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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Mammary Glands, Animal (0):
Recent article
Mammary Glands, Animal
Abstract
We used a gene-targeting approach and generated two novel knock-in mouse models of mutated IGF1, in which the native Igf1 gene was replaced by Des-Igf1 (KID mice) or R3-Igf1 (KIR mice). The KID and KIR mutant proteins have reduced affinity for the IGFBPs, and therefore present as unbound IGF1, or 'f...
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PMID: 21628395
PDF is available here.
PDF is available here.
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British Journal of Nutrition (105)1 2011
Abstract
We investigated the effect of supplemental β-carotene for maternal mice during pregnancy and lactation on IgA antibody-secreting cells (ASC) in mammary gland and guts and on IgA transfer from milk to neonatal mice. Pregnant mice were fed untreated or 50 mg/kg β-carotene-supplemented diets from 6...
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PMID: 20727240
PDF is available here.
PDF is available here.
Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents.
Abstract
The synthesis and antiproliferative activity of a new series of rigid analogues of combretastatin A-4 are described which contain the 1,4-diaryl-2-azetidinone (β-lactam) ring system in place of the usual ethylene bridge present in the natural combretastatin stilbene products. These novel compounds...
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PMID: 21080725
PDF is available here.
PDF is available here.
Toxicologic Pathology (38)6 2010
Abstract
Interpretation of chemical-induced effects on the female beagle mammary gland can be difficult owing to the wide variation of normal glandular morphology. In this retrospective study, morphological features of the gland in four (proestrus, estrus, diestrus, and anestrus) phases of th...
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PMID: 20651098
PDF is available here.
PDF is available here.
Abstract
To examine the effect of setting a maximum milking time, from peak lactation until drying-off, on production, duration of milking, and udder health of dairy cows.
Forty cows were assigned in twin-pairs to be either milked until cups were removed at a milk flow-rate threshold of 0.35 kg/minute (Contr...
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PMID: 20927175
PDF is available here.
PDF is available here.
Food and Chemical Toxicology (48)10 2010
Abstract
We questioned whether this mycotoxin, administered during known critical exposure periods such as the fetal period and the first days of life, at doses compatible with mean daily intake in humans, could have an effect on mammary gland development in rodents. Wistar female rats were exposed to zearal...
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PMID: 20637251
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)10 2010
Abstract
Selenium (Se) deficiency has been associated with lowered resistance to mastitis in dairy cattle. However, little published data exists on the effect of Se supplementation before calving on udder health of pastured dairy heifers. Further, the relative efficacy of injectable barium selenate and oral...
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PMID: 20854994
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)10 2010
Abstract
Cows (n=2,053) from 6 seasonally calving dairy herds were enrolled in a trial to compare the efficacy of 2 dry cow treatments. Cows received either a combination dry cow therapy of 600 mg of cloxacillin (CL) followed by an internal teat sealant (ITS) containing 2.6 g of bismuth subnitrate in all 4 q...
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PMID: 20854992
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)10 2010
Abstract
Our data indicate that SREBP1 is regulated by LXR activation in BME-UV. Controlling LXR activation may prove useful in regulating milk fat production in lactating dairy cows.
Copyright © 2010 American Dairy Science Association. Published by Elsevier Inc. All rights reserved....
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PMID: 20854999
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)10 2010
Abstract
We evaluated gene and protein expression of the activin and inhibin subunits βA, βB, and α-inhibin and follistatin and ActRIB and ActRIIA receptors in the mammary gland of nonpregnant and pregnant heifers. Mammary glands were obtained from nonpregnant Nelore (Bos indicus) heifers (n=9) and from p...
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PMID: 20854993
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)10 2010
Abstract
Soils and plants in Atlantic Canadian provinces are known to contain low concentrations of selenium (Se). Earlier studies have indicated that dairy producers in Atlantic Canada are providing insufficient supplementary Se in the ration to meet the Se requirements of dairy cattle, as measured by herd-...
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PMID: 20855004
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)10 2010
Abstract
The objectives of the study were to define the sensitivity and specificity of the California Mastitis Test (CMT) in determining the presence of intramammary infection in postpartum dairy goats and to determine whether antibiotic therapy increased bacteriological cure rate and lowered somatic cell co...
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PMID: 20855005
PDF is available here.
PDF is available here.
Integrative Biology (2)9 2010
Abstract
We show that the pattern of branching morphogenesis of three-dimensional (3D) engineered epithelial tissues is controlled in part by gradients of endogenous mechanical stress. We used microfabrication to build model mammary epithelial tissues of defined geometry that branched in a stereotyped patter...
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PMID: 20717570
PDF is available here.
PDF is available here.
Abstract
We investigated the expression of VEGF, using immunohistochemistry and immunoblotting, in the mouse mammary gland during the reproductive cycle. Immunohistochemical studies localized VEGF protein predominantly in the cytoplasm of the mammary epithelium and revealed it to be strongly expressed in lat...
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PMID: 20431252
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)9 2010
Abstract
We show that expression of CSN1S1 in the mammary gland of lactating goats is significantly lower in animals with 2 weak haplotypes. Moreover, the effects of defective alleles were not detected in animals having 1 strong and 1 weak haplotype. Expression levels of other genes in the casein cluster wer...
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PMID: 20723707
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)9 2010
Abstract
Selection of the antimicrobial agent and maintenance of adequate drug concentrations at the site of infection are the most relevant problems in mastitis antibiotic therapy. Intramammary drug efficacy can be maximized by keeping drug concentrations at the site of infection above the minimum inhibitor...
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PMID: 20723685
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)9 2010
Abstract
We hypothesized that the immediate response would be associated with a local increase in insulin-like growth factor (IGF)-I signaling and a consequent increase in mammary growth. Four multiparous cows were assigned at parturition to unilateral frequent milking [UFM; milking of the left udder half tw...
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PMID: 20723680
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)9 2010
Abstract
Poor hygiene is an important risk factor for reduced udder health. Because the teat cleaning process is done automatically on farms with an automatic milking system (AMS), hygiene management might differ. The aim of this study was to determine the relationship between hygiene and udder health on far...
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PMID: 20723676
PDF is available here.
PDF is available here.
Abstract
We developed a time-resolved FRET strategy that is based on receptor labeling with selective fluorescent ligands. Specific FRET signals were observed with four different receptors expressed in cell lines, consistent with their dimeric or oligomeric nature in these transfected cells. More notably, th...
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PMID: 20622858
PDF is available here.
PDF is available here.
Nutrition and Cancer (62)6 2010
Abstract
We evaluated whether mammary tumor progression in tumor-bearing rats lifetime exposed to SPI is associated with deregulated progesterone receptor (PR) isoform expression. In histologically normal mammary glands of rats with invasive ductal carcinoma lesions, PR-A protein levels were higher for SPI-...
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PMID: 20661826
PDF is available here.
PDF is available here.
Abstract
We sequenced most of the coding region of the caprine PRLR gene in several individuals from the Malagueña and Murciano-Granadina breeds. This approach allowed us to identify 2 long and short mRNA isoforms, produced by alternative splicing, and 4 single-nucleotide polymorphisms (SNPs), namely, c.177...
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PMID: 20399061
PDF is available here.
PDF is available here.
Transgenic Research (19)4 2010
Abstract
We now consider whether aspects of codon usage and/or protein tertiary structure underlie this variation in mammary transgene expression....
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PMID: 20563642
PDF is available here.
PDF is available here.
Abstract
We generated and characterized a transgenic mouse model of Cav-1 overexpression under the control of a mouse mammary tumor virus (MMTV) long terminal-repeat promoter, which is predominantly expressed in specific epithelial cells. The MMTVcav-1(+) transgenic mice were fertile, and females bore litter...
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PMID: 20399205
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)8 2010
Abstract
To study the effects of a milking system that partially compensates for milk flow-dependent vacuum loss compared with a standard (high-line) milking unit in a tie-stall barn, milk flow and vacuum patterns were recorded in 10 cows during machine milking with 2 milking systems in a crossover design fo...
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PMID: 20655427
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)8 2010
Abstract
The objectives of this experiment were to determine interrelationships among mastitis indicators and evaluate the subclinical mastitis detection ability of infrared thermography (IRT) in comparison with the California Mastitis Test (CMT). Somatic cell count (SCC), CMT, and udder skin surface tempera...
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PMID: 20655420
PDF is available here.
PDF is available here.
Abstract
We have used animal models of mammary carcinoma to interrogate the contribution of PERK in the neoplastic process. The ablation of PERK in tumor cells resulted in impaired regeneration of intracellular antioxidants and accumulation of reactive oxygen species triggering oxidative DNA damage. Ultimate...
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PMID: 20453876
PDF is available here.
PDF is available here.
Abstract
This study sought to establish an in vitro lactating BMEC (bovine mammary epithelial cell) model, which may maintain the native function for a period of time. Mammary tissues of midlactation Holstein dairy cows were dispersed and cultured in a medium containing insulin, prolactin, hydrocortisone, tr...
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PMID: 20214659
PDF is available here.
PDF is available here.
Abstract
We assessed genomic profiles of glandular tissue and established tumors from MMTV-neu mice fed adequate (250 IU/kg) or high (5000 IU/kg) vitamin D (cholecalciferol). Genomic profiles were also obtained in murine mammary cells that differentially express VDR that were cultured in vitro with 100 nM 1,...
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PMID: 20412854
PDF is available here.
PDF is available here.
Abstract
We found that mutation of the C-terminus of transcription factor hexamethylene bisacetamide-inducible protein 1 (HEXIM1) in mice leads to abnormalities in cardiovascular development because of aberrant vascular endothelial growth factor (VEGF) expression. HEXIM1 regulation of some genes has also bee...
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PMID: 20453883
PDF is available here.
PDF is available here.
Abstract
We show that PMCA2 is down-regulated early in mammary involution associated with changes in MEC shape. We demonstrate that loss of PMCA2 expression raises intracellular calcium levels and sensitizes MECs to apoptosis. In contrast, overexpression of PMCA2 in T47D breast cancer cells lowers intracellu...
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PMID: 20534448
PDF is available here.
PDF is available here.
Abstract
To study gene expression within the mammary glands of dairy goats with mastitis, mRNA was collected from milk somatic cells (MSCs) of left udder halves challenged with Staphylococcus aureus and right udder halves infused with PBS, as control, at different time points (0, 12, 24 and 48h post-infectio...
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PMID: 20060596
PDF is available here.
PDF is available here.
Abstract
We demonstrate that mouse mammary stem cells (MaSCs) are highly responsive to steroid hormone signalling, despite lacking the oestrogen and progesterone receptors. Ovariectomy markedly diminished MaSC number and outgrowth potential in vivo, whereas MaSC activity increased in mice treated with oestro...
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PMID: 20383121
PDF is available here.
PDF is available here.
Abstract
Abstract
We show that the MaSC pool increases 14-fold during maximal progesterone levels at the luteal dioestrus phase of the mouse. Stem-cell-enriched CD49fhi cells amplify at dioestrus, or with exogenous progesterone, demonstrating a key role for progesterone in propelling this expansion. In aged mice, CD4...
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PMID: 20445538
PDF is available here.
PDF is available here.
Cancer Research (70)12 2010
Abstract
We overexpressed it in mouse mammary glands using a transplant system. Ectopic expression of ING4 suppressed MYC-induced mammary hyperplasia, but not tumorigenesis. In the same model system, we show that a COOH-terminal truncation mutant of ING4 found in human cancer cells could act alone to induce...
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PMID: 20501848
PDF is available here.
PDF is available here.
Abstract
We used a genetic approach to determine the role of SLITs in regulating the growth and organization of blood vessels in the mammary gland. We demonstrate that vascularization of the gland is not affected by loss of Slit expression in the epithelial compartment. Instead, we identify a stromal source...
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PMID: 20498081
PDF is available here.
PDF is available here.
Proteomics (10)12 2010
Abstract
We have used this animal model to characterize the quantitiative response in the milk proteome during the time course before and immediately after the LPS challenge. Milk samples from three healthy cows collected 3 h before the LPS challenge were compared with milk samples collected 4 and 7 h after...
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PMID: 20352626
PDF is available here.
PDF is available here.
Proteomics (10)12 2010
Abstract
We have used this animal model to characterize the quantitiative response in the milk proteome during the time course before and immediately after the LPS challenge. Milk samples from three healthy cows collected 3 h before the LPS challenge were compared with milk samples collected 4 and 7 h after...
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PMID: 20352626
PDF is available here.
PDF is available here.
Proteomics (10)12 2010
Abstract
We have used this animal model to characterize the quantitiative response in the milk proteome during the time course before and immediately after the LPS challenge. Milk samples from three healthy cows collected 3 h before the LPS challenge were compared with milk samples collected 4 and 7 h after...
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PMID: 20352626
PDF is available here.
PDF is available here.
Proteomics (10)12 2010
Abstract
We have used this animal model to characterize the quantitiative response in the milk proteome during the time course before and immediately after the LPS challenge. Milk samples from three healthy cows collected 3 h before the LPS challenge were compared with milk samples collected 4 and 7 h after...
|
PMID: 20352626
PDF is available here.
PDF is available here.
Proteomics (10)12 2010
Abstract
We have used this animal model to characterize the quantitiative response in the milk proteome during the time course before and immediately after the LPS challenge. Milk samples from three healthy cows collected 3 h before the LPS challenge were compared with milk samples collected 4 and 7 h after...
|
PMID: 20352626
PDF is available here.
PDF is available here.
Proteomics (10)12 2010
Abstract
We have used this animal model to characterize the quantitiative response in the milk proteome during the time course before and immediately after the LPS challenge. Milk samples from three healthy cows collected 3 h before the LPS challenge were compared with milk samples collected 4 and 7 h after...
|
PMID: 20352626
PDF is available here.
PDF is available here.
Proteomics (10)12 2010
Abstract
We have used this animal model to characterize the quantitiative response in the milk proteome during the time course before and immediately after the LPS challenge. Milk samples from three healthy cows collected 3 h before the LPS challenge were compared with milk samples collected 4 and 7 h after...
|
PMID: 20352626
PDF is available here.
PDF is available here.
Proteomics (10)12 2010
Abstract
We have used this animal model to characterize the quantitiative response in the milk proteome during the time course before and immediately after the LPS challenge. Milk samples from three healthy cows collected 3 h before the LPS challenge were compared with milk samples collected 4 and 7 h after...
|
PMID: 20352626
PDF is available here.
PDF is available here.
Proteomics (10)12 2010
Abstract
We have used this animal model to characterize the quantitiative response in the milk proteome during the time course before and immediately after the LPS challenge. Milk samples from three healthy cows collected 3 h before the LPS challenge were compared with milk samples collected 4 and 7 h after...
|
PMID: 20352626
PDF is available here.
PDF is available here.
Proteomics (10)12 2010
Abstract
We have used this animal model to characterize the quantitiative response in the milk proteome during the time course before and immediately after the LPS challenge. Milk samples from three healthy cows collected 3 h before the LPS challenge were compared with milk samples collected 4 and 7 h after...
|
PMID: 20352626
PDF is available here.
PDF is available here.
Proteomics (10)12 2010
Abstract
We have used this animal model to characterize the quantitiative response in the milk proteome during the time course before and immediately after the LPS challenge. Milk samples from three healthy cows collected 3 h before the LPS challenge were compared with milk samples collected 4 and 7 h after...
|
PMID: 20352626
PDF is available here.
PDF is available here.
Proteomics (10)12 2010
Abstract
We have used this animal model to characterize the quantitiative response in the milk proteome during the time course before and immediately after the LPS challenge. Milk samples from three healthy cows collected 3 h before the LPS challenge were compared with milk samples collected 4 and 7 h after...
|
PMID: 20352626
PDF is available here.
PDF is available here.
Proteomics (10)12 2010
Abstract
We have used this animal model to characterize the quantitiative response in the milk proteome during the time course before and immediately after the LPS challenge. Milk samples from three healthy cows collected 3 h before the LPS challenge were compared with milk samples collected 4 and 7 h after...
|
PMID: 20352626
PDF is available here.
PDF is available here.
Proteomics (10)12 2010
Abstract
We have used this animal model to characterize the quantitiative response in the milk proteome during the time course before and immediately after the LPS challenge. Milk samples from three healthy cows collected 3 h before the LPS challenge were compared with milk samples collected 4 and 7 h after...
|
PMID: 20352626
PDF is available here.
PDF is available here.
Proteomics (10)12 2010
Abstract
We have used this animal model to characterize the quantitiative response in the milk proteome during the time course before and immediately after the LPS challenge. Milk samples from three healthy cows collected 3 h before the LPS challenge were compared with milk samples collected 4 and 7 h after...
|
PMID: 20352626
PDF is available here.
PDF is available here.
Proteomics (10)12 2010
Abstract
We have used this animal model to characterize the quantitiative response in the milk proteome during the time course before and immediately after the LPS challenge. Milk samples from three healthy cows collected 3 h before the LPS challenge were compared with milk samples collected 4 and 7 h after...
|
PMID: 20352626
PDF is available here.
PDF is available here.
Biotechnology Letters (32)6 2010
Abstract
The bovine prolactin vector was injected directly into the mammary glands of mice carrying the human transferrin transgene to investigate its effect on the production of human transferrin in milk. The mean levels of human transferrin in two experimental groups were increased by approx. 60% compared...
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PMID: 20213525
PDF is available here.
PDF is available here.
Preventive Veterinary Medicine (95)1-2 2010
Abstract
Our objective was to determine the risk factors associated with bacteriological quality of bulk tank milk. Bulk tank milk samples were collected from all Prince Edward Island dairy herds (n=235) from March 2005 to March 2007. Biweekly total bacterial, preliminary incubation, laboratory pasteurizatio...
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PMID: 20381889
PDF is available here.
PDF is available here.
Preventive Veterinary Medicine (95)1-2 2010
Abstract
Our results indicate that the developed English and French questionnaires can be used simultaneously to accurately measure the udder health related management practices used on Canadian dairy farms. This questionnaire is adaptable for use in other developed dairy industry populations. The questionna...
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PMID: 20347164
PDF is available here.
PDF is available here.
Abstract
We report the establishment of two immortal bovine MEC lines by expression of hTERT gene alone under serum-containing culture conditions. This two cell lines maintain the general characteristics of MECs and have been stably passed more than 200 generations accompanying telomere extension, and were i...
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PMID: 20175753
PDF is available here.
PDF is available here.
Abstract
Abstract
We demonstrate a significant regulatory mechanism for CCL2 expression in fibroblasts in mediating mammary tumor progression and characterize multiple functions for CCL2 in regulating stromal-epithelial interactions. Targeted ablation of the transforming growth factor-beta (TGF-beta) type 2 receptor...
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PMID: 20454514
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
Our recent study revealed a stimulatory effect of peripubertal PFOA treatment (5 mg/kg) on mammary gland development in C57Bl/6 mice. The present study was designed to examine the underlying mechanism(s). It was found that mammary gland stimulation by PFOA was similarly observed in PPARalpha knockou...
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PMID: 20118188
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
Our recent study revealed a stimulatory effect of peripubertal PFOA treatment (5 mg/kg) on mammary gland development in C57Bl/6 mice. The present study was designed to examine the underlying mechanism(s). It was found that mammary gland stimulation by PFOA was similarly observed in PPARalpha knockou...
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PMID: 20118188
PDF is available here.
PDF is available here.