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Mice, Congenic (0):
Recent article
Mice, Congenic
Abstract
We generated p53(null)CD45.1 mice by crossing p53(null)CD45.2 and CD45.1 mice. We demonstrate that p53(null)CD45.1 mice spontaneously developed autoimmunity, with a significant increase in IL-17-producing Th17 effectors in their lymph nodes (4.7 ± 1.0%) compared to the age-matched counterparts (1.9...
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PMID: 21471252
PDF is available here.
PDF is available here.
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Abstract
We developed an animal model of meningococcal sepsis in transgenic BALB/c mice expressing human transferrin. We studied experimental meningococcal sepsis in congenic transgenic BALB/c mice expressing human transferrin by transcriptional profiling using microarray analysis of blood and brain samples....
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PMID: 21811575
PDF is available here.
PDF is available here.
JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis. LID - 10.1002/art.30271 [doi]
Abstract
To elucidate the nonredundant roles of JNK-1 and JNK-2 in antigen-induced arthritis (AIA).
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PMID: 21305529
PDF is available here.
PDF is available here.
Abstract
We investigated whether ceramide concentrations are also altered in the trachea and the intestine of cystic fibrosis mice and whether an accumulation of ceramide in these organs has functional consequences that are typical of cystic fibrosis. Our findings demonstrate a marked accumulation of ceramid...
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PMID: 21078296
PDF is available here.
PDF is available here.
Abstract
We have overcome these obstacles and describe a method whereby whole-mounts of bone marrow tissue were immunostained and imaged in 3 dimensions by confocal fluorescence and reflection microscopy. We have successfully mapped by multicolor immunofluorescence the localization pattern of as many as 4 ce...
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PMID: 20647571
PDF is available here.
PDF is available here.
Abstract
The Sle1c subinterval on distal murine chromosome 1 confers loss of tolerance to chromatin. Cr2, which encodes complement receptors 1 and 2 (CR1/CR2; CD35/CD21), is a strong candidate gene for lupus susceptibility within this interval based on structural and functional alterations in its protein prod...
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PMID: 20660348
PDF is available here.
PDF is available here.
Abstract
We previously showed that responsiveness of hematopoietic stem and progenitor cells (HSPCs) to transforming growth factor-beta 2, a positive regulator of HSPC proliferation, is regulated by a quantitative trait locus (QTL) on chr. 4, Tb2r1. Interestingly, Tgfb2(+/-) mice have delayed thymic involuti...
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PMID: 20371546
PDF is available here.
PDF is available here.
Abstract
We report genetic mapping of social interaction behavior using inter-subspecific consomic strains established from MSM/Ms (MSM) and C57BL/6J (B6) mice. Two animals of the same strain and sex, aged 10 weeks, were introduced into a novel open-field for 10 min. Social contact was detected by an automat...
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PMID: 19936911
PDF is available here.
PDF is available here.
Abstract
We demonstrated decreased of exploratory behavior in the open field test and an increased of intermale aggression of AKR.CBA-D 13Mit76 mice compared with the parent strain AKR. No differences were found in the forced swim test between AKR.CBA-D 13Mit76 and AKR mice. Behavior of congenic mice AKR.CBA...
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PMID: 20583570
PDF is available here.
PDF is available here.
Mammalian Genome (21)3-4 2010
Abstract
We used chromosomal mapping to determine the genomic background associated with small testis size in MRL mice. We prepared and analyzed C57BL/6-based congenic mice carrying MRL mouse loci. Quantitative trait loci (QTL) analysis revealed susceptibility loci for small testis size at 100 cM on chromoso...
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PMID: 20157820
PDF is available here.
PDF is available here.
Mammalian Genome (21)3-4 2010
Abstract
We previously identified a Chr 15 quantitative trait locus (QTL) Fob3b in lines of mice selected for high (Fat line) and low (Lean line) body fat content that represent a unique model of polygenic obesity. Here we genetically dissected the Fob3b interval by analyzing the phenotypes of eight overlapp...
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PMID: 20204375
PDF is available here.
PDF is available here.
Critical Care Medicine (38)3 2010
Abstract
Metabolic and myosin isoform gene expression switch in sepsis-induced myocardial depression is inducible nitric oxide synthase-dependent. Furthermore, we suggest that the molecular switch favoring the expression of fetal isoforms of contraction related proteins is associated with regulation of proli...
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PMID: 20101178
PDF is available here.
PDF is available here.
Abstract
Our findings establish X-inactivation as a major modifier of the carrier phenotype in X-linked Alport syndrome. Thus, X-inactivation patterns may offer prognostic information and point to possible treatment strategies for symptomatic carriers....
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PMID: 19854849
PDF is available here.
PDF is available here.
Abstract
We show that IL-2 receptor alpha (CD25) plays a crucial role in IL-2 homeostasis. Thus, prolongation of IL-2 half-life and blocking of CD25 using antibodies or CD25-deficient mice led in combination, but not alone, to vigorous IL-2-mediated T cell proliferation, similar to IL-2/anti-IL-2 antibody co...
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PMID: 20133862
PDF is available here.
PDF is available here.
Mammalian Genome (21)1-2 2010
Abstract
We report the refinement of the Chr 17 QTL in a subcongenic strain of the B6.CAST-( D17Mit19-D17Mit91 ) congenic mice described previously. This new subcongenic strain possesses CAST Chr 17 donor alleles from 4.8 to 45.4 Mb on a B6 background. Similar to CAST, the subcongenic mice exhibit increased...
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PMID: 20033694
PDF is available here.
PDF is available here.
Journal of Heredity (101)3 2010
Abstract
The congenic HG.CAST-(D17Mit196-D17Mit190) (HQ17(hg/hg)) mouse strain showed a significant departure on the expected 50%/50% offspring sex ratio in more than 2400 progeny (55.7% females). The entire pedigree file included data from 13 nonoverlapping purebred generations and an F(2) c...
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PMID: 20032064
PDF is available here.
PDF is available here.
Journal of Heredity (101)3 2010
Abstract
The congenic HG.CAST-(D17Mit196-D17Mit190) (HQ17(hg/hg)) mouse strain showed a significant departure on the expected 50%/50% offspring sex ratio in more than 2400 progeny (55.7% females). The entire pedigree file included data from 13 nonoverlapping purebred generations and an F(2) c...
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PMID: 20032064
PDF is available here.
PDF is available here.
Journal of Heredity (101)3 2010
Abstract
The congenic HG.CAST-(D17Mit196-D17Mit190) (HQ17(hg/hg)) mouse strain showed a significant departure on the expected 50%/50% offspring sex ratio in more than 2400 progeny (55.7% females). The entire pedigree file included data from 13 nonoverlapping purebred generations and an F(2) c...
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PMID: 20032064
PDF is available here.
PDF is available here.
Journal of Heredity (101)3 2010
Abstract
The congenic HG.CAST-(D17Mit196-D17Mit190) (HQ17(hg/hg)) mouse strain showed a significant departure on the expected 50%/50% offspring sex ratio in more than 2400 progeny (55.7% females). The entire pedigree file included data from 13 nonoverlapping purebred generations and an F(2) c...
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PMID: 20032064
PDF is available here.
PDF is available here.
Journal of Heredity (101)3 2010
Abstract
The congenic HG.CAST-(D17Mit196-D17Mit190) (HQ17(hg/hg)) mouse strain showed a significant departure on the expected 50%/50% offspring sex ratio in more than 2400 progeny (55.7% females). The entire pedigree file included data from 13 nonoverlapping purebred generations and an F(2) c...
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PMID: 20032064
PDF is available here.
PDF is available here.
Journal of Heredity (101)3 2010
Abstract
The congenic HG.CAST-(D17Mit196-D17Mit190) (HQ17(hg/hg)) mouse strain showed a significant departure on the expected 50%/50% offspring sex ratio in more than 2400 progeny (55.7% females). The entire pedigree file included data from 13 nonoverlapping purebred generations and an F(2) c...
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PMID: 20032064
PDF is available here.
PDF is available here.
Journal of Heredity (101)3 2010
Abstract
The congenic HG.CAST-(D17Mit196-D17Mit190) (HQ17(hg/hg)) mouse strain showed a significant departure on the expected 50%/50% offspring sex ratio in more than 2400 progeny (55.7% females). The entire pedigree file included data from 13 nonoverlapping purebred generations and an F(2) c...
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PMID: 20032064
PDF is available here.
PDF is available here.
Journal of Heredity (101)3 2010
Abstract
The congenic HG.CAST-(D17Mit196-D17Mit190) (HQ17(hg/hg)) mouse strain showed a significant departure on the expected 50%/50% offspring sex ratio in more than 2400 progeny (55.7% females). The entire pedigree file included data from 13 nonoverlapping purebred generations and an F(2) c...
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PMID: 20032064
PDF is available here.
PDF is available here.
Journal of Heredity (101)3 2010
Abstract
The congenic HG.CAST-(D17Mit196-D17Mit190) (HQ17(hg/hg)) mouse strain showed a significant departure on the expected 50%/50% offspring sex ratio in more than 2400 progeny (55.7% females). The entire pedigree file included data from 13 nonoverlapping purebred generations and an F(2) c...
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PMID: 20032064
PDF is available here.
PDF is available here.
Journal of Heredity (101)3 2010
Abstract
The congenic HG.CAST-(D17Mit196-D17Mit190) (HQ17(hg/hg)) mouse strain showed a significant departure on the expected 50%/50% offspring sex ratio in more than 2400 progeny (55.7% females). The entire pedigree file included data from 13 nonoverlapping purebred generations and an F(2) c...
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PMID: 20032064
PDF is available here.
PDF is available here.
Journal of Heredity (101)3 2010
Abstract
The congenic HG.CAST-(D17Mit196-D17Mit190) (HQ17(hg/hg)) mouse strain showed a significant departure on the expected 50%/50% offspring sex ratio in more than 2400 progeny (55.7% females). The entire pedigree file included data from 13 nonoverlapping purebred generations and an F(2) c...
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PMID: 20032064
PDF is available here.
PDF is available here.
Journal of Heredity (101)3 2010
Abstract
The congenic HG.CAST-(D17Mit196-D17Mit190) (HQ17(hg/hg)) mouse strain showed a significant departure on the expected 50%/50% offspring sex ratio in more than 2400 progeny (55.7% females). The entire pedigree file included data from 13 nonoverlapping purebred generations and an F(2) c...
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PMID: 20032064
PDF is available here.
PDF is available here.
Abstract
We confirmed findings derived from studies of mast cell-deficient WBB6F(1)-Kit(W/W-v) mice indicating that mast cells can promote survival in cecal ligation and puncture (CLP) of moderate severity. However, we found that the beneficial role of mast cells in this setting can occur independently of ma...
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PMID: 20035049
PDF is available here.
PDF is available here.
Abstract
We generated congenic strains in which the Mx or Oas locus of the MSM/Ms (MSM) mouce was introduced to the most widely used mouse strain, C57BL/6J (B6). B6.MSM-Mx mice showed resistance to the infection of influenza virus but not of West Nile virus. On the other hand, B6.MSM-Oas mice showed resistan...
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PMID: 19827744
PDF is available here.
PDF is available here.
Abstract
We have shown, in both implanted and in situ-induced mouse tumor models, that the appearance of tumor cells is immediately sensed by CD44hi memory Tregs that are specific for self antigens. The rapid response of these Tregs preceded and prevented activation of naive antitumor Teffs. The relative spe...
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PMID: 19652360
PDF is available here.
PDF is available here.
Genetics Research (91)4 2009
Abstract
We recently identified a quantitative trait locus (QTL) influencing litter size. This locus is now denoted Fecq4, and it is present on the murine chromosome 9. In the present paper, we describe how the Fecq4 fragment originating form the NFR/N mouse strain will affect B10.Q mice by means of breeding...
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PMID: 19640321
PDF is available here.
PDF is available here.
Genes and Immunity (10)5 2009
Abstract
We have recently reported that renal kallikrein expression was upregulated by anti-GBM antibody challenge in a strain-specific manner and that it was significantly underexpressed in the anti-GBM-sensitive strains, including B6.Sle3. Further sequencing and functional studies reported earlier provided...
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PMID: 19262577
PDF is available here.
PDF is available here.
Abstract
We face is how to encourage researchers to comply with existing or emerging standard terminologies and nomenclatures. This is both an educational and a regulatory task, one in which it is vital to succeed if we are to efficiently and accurately share and use the huge volume of data emerging in the b...
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PMID: 19521404
PDF is available here.
PDF is available here.
Journal of Immunology (182)10 2009
Abstract
We show that the immune response to neoantigenic determinants on apoptotic thymocytes is dominated by Abs to oxidation-associated Ags, phosphorylcholine (PC), a head group that becomes exposed during programmed cell death, and malondialdehyde (MDA), a reactive aldehyde degradation product of polyuns...
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PMID: 19414754
PDF is available here.
PDF is available here.
Abstract
We demonstrate that deficiency in Foxo3 resulted in greater expansion of T cell populations after viral infection. This exaggerated expansion was not T cell intrinsic. Instead, it was caused by the enhanced capacity of Foxo3-deficient dendritic cells to sustain T cell viability by producing more int...
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PMID: 19363483
PDF is available here.
PDF is available here.
Abstract
We present experimental evidence that chronic TB infection induces cell dysplasia and squamous cell carcinoma (SCC) in a lung-specific manner. First, squamous cell aggregates consistently appeared within the lung tissue associated with chronic TB lesions, and in some cases resembled SCCs. A transpla...
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PMID: 19330024
PDF is available here.
PDF is available here.
Abstract
The role of exercise training (ET) on cardiac renin-angiotensin system (RAS) was investigated in 3-5 month-old mice lacking alpha(2A-) and alpha(2C-)adrenoceptors (alpha(2A)/alpha(2C)ARKO) that present heart failure (HF) and wild type control (WT). ET consisted of 8-week running sessions of 60 min,...
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PMID: 19125280
PDF is available here.
PDF is available here.
Abstract
We use a mouse model of cytomegalovirus infection to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000-fold in the liver after infection. After a contraction phase, Ly49H-positive NK cells reside in lymphoid and non-lymphoid orga...
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PMID: 19136945
PDF is available here.
PDF is available here.
Abstract
We previously reported that B-lymphopenic A/WySnJ mice develop a lupus-like syndrome and linked this syndrome to the B-cell maturation defect-1 (Bcmd-1) mutant allele of the B-cell-activating factor belonging to the TNF family-receptor (Baffr) gene. Here, we further evaluate the genetic basis for au...
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PMID: 19152335
PDF is available here.
PDF is available here.
Abstract
Il2 is the Idd3 diabetes susceptibility gene and can influence the outcome of T-cell deletion and islet allograft survival in mice treated with costimulation blockade. These data suggest that Idd loci can facilitate induction of transplantation tolerance by costimulation blockade and that IL-2/Idd3...
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PMID: 18984741
PDF is available here.
PDF is available here.
Abstract
Recent evidence supports the idea that following a break in tolerance, CD8 cytotoxic T lymphocytes (CTL) may be an important but unrecognized mechanism for limiting expansion of autoreactive B cells. Failure of this mechanism could allow persistence of CD4 T cell driven polyclonal B cell activation...
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PMID: 18725326
PDF is available here.
PDF is available here.
Abstract
We visualized the branched organization of lymph node cortical sinuses and found that after entry, some T cells were retained, whereas others returned to the parenchyma. T cells deficient in sphingosine 1-phosphate receptor type 1 probed the sinus surface but failed to enter the sinuses. In some sin...
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PMID: 19060900
PDF is available here.
PDF is available here.
Abstract
Our results suggest that SVP may be valuable natural peptides that relieve myelosuppression caused by radiation. The effect of SVP accelerating the hematopoietic recovery was potentially through a mechanism of stimulating the release of cytokines....
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PMID: 19655408
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (134)1 2009
Abstract
These results indicate that the volatiles in scent-marks provide information about genetic similarity of the mice, and support the idea that the production of these genetically determined volatiles is influenced by commensal microflora. This paper describes the application of consensus methods to re...
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PMID: 19082183
PDF is available here.
PDF is available here.
Abstract
Sjögren's syndrome (SjS) is chronic autoimmune disease manifested by the loss of saliva and/or tear secretion by salivary and/or lacrimal glands, respectively. The pathogenesis of the disease remains elusive, perhaps due to the multiple triggers of the disease. However, substantial advances have be...
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PMID: 19219532
PDF is available here.
PDF is available here.
Neuroimmunomodulation (16)3 2009
Abstract
Our data demonstrate the existence of a relationship between H-2 haplotypes and hippocampal neurotransmitter levels in mice.
Copyright 2009 S. Karger AG, Basel....
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PMID: 19246941
PDF is available here.
PDF is available here.
Abstract
We still know little about the number of genes that underlie these traits, the magnitude of their effects, or the extent to which they interact. Chromosome substitution strains (CSSs) enable statistically powerful studies based on testing engineered inbred strains that have single, unique, and nonov...
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PMID: 19066216
PDF is available here.
PDF is available here.
Kidney International (75)4 2008
Abstract
We introgressed a 50 Mb interval, encompassing this HIVAN1 locus, from CAST into the TgFVB genome (TgFVB-HIVAN1(CAST) congenic mice). Compared to the TgFVB strain, these congenic mice developed an earlier onset of proteinuria, a rapid progression to kidney failure, and increased mortality. A prospec...
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PMID: 19092797
PDF is available here.
PDF is available here.
Journal of Immunology (181)12 2008
Abstract
We show that a splenic population of murine CD11c(+) cells expressing pDC markers Gr-1, B220, and PDCA-1 is preferentially parasitized after infection with the virulent RH strain of Toxoplasma gondii. Although these markers are closely associated with pDCs, the population we identified was unusual b...
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PMID: 19050266
PDF is available here.
PDF is available here.
Abstract
These studies confirm the proatherogenic activity of a novel gene(s) in the MOLF-derived Athsq1 locus and provide in vivo evidence for a causative role of versican in lesion development....
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PMID: 18818413
PDF is available here.
PDF is available here.
Journal of Physiology (586)Pt 22 2008
Abstract
We refined the stereociliary localization of TRPML3 and investigated cochlear hair cell function in varitint-waddler (Va(J)) mice carrying the TRPML3 mutations. Using a TRPML3-specific antibody we detected a approximately 68 kDa protein with near-equal expression levels in cochlea and v...
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PMID: 18801844
PDF is available here.
PDF is available here.
Nature Immunology (9)11 2008
Abstract
We characterize a unique subset of tolerogenic DCs that expressed the chemokine receptor CCR9 and migrated to the CCR9 ligand CCL25, a chemokine linked to the homing of T cells and DCs to the gut. CCR9(+) DCs were of the plasmacytoid DC (pDC) lineage, had an immature phenotype and rapidly downregula...
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PMID: 18836452
PDF is available here.
PDF is available here.
Journal of Immunology (181)9 2008
Abstract
We have previously shown that TGF-beta2 at low concentrations enhances flt3 ligand-induced growth of HSPCs, while it is potently antiproliferative at higher concentrations. This in vitro enhancing effect was subject to quantitative genetic variation, for which a quantitative trait locus (QTL) was te...
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PMID: 18941179
PDF is available here.
PDF is available here.
Journal of Immunology (181)9 2008
Abstract
We asked whether Idd3(B6) protective alleles in the NOD mouse model confer T1D resistance by promoting the cellular frequency, function, or homeostasis of nT(reg) cells in vivo. We show that resistance to T1D in NOD.B6 Idd3 congenic mice correlates with increased levels of IL-2 mRNA and protein prod...
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PMID: 18941219
PDF is available here.
PDF is available here.
Abstract
We show that decreased androgen signaling leads to enhanced immigration of bone marrow T-cell precursors, as manifested by both an early increase of early thymic progenitors (ETP) and improved uptake of adoptively transferred quantified precursors into congenic castrated hosts. We provide evidence t...
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PMID: 18694999
PDF is available here.
PDF is available here.
Journal of Neuroimmunology (203)1 2008
Abstract
We investigated the transcriptional profile induced by C5 in chronic experimental allergic encephalomyelitis (EAE) using oligonucleotide arrays. We used C5-deficient (C5-d) and C5-sufficient (C5-s) mice to compare the gene expression profile and we found that 390 genes were differentially regulated...
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PMID: 18692252
PDF is available here.
PDF is available here.
Abstract
We dissected a known locus, Cia6, as well as a genomic region on chromosome 14 with no previously known arthritis loci, using a partial advanced intercross and a collection of congenic strains. The chromosome 14 congenic fragment, containing the T-cell receptor alpha (Tcra) locus, was included based...
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PMID: 18782270
PDF is available here.
PDF is available here.
Neuropsychopharmacology (33)11 2008
Abstract
We used a combined pharmacological and genetic approach. In congenic C57BL/6 J wild-type mice, we tested whether the D1R antagonist SCH23390 or the D2/3R antagonist raclopride would attenuate the effects of the indirect DA agonist cocaine (40 mg/kg). Both the D1R and D2/3R antagonists attenuated the...
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PMID: 18075489
PDF is available here.
PDF is available here.
Experimental Animals (57)5 2008
Abstract
We generated a NOG-enhanced green fluorescent protein (EGFP) transgenic (Tg) mouse (NOG-EGFP) that was introduced the EGFP transgene from the C57BL/6-EGFP Tg mouse using the speed congenic method with a marker-assisted selection protocol (MASP). With this method, the selection of the male with the c...
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PMID: 18946184
PDF is available here.
PDF is available here.
Genes and Immunity (9)7 2008
Abstract
Our study supports the idea that each congenic strain represents a different immunologic subtype of PGIA, providing an explanation for the complex etiology and various clinical phenotypes of rheumatoid arthritis....
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PMID: 18650834
PDF is available here.
PDF is available here.