processive degradation enzymes gaining access to the mRNA. Control of mRNA stability in eukaryotes is also...
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PMID: 20659018
PDF is available here.
PDF is available here.
Abstract
Selector proteins are transcription factors that coordinate the formation and identity of organs and appendages. The proper formation of these tissues requires the selector proteins to regulate the expression of a large set of genes. Many selector proteins are involved in regulating multiple develop...
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PMID: 20725144
PDF is available here.
PDF is available here.
Abstract
We found that heart progenitor cells of the simple chordate Ciona intestinalis also generate precursors of the atrial siphon muscles (ASMs). These precursors express Islet and Tbx1/10, evocative of the splanchnic mesoderm that produces the lower jaw muscles and SHF of vertebrates. Evidence is presen...
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PMID: 20671188
PDF is available here.
PDF is available here.
Abstract
We have studied the function of NO and its signaling cascade via cyclic GMP in the locust embryo. Its developing nervous system is well suited for pharmacological manipulations in tissue culture. The components of this signaling pathway are localized by histochemical and immunofluorescence technique...
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PMID: 20361970
PDF is available here.
PDF is available here.