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Antlers (0):
Recent article
Antlers
Abstract
Roe deer antlers/mandibles are a useful tool for determination of ambient fluoride pollution. Antlers have a well-defined annual cycle of growth, therefore they represent a natural standardisation of samples during winter months. On the contrary, mandibles accumulate fluorides during the whole life...
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PMID: 21093890
PDF is available here.
PDF is available here.
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Abstract
We used eight sika deer stag calves and selected one side of future antler growth region for implanting inverted AP and the contralateral side for noninverted AP as the control. The results showed that implantation of the AP discs in an inverted orientation generated pedicles with final height (17 ...
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PMID: 20730865
PDF is available here.
PDF is available here.
Abstract
These results suggested that administration of pilose antler blood was effective in alleviating osteoporosis in ovariectomized rats....
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PMID: 20882756
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To research the effect of anthraquinone extracted from rubiqmnone on growth inhibition, introduction apoptosis and expression of relative gene of bcl-2 of hepatocarcinoma cell SMMC 7721, and provide the effective target of gene therapy. METHOD: The growth inhibition effect was detected by...
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PMID: 20545205
PDF is available here.
PDF is available here.
Abstract
Different types of cells require activation, and take part in annual, dynamic growth of deer antlers. Stem cells play the most important role in this process. This report shows the results of a two-year long observation of xenogenic implant of antlerogenic stem cells (cell line MIC-1). The cells wer...
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PMID: 20363989
PDF is available here.
PDF is available here.
Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo (23)3 2010
Abstract
The article presents the results of clinical studies of biocomplexes based on antlers raw materials as means to prevent the aging process in elderly patients with associated pathology (ischemic heart disease, chronic obstructive pulmonary disease).
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PMID: 21137225
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To establish a convenient, quick and accurate molecular method for the identification of crude drugs of antlers due to the difficult discrimination between the genuine antler and its adulterants. METHOD: According to the alignment analysis of full length sequences of Cyth gene from closel...
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PMID: 20222413
PDF is available here.
PDF is available here.
Abstract
We envisage that epimorphic regeneration of mammalian appendages, other than antler, could be made possible by recreating comparable milieu to that which supports the elaboration of that structure from the pedicle periosteum....
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PMID: 19492976
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To investigate the cardioprotective effects of the peptides from the velvet antler (VAP) of Cervus nippon on acute ischemic myocardial injury in rats and its underlying mechanisms. METHOD: The model rats of myocardial ischemia injury (MI) was produced by ligating the left anterior descend...
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PMID: 19894547
PDF is available here.
PDF is available here.
Abstract
The cable-tie method was no different from the standard method as a procedure for producing analgesia in the antlers of yearling stags and should be accepted as an appropriate procedure for applying analgesic rings to yearling stags. The analgesia produced in the antlers of yearling stags by rubber...
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PMID: 19521464
PDF is available here.
PDF is available here.
Zhongguo Xiufu Chongjian Waike Zazhi/Chinese Journal of Reparative and Reconstructive Surgery (23)5 2009
Abstract
The composite microsphere material was about 10 microm in diameter and had good spherical geometry, high monodispersity with nanometer size holes on the surface. Toxic symptoms such as hyperspasmia, palsy and death did not appear during the observing stage in acute toxicity test. Maximum hemolysis r...
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PMID: 19514585
PDF is available here.
PDF is available here.
Abstract
We found nude mice could support the singularly implanted antlerogenic periosteum (AP) to form pedicle-like, but not antler-like, bony protuberances. To further develop the model and at the same time to use the updated model for the investigation of antler formation, three experiments were carried o...
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PMID: 19051317
PDF is available here.
PDF is available here.
Abstract
The microscopic identification of seven kinds of pilose antler velvet indicators were made and effectively classified. CONCLUSION: This method is useful in the identification of pilose antler,and provides reference for its qualitative evaluation....
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PMID: 19565708
PDF is available here.
PDF is available here.
Abstract
I collagen and a mineral phase (carbonated apatite), arranged in osteons in compact (cortical bone) sections and a lamellar structure in the cancellous (spongy or trabecular bone) sections. The mineral content is lower in antler bone and it has a core of cancellous bone surrounded by compact bone ru...
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PMID: 18951859
PDF is available here.
PDF is available here.
Abstract
After 13 weeks, the high-dose group and antler glue group could significantly improve the BMD and bone mineral content of the ovariectomized rats, reduce BGP and ALP content, and remarkably increase the width of trabecula bone and bone trabecula area percentage, increase osteoblasts significantly, a...
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PMID: 19504956
PDF is available here.
PDF is available here.
Zhongguo Xiufu Chongjian Waike Zazhi/Chinese Journal of Reparative and Reconstructive Surgery (22)12 2008
Abstract
All rats survived to the end of the experiment, without foot ulcer or neuroma. Severer nervous adherence was observed in group A, mild adherence in group B, and no adherence in groups C and D 2, 4 and 6 weeks after operation, respectively. The recovery rate of the evoked potential of triceps surae i...
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PMID: 19137890
PDF is available here.
PDF is available here.
Abstract
Along with cell's replicative senescence, pl6, pRb and Cyclin D express significantly rised (P < 0.01), while E2F, CDK4 and telomerase express significantly lowerd (P < 0.01). Meanwhile, in PAP interfered group compared with which in 4th passage group, pl6, pRb and Cyclin D express significantly low...
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PMID: 19108381
PDF is available here.
PDF is available here.
Abstract
PAP significantly inhibited chondrocyte's express of S-A-beta-gal (P<0.01), promoted chondrocyte's proliferation (P<0.01), reduced cell content on G1 phase, enhanced the content of GAG, type II collagen and Aggrecan of ECM (P<0.01). CONCLUSION: PAP can significantly resist rat chondrocyte senescence...
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PMID: 19102153
PDF is available here.
PDF is available here.
Abstract
Heterotypic tissue interactions play an indispensable role in organ generation and regeneration. In contrast to the classic examples of tissue interactions prevailing in the formation of tetrapod limbs or pectoral fins that can only take place when the interactive tissues are in intimate contacts, t...
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PMID: 18214837
PDF is available here.
PDF is available here.
Abstract
Seven days after treatment with different doses of antler polypeptide, rat's motor activity was recovered in some extent. Significant difference (P < 0.001)was found between the antler polypeptide treatment group and operation group. The effect could be enhanced by increase of the doses. We observer...
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PMID: 19102191
PDF is available here.
PDF is available here.
Toxicology In Vitro (22)1 2008
Abstract
We have compared (using the same series of experimental samples) the levels of activity of a comprehensive range of cytoplasmic, lysosomal and matrix protease types, together with the levels of free radical induced protein damage (determined as protein carbonyl derivative) and total antioxidant in s...
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PMID: 17920231
PDF is available here.
PDF is available here.
Abstract
We demonstrate the presence of cells positive for the mesenchymal stem cell marker STRO-1 in the chondrogenic growth zone and the perivascular tissue of the cartilaginous zone in primary and regenerating antlers as well as in the pedicle of fallow deer (Dama dama). In addition, cells positive for th...
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PMID: 18446198
PDF is available here.
PDF is available here.
Abstract
This article examines the effects of elk velvet antler on joint pain and swelling, patient/physician global assessment of disease activity, functional ability, quality of life, blood levels of C-reactive protein, and adverse events in persons with stage 2 to 3 rheumatoid arthritis experiencing resid...
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PMID: 18077778
PDF is available here.
PDF is available here.
Abstract
The authors have developed a simple, cost-saving experimental design, plaque-based competitive hybridization (PBCH), for genome-wide identification of genes differentially expressed in different tissues. PBCH offers advantages in comparison with other methods used in comparative genomics by combining...
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PMID: 18227228
PDF is available here.
PDF is available here.
Abstract
To elucidate the influence of processing conditions on pilose antlerÅ therapic effects, the protein composition and activities were compared on three kinds of pilose antler processed by lyophilization, freezing and traditional short-time heating, respectively. The concentration of the water solub...
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PMID: 18589739
PDF is available here.
PDF is available here.
Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo (21)3 2008
Abstract
We investigated effect of water extract of reindeer mature antler powder (ERAP) on the kinetics of growth and "stationary phase aging" of HeLa (clone 11) cell line. Cell suspension was placed in the wells of 24-well plastic tissue culture plates with seeding density of 15 10(3)/cm2. The growth mediu...
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PMID: 19432198
PDF is available here.
PDF is available here.
Abstract
This study was conducted to investigate the effects of aging and long-term dietary antler supplementation on the calcium-regulating hormones and bone status in ovariectomized (Ovx) SAMP8 mice. The female SAMP8 mice were divided into four groups (in each group n = 6), Ovx or sham operated at the age...
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PMID: 18442014
PDF is available here.
PDF is available here.
Journal of Ethnopharmacology (113)2 2007
Abstract
We investigated the effects of deer antler extracts on osteoclast differentiation and bone-resorption in vitro. Chloroform extract (CE-C) of deer antler inhibited osteoclast differentiation in mouse bone marrow cultures stimulated by receptor activator of NF-kappaB ligand (RANKL) and macrophage-colo...
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PMID: 17646068
PDF is available here.
PDF is available here.
Biology of Reproduction (77)3 2007
Abstract
We cloned a new species, red deer (Cervus elaphus), from multipotent antler stem cells and their differentiated progeny. Cultured donor cell lines from male antlerogenic periosteum (AP) were left undifferentiated or chemically induced to initiate osteogenesis or adipogenesis. Based on their morpholo...
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PMID: 17522075
PDF is available here.
PDF is available here.
Abstract
We consider here alternative approaches to separating the relative contributions of these two sources to phenotypic covariances, comparing experimental approaches such as cross-fostering, traditional statistical techniques and more complex statistical models, specifically the 'animal model'. Using b...
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PMID: 17714306
PDF is available here.
PDF is available here.
Journal of Morphology (268)8 2007
Abstract
The periodic replacement of antlers is an exceptional regenerative process in mammals, which in general are unable to regenerate complete body appendages. Antler regeneration has traditionally been viewed as an epimorphic process closely resembling limb regeneration in urodele amphib...
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PMID: 17538973
PDF is available here.
PDF is available here.
Growth Factors (25)4 2007
Abstract
We used reverse transcriptase polymerase chain reaction (RT-PCR) and real-time reverse transcriptase polymerase chain reaction (real time RT-PCR), in situ hybridization, immunohistochemistry and Western blot techniques to localize IGF-I messenger ribonucleic acid (mRNA) and IGF-I peptide in the four...
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PMID: 18092234
PDF is available here.
PDF is available here.
Theriogenology (67)8 2007
Abstract
These results were considered a model for the use of assisted reproductive techniques to conserve other critically endangered deer species of India....
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PMID: 17383719
PDF is available here.
PDF is available here.
American Naturalist (169)4 2007
Abstract
We investigated phenotypic and environmental factors affecting both absolute and relative antler size of male roe deer in three contrasting populations in France and Sweden. In the three populations, we found marked age-specific variation in antler size, with an increase in both absolute and relativ...
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PMID: 17273980
PDF is available here.
PDF is available here.
Cell and Tissue Research (328)1 2007
Abstract
We have reported that histogenesis of antler regeneration relies on cells resident within the pedicle periosteum (PP). The present study elaborates this finding by means of functional studies involving the deletion of PP. Four yearling and four 2-year-old stags were selected for total PP deletion or...
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PMID: 17120051
PDF is available here.
PDF is available here.
Hereditas (Beijing) (29)3 2007
Abstract
We report the effects of candidate gene growth hormone (GH) gene on antler production in the current study. Single nucleotide polymorphisms (SNPs) of the GH gene were identified and genotyped by polymerase chain reaction followed by single strand conformation polymorphism (PCR-SSCP) analysis and DNA...
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PMID: 17369156
PDF is available here.
PDF is available here.
Abstract
We have introduced a 3 K heterologous microarray set-up (deer cDNA versus mouse template). Fifteen genes were differentially expressed; genes for housekeeping, regulatory functions (components of different signaling pathways, including FGF, TGFbeta, Wnt), and genes encoding members of the Polycomb g...
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PMID: 17146666
PDF is available here.
PDF is available here.
Abstract
We have introduced a 3 K heterologous microarray set-up (deer cDNA versus mouse template). Fifteen genes were differentially expressed; genes for housekeeping, regulatory functions (components of different signaling pathways, including FGF, TGFbeta, Wnt), and genes encoding members of the Polycomb g...
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PMID: 17146666
PDF is available here.
PDF is available here.
Journal of Microscopy (Oxford) (225)Pt 3 2007
Abstract
X-ray microtomography coupled with image analysis was tested as a non-destructive alternative method for the textural characterization of the trabecular part of deer antlers (Cervus Elaphus). As gas adsorption and mercury intrusion cannot be applied on this soft and spongy material, its pore texture...
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PMID: 17371448
PDF is available here.
PDF is available here.
Tissue & Cell (39)1 2007
Abstract
Our data are consistent with the findings of others in suggesting that FGF-2 induces expression of VEGF, to stimulate and maintain high rates of neovascularisation and angiogenesis, thereby providing nutrients to both velvet and bone as they rapidly grow and develop. The presence of FGF and VEGF and...
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PMID: 17316726
PDF is available here.
PDF is available here.
Abstract
We hypothesized that a mineral deficiency in the diet predisposed male elk to antler breakage. We analyzed elk antler, liver, and forage samples to identify mineral imbalances. We compared the mineral content of livers and antlers from elk in Owens Valley to samples taken from tule elk at Grizzly Is...
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PMID: 17347394
PDF is available here.
PDF is available here.
Abstract
The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology (288)12 2006
Abstract
We isolated cervine VEGF121 and VEGF165 from deer antler and found that mRNA is produced for VEGF in the precartilage and cartilage regions. By in situ hybridization, we examined whether the VEGF receptors Flt-1 and KDR are present in deer antler and found only KDR mRNA within the endothelial cells...
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PMID: 17054117
PDF is available here.
PDF is available here.
Animal Reproduction Science (96)1-2 2006
Abstract
We induced since puberty in the Iberian deer is usually attained during second autumn of life at 15-16 months of age. Finally, calving advance also affected antler development. Thus, two of the five males whose birth was advanced, showed two antler cycles in their first year of life....
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PMID: 16406397
PDF is available here.
PDF is available here.
Journal of Morphology (267)9 2006
Abstract
We performed three-point bending tests on bone specimens extracted from antlers of moose (Alces alces) to test for three types of variation in bone material stiffness (Young's modulus): within the antler structure, between populations of moose, and between moose and other deer species. Because super...
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PMID: 16752424
PDF is available here.
PDF is available here.
Journal of Anatomy (209)1 2006
Abstract
We show how deer antlers can be used as natural analogues for the successful development of specialized orthopaedic amputation prosthetics. We have used quantitative and qualitative findings from a study of the morphology of deer antlers to develop a device that mimics their structure, which creates...
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PMID: 16822270
PDF is available here.
PDF is available here.
Abstract
The metabolomic analysis of various types of deer antler was performed by 1H NMR spectrometry and principal components analysis (PCA). The PCA of the 1H NMR spectra of the aqueous fractions allowed a clear discrimination between antler samples according to their origins by the first three principal...
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PMID: 16495028
PDF is available here.
PDF is available here.
Developmental Dynamics (235)5 2006
Abstract
Wnt signalling regulates many developmental processes, including the fate specification, polarity, migration, and proliferation of cranial neural crest. The canonical Wnt pathway has also been shown to play an important role in bone physiology and there is evidence for its recapitulation during orga...
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PMID: 16552759
PDF is available here.
PDF is available here.
Environmental Health Perspectives (114 Suppl 1) 2006
Abstract
We sought to better understand the problem and investigated 171 male deer for phenotypic aberrations and 12 for detailed testicular histopathology. For the low-lying Aliulik Peninsula (AP), 61 of 94 deer were bilateral cryptorchids (BCOs); 70% of these had abnormal antlers. Elsewhere on the Kodiak A...
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PMID: 16818246
PDF is available here.
PDF is available here.
Annales Academiae Medicae Stetinensis (52 Suppl 1) 2006
Abstract
Statistical analysis demonstrated differences in the content of the elements depending on age and environmental pollution. Correlations between the content of elements in skull bones and antlers were found....
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PMID: 17469509
PDF is available here.
PDF is available here.
Hormones and Behavior (49)1 2006
Abstract
We found that glucocorticoid levels were higher in groups with three or more males than in groups with only one male. The flight distances showed positive correlation with fecal glucocorticoid. These data indicate that fecal glucocorticoid provides a useful approach in the evaluation of physiologica...
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PMID: 16000199
PDF is available here.
PDF is available here.
Abstract
Unossified horn or pilose antler cut from deer, which belong to the Cervidae generally is termed Nokyong. Nokyong is one of the most famous Korean traditional medicines and has been considered to possess sexual-reinforcing and antiaging actions. In this study, water extract of deer antler extract (D...
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PMID: 16759146
PDF is available here.
PDF is available here.
Abstract
We present a new phylogenetic analysis encompassing morphological and DNA sequence evidence, and find that both sets of data independently support a sister-group relationship of giant and fallow deer. Our results include the successful extraction and sequencing of DNA from this extinct species, and...
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PMID: 16148942
PDF is available here.
PDF is available here.
Journal of Anatomy (207)5 2005
Abstract
We still know very little about the molecular machinery required for antler regeneration, although there is evidence that developmental signalling pathways with pleiotropic functions are important and that novel 'antler-specific' molecules may not exist. Identifying these pathways and factors, decip...
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PMID: 16313394
PDF is available here.
PDF is available here.
Abstract
We analysed intercohort variability of live weight and antler length of 5,123 reindeer calves. We further assessed the influence of climate and density on the interannual variation in antler length, and discussed sex-specific resource allocation and response to climate variability. Antler length var...
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PMID: 16025353
PDF is available here.
PDF is available here.
Journal of Anatomy (207)4 2005
Abstract
Antlers are the only mammalian appendages capable of epimorphic regeneration and thus provide a unique model for investigating the mechanisms that underlie mammalian regeneration. Antlers elongate by a modified endochondral ossification process while intramembranous ossification takes place concurre...
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PMID: 16191163
PDF is available here.
PDF is available here.
Abstract
Theriogenology (63)8 2005
Abstract
We inferred that Pampas deer stags exhibited a seasonal cycle that modulated sexual behavior and the antler cycle, and we concluded that fecal steroid analysis was a practical and reliable non-invasive method for the evaluation of the endocrine status of free-ranging Pampas deer....
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PMID: 15826677
PDF is available here.
PDF is available here.
Matrix Biology (24)2 2005
Abstract
Deer antler regeneration is a uniquely intense and complex process, which involves chondrogenic and intramembranous ossification. Cell differentiation in the developing antler of red deer, Cervus elaphus, was characterized with extracellular matrix markers. Expression of the four matrilin genes was...
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PMID: 15890263
PDF is available here.
PDF is available here.
Abstract
A sensitive liquid chromatographic (LC) method with UV detection was developed for the determination of residues of lidocaine (LID) and its major metabolite, monoethylglycinexylidide (MEGX), in elk velvet antler. The drugs were extracted from alkaline velvet antler homogenates, cleaned up on a C(18)...
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PMID: 15796567
PDF is available here.
PDF is available here.