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Drosophila (1):
Recent article
Drosophila
Abstract
We show that, in the peripheral nerves of Drosophila melanogaster, two integrin complexes (αPS2βPS and αPS3βPS) are expressed in the different glial layers and form adhesion complexes with integrin-linked kinase and Talin. Knockdown of the common beta subunit (βPS) using inducible RNAi in all g...
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PMID: 21828098
PDF is available here.
PDF is available here.
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Abstract
Abstract
We show that the dynamics of the PLS is controlled by Blown fuse (Blow), a cytoplasmic protein required for myoblast fusion but whose molecular function has been elusive. We demonstrate that Blow is an FCM-specific protein that colocalizes with WASP, WIP/Solitary, and the actin focus within the PLS....
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PMID: 21571220
PDF is available here.
PDF is available here.
Abstract
We found that (z)-7-tricosene, a male-enriched cuticular hydrocarbon that was previously shown to inhibit male-male courtship, was essential for normal levels of aggression. The mechanisms by which (z)-7-tricosene induced aggression and suppressed courtship were independent, but both required the gu...
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PMID: 21516101
PDF is available here.
PDF is available here.
Abstract
We show here that establishment of select CNS longitudinal tracts and formation of precise mechanosensory afferent innervation to the same CNS region are coordinately regulated by the secreted semaphorins Sema-2a and Sema-2b. Both Sema-2a and Sema-2b utilize the same neuronal receptor, plexin B (Ple...
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PMID: 21521614
PDF is available here.
PDF is available here.
Abstract
I and II", but which is today more well-known as classical (Pavlovian) and operant (instrumental) conditioning. Subsequent decades of research have confirmed that the interactions between the various learning systems engaged during operant conditioning are complex and difficult to disentangle. Today...
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PMID: 21392558
PDF is available here.
PDF is available here.
Abstract
We study temperature coding in Drosophila, and show that temperature is represented by a spatial map of activity in the brain. First, we identify TRP channels that function in the fly antenna to mediate the detection of cold stimuli. Next, we identify the hot-sensing neurons and show that hot and co...
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PMID: 21335241
PDF is available here.
PDF is available here.
Abstract
We identify five distinct classes of fru neuron that trigger or compose the song. Our data suggest that P1 and pIP10 neurons in the brain mediate the decision to sing, and to act upon this decision, while the thoracic neurons dPR1, vPR6, and vMS11 are components of a central pattern generator that t...
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PMID: 21315261
PDF is available here.
PDF is available here.
Abstract
We have used an evolutionary approach to study DIA1 and DIA1R. We found DIA1 conserved from cnidarians to humans, indicating DIA1 evolution coincided with the development of the first primitive synapses. Nematodes lack a DIA1 homologue, indicating Caenorhabditis elegans is not suitable for studying...
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PMID: 21283809
PDF is available here.
PDF is available here.
Abstract
We developed potential Drosophila models for Zellweger syndrome, in which the Drosophila pex3 or pex16 gene was disrupted. As found in Zellweger syndrome patients, peroxisomes were not observed in the homozygous Drosophila pex3 mutant, which was larval lethal. However, the pex16 homozygote lacking i...
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PMID: 21826223
PDF is available here.
PDF is available here.
Abstract
We addressed this question in vivo by analyzing the role of G-proteins in olfactory signaling using electrophysiological recordings. We found that Gα(s) plays a crucial role for odorant induced signal transduction in OR83b expressing olfactory sensory neurons, but not in neurons expressing CO(2) re...
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PMID: 21490930
PDF is available here.
PDF is available here.
Abstract
We speculate that intrastrain transposition of the three retroelements studied is controlled predominantly at the post-transcriptional level....
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PMID: 21779346
PDF is available here.
PDF is available here.
Abstract
We generated and analyzed phenotypes associated with a complete loss-of-function allele of Toll-9. Our results suggest that Toll-9 is neither required to maintain a basal anti-microbial response nor to mount an efficient immune response to bacterial infection....
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PMID: 21386906
PDF is available here.
PDF is available here.
Abstract
We have sought to more fully characterize the inputs these cells receive in vivo over the course of their developmental dispersal. These studies have recently revealed that hemocyte migration is intimately associated with the development of the ventral nerve cord (VNC), a structure used by hemocytes...
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PMID: 21150318
PDF is available here.
PDF is available here.
EMBO Journal (30)18 2011
Abstract
We found that ERK7 negatively regulates secretion in response to serum and amino-acid starvation, in both Drosophila and human cells. Under these conditions, ERK7 turnover through the proteasome is inhibited, and the resulting higher levels of this kinase lead to a modification in a site within the...
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PMID: 21847093
PDF is available here.
PDF is available here.
Cytogenetic and Genome Research (132)1-2 2011
Abstract
We aimed to characterize TEs to help elucidate their impact on the genomic architecture, diversity and evolution of chromosomes in the D. buzzatii cluster of species (repleta group).
A full TE element of D. buzzatii, named PERI, was identified in a BAC clone available in GenBank. PERI was further an...
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PMID: 20938165
PDF is available here.
PDF is available here.
EMBO Journal (29)24 2010
Abstract
We report the identification of MTM-6 and MTM-9 as novel regulators of MIG-14/Wls trafficking in Caenorhabditis elegans. MTM-6 and MTM-9 are myotubularin lipid phosphatases that function as a complex to dephosphorylate phosphatidylinositol-3-phosphate, a central regulator of endosomal trafficking. W...
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PMID: 21076391
PDF is available here.
PDF is available here.
Abstract
We address this question using species-specific microarrays designed from six sequenced Drosophila species separated by up to 40 million years. We quantify divergence at different times during embryogenesis, and show that expression is maximally conserved during the arthropod phylotypic period. By f...
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PMID: 21150996
PDF is available here.
PDF is available here.
Abstract
Abstract
We show that expression of a dominant-negative subunit of the v-ATPase in neural precursors of the developing mouse cortex depleted neural stem cells by promoting their differentiation and the generation of neurons. Moreover, inhibition of the v-ATPase reduced endogenous Notch signalling and prevent...
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PMID: 21126173
PDF is available here.
PDF is available here.
Abstract
We generated high-resolution maps of homotypic and heterotypic Drosophila H2A.Z (H2Av) nucleosomes. Although homotypic and heterotypic H2A.Z nucleosomes mapped throughout most of the genome, homotypic nucleosomes were enriched and heterotypic nucleosomes were depleted downstream of active promoters...
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PMID: 21057526
PDF is available here.
PDF is available here.
Lab On a Chip (10)22 2010
Abstract
Our approach yields a detection limit of 800 cells mL(-1), one of the highest-sensitivity immunosensors to date....
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PMID: 20862443
PDF is available here.
PDF is available here.
Abstract
We focus on two intriguing candidates for fulfilling this role, Drosophila Dscams and vertebrate clustered protocadherins (Pcdhs). In each, a complex genomic locus encodes large numbers of neuronal transmembrane proteins with homophilic binding specificity, individual members of which are expressed...
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PMID: 21029858
PDF is available here.
PDF is available here.
Cell Biology International (34)11 2010
Abstract
We have shown that mutation in Rab11 (a subfamily of the Ypt/Rab gene family) results in the activation of JNK signalling pathways in Drosophila eye. Here, we report that Rab11 regulates JNK and Raf/MAPK-ERK signalling pathways during Drosophila wing development. Using immunofluorescence and immunoh...
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PMID: 20642455
PDF is available here.
PDF is available here.
Journal of Insect Physiology (56)11 2010
Abstract
We studied the effects of thermal treatments on a life history trait (developmental rate) and a physiological trait (metabolic rate) during development in the fruitfly Drosophila buzzatii. First, we estimated the rate of development during larval life (LDR) and the pupal stage (PDR) in flies derived...
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PMID: 20615413
PDF is available here.
PDF is available here.
Abstract
We demonstrate a role for Lon in mtDNA metabolism. An RNA interference (RNAi) construct was designed that reduces Lon to less than 10% of its normal level in Drosophila Schneider cells. RNAi knockdown of Lon results in increased abundance of mitochondrial transcription factor A (TFAM) and mtDNA copy...
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PMID: 20930118
PDF is available here.
PDF is available here.
Abstract
We show that serine 197 (S197) in the cytoplasmic tail of Ig-α is phosphorylated upon B-cell antigen receptor activation, and that this modification inhibits the signal output of the B-cell antigen receptor. Surprisingly, we found that the well-known protein tyrosine kinase Syk (spleen tyrosine kin...
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PMID: 20940318
PDF is available here.
PDF is available here.
Abstract
We find that Toll is recruited from the plasma membrane to Rab5(+) early endosomes. The distribution of a constitutively active form of Toll, Toll(10b), is shifted from the plasma membrane to early endosomes. Inhibition of endocytosis on the ventral side of the embryo attenuates Toll signaling ventr...
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PMID: 20921412
PDF is available here.
PDF is available here.
Abstract
Beyond the age of ~15 h (at 25°C), Drosophila embryos become impenetrable to aqueous fixatives and staining methods as a result of cuticle deposition. This problem can be overcome using flat or fillet preparations, as described in this protocol.
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PMID: 20889695
PDF is available here.
PDF is available here.
Abstract
This protocol presents methods for the specific detection of neuronal cell-surface receptors and secreted factors. These techniques allow visualization of surface pools of receptor proteins and also reveal the surface distribution of secreted cues. Live dissection of embryos to expose the ventral ne...
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PMID: 20889701
PDF is available here.
PDF is available here.
Abstract
This article describes the dissection of early Drosophila embryos to generate flat or fillet preparations. For the procedure, a modified chamber or well is designed using glass slides and sealant. Embryos are dissected by removing the chorionic (outer) membrane (performed outside the chamber) and th...
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PMID: 20889694
PDF is available here.
PDF is available here.
Abstract
We describe methods for using fluorescent antibody staining as well as horseradish peroxidase (HRP) immunohistochemistry to reveal axon-projection patterns and identify specific guidance molecules. In the presence of 3,3'-diaminobenzidine tetrahydrochloride (DAB), HRP forms a brown, stable precipita...
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PMID: 20889700
PDF is available here.
PDF is available here.
Abstract
1,3-Butadiene’s (BD’s) major electrophilic metabolites 1,2-epoxy-3-butene (EB), 1,2-dihydroxy-3,4-epoxybutane (EBD), and 1,2,3,4-diepoxybutane (DEB) are responsible for both its mutagenicity and carcinogenicity. EB, EBD, and DEB are DNA reactive, forming a variety of adducts. All three...
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PMID: 20868267
PDF is available here.
PDF is available here.
Cell Research (20)10 2010
Abstract
I report the biochemical purification of iron-loaded ferritin as an active ingredient of fly extract that is required for promoting the growth of clone 8 imaginal disc cells. Consistent with an essential role for iron-loaded ferritin in cultured cells, overexpression of ferritin or addition of iron...
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PMID: 20628369
PDF is available here.
PDF is available here.
Kidney International (78)10 2010
Abstract
Abstract
The Drosophila larval neuromuscular junction (NMJ) shares many structural and functional similarities to synapses in other animals, including humans. These include the basic feature of synaptic transmission, as well as the molecular mechanisms regulating the synaptic vesicle cycle. Because of its la...
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PMID: 20810633
PDF is available here.
PDF is available here.
Abstract
The Drosophila larval neuromuscular junction (NMJ) shares many structural and functional similarities to synapses in other animals, including humans. These include the basic feature of synaptic transmission, as well as the molecular mechanisms regulating the synaptic vesicle cycle. Because of its la...
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PMID: 20810634
PDF is available here.
PDF is available here.
Abstract
The Drosophila larval neuromuscular junction (NMJ) shares many structural and functional similarities to synapses in other animals, including humans. These include the basic feature of synaptic transmission as well as the molecular mechanisms regulating the synaptic vesicle cycle. Because of its lar...
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PMID: 20810635
PDF is available here.
PDF is available here.
Abstract
The Drosophila larval neuromuscular junction (NMJ) shares many structural and functional similarities to synapses in other animals, including humans. These include the basic feature of synaptic transmission, as well as the molecular mechanisms regulating the synaptic vesicle cycle. Because of its la...
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PMID: 20810636
PDF is available here.
PDF is available here.
Abstract
The Drosophila larval neuromuscular junction (NMJ) shares many structural and functional similarities to synapses in other animals, including humans. These include the basic feature of synaptic transmission, as well as the molecular mechanisms regulating the synaptic vesicle cycle. Because of its la...
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PMID: 20810637
PDF is available here.
PDF is available here.
Abstract
Abstract
We provide evidence that Drosophila Klp64D, a homolog of Kif3A motor subunit of the heterotrimeric Kinesin II complex, is essential for viability of developing photoreceptors and localization of junctional proteins. Genetic analysis of mutant clones shows that absence of Klp64D protein in early larv...
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PMID: 20506262
PDF is available here.
PDF is available here.
Abstract
The effect of a rise in dopamine (DA) level as a result of a mutation, stress or pharmacological treatment on the activity of the enzyme of its synthesis, alkaline phosphatase (ALP) in females of Drosophila virilis and Drosophila melanogaster has been studied. It has been found that regardless of it...
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PMID: 20303975
PDF is available here.
PDF is available here.
Theory in Biosciences (129)2-3 2010
Abstract
We celebrate Charles Darwin's second centenary, and 150 years since the publication of 'The Origin of Species'. After so many years, what has changed in the way we understand Evolution? Obviously we have now a full understanding of the mechanisms underlying heritability. Many molecular tools are ava...
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PMID: 20502983
PDF is available here.
PDF is available here.
Theory in Biosciences (129)2-3 2010
Abstract
Adaptation to a new environment (as well as its underlying mechanisms) is one of the most important topics in Evolutionary Biology. Understanding the adaptive process of natural populations to captivity is essential not only in general evolutionary studies but also in conservation programmes. Since...
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PMID: 20532673
PDF is available here.
PDF is available here.
Genetika (Moskva) (46)9 2010
Abstract
We observed unusually high mobility of flies and high sexual activity of males carrying these mutations. We used special tests for evaluation of energy metabolism of CDL mutants. Indirect calorimetry (CO2 excretion measurement) has been used for estimation of energy exchange in four mutant and two c...
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PMID: 21061617
PDF is available here.
PDF is available here.
Genetika (Moskva) (46)9 2010
Abstract
Different genome regions differ in replication timing during the S phase. Late-replicating sequences are often underreplicated in the Drosophila salivary-gland polytene chromosomes. The SuUR gene, whose mutation changes the replication time of late-replicating regions in salivary-gland cells, has be...
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PMID: 21061633
PDF is available here.
PDF is available here.
Abstract
We analyzed zebrafish embryos null for cohesin subunit rad21 using microarrays to determine global effects of cohesin on gene expression during embryogenesis. This identified Rad21-associated gene networks that included myca (zebrafish c-myc), p53 and mdm2. In zebrafish, cohesin binds to the transcr...
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PMID: 20553708
PDF is available here.
PDF is available here.
Developmental Biology (344)2 2010
Abstract
We have rescued the developmental defect of a strong toy mutant allele and analyzed so expression in the ocelli primordium of toy loss-of-function eye-antennal discs during third instar larva. The results show that so expression is only marginally affected in the absence of Toy transcriptional activ...
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PMID: 20580700
PDF is available here.
PDF is available here.
Developmental Biology (344)2 2010
Abstract
We present a working model meant to illustrate how during a critical period, the second larval stage, changes in cells' proliferative pattern are coordinated with the initiation of the Retinal Determination (RD) gene program. Such changes are regulated in response to two different sources of signal...
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PMID: 20599903
PDF is available here.
PDF is available here.
Developmental Biology (344)2 2010
Abstract
We identified zipper (zip), encoding a Drosophila non-muscle myosin II (myosin II) heavy chain, as a gene required for LR asymmetric development of the embryonic anterior midgut (AMG). Myosin II is known to directly generate mechanical force in various types of cells during morphogenesis and cell mi...
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PMID: 20553709
PDF is available here.
PDF is available here.
Abstract
We have employed pharmacological approaches to modify the lifespan phenotype of DJ-1beta mutant flies. We have assessed the effects of chronic treatments with antiparkinsonian drugs as well as with antioxidant compounds on such phenotype finding that only antioxidants show statistically significant...
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PMID: 20423725
PDF is available here.
PDF is available here.
Abstract
We designed a high-throughput western blot-based screen to examine the generation of the smallest N-terminal polyglutamine-containing Htt fragment. We screened 514 siRNAs targeting the repertoire of human protease genes. This screen identified 11 proteases that, when inhibited, reduced Htt fragment...
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PMID: 20670829
PDF is available here.
PDF is available here.
Abstract
We have also introduced Penelope into Drosophila melanogaster, which are otherwise naive to the element. We have taken advantage of these natural and experimentally induced colonization processes to probe the evolution of small RNA pathways in response to transposon challenge. In both species, Penel...
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PMID: 20581131
PDF is available here.
PDF is available here.
Nature Neuroscience (13)8 2010
Abstract
We devised a new method for optical recording of visually evoked changes in intracellular Ca2+ in neurons using targeted expression of a genetically encoded Ca2+ indicator. Ca2+ in single terminals of L2 neurons in the medulla carried no information about the direction of motion. However, we found t...
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PMID: 20622873
PDF is available here.
PDF is available here.
Nature Cell Biology (12)8 2010
Abstract
We show here that the principal signalling pathway implicated in this niche, chemokine activation of STAT, does not primarily regulate self-renewal of germline stem cells (GSCs), but rather governs GSC adhesion to hub cells. In fact, GSC renewal does not require hub cell contact, as GSCs can be rene...
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PMID: 20622868
PDF is available here.
PDF is available here.
Abstract
We have analysed binding properties of ELAV in vitro and ELAV-dependent regulation of its major target ewg (erect wing) in neurons. These studies reveal that an integral part of ELAV gene-specific regulation involves combinatorial binding to variably spaced short U-rich motifs on an extensive bindin...
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PMID: 20659015
PDF is available here.
PDF is available here.
Abstract
Our data clearly distinguish tau-dependent neuronal degeneration and dysfunction and suggest that temporal differences in occupation of the same phosphorylation sites are likely to mediate these distinct effects of tau....
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PMID: 20658989
PDF is available here.
PDF is available here.
Developmental Biology (344)1 2010
Abstract
We report here the physiological characterization of MAP4K3 mutant flies. Flies lacking MAP4K3 have reduced TORC1 activity detected by phosphorylation of S6K and 4EBP. Furthermore MAP4K3 mutants display phenotypes characteristic of low TORC1 activity and low nutrient availability, such as reduced gr...
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PMID: 20457147
PDF is available here.
PDF is available here.
Abstract
We report the first genomic mutant phenotype of Drosophila melanogaster VHL (dVHL) in the epithelial tubule network, the trachea, and show that dVHL regulates branch migration and lumen formation via its endocytic function. The endocytic function regulates the surface level of the chemotactic signal...
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PMID: 20516215
PDF is available here.
PDF is available here.