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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Haplorhini (3):
Recent article
Haplorhini
New England Journal of Medicine (365)14 2011
Abstract
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Abstract
Physiologically based pharmacokinetic (PBPK) modelling can assist in the development of drug therapies and regimens suitable for challenging patient populations such as very young children. This study describes a strategy employing PBPK models to investigate the intravenous use of th...
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PMID: 21827216
PDF is available here.
PDF is available here.
Stem Cell Research (7)1 2011
Abstract
Unequivocal evidence for pluripotency in which embryonic stem cells contribute to chimeric offspring has yet to be demonstrated in human or nonhuman primates (NHPs). Here, rhesus and baboons ESCs were investigated in interspecific mouse chimera generated by aggregation or blastocyst...
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PMID: 21543277
PDF is available here.
PDF is available here.
Abstract
We detail SAR converting leads 1 and 2 to druglike molecules. The pivotal structural motif enabling this transition was the secondary sulfonamide substituent. Further fine-tuning of the substituent pattern in the sulfonamide paved the way to enhancing potency and bioavailability and minimizing hERG...
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PMID: 21539377
PDF is available here.
PDF is available here.
Abstract
We have disclosed evidence that the larval-stage-specific chitinase, OvCHT1, may be a potential biological target for affecting nematode development. On the basis of screening efforts, closantel, a known anthelmintic drug, was discovered as a potent and highly specific OvCHT1 inhibitor. Originally,...
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PMID: 21534605
PDF is available here.
PDF is available here.
Abstract
Abstract
Dendritic cells (DCs) and natural killer (NK) cells have central roles in antiviral immunity by shaping the quality of the adaptive immune response to viruses and by mediating direct antiviral activity. HIV-1 infection is characterized by a severe dysregulation of the antiviral immun...
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PMID: 21350578
PDF is available here.
PDF is available here.
Abstract
Abstract
We investigated the pathogenicity of Dsc3-reactive IgG autoantibodies that were identified previously in a subset of patients with atypical pemphigus. We here demonstrate that IgG against Dsc3 causes loss of adhesion of epidermal keratinocytes. Specifically, IgG against Dsc3 was purified from Dsc3-r...
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PMID: 21281804
PDF is available here.
PDF is available here.
Abstract
We demonstrate the presence of memory B cell populations and define their distribution, frequency and immunophenotype with regards to activation, proliferation, maturation, and antibody production in normal rhesus macaques from different lymphoid tissues....
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PMID: 21304587
PDF is available here.
PDF is available here.
Abstract
The cortex is spontaneously active, even in the absence of any particular input or motor output. During development, this activity is important for the migration and differentiation of cortex cell types and the formation of neuronal connections(1). In the mature animal, ongoing activ...
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PMID: 21841767
PDF is available here.
PDF is available here.
Abstract
Together the results suggest rotavirus infection activates the UPR, but modulates its effects by sequestering sensor, transcription factor, and effector proteins in viroplasms. The data consequently also suggest that viroplasms may directly or indirectly play a fundamental role in regulating signali...
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PMID: 21774819
PDF is available here.
PDF is available here.
Abstract
In this study, a 10-channel up-converting phosphor technology-based lateral flow (TC-UPT-LF) assay was developed to profile antibodies against Yersinia pestis. Ten expressed Y. pestis proteins were covalently conjugated with an up-converting phosphor particle to develop double-antigen sandwich immun...
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PMID: 20801166
PDF is available here.
PDF is available here.
Abstract
Brain-machine interfaces (BMIs) are artificial systems that control external devices or body muscles with signals generated by the neural activities of working brains. The BMIs currently under development can be divided into 2 types,i.e.,conventional (noninvasive) BMIs and complete (invasive) BMIs....
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PMID: 20940505
PDF is available here.
PDF is available here.
Abstract
One of the primary impediments to successful drug R&D is the frequent failure of successfully translating positive results obtained in animal models to human disease. To a large degree, this discrepancy is secondary to the substantial biological differences between species. Non-human primate models...
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PMID: 20730697
PDF is available here.
PDF is available here.
Abstract
We herein report the discovery of a series of potent and selective serotonin 5-HT(2A) receptor antagonists based on a phenethylpiperazine amide core structure. When tested in a rat sleep pharmacology model, these compounds increased both sleep consolidation and deep sleep. Within this series of comp...
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PMID: 20684606
PDF is available here.
PDF is available here.
Bioanalysis (2)8 2010
Abstract
An investigation was performed in order to establish if dried blood spots (DBS) could be applied to the quantitation of biopharmaceuticals in biological matrices and perform equivalently in terms of accuracy, precision and stability to traditional plasma methods.
A me...
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PMID: 21083346
PDF is available here.
PDF is available here.
Journal of Virology (84)16 2010
Abstract
We demonstrated previously that expression of simian virus 40 (SV40) large T antigen (LT), without a viral origin, is sufficient to induce the hallmarks of a cellular DNA damage response (DDR), such as focal accumulation of gamma-H2AX and 53BP1, via Bub1 binding. Here we expand our characterization...
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PMID: 20519379
PDF is available here.
PDF is available here.
Abstract
Species differences in microsomal binding were evaluated for 43 drug molecules in human, monkey, dog and rat liver microsomes, using a fixed concentration of microsomal protein. The dataset included 32 named drugs and 11 proprietary compounds encompassing a broad spectrum of physicoc...
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PMID: 20229604
PDF is available here.
PDF is available here.
Abstract
Anesthesiology (113)1 2010
Abstract
L-cysteine adduction occurs at different rates by design in olefinic isoquinolinium diester neuromuscular blockers, yielding corresponding durations of action. Antagonism by exogenous L-cysteine is superior to anticholinesterases, inducing inactivation of the active molecules to restore function rap...
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PMID: 20526187
PDF is available here.
PDF is available here.
Journal of Virology (84)13 2010
Abstract
We report role of rotavirus nonstructural protein 1 (NSP1) in regulating apoptosis by activating prosurvival pathways such as phosphatidylinositol 3-kinase (PI3K)/Akt and NF-kappaB (nuclear factor kappaB) during early hours of infections (2 to 8 hpi). The NSP1 mutant strain A5-16 induces weak and tr...
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PMID: 20392855
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)23 2010
Abstract
We compare responses to two sets of images, one composed of spatially separate and the other of abutting parts. We show that the influences of spatially separate parts combine, to a very close approximation, according to a linear rule. Nonlinearities are more prominent--although still weak--in respo...
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PMID: 20534843
PDF is available here.
PDF is available here.
Abstract
Intracellular recording in the retina of the snail, Helix pomatia L., reveals the existence of two types of cell responsive to diffuse flashes of achromatic or monochromatic light: B-type cells, which respond with sustained depolarization that is sometimes accompanied by spikes, and D-type cells, wh...
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PMID: 20480676
PDF is available here.
PDF is available here.
Abstract
For the purpose of reducing the strong CYP3A4 inhibitory potency of diamide prodrug 4, cyclic prodrugs of tricyclic-based FBPase inhibitors were synthesized. Extensive SAR studies led to the discovery of pyridine-containing cyclic prodrug 20, which strongly inhibited glucose production in monkey hep...
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PMID: 20359891
PDF is available here.
PDF is available here.
Abstract
The development and synthesis of potent p38alpha MAP kinase inhibitors containing a 2H-quinolizin-2-one platform is described. Evolution of the 2H-quinolizin-2-one series from an early lead to solving off target activity and pharmacokinetic issues is also discussed.
2010 Elsevier Ltd. All rights res...
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PMID: 20378346
PDF is available here.
PDF is available here.
Abstract
Tricyclic pyrazole tetrazoles which are potent partial agonists of the high affinity niacin receptor, GPR109a, have been discovered and optimized. One of these compounds has proven to be effective at lowering free fatty acids in vitro and in vivo.
2010 Elsevier Ltd. All rights reserved.
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PMID: 20363624
PDF is available here.
PDF is available here.
Abstract
We compared the baboons' behavior when the ADLM systems were either accessible or closed. ALDM reduced frequencies of object-directed behaviors, but had no overt consequence on social conflicts. In Experiment 3, we tested the process of the global or local attributes of visual stimuli in MTS-trained...
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PMID: 20479182
PDF is available here.
PDF is available here.
Neuropsychologia (48)6 2010
Abstract
We found neural specialization, in infants who received 3 months of training with six individually labeled monkey faces. However, neural specialization was not found after an equal amount of training with the same six faces labeled at the category-level (i.e., all faces labeled "monkey") or when inf...
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PMID: 20153343
PDF is available here.
PDF is available here.
Abstract
The nucleoside reverse transcriptase inhibitors (NRTIs) are used in antiretroviral therapy worldwide for the treatment of HIV infections. These drugs act by blocking reverse transcriptase enzyme activity, causing pro-viral DNA chain termination. As a consequence, NRTIs could cause genomic instabilit...
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PMID: 20377473
PDF is available here.
PDF is available here.
Abstract
Many microorganisms produce extracellular polymers referred to collectively as "slime" or glycocalyx, and form biofilms on solid surfaces in natural ecosystems. Campylobacter jejuni, one of the most important foodborne pathogens, also has the ability to form biofilm on stainless steel, glass, or pol...
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PMID: 20009353
PDF is available here.
PDF is available here.
Abstract
We report the design, synthesis and properties of spiroindane based compound 1, a potent, selective, orally bioavailable, non-peptide melanocortin subtype-4 receptor agonist. Compound 1 shows excellent erectogenic activity in the rodent models.
2010 Elsevier Ltd. All rights reserved.
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PMID: 20207541
PDF is available here.
PDF is available here.
Environmental Entomology (39)2 2010
Abstract
Many studies have evaluated the effect of forest fragmentation on dung beetle assemblage structure. However, few have analyzed how forest fragmentation affects the processes carried out by these insects in tropical forests where their food sources consist mainly of dung produced by native herbivore...
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PMID: 20388260
PDF is available here.
PDF is available here.
Neuroreport (21)4 2010
Abstract
The perforant path (PP) connects two key components of the medial temporal memory system, the entorhinal cortex and hippocampus. Entorhinal layer II projects densely to the outer portion of the molecular layer of the dentate gyrus and the stratum lacunosum-moleculare of CA2 and CA3 of the hippocampu...
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PMID: 20087236
PDF is available here.
PDF is available here.
Abstract
The present review discusses recent reports showing that reciprocal changes in T helper interleukin-17-secreting CD4 Th17 cells and CD4CD25FoxP3 regulatory T cells (Tregs) may play a role in the progressive disease caused by the HIV and by simian immunodeficiency virus.
Studies in nonhuman primate m...
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PMID: 20543593
PDF is available here.
PDF is available here.
Abstract
We report on several compounds that have been developed to remove allogenic T cells and/or to inhibit T-cell activation. We also discuss compounds that interfere with antibody-mediated rejection....
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PMID: 20125095
PDF is available here.
PDF is available here.
Abstract
Abstract
We investigated the role of auto-antibodies as detected by different serological assays. Nine reports containing data on 143 patients were analyzed. Pre-treatment data showed that indirect immunofluorescence, enzyme-linked immunosorbent assay (ELISA) and immunoblotting offer an 82.2% or greater prob...
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PMID: 20169293
PDF is available here.
PDF is available here.
Annales d'Endocrinologie (71)2 2010
Abstract
Pioneer in the field of hormone therapy, Charles-Edward Brown-Séquard (1817-1894) tried to stop the effects of aging on his contemporaries by injecting animal testicle extracts. His therapy was very popular in the last years of the 19th century. He even had followers in the following century, among...
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PMID: 20167305
PDF is available here.
PDF is available here.
Abstract
We review the recent advance of NeuroAIDS research including neuropathological study of macaque AIDS dementia model....
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PMID: 20229798
PDF is available here.
PDF is available here.
Pharmacogenomics Journal (11)1 2010
Abstract
The clinical development of a candidate p38 kinase inhibitor was terminated because of its unexpectedly rapid clearance in human subjects. Its short half-life and metabolic profile in human beings were vastly different from that in rats, dogs, and monkeys characterized during routine...
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PMID: 20177421
PDF is available here.
PDF is available here.
Abstract
We have developed a novel polydimethylsiloxane (PDMS) substrate capable of applying tensile and compressive strain (up to 45%) to cells and tissues while allowing in situ observation with high resolution optics. The strain field of the substrate was characterized experimentally using digital image c...
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PMID: 20188869
PDF is available here.
PDF is available here.
Abstract
We review the current state of knowledge on vaccine candidates based on domain III. Due to the results obtained concerning the immune response and protection in mice and monkeys, particular attention is paid to the chimeric protein domain III fused to p64k of Neisseria meningitidis....
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PMID: 20109025
PDF is available here.
PDF is available here.
Planta Medica (76)3 2010
Abstract
Hydroalcoholic extracts and pressed juice from Echinacea pallida were phytochemically characterised by HPLC-MS analyses. Ferulic and caffeic acid derivatives were identified as major constituents. All tested extracts and pressed juice from Echinacea pallida exhibited a low cytotoxic activity on monk...
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PMID: 19790030
PDF is available here.
PDF is available here.
Abstract
The beginning of the third millennium has been characterized by the emerging and progressive characterization of a novel malaria Plasmodium pathogen of simian origin (Plasmodium knowlesi), which now represents the fifth human malaria parasite. Evolutionary, environmental, and diagnostic-clinical fea...
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PMID: 20433003
PDF is available here.
PDF is available here.
Journal of Virology (84)4 2010
Abstract
Although few simian rotaviruses (RVs) have been isolated, such strains have been important for basic research and vaccine development. To explore the origins of simian RVs, the complete genome sequences of strains PTRV (G8P[1]), RRV (G3P[3]), and TUCH (G3P[24]) were determined. These data allowed th...
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PMID: 19939934
PDF is available here.
PDF is available here.
Abstract
These results suggest that SCY-635 warrants further investigation as a novel therapeutic agent for the treatment of individuals who are chronically infected with HCV....
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PMID: 19933795
PDF is available here.
PDF is available here.
Abstract
This study assessed the pharmacokinetic profiles for intramuscular and intravenous ceftaroline treatment for rats, rabbits, and monkeys. Ceftaroline, a novel cephalosporin with broad-spectrum activity against Gram-positive and Gram-negative pathogens, demonstrated favorable pharmacokinetic profiles...
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PMID: 19949051
PDF is available here.
PDF is available here.
Abstract
We show that NSCs can be efficiently grown in adherent cell cultures when angiogenic signals are included in the medium. These signals include both anti-angiogenic factors (the soluble form of the Notch receptor ligand, Dll4) and pro-angiogenic factors (the Tie-2 receptor ligand, Angiopoietin 2). Th...
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PMID: 20195471
PDF is available here.
PDF is available here.
Abstract
We investigated the selective activity of crude extracts of Margaritaria discoidea and Homalium africanum on Onchocerca ochengi, a model parasite for O. volvulus. These plants are used to treat the disease in North West Cameroon.
Sixteen crude extracts were prepared from various parts of M. discoide...
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PMID: 21029456
PDF is available here.
PDF is available here.
Abstract
We characterize the immunotargeting properties and pharmacokinetics of the APP-specific recombinant antibody 833c.
We used in situ binding, biodistribution analysis and in vivo imaging to assess the lung targeting of 833c.
More than 80% of 833c bound during the first pass through isolated perfused l...
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PMID: 20431301
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
We evaluate the hypothesis that ball-and-sockets and protrusions possess important structural and functional differences during fiber cell differentiation and maturation.
Intact lenses of leghorn chickens (E7 days to P62 weeks old) and rhesus monkeys (1.5-20 years old) were studied with SEM, freeze-...
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PMID: 21139982
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
To investigate the efficacy and safety of cationic nano-copolymers CS-g-(PEI-b-mPEG) mediated IκB kinase beta (IKKβ) targeting siRNA in modulating wound healing in a monkey model of glaucoma filtration surgery.
The IKKβ targeting siRNAs were chemically synthesized and screened in cultured monkey...
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PMID: 21139997
PDF is available here.
PDF is available here.
Abstract
I domain, and based on identification of phylogenetic position for Chlamydophila pneumoniae and Chlamydia trichomatis strains released from monkeys, relatedness of the above stated isolates with similar strains released from humans and with strains having nucleotide sequences presented in the GenBan...
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PMID: 20671971
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
Advanced glycation end products of BSA (AGE-BSA) participate in the pathogenesis of diabetic vascular disease. However, the role of AGE-BSA in diabetic retinopathy, especially in retinal neovascularization, remains incomplete. This study aimed to determine the contributions of AGE-BSA in the endothe...
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PMID: 21179235
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
Lentivirus-mediated RNAi of VEGF may be a new strategy to treat iris neovascularization, while further studies are needed to investigate the long-term effect....
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PMID: 20806089
PDF is available here.
PDF is available here.
Abstract
We previously reported the presence of an antibody which reacts to beta-glucan, anti-beta-glucan (BG) antibody, in human sera. In livestock and domestic pets, the antibody's response to fungal cell wall beta-glucan is little understood. In this study, we examined the existence and reactivity of anti...
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PMID: 20467198
PDF is available here.
PDF is available here.
Abstract
Neurophysiological studies reveal phasic dopamine signals that transmit information related predominantly but not exclusively to reward. Although not being entirely homogeneous, the dopamine signal is more restricted and stereotyped than neuronal activity in most other brain structures involved in g...
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PMID: 20416052
PDF is available here.
PDF is available here.
Abstract
We provide a detailed description of each step required together with exemplary images of good and bad outcomes that will help when setting up the technique. In our experience, a few steps proved critical for the successful application of DiOLISTICS. These considerations include the quality of the D...
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PMID: 20644510
PDF is available here.
PDF is available here.
Perception (39)4 2010
Abstract
We extract salient facial information? Here, we systematically compared non-pet-owners' gaze patterns while exploring human, monkey, dog, and cat faces in a passive viewing task. Our analysis revealed that the faces of different species induced similar patterns of fixation distribution between left...
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PMID: 20515000
PDF is available here.
PDF is available here.