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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Mycobacterium tuberculosis (0):
Recent article
Mycobacterium tuberculosis
New England Journal of Medicine (365)12 2011
Abstract
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Abstract
We identify a previously unknown target of POA as the ribosomal protein S1 (RpsA), a vital protein involved in protein translation and the ribosome-sparing process of trans-translation. Three PZA-resistant clinical isolates without pncA mutation harbored RpsA mutations. RpsA overexpression conferred...
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PMID: 21835980
PDF is available here.
PDF is available here.
The Lancet (378)9790 2011
Abstract
The Lancet (378)9790 2011
Abstract
The Lancet (378)9790 2011
Abstract
Abstract
In the current study, the applicability and scope of descriptor based QSAR models to complement virtual screening using molecular docking approach have been applied to identify potential virtual screening hits targeting DNA gyrase A from Mycobacterium tuberculosis, an effective and v...
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PMID: 20953648
PDF is available here.
PDF is available here.
Abstract
Annual reports of tuberculosis (TB) statistics have been compiled using a database built through the nationwide computerized TB surveillance system in Japan. Using the annual report database for 2007-2009, this study compared the drug resistance rates among eight geographical districts. The proportio...
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PMID: 21922783
PDF is available here.
PDF is available here.
Abstract
To evaluate GenoType MTBDRplus (Hain Lifescience, Germany) for its capacity to detect the resistance of rifampicin (RFP) and isoniazid (INH).
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PMID: 21922778
PDF is available here.
PDF is available here.
Abstract
We make use of the random partial least squares regression technique (r-PLS) to trace connections between co-expressed genes in Mycobacterium tuberculosis using data downloaded from public microarray databases. We generated the overall topology of a microbial co-expression network with the exact com...
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PMID: 21514402
PDF is available here.
PDF is available here.
Nature Genetics (43)5 2011
Abstract
New England Journal of Medicine (364)15 2011
Abstract
Abstract
We have conducted studies on the drug resistance through docking and binding analysis supported by time-scale (∼ 1000 ps) and unrestrained all-atom molecular dynamics simulations of wild and mutant MtBKatG. The study showed conformational changes of binding residues. Mutant (S315T) showed high doc...
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PMID: 20593210
PDF is available here.
PDF is available here.
Abstract
We review the genes required for M. tuberculosis persistence and propose a regulatory network for the action of these genes using text mining. This should provide fresh insights into the persistence mechanisms of M. tuberculosis and suggest candidates for new drug targets and immune intervention....
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PMID: 21267668
PDF is available here.
PDF is available here.
Investigacion clinica (52)1 2011
Abstract
In recent years, better diagnostics for tuberculosis (TB) has received increasing attention, especially the diagnosis of tuberculous pleural effusion, which is difficult and at present the main tool in TPE diagnostic is pleural effusion smear and culture, but unfortunately, sensitivi...
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PMID: 21612137
PDF is available here.
PDF is available here.
Abstract
Abstract
The objectives of this study were to determine drug resistance pattern in new and previously treated tuberculosis (TB) patients, to assess function of TB control program, and to characterize multidrug resistant TB (MDR-TB) by molecular fingerprinting methods. Anti-microbial susceptib...
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PMID: 21338958
PDF is available here.
PDF is available here.
Abstract
We used whole-genome sequencing and social-network analysis in an effort to describe the outbreak dynamics at a higher resolution.
We sequenced the complete genomes of 32 Mycobacterium tuberculosis outbreak isolates and 4 historical isolates (from the same region but sampled before t...
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PMID: 21345102
PDF is available here.
PDF is available here.
Abstract
Abstract
We performed mRNA profiling studies and characterized immune cells in M.tuberculosis-infected lungs at early stages of infection in the mouse model. Our data show that induction of mRNAs involved in the recognition of pathogens, expression of inflammatory cytokines, activation of APCs and generation...
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PMID: 21249199
PDF is available here.
PDF is available here.
Epidemiology and Infection (139)1 2011
Abstract
Despite the adoption of strategies to prevent and treat multidrug-resistant tuberculosis (MDR-TB) over the past decade, Latvia continues to have one of the highest rates of MDR-TB in the world. It is important to identify modifiable factors that may impact on MDR-TB patient outcomes. A study was con...
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PMID: 20429966
PDF is available here.
PDF is available here.
Epidemiology and Infection (139)1 2011
Abstract
Our data suggest that MIRU genotype 223325173533 of the Beijing family is associated with MDR and increased transmissibility....
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PMID: 20429968
PDF is available here.
PDF is available here.
Abstract
We tested this genotyping system for molecular epidemiological analysis of 369 M. tuberculosis isolates from 3 regions of Brazil, a high TB-burden country. Deligotyping, targeting 43 large sequence polymorphisms (LSPs), and the MIRU-VNTRplus identification database were used to assess phylogenetic p...
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PMID: 21464915
PDF is available here.
PDF is available here.
Abstract
We propose that the impact of HIV infection might better be conceptualised as a shift of the spectrum towards poor immune control, higher mycobacterial metabolic activity, and greater organism load, with subsequent increased risk of progression to active disease. Here we discuss the evidence for suc...
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PMID: 20936108
PDF is available here.
PDF is available here.
Abstract
We found that Mtb-infected monocytes preferentially express a proinflammatory cytokine profile, including IL-6, TNF-α, and IL-1β. Conversely, among the regulatory cytokines, Mtb elicited IL-10 and IL-23 release while no expression of IL-12p70, IL-27, and IFN-β was observed. The analysis of the si...
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PMID: 21197399
PDF is available here.
PDF is available here.
Abstract
We combined drug susceptibility results and molecular strain typing data with treatment outcome reports to assess the influence of drug resistance on TB treatment outcomes in a prospective cohort of patients from Abkhazia (Georgia). Patients received individualized treatment regimens based on drug s...
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PMID: 21886778
PDF is available here.
PDF is available here.
Abstract
I (4, 3.08%), LAM (2, 1.54%), X (N = 1, 0.77%) and S (2, 1.54%). Nine isolates had SIT numbers with no identified sub-lineages while 17 had no SIT numbers. MTBss isolates were more likely to be resistant to streptomycin (p<0.008) and to any drug resistance (p<0.03) when compared to M. africanum....
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PMID: 21779354
PDF is available here.
PDF is available here.
Abstract
We conducted this retrospective study to analyze the characteristics and treatment outcomes in MDR- and XDR-TB patients in the 309 Hospital in Beijing, China during 1996-2009. Socio-demographic and clinical data were retrieved from medical records and analyzed. Logistic regression analysis was perfo...
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PMID: 21559362
PDF is available here.
PDF is available here.
Abstract
We report results of TIGRA in our first 63 patients commencing TNF-a inhibitors for severe psoriasis. Of the 63 patients, 5 (7.9%) had a positive TIGRA result and were started on treatment for latent TB. We found that the only risk factor for TB associated with a positive TIGRA was a history of trav...
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PMID: 20456401
PDF is available here.
PDF is available here.
Chemmedchem (5)12 2010
Abstract
We report the discovery of highly potent and selective mPTPB inhibitors using a novel, double Click chemistry strategy. The most potent mPTPB inhibitor from this approach possesses a K(i) value of 160 nM and a >25-fold selectivity for mPTPB over 19 other protein tyrosine phosphatases (PTBs). Molec...
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PMID: 20957718
PDF is available here.
PDF is available here.
Microbial Pathogenesis (49)6 2010
Abstract
Tuberculosis remains a serious threat to global public health. As one of the most successful pathogens, Mycobacterium tuberculosis is an adept in evasion the host immune response. M. tuberculosis PE_PGRS family has been widely proposed as molecular mantra to deflect host immunity. The feature of thi...
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PMID: 20638467
PDF is available here.
PDF is available here.
Abstract
We report a structural and functional study of cold shock protein A from Mycobacterium tuberculosis, MTB-CspA. Structural investigations by CD and NMR reveal that MTB-CspA is less ordered than expected and is the least thermal stable cold shock protein so far characterized. However, electrophoretic...
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PMID: 20977881
PDF is available here.
PDF is available here.
Molecular characteristics of "Mycobacterium canettii" the smooth Mycobacterium tuberculosis bacilli.
Abstract
We have collected 59 SmTB isolates of which 14 were newly recovered since previous reports, and performed extensive phenotypical and genotypical characterization. We take advantage of these investigations to review the current knowledge of "M. canettii". Their characteristics and the apparent lack o...
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PMID: 20692377
PDF is available here.
PDF is available here.
Abstract
We retrospectively reviewed the medical charts of adult patients with a diagnosis of spinal TB. Only those with positive culture results and/or characteristic pathologic findings were enrolled. Demographic data, clinical manifestations and susceptibility to anti-TB drugs were reviewed and analyzed....
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PMID: 21195972
PDF is available here.
PDF is available here.
Abstract
Recent outbreaks involving multidrug-resistant bacteria have prompted governments to alter the regulations governing antibiotic sales. By combining the new regulations with calls for new drug development and dispensing regimes, can antibiotic resistance be managed?
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PMID: 21125698
PDF is available here.
PDF is available here.
Lab On a Chip (10)22 2010
Abstract
Our approach yields a detection limit of 800 cells mL(-1), one of the highest-sensitivity immunosensors to date....
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PMID: 20862443
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We show that PhoPN, on its own, demonstrates PhoR-dependent phosphorylation. PhoPC, the truncated variant bearing the DNA binding domain, binds in vitro to the target site with affinity similar to that of the full-length protein. To complement the finding that residues spanning Met(1) to Arg(138) of...
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PMID: 20814030
PDF is available here.
PDF is available here.
Abstract
The Mycobacterium tuberculosis enzyme Rv2275 catalyzes the formation of cyclo(L-Tyr-L-Tyr) using two molecules of Tyr-tRNA(Tyr) as substrates. The three-dimensional (3D) structure of Rv2275 was determined to 2.0-Å resolution, revealing that Rv2275 is structurally related to the class Ic aminoacyl-t...
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PMID: 20852636
PDF is available here.
PDF is available here.
Abstract
Abstract
2-[4-(4-Methoxyphenylcarbonyloxy)benzylidene]-6-dime-thylaminomethyl cyclohexanone hydrochloride 1 has a MIC value of 0.78 microg/mL towards Mycobacterium tuberculosis H37Rv and displays similar or identical MIC figures towards various drug-resistant strains of this microorganism. The enone 1 along...
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PMID: 21155394
PDF is available here.
PDF is available here.
Abstract
We believe that it is important to consider tuberculosis when deciding about admission, in order not to delay diagnosis. Furthermore, ventilation of general rooms must be sufficient when dealing with the unexpected admission of patients with tuberculosis, and ability of health-care workers to use N9...
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PMID: 21141057
PDF is available here.
PDF is available here.
Chemical Communications (46)40 2010
Abstract
M. tuberculosis PtpA and PtpB, the only two phosphotyrosine phosphatases (Ptps) present in this pathogen, play an important role in mycobacteria survival inside macrophages. The aim of the present work was to investigate M. tuberculosis PtpA and PtpB susceptibility to S-nitrosylation, a reversible c...
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PMID: 20830431
PDF is available here.
PDF is available here.
Abstract
We review current and future strategies toward the rational design of novel vaccines against TB, as well as the progress made thus far, and the hurdles that need to be overcome in the near and distant future.
Copyright © 2010 Elsevier Inc. All rights reserved....
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PMID: 21029966
PDF is available here.
PDF is available here.
Abstract
Abstract
We have saved valuable time by omitting the pre-isolation step and conclude that DNRA is a rapid, accurate and inexpensive method for direct DST of MTB and may become an appropriate alternative method for the resource limited settings....
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PMID: 21252446
PDF is available here.
PDF is available here.
Medicine (Baltimore) (89)6 2010
Abstract
We undertook an international survey of 141 patients from 102 kindreds in 30 countries. Among 102 probands, the first infection occurred at a mean age of 2.4 years. In 78 patients, this infection was caused by Bacille Calmette-Guérin (BCG; n = 65), environmental mycobacteria (EM; also known as atyp...
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PMID: 21057261
PDF is available here.
PDF is available here.
Ugeskrift for laeger (172)42 2010
Abstract
Intestinal tuberculosis (ITB) is a rare differential diagnosis of inflammatory bowel disease (IBD) in Denmark. In the presented case, a 44-year-old native Danish man was examined for IBD symptoms. Colonoscopy and microscopy of colonic biopsies suggested IBD. The patient was started on steroid therap...
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PMID: 21040665
PDF is available here.
PDF is available here.
Clinica Chimica Acta (411)19-20 2010
Abstract
The combination of optimal multiple antigens to detect anti-MTB antibody responses increased the sensitivity and specificity. Therefore, detection of anti-MTB antibody responses with multiple antigens may be valuable in the clinical diagnosis of TB patients.
Copyright 2010. Published by Elsevier B.V...
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PMID: 20599865
PDF is available here.
PDF is available here.
Annals of Medicine (42)7 2010
Abstract
The main objective of this 1.5-year prospective study was to evaluate the value of T-SPOT®.TB as compared to the tuberculin skin test (TST) for the first-line assessment of uveitis.
A total of 108 consecutive non-immunocompromised patients with acute or chronic uveitis, including 92/108 (85.2%) wit...
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PMID: 20868342
PDF is available here.
PDF is available here.
Abstract
We report the case of a 47-year-old man referred for abdominal pain and weight loss, in whom several imaging techniques revealed a solid mass in the head of the pancreas. CT-guided fine-needle aspiration cytology was consistent with necrotic granuloma. Intradermic tuberculin reaction was positive, b...
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PMID: 20851504
PDF is available here.
PDF is available here.
Abstract
As a continuation of our research and with the aim of obtaining new anti-tuberculosis agents which can improve the current chemotherapeutic anti-tuberculosis treatments, forty-three new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives were synthesized and evaluated for in vitro anti-tuberculosis...
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PMID: 20656380
PDF is available here.
PDF is available here.
Abstract
We review the current knowledge on Xpert MTB/RIF, discuss the potential value of Xpert MTB/RIF as a point-of-care diagnostic for drug-sensitive and drug-resistant TB, and outline the potential indications for the assay in resource-limited, high-HIV burden settings. We also discuss key research quest...
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PMID: 20964612
PDF is available here.
PDF is available here.
Abstract
Purine analogs modified in the five-membered ring have been synthesized and examined for antibacterial activity against Mycobacterium tuberculosis H(37)Rv in vitro employing the microplate alamar blue assay (MABA). The 9-deaza analogs were only found to be weak inhibitors, but the 8-aza-, 7-deaza- a...
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PMID: 20833056
PDF is available here.
PDF is available here.
Abstract
Our study revealed eight inducible proteins (DnaK, fabG4, DNA-binding, hypothetical, two 14 kDa antigen and two 10 kDa chaperonin) that were upregulated in the presence of drug.
This preliminary study has thrown light on whether or not and how the resistant isolate responds to streptomycin at its no...
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PMID: 20966518
PDF is available here.
PDF is available here.
Abstract
We retrospectively reviewed children with sputum culture-confirmed XDR-TB from Tugela Ferry, South Africa, from January 2006 to December 2007. Demographic, clinical and microbiologic data were abstracted from medical records.
Four children aged 6-8 years with XDR-TB were reviewed. Two had previous h...
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PMID: 20843414
PDF is available here.
PDF is available here.
Emerging Infectious Diseases (16)10 2010
Abstract
We performed a single Myco/F Lytic blood culture. Fifty-eight (2.9%) had a clinically significant BSI (i.e., a blood culture positive for an organism known to be a pathogen). Mycobacterium tuberculosis accounted for 31 (54%) of all BSIs, followed by fungi (13 [22%]) and bacteria (9 [16%]). Of patien...
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PMID: 20875282
PDF is available here.
PDF is available here.
Abstract
The human immunodeficiency virus (HIV) alters the presentation of pulmonary tuberculosis (PTB), but it remains unclear whether alterations occur at a CD4 cell threshold or throughout HIV infection.
To better understand the relationship between CD4 count and clinical and radiographic presentation of...
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PMID: 20843421
PDF is available here.
PDF is available here.
Abstract
We analyzed Mycobacterium tuberculosis isolates from 132 new TB cases of treatment-naïve patients in Goiás, Brazil by drug susceptibility tests, partial sequencing of the rpoB and katG genes, inhA(C-15T) mutation analysis by PCR, and RFLP-IS6110 genotyping. A high frequency of drug resistance was...
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PMID: 20619356
PDF is available here.
PDF is available here.
Abstract
The design and synthesis of new inhibitor analogues for the Mycobacterium tuberculosis (Mtb) phosphatase PtpB is described. Analogues were synthesized by incorporation of two common and effective phosphate mimetics, the isothiazolidinone (IZD) and the difluoromethylphosphonic acid (DFMP). The basic...
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PMID: 20644889
PDF is available here.
PDF is available here.
Kidney International (78)10 2010
Abstract