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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Mycobacterium tuberculosis (0):
Recent article
Mycobacterium tuberculosis
Abstract
Tuberculosis (TB) remains to be a major infectious disease throughout the world. However, the current vaccine for TB has variable protective efficacy, and there is no commercially available serodiagnostic test for this disease with acceptable sensitivity and specificity for routine laboratory use. O...
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PMID: 20690665
PDF is available here.
PDF is available here.
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Abstract
The triazole analogs were obtained via. multistep synthesis sequence beginning with ethyl nicotinoate 3 which on treatment with hydrazine hydrate yields nicotinoyl hydrazide 4. Intermolecular cyclisation of 4 with 4-methylbenzoic acid in presence of phosphorous oxy chloride affords 2-(3-pyridyl)-5-(...
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PMID: 20630629
PDF is available here.
PDF is available here.
Abstract
We investigated the CD4(+)CD25(+)FoxP3(+) circulating regulatory T cells (T(reg)) in patients with cavity multidrug-resistant tuberculosis (MDR-TB) before and after surgery.
We compared the proportion of T(reg) cells in 13 patients with cavity MDR-TB pre- and postoperatively and in 10 healthy contro...
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PMID: 20655262
PDF is available here.
PDF is available here.
Abstract
The recent development of molecular biology methods has substantially improved the identification of many bacterial pathogens, both at the species and strain level. Microbial strain genotyping refers to the process of discriminating among individuals within particular species based on the detection...
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PMID: 20931834
PDF is available here.
PDF is available here.
Abstract
At present, molecular typing methods of Mycobacterium tuberculosis have become increasingly integrated into the epidemiological studies of tuberculosis. Molecular typing is a process of discriminating between strains of tubercle bacilli, based on the detection of genomic DNA polymorphisms, most freq...
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PMID: 20931835
PDF is available here.
PDF is available here.
Abstract
A microsphere-based multiplex assay was developed, by using the xMAP technology, for the simultaneous rapid detection of the Mycobacterium tuberculosis complex (MTC) and the differentiation of M. tuberculosis and M. bovis. The assay simultaneously detected 4 target sequences, including specific inse...
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PMID: 20736748
PDF is available here.
PDF is available here.
Abstract
Cutaneous tuberculosis as a result of a needle injection is a rare event; it generally occurs among medical and laboratory personnel and among patients receiving percutaneous treatment.
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PMID: 21713332
PDF is available here.
PDF is available here.
Proteomics (10)17 2010
Abstract
We hypothesized that macrophages treated with M. tuberculosis culture filtrate proteins (CFPs) would release exosomes containing mycobacterial proteins. We found 29 M. tuberculosis proteins in exosomes released from CFP-treated J774 cells, the majority of which were also present in exosomes isolated...
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PMID: 20662102
PDF is available here.
PDF is available here.
Abstract
Smear-positive samples were LiPA positive in 69 of 73 samples (sensitivity: 94.5%), and smear-negative samples were LiPA positive in 25 of 37 samples (67.6%). More than half of the samples were LiPA positive, even those that were culture-negative or contaminated. Comparison of the 76 culture-positiv...
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PMID: 20960950
PDF is available here.
PDF is available here.
Cell Host & Microbe (8)2 2010
Abstract
We demonstrate that in response to Th1-polarizing intracellular bacterial or viral pathogens, only 80%-90% of responding polyclonal T cells become indelibly committed to this lineage. Th1 commitment was nearly invariant in cells that proliferated extensively, but perturbations to the extrinsic cytok...
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PMID: 20709293
PDF is available here.
PDF is available here.
Abstract
I (Cmpd I) mediated deformylation of the geminal diol was considered in the context of the protein environment. In contrast to gas phase calculations, triradicaloid and pentaradicaloid Cmpd I states failed to initiate a concerted deformylation of the geminal diol. This study provides a unified mecha...
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PMID: 20662512
PDF is available here.
PDF is available here.
Abstract
The PCR assay detected viral DNA to a level of 1,200 copies/mL of whole blood. It was used to detect EEHV1 in trunk secretions of 3 of the 5 elephants surveyed during the 15-week period. Viral gene subtyping analysis identified 2 distinct elephant herpesviruses, 1 of which was identical to the virus...
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PMID: 20673092
PDF is available here.
PDF is available here.
Abstract
A total of the 1,961 patients were analyzed. The majority (66.5%) of cases were >/= 65 years of age. A total of 151 patients had undergone previous anti-TB treatment. Individual drug resistance was as follows: 229 isolates (11.7%) were resistant to isoniazid, 55 (2.8%) to rifampin, 49 (2.5%) to etha...
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PMID: 20688288
PDF is available here.
PDF is available here.
Abstract
Uracil N-glycosylase (Ung) is the most thoroughly studied of the group of uracil DNA-glycosylase (UDG) enzymes that catalyse the first step in the uracil excision-repair pathway. The overall structure of the enzyme from Mycobacterium tuberculosis is essentially the same as that of the enzyme from ot...
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PMID: 20693660
PDF is available here.
PDF is available here.
Abstract
Clinical Nutrition (29)4 2010
Abstract
Malnutrition is a prominent feature of tuberculosis. Little is known about the role of the appetite-related hormones, ghrelin and leptin, in malnutrition in tuberculosis. This study was undertaken to determine whether ghrelin and leptin contribute to malnutrition in active pulmonary tuberculosis.
Nu...
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PMID: 20153570
PDF is available here.
PDF is available here.
Abstract
ACH-702 is a new isothiazoloquinolone with potent in vitro and in vivo activities against important bacterial pathogens, including Staphylococcus aureus. In this study, ACH-702 was found to have promising in vitro antibacterial activity against Mycobacterium tuberculosis, with MICs of
PDF is available here.
PDF is available here.
Abstract
Intraocular manifestations of tuberculosis (TB) are rare, but TB infection is common worldwide, especially in developing economies, and in immigrant populations and immunocompromised patients in developed nations. The current review focuses on the clinical characteristics and diagnostic modalities u...
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PMID: 20662660
PDF is available here.
PDF is available here.
Abstract
This review is focused on the virulent traits of lipolytic enzymes from bacteria with special emphasis on Mycobacterium tuberculosis. In vivo, triacylglycerols in the form of inclusion bodies are present in tubercle bacilli in the lungs. This pathogenic bacterium possesses a lipase gene (Lip) family...
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PMID: 20500016
PDF is available here.
PDF is available here.
Abstract
During a 10-year period of the present study, 35 new cases of urinary tract TB were diagnosed, with a male/female ratio of 1.3:1 and a common age group of 31-40 years. 34.3% of the patients were farmers. The most presenting symptoms were polyuria, dysuria and acidic urinary pH with pyuria. 80% ofthe...
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PMID: 20718167
PDF is available here.
PDF is available here.
Abstract
The human pathogen Mycobacterium tuberculosis (Mtb) encodes 20 cytochrome P450 (P450) enzymes. Gene essentiality for viability or host infection was demonstrated for Mtb P450s CYP128, CYP121 and CYP125. Structure/function studies on Mtb P450s revealed key roles contributing to bacter...
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PMID: 21426022
PDF is available here.
PDF is available here.
Abstract
We describe the transcriptional programs mediated by isoniazid (INH) during the transition from log-phase to nonreplicating bacilli, from INH-sensitive to INH-tolerant bacilli respectively, using the Wayne model.
INH treatment did not elicit a transcriptional response from nonreplica...
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PMID: 21426023
PDF is available here.
PDF is available here.
Abstract
There have been no new antituberculous drugs since the introduction of rifampin in 1952. The collision of the HIV and tuberculosis (TB) epidemics in developing regions of the world together with the emergence of multidrug resistance and extensively drug-resistant strains of TB has em...
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PMID: 20559756
PDF is available here.
PDF is available here.
Abstract
We built a homology model of Asp kinase using the crystallized Asp kinase from M. Jannaschii, as template structures (2HMF and 3C1M). After the molecular dynamics refinement, the optimized homology model was assessed as a reliable structure by PROCHECK, ERRAT, WHAT-IF, PROSA2003 and VERIFY-3D. The r...
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PMID: 20140471
PDF is available here.
PDF is available here.
Journal of Medical Microbiology (59)Pt 8 2010
Abstract
These results implied that, to determine whether the patient's sputum contains living AFB, more sensitive techniques should be employed during the follow-up of the patients. These observations suggest that the GTMD method can be useful for early diagnosis of clinically and radiologically suspicious...
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PMID: 20448064
PDF is available here.
PDF is available here.