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Borna Disease (0)
Articles on Borna Disease
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Avian bornavirus associated with fatal disease in psittacine birds.
J Virol 84(13):6269-75 (2010) PMID 20219910 PMCID PMC2903261
Thanks to new technologies which enable rapid and unbiased screening for viral nucleic acids in clinical specimens, an impressive number of previously unknown viruses have recently been discovered. Two research groups independently identified a novel negative-strand RNA virus, now designated avian b... -
Distribution of Borna disease virus antigen and RNA in tissues of naturally infected bicolored white-toothed shrews, Crocidura leucodon, sup...
Vet Pathol 47(2):236-44 (2010) PMID 20133953
Borna disease is a severe viral-induced disorder of the central nervous system of horses, sheep, and a few other animal species, occurring in certain areas of central Europe. Pathogenesis and epidemiology of natural Borna disease virus (BDV) infections are still not fully understood;... -
Borna disease in an adult alpaca stallion (Lama pacos).
J Comp Pathol 143(2-3):203-8 (2010) PMID 20153871
Borna disease (BD) was diagnosed in a 2-year-old male alpaca with a history of chronic suppressed sexual desire and acute stretching convulsions. Microscopical examination of the central nervous system revealed non-purulent meningoencephalitis with mononuclear perivascular cuffing. T... -
Borna disease virus infection alters synaptic input of neurons in rat dentate gyrus
Cell Tissue Res 338(2):179-190 (2009) PMID 19806365
We have investigated the extent to which entorhinal axons react to this loss of granule cells. Unexpectedly, anterograde DiI tracing has shown a prominent layered termination of the entorhinal projection, despite an almost complete loss of granule cells at 9 weeks after infection. Combined light- an... -
[Epidemiological investigation on natural infection of different canine breeds with Borna disease virus in Ili, China].
Zhonghua Liu Xing Bing Xue Za Zhi 30(10):993-7 (2009) PMID 20193374
BDV p24 RNA fragments were found only in Kazakh Tobet (a shepherd dog) in 8 breeds of 150 cases and their overall positive rate was 11.0% (10/91). Compared with the strain of He/80 from horse and that of S6 from sheep in Germany, the homologous similarities of Kazakh Tobet was 99.2% and 95.7%, and t... -
[Expressing borna disease virus phosphoprotein in PC-12 cell and its influence on the cell proliferation].
Wei Sheng Wu Xue Bao 49(1):123-7 (2009) PMID 19388275
We performed reverse transcriptase polymerase chain reaction (RT-PCR) in the 10th generation of treated cells to examine the expression of BDV phosphoprotein. The proliferation of treated cells and control cells was examined by methyl thiazolyl tetrazolium assay (MT). RESULT: The recombinant plasmid... -
Borna disease virus circulating immunocomplex positivity and psychopathology in psychiatric patients in the Czech Republic.
Neuro Endocrinol Lett 30(3):414-20 (2009) PMID 19855370
BDV CIC positivity was detected in 66.7% of psychiatric patients (26/39) on day 0, in 53.9% (14/26) on day 28 and in 52.9% on day 56 (9/17). The control group was 22.2% (28/126) positive. The incidence of BDV CIC was significantly higher in psychiatric patients than in healthy individuals (p=0.001).... -
Ribavirin inhibits Borna disease virus proliferation and fatal neurological diseases in neonatally infected gerbils
Antiviral Res 80(3):5 (2008) PMID 18778737
We assessed the effect of ribavirin on the proliferation of Borna disease virus (BDV) in the brain. The intracranial inoculation of ribavirin reduced viral propagation in the acutely infected brain, resulting in protection from fatal neurological disorders. We found that the treatment with ribavirin... -
Restricted expression of Borna disease virus glycoprotein in brains of experimentally infected Lewis rats.
Audio, Transactions of the IRE Professio... 34(6):590-602 (2008) PMID 18282160
The expression profiles of BDV-GP, BDV-N and their mRNAs are significantly different, indicating that BDV-GP expression is regulated in vivo. This might be achieved by restricted nuclear export and/or maturation of BDV-intron II mRNA or limited translation as a viral mechanism to escape from the imm... -
Isotype analysis of human anti-Borna disease virus antibodies in Japanese psychiatric and general population
J Clin Virol 43(3):6 (2008) PMID 18786855
Our results suggested common exposure to BDV or a related virus in the general Japanese population. Low avidity IgG and persistent IgM suggested delayed immune response against BDV or a related virus. The specific IgA indicated mucosal involvement....
