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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Primates (2):
Recent article
Primates
Abstract
In the context of increasing extinction rates and the potential loss of essential evolutionary biological and anthropological information, it is an important task to support efforts to prepare, preserve, and curate collections of histological brain sections; to disseminate informatio...
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PMID: 21599701
PDF is available here.
PDF is available here.
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Abstract
We evaluate the ability of a chimeric CD40-specific monoclonal antibody (Chi220) to protect islet xenografts. Neonatal porcine islets (∼50 000 IEQ/kg) were transplanted intraportally into pancreatectomized diabetic macaques. Immunosuppression consisted of induction therapy with Chi220 and the IL-2...
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PMID: 21521467
PDF is available here.
PDF is available here.
Abstract
We previously demonstrated that dimethyl-prostaglandin E2 (dmPGE2) increased HSCs in vertebrate models. Here, we describe preclinical analyses of the therapeutic potential of dmPGE2 treatment by using human and nonhuman primate HSCs. dmPGE2 significantly increased total human hematopoietic colony fo...
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PMID: 21474107
PDF is available here.
PDF is available here.
Abstract
We lack definitive information about the effects of these agents on the development of the immune system of the human fetus and the newborn baby. Anti-TNF agents fall within US Food and Drug Administration's (FDA) category B regarding fetal risk, indicating that no adequate and well-controlled studi...
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PMID: 21468063
PDF is available here.
PDF is available here.
Abstract
Abstract
Generation of the HLA-B*15 group of alleles has been analyzed using exon 1, intron 1, exon 2, intron 2, and exon 3 sequences from human and nonhuman primates. Results indicated that the 230 alleles analyzed could be grouped into 5 different lineages of evolution coming from nonhuman primate MHC-B* al...
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PMID: 21376098
PDF is available here.
PDF is available here.
Abstract
Abstract
We wanted to test in humans whether a remapping of motion adaptation occurs in visual perception.The motion aftereffect (MAE) occurs after viewing of a moving stimulus as an apparent movement to the opposite direction. We designed a saccade paradigm suitable for revealing pre-saccadic remapping of t...
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PMID: 21298104
PDF is available here.
PDF is available here.
Abstract
I review the current knowledge of nonhuman primate NK cell receptors that interact with major histocompatibility complex class I proteins....
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PMID: 21411971
PDF is available here.
PDF is available here.
Abstract
Abstract
We present an improved osteogenic differentiation protocol based on the hanging drop method and a time-optimized use of 1α,25-(OH)(2) vitamin D(3), all-trans retinoic acid, and bone morphogenetic protein 2 (BMP-2) with an end point efficiency increased up to 90% and a protocol for chondrogenic diff...
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PMID: 21042995
PDF is available here.
PDF is available here.
Journal of Physiology (589)Pt 1 2011
Abstract
Abstract
Since serial studies of patients are limited, researchers interested in Chagas disease have relied on animal models of Trypanosoma cruzi infection to explore many aspects of this important human disease. These studies have been important for evaluation of the immunology, pathology, physiology and oth...
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PMID: 21820557
PDF is available here.
PDF is available here.
Abstract
Systematic Biology (59)6 2010
Abstract
I present a phylogenetic likelihood-based method (quantitative state speciation and extinction [QuaSSE]) that can be used to test such hypotheses using extant character distributions. This approach assumes that diversification follows a birth-death process where speciation and extinction rates may v...
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PMID: 20884813
PDF is available here.
PDF is available here.
Abstract
We have determined the degeneration process of the TPC3 gene that encodes a member of the two-pore channel (TPC) family recently implicated in Ca(2+) release by nicotinic acid adenine dinucleotide phosphate from intracellular acidic stores in animals. We show that degeneration of TPC3 likely began i...
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PMID: 20463046
PDF is available here.
PDF is available here.
Abstract
We identified the α-defensin repertoires in human, chimpanzee, orangutan, macaque, and marmoset. The α-defensin genes in primates can be classified into three phylogenetic classes (class I, II, and III). The presence of all three classes in the marmoset indicates that their divergence occurred bef...
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PMID: 20457584
PDF is available here.
PDF is available here.
Nature Reviews: Genetics (11)9 2010
Abstract
Abstract
We review data from clinical studies primarily of poxvirus and adenovirus vector vaccines, used in a heterologous prime-boost combination strategy. Currently, this strategy appears to hold the most promise for an effective vaccine based on results from immunogenicity testing and nonhuman primate cha...
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PMID: 20822348
PDF is available here.
PDF is available here.
Abstract
One of the primary impediments to successful drug R&D is the frequent failure of successfully translating positive results obtained in animal models to human disease. To a large degree, this discrepancy is secondary to the substantial biological differences between species. Non-human primate models...
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PMID: 20730697
PDF is available here.
PDF is available here.
Abstract
HIV's primary site of infection is at mucosal surfaces. To successfully defend against sexually transmitted diseases (STDs), including HIV, protection may need to be specifically elicited at the mucosal interface, where the organism enters the host. Recent advances in measuring adapt...
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PMID: 20978380
PDF is available here.
PDF is available here.
Abstract
We review the traditional roles of NHP model systems in vaccine development and compare this with how NHP models have been used in HIV vaccine research and development. Comparisons of the immune responses elicited by cellular immune response-inducing vaccines in macaques and humans illustrate the va...
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PMID: 20978377
PDF is available here.
PDF is available here.
Abstract
We review the traditional roles of NHP model systems in vaccine development and compare this with how NHP models have been used in HIV vaccine research and development. Comparisons of the immune responses elicited by cellular immune response-inducing vaccines in macaques and humans illustrate the va...
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PMID: 20978377
PDF is available here.
PDF is available here.
Trends in Microbiology (18)9 2010
Abstract
We review this new host-pathogen relationship and discuss its impact on the evolution of primate lentiviruses and the origins of the HIV pandemic.
Published by Elsevier Ltd....
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PMID: 20688520
PDF is available here.
PDF is available here.
Genetika (Moskva) (46)9 2010
Abstract
Establishing chromosomal homology in comparative cytogenetics remained speculative until the advent of molecular cytogenetics. Chromosome sorting by flow cytometry and degenerate oligonucleotide primed-PCR (DOP-PCR) brought a significant simplification and impetus to chromosome painting. Comparative...
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PMID: 21058511
PDF is available here.
PDF is available here.
Genetika (Moskva) (46)9 2010
Abstract
We have studied the molecular evolution of two gene families specific for primates: POLR2J of the transcription system and PMS2 of the MMR repair system. The appearance and improvement of the genetic structure in each of the families was shown to strongly correlate with the main stages of the higher...
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PMID: 21061629
PDF is available here.
PDF is available here.
Abstract
With the increasing availability of pigs genetically engineered to protect their tissues from the human immune response, research into xenotransplantation is progressing steadily. One potential route to the clinic would be the use of a pig heart as a bridge to allotransplantation. This would only be...
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PMID: 20488729
PDF is available here.
PDF is available here.
Abstract
We present a comprehensive review of the literature, allowing us to pinpoint the major gaps in knowledge and determine what research challenges lay ahead. An exhaustive search of five scientific databases identified 210 relevant research reports. These articles began to appear in the 1930s, but it w...
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PMID: 20568079
PDF is available here.
PDF is available here.
Abstract
I reviewed available clinical, neuroimaging, and neuropathological studies in humans and nonhuman primates exposed to Mn or other human conditions that result in elevated brain Mn concentrations.
Human and nonhuman primate literature was examined to compare clinical, neuroimaging, and neuropathologi...
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PMID: 20403794
PDF is available here.
PDF is available here.
Abstract
We used a simian/human immunodeficiency virus model of HIV infection to study pulmonary effects of Pneumocystis colonization. Simian/human immunodeficiency virus-infected/Pneumocystis-colonized monkeys developed progressive obstructive pulmonary disease characterized by increased emphysematous tissu...
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PMID: 20533880
PDF is available here.
PDF is available here.
Abstract
Several patterns of brain allometry previously observed in mammals have been found to hold for sharks and related taxa (chondrichthyans) as well. In each clade, the relative size of brain parts, with the notable exception of the olfactory bulbs, is highly predictable from the total brain size. Compa...
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PMID: 20616012
PDF is available here.
PDF is available here.
Psychological Review (117)3 2010
Abstract
We propose that conscious thought is for internal processing, to facilitate downstream interaction with the social and cultural environment. Human consciousness enables the construction of meaningful, sequential thought, as in sentences and narratives, logical reasoning, counting and quantification,...
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PMID: 20658859
PDF is available here.
PDF is available here.
Abstract
Abstract
We review how the experimental autoimmune encephalomyelitis (EAE) model in the Neotropical primate "common marmoset" can help to bridge the gap between rodent EAE models and MS. The EAE model in the marmoset closely resembles MS in the clinical as well as pathological presentation and can be used fo...
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PMID: 19826959
PDF is available here.
PDF is available here.
Abstract
We performed comparative genomic hybridization (CGH) between these two closely related species with the aim of going a step further in the dissection of Cebus genomes. CGH evidenced that the DNA imbalances between them involved different genome regions, i.e. preferentially repetitive DNA in CPA and...
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PMID: 20389045
PDF is available here.
PDF is available here.
Abstract
We describe isolated teeth of a previously undocumented primate from the earliest late Eocene ( approximately 37 Ma) of northern Egypt, Nosmips aenigmaticus, whose phylogenetic placement within Primates is unclear. Nosmips is smaller than the sympatric adapiform Afradapis but is considerably larger...
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PMID: 20457923
PDF is available here.
PDF is available here.
Health Physics (98)6 2010
Abstract
Treatment of the hematopoietic syndrome includes replacement with blood products, stem cell transplantation, and the use of hematopoietic cytokines. Cytokines have predictable effects based upon their mechanism of action. Those acting on early hematopoietic stem/progenitor cells have multilineage ef...
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PMID: 20445391
PDF is available here.
PDF is available here.
Abstract
We developed a novel immunochromatographic test (ICT) to efficiently detect F. tularensis-specific antibodies in sera from humans and other mammalian species (nonhuman primate, pig, and rabbit). This new tool requires none or minimal laboratory equipment, and the results are obtained within 15 min....
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PMID: 20220165
PDF is available here.
PDF is available here.
Abstract
We analyzed OR gene repertoires of five primate species including NWMs, OWMs, and hominoids for which high-coverage genome sequences are available, together with two prosimians and tree shrews with low-coverage genomes. The results showed no significant differences in the number of functional OR gen...
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PMID: 20061342
PDF is available here.
PDF is available here.
Veterinary Pathology (47)3 2010
Abstract
Despite numerous advances in the diagnosis and control of infectious diseases of nonhuman primates in the laboratory setting, a number of infectious agents continue to plague colonies. Some, such as measles virus and Mycobacterium tuberculosis, cause sporadic outbreaks despite well-established biose...
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PMID: 20472806
PDF is available here.
PDF is available here.
Veterinary Parasitology (169)1-2 2010
Abstract
Visceral leishmaniasis (VL) is a chronic and often fatal protozoal disease that is endemic in Belo Horizonte (State of Minas Gerais, Brazil). Leishmania sp. is an intracellular obligatory parasite of macrophages that can naturally infect several mammalian species. Non-human primates (NHP) have been...
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PMID: 20056328
PDF is available here.
PDF is available here.
Abstract
It has been suggested that the degree of ecological diversity that characterizes a primate community correlates positively with both its phylogenetic richness and the time since the members of that community diverged (Fleagle and Reed in Primate communities. Cambridge University Press, New York, pp...
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PMID: 20037832
PDF is available here.
PDF is available here.
Abstract
These results indicate that the majority of captive nonhuman primates in Thailand were exposed to HAV. It is possible that some of the animals were infected prior to capture....
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PMID: 19821010
PDF is available here.
PDF is available here.
Biological Cybernetics (102)4 2010
Abstract
We presented MNS2, an extension of the Mirror Neuron System model of the monkey mirror system trained to recognize the external appearance of its own actions as a basis for recognizing the actions of other animals when they perform similar actions. Here we further extend the study of the mirror syst...
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PMID: 20217428
PDF is available here.
PDF is available here.
Abstract
We performed pair wise comparisons (human vs. chimpanzee, gorilla and orangutan) by using cDNA array comparative genomic hybridization (CGH). A set of 23 genes with HLS duplications were identified, as well as other lineage differences in gene copy number specific of chimpanzee, gorilla and oranguta...
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PMID: 20153417
PDF is available here.
PDF is available here.
Abstract
We review some important findings, with an emphasis on computational models, human fMRI, and monkey neurophysiology studies.
(c) 2010 Elsevier Ltd. All rights reserved....
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PMID: 20338744
PDF is available here.
PDF is available here.
Abstract
We will review data from studies emphasizing these approaches to argue that the orbitofrontal cortex forms a crucial part of a network of structures that signals information about expected outcomes. Further we will suggest that, within this network, the orbitofrontal cortex provides the critical abi...
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PMID: 20206497
PDF is available here.
PDF is available here.
Naturwissenschaften (97)4 2010
Abstract
We describe a fragmentary humerus and two fragmentary ulnae from the latest Cretaceous of India that bear significantly on this issue. The fossils are tentatively referred to Deccanolestes cf. hislopi due to their small size and the fact that Deccanolestes is the only eutherian dental taxon to have...
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PMID: 20130827
PDF is available here.
PDF is available here.
Abstract
Dietary restriction (DR) delays or prevents age-related diseases and extends lifespan in species ranging from yeast to primates. Although the applicability of this regimen to humans remains uncertain, a proportional response would add more healthy years to the average life than even a cure for cance...
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PMID: 20219519
PDF is available here.
PDF is available here.
Abstract
Abstract
Reproduction (139)3 2010
Abstract
Spermatogonial stem cells (SSCs) maintain spermatogenesis throughout the reproductive life of mammals. While A(single) spermatogonia comprise the rodent SSC pool, the identity of the stem cell pool in the primate spermatogenic lineage is not well established. The prevailing model is that primate spe...
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PMID: 19880674
PDF is available here.
PDF is available here.
Biological Cybernetics (102)3 2010
Abstract
We examined the performance of a dynamic neural network that replicates much of the psychophysics and neurophysiology of eye-head gaze shifts without relying on gaze feedback control. For example, our model generates gaze shifts with ocular components that do not exceed 35 degrees in amplitude, what...
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PMID: 20094729
PDF is available here.
PDF is available here.
Abstract
The HIV vaccines tested in the halted Step efficacy trial and the modestly successful phase 3 RV144 trial were designed to elicit strong systemic immune responses; therefore, strategies to direct immune responses into mucosal sites should be tested in an effort to improve AIDS vaccine efficacy. Howe...
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PMID: 20425054
PDF is available here.
PDF is available here.
Abstract
BACKGROUND Female cancer patients are offered 'banking' of gametes before starting fertility-threatening cancer therapy. Transplants of fresh and frozen ovarian tissue between healthy fertile and infertile women have demonstrated the utility of the tissue banked for restoration of en...
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PMID: 20124287
PDF is available here.
PDF is available here.
Abstract
African nonhuman primates that are natural hosts of simian immunodeficiency virus (SIV) are generally spared from disease progression. Pathogenic and nonpathogenic SIV infections share some major features: high viral replication, massive acute depletion of mucosal CD4(+) T cells, and partial control...
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PMID: 20425055
PDF is available here.
PDF is available here.
Abstract
We combined magnetic pulling cytometry of isolated cultured human SC cells with finite element modeling of the mechanical response of the cell to traction forces applied by adherent beads. Preliminary work showed that the immersion angles of beads attached to the SC cells had a major influence on be...
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PMID: 19387710
PDF is available here.
PDF is available here.
Abstract
We combined magnetic pulling cytometry of isolated cultured human SC cells with finite element modeling of the mechanical response of the cell to traction forces applied by adherent beads. Preliminary work showed that the immersion angles of beads attached to the SC cells had a major influence on be...
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PMID: 19387710
PDF is available here.
PDF is available here.