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Mycobacteriaceae (1):
Recent article
Mycobacteriaceae
Microbiology (155)Pt 7 2009
Abstract
We have evaluated the performance of nine signal peptide prediction algorithms on a positive validation set, consisting of 57 proteins with a verified signal peptide and cleavage site, and a negative set, consisting of 61 proteins that have an N-terminal sequence that confirms the annotated translat...
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PMID: 19389770
PDF is available here.
PDF is available here.
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Abstract
The phenotypic identification was concordant with genotypic identification in 33 (70.2%) isolates of 14 Mycobacterium tuberculosis, 11 M. fortuitum, 7 M. abscessus and 1 M. duvalii. For the discrepant isolates, identification was possible only by DNA sequencing in 14 (29.7%) isolates. The 14 discrep...
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PMID: 19293445
PDF is available here.
PDF is available here.
Abstract
These results highlight the importance of NTM in HIV-negative patients as a case of lymphadenitis, and indicates the re-emergence of NTM as potential lymph node pathogens in this part of the country. Further studies on a larger scale are needed to delineate the association between NTM infections in...
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PMID: 18567452
PDF is available here.
PDF is available here.
Protein Science (16)9 2007
Abstract
We have determined the structure of ML2640c in two distinct crystal forms. As expected, ML2640c has a typical MTase core domain and binds the methyl donor substrate AdoMet in a manner consistent with other known members of this structural family. The putative acceptor substrate-binding site of ML264...
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PMID: 17660248
PDF is available here.
PDF is available here.
Abstract
We assessed AAT protein anomalies as a risk factor for RGM lung disease. In a cohort of 100 patients with RGM lung disease, Mycobacterium (M.) abscessus was the most prevalent organism, isolated in 64 (64%) subjects. Anomalous AAT proteins were present in 27% of the cohort, which is 1.6 times the es...
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PMID: 17654345
PDF is available here.
PDF is available here.
Molecular Cell (23)2 2006
Abstract
We show here that tlyA encodes a 2'-O-methyltransferase that modifies nucleotide C1409 in helix 44 of 16S rRNA and nucleotide C1920 in helix 69 of 23S rRNA. Loss of these previously unidentified rRNA methylations confers resistance to capreomycin and viomycin. Many bacterial genera including enterob...
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PMID: 16857584
PDF is available here.
PDF is available here.
Abstract
Peripheral blood mononuclear cells taken from 32 patients with Rheumatoid Arthritis (RA) receiving neither steroids nor methotrexate and 34 healthy controls were examined for lymphoproliferation in the presence of ultrasonic extracts of 14 different mycobacterial species or serotypes...
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PMID: 16914096
PDF is available here.
PDF is available here.
Pneumonologia i alergologia polska : organ Polskiego Towarzystwa Ftyzjopneumonologicznego, Polskiego Towarzystwa Alergologicznego, i Instytutu Gruzlicy i Chorob Pluc (74)1 2006
Abstract
We analysed 58 strains representing 25 different mycobacterial species (24 reference strains and 34 clinical isolates). The results obtained by PCR-RFLP and HPLC identification techniques were highly concordant The results were compatible for 87,5% (21 / 24) reference strains and for 97,1% (33/34) c...
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PMID: 17175986
PDF is available here.
PDF is available here.
Cellular Immunology (237)1 2005
Abstract
The contribution of inducible costimulatory molecule (ICOS) to Th1 and Th2 cell-mediated immune responses was examined in well-defined pathogen antigen-elicited models of cell-mediated granuloma formation. Th1 and Th2 granulomas were respectively induced by intravenous challenge of CBA/J mice with M...
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PMID: 16300749
PDF is available here.
PDF is available here.
Microbial Ecology (50)1 2005
Abstract
Ability to degrade high molecular weight polycyclic aromatic hydrocarbons (PAHs) has been found in diverse species of fast-growing mycobacteria. This study included several PAH-degrading mycobacteria from heavily contaminated sites and an uncontaminated humus soil in the Natural Park, Schwäbische A...
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PMID: 16132428
PDF is available here.
PDF is available here.
Abstract
Abstract
PCR was sensitive to detect 2.5 pg of H37Rv DNA (370 bp for slow grower mycobacteria) and 1.5 pg of M. fortuitum DNA (450 bp for rapid grower mycobacteria). Based on the PCRRFLP products obtained the 51 mycobacterial isolates were classified into 41 slow growers and 10 rapid growers. Among the 41 sl...
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PMID: 15937375
PDF is available here.
PDF is available here.
Antonie Van Leeuwenhoek (87)3 2005
Abstract
The nitrile metabolising strains AJ270, AJ300 and AJ115 were isolated from the same location. The strains have very similar nitrile metabolising profiles. Sequencing of the 16S rRNA gene indicates that strains AJ270 and AJ300 are novel strains of Rhodococcus erythropolis while strain AJ115 is a nove...
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PMID: 15803388
PDF is available here.
PDF is available here.
Journal of Bacteriology (187)4 2005
Abstract
WE synthesis in eukaryotes. The enzyme was purified by a three-step purification protocol to apparent homogeneity from the soluble fraction of recombinant Escherichia coli Rosetta (DE3)pLysS (pET23a::atfA). Purified WS/DGAT revealed a remarkably low substrate specificity, accepting a broad range of...
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PMID: 15687201
PDF is available here.
PDF is available here.
Medical Hypotheses (65)3 2005
Abstract
The thought that tuberculosis and the mycobacteria could cause diabetes seems farfetched, but is not. The peculiar relationship and frequent association of diabetes mellitus and tuberculosis has been observed for more than 2000 years, yet the reason for this correlation is, to this day, not known. B...
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PMID: 15967589
PDF is available here.
PDF is available here.
Abstract
Recombination is a ubiquitous genetic process which results in the exchange of DNA between two substrates. Homologous recombination occurs between DNA species with identical sequence whereas illegitimate recombination can occur between DNA with very little or no homology. Site-specific recombination...
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PMID: 15119825
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (279)21 2004
Abstract
We demonstrate via electrospray ionization mass spectrometry that GS from pathogenic M. tuberculosis is adenylylated by the Escherichia coli ATase. The adenylyl group can be hydrolyzed by snake venom phosphodiesterase to afford the unmodified enzyme. The site of adenylylation of MTb GS by the E. col...
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PMID: 15037612
PDF is available here.
PDF is available here.
Abstract
Changing regulations to lower disinfectant byproducts in drinking water is forcing utilities to switch disinfection from chlorine to monochloramine. It is generally unknown whether this will impact positively or negatively on the microbiological quality of drinking water. A utility in Florida, using...
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PMID: 15318491
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (278)51 2003
Abstract
Phagocytosis by macrophages represents the early step of the mycobacterial infection. It is governed both by the nature of the host receptors used and the ligands exposed on the bacteria. The outermost molecules of the nonpathogenic Mycobacterium smegmatis were extracted by a mechanical treatment an...
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PMID: 14534313
PDF is available here.
PDF is available here.
Nature Cell Biology (5)9 2003
Abstract
Pathogenic mycobacteria such as Mycobacterium tuberculosis and Mycobacterium avium facilitate disease by surviving intracellularly within a potentially hostile environment: the macrophage phagosome. They inhibit phagosome maturation processes, including fusion with lysosomes, acidification and, as s...
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PMID: 12942085
PDF is available here.
PDF is available here.
Abstract
A screening programme was set up to isolate microorganisms able to hydrolyse the complex biopolymer clavan produced by Clavibacter michiganensis subsp. michiganensis LMG 5604. This valuable exopolysaccharide is very rich in L-fucose (37.5% w/w), a rare sugar, used in the medical field (Vanhooren, 19...
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PMID: 15296189
PDF is available here.
PDF is available here.
Journal of Autoimmunity (18)4 2002
Abstract
We have recently described a CD8(+) T-cell clone recognizing defined epitopes of both mycobacterial and murine hsp60 that are not sequence homologues. Adoptive transfer of this T-cell clone into T-cell deficient mice induced an autoimmune intestinal pathology. TCR analysis revealed the productive in...
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PMID: 12144809
PDF is available here.
PDF is available here.
Planta Medica (68)5 2002
Abstract
Licochalcone A, extracted and purified from Chinese licorice roots, showed in vitro inhibitory effect on human pathogenic Mycobacteria species and Legionella species. M. tuberculosis, M. bovis and BCG were inhibited by < 20 mg/l licochalcone A, whereas all non- M. tuberculosis complex species were r...
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PMID: 12058317
PDF is available here.
PDF is available here.
Immunobiology (205)1 2002
Abstract
Serum autoantibodies produce typical immunofluorescence staining patterns on HEp-2 cells, which are frequently used for diagnostic purposes. These include antibodies recognizing cytoskeletal and nuclear epitopes. The detailed analysis of human monoclonal antibodies (MAbs) should help to understand w...
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PMID: 11999339
PDF is available here.
PDF is available here.
BMC Microbiology (2) 2002
Abstract
In our hands, automated culture in combination with ARDRA provides with accurate, practically applicable, wide range identification of mycobacterial species. The existing identification library covers most species, and can be easily updated when new species are studied or described. The drawback is...
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PMID: 11945178
PDF is available here.
PDF is available here.
Abstract
A new series of S-alkylisothiosemicarbazones of 3- and 4-pyridincarboxaldehyde and 4-fluoro- and 4-trifluoromethylbenzaldehyde was synthesized and evaluated for biological activity against various Mycobacterium strains. Inhibitory activity against Mycobacterium tuberculosis H37Rv ATCC 27294 and INH-...
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PMID: 11814835
PDF is available here.
PDF is available here.
Water Research (35)17 2001
Abstract
We studied the influence of electrolytically released copper and silver ions on the microbiological quality in a warm water system of a hospital. The concentration of nontuberculous mycobacteria was followed for three, and that of legionellae and other heterotrophic bacteria in the water for four ye...
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PMID: 11791852
PDF is available here.
PDF is available here.
Abstract
Genotypic-based methods hold promise for the rapid and accurate detection or confirmation of antimicrobial resistance; however, phenotypic methods will continue to have an advantage when resistance to the same antimicrobial agent may be caused by several different mechanisms. The diversity of geneti...
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PMID: 11780272
PDF is available here.
PDF is available here.
Journal of Infection (43)3 2001
Abstract
Abstract
Three known compounds, 2-hexylidene-3-methylsuccinic acid (1), cytochalasin Q (2), and 5-carboxymellein (3), together with two new derivatives, 2-hexylidene-3-methylsuccinic acid 4-methyl ester (4) and an ophiobolane sesterterpene named halorosellinic acid (5), were isolated from culture broth of th...
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PMID: 11454459
PDF is available here.
PDF is available here.
Abstract
We interfaced online HPAEC (high performance anion-exchange chromatography) with ESI-ITMS (electrospray ionization ion trap mass spectrometry) to identify such pyrophosphorylated molecules. A self-regenerating anion suppressor located upstream of electrospray ionization enabled the simultaneous dete...
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PMID: 11510819
PDF is available here.
PDF is available here.
Preventing drug access to targets: cell surface permeability barriers and active efflux in bacteria.
Abstract
Bacteria, being unicellular, are constantly exposed to toxic compounds in their environment. Gram-negative bacteria and mycobacteria are unusually successful in surviving in the presence of toxic compounds because they combine two mechanisms of resistance. They produce effective permeability barrier...
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PMID: 11428914
PDF is available here.
PDF is available here.
Natural Product Reports (18)3 2001
Abstract
Abstract
Pneumonologia i alergologia polska : organ Polskiego Towarzystwa Ftyzjopneumonologicznego, Polskiego Towarzystwa Alergologicznego, i Instytutu Gruzlicy i Chorob Pluc (69)1-2 2001
Abstract
1. Determination of BALF-ACE activity may be helpful in diagnosis of sarcoidosis but it is recommended to continue the study on more numerous groups of patients taking into consideration polymorphism in the ACE gene. 2. High level of antibodies against 38 kDa and ACE activity in serum are specific f...
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PMID: 11475558
PDF is available here.
PDF is available here.
Abstract
Abstract
The ability of iron utilizing by means of siderophores (extracellular exochelins and cell-associated mycobactins) produced by mycobacteria (7 stains) by 24 staphylococcal strains was investigated. The mycobacterial donor strains belonged to rapid growing species: M. fortuitum, M. smegmatis, M. aurum...
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PMID: 10222739
PDF is available here.
PDF is available here.
Veterinary Microbiology (56)3-4 1997
Abstract
Recent progress towards an understanding of the architecture of the mycobacterial cell envelope (P.J. Brennan and H. Nikaido, Annual Review of Biochemistry 64 (1995) 29-63) provides a model with features more generally applicable to cell envelope organisation in other mycolic acid-containing bacteri...
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PMID: 9226843
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
The optimal diagnostic approach to pneumonia provides a rapid microbiologic identification of pulmonary pathogens by the least invasive means. The technique of sputum induction has been useful in the evaluation of patients with Pneumocystis carinii or mycobacterial pneumonia. It is not known whether...
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PMID: 8126167
PDF is available here.
PDF is available here.
Presse Medicale (22)32 1993
Abstract
Abstract
Abstract
We have developed a viral system through a detailed characterization of mycobacteriophage L5, a temperate phage that infects both fast- and slow-growing mycobacteria. We describe here the complete DNA sequence of the L5 genome and initial characterization of L5 virion structure and gene expression....
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PMID: 8459766
PDF is available here.
PDF is available here.
Abstract
We show here that the 183-amino-acid product of L5 gene 71 confers immunity to L5 superinfection, is required for maintenance of the lysogenic state and contains a helix-turn-helix DNA-binding motif--properties associated with repressors of temperate phages. We have utilized these observations to de...
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PMID: 8459767
PDF is available here.
PDF is available here.
Abstract
The microbiological flora of 108 water samples was explored to evaluate the role of recreational waters as a possible source of human diseases in Araraquara, S.P., Brazil. These waters included six swimming pools and three lakes with beaches. The number of total and fecal coliforms, Escherichia coli...
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PMID: 8424153
PDF is available here.
PDF is available here.
Immunitat und Infektion (19)5 1991
Abstract
Comparative 16S rRNA sequencing allows to infer natural relationships among bacteria, to characterize and identify microorganisms at a molecular level and to develop DNA probes specific at any desired taxonomic level (e.g. family, genus, species). Probes targeted at ribosomal RNA are suitable for in...
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PMID: 1722188
PDF is available here.
PDF is available here.
Abstract
Forty-five bronchoalveolar lavages (BAL) were performed in Brazzaville in AIDS patients who did not expectorate acid- and alcohol-resistant bacilli (AARB). All patients presented with respiratory symptoms (cough, dyspnoea or chest pain), and all but 6 of them had abnormal radiography of the chest. F...
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PMID: 1882160
PDF is available here.
PDF is available here.
Research in Microbiology (142)6 1991
Abstract
Integrative plasmid vectors based on the pSAM2 system of Streptomyces ambofaciens offer great potential for the genetic analysis of Mycobacterium leprae. To assess this, the chromosomal attachment site of M. leprae, att-pSAM2, has been cloned, mapped and characterized. Nucleotide sequence analysis s...
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PMID: 1683711
PDF is available here.
PDF is available here.
Research in Microbiology (141)5 1990
Abstract
Our results showed that, although Ptb and WP mycobacteria shared common peroxidase isoenzymes and antigens, they also had specific immunoprecipitates showing the differences between the two groups of bacteria....
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PMID: 2218060
PDF is available here.
PDF is available here.
Abstract
During a ten month period, 117 fibreoptic bronchoscopies and bronchoalveolar lavages (BAL) were performed in human immunodeficiency virus (HIV) infected patients suspected of having opportunistic pulmonary infections. The BAL were classified into 3 groups, according to clinical manifestations relate...
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PMID: 2160374
PDF is available here.
PDF is available here.
Journal of Bacteriology (171)12 1989
Abstract
The ability of nitrogenase-containing Frankia sp. strain CpI1 vesicles to regrow vegetative hyphae is demonstrated. Vesicles attached to hyphae in N2-fixing CpI1 cultures and sucrose gradient-isolated vesicles exhibited hyphal outgrowths when incubated in certain defined liquid media. Single or mult...
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PMID: 2592353
PDF is available here.
PDF is available here.
Abstract
The quinolones are new antimicrobial agents that are descendants of nalidixic acid. As a new class of synthetic antimicrobials they exhibit a wide spectrum of activity. Newer quinolones such as ciprofloxacin, norfloxacin, enoxacin, and pefloxacin are highly active against gram negative bacilli of th...
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PMID: 2537695
PDF is available here.
PDF is available here.
Abstract
Among 28 mycobacterial species studied, only Mycobacterium tuberculosis, M. bovis, M. africanum, M. marinum, M. kansasii, M. gastri and M. ulcerans produced waxes yielding long-chain beta-diol components (called phthiocerol and companions) and polymethyl-branched fatty acids on saponification. The s...
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PMID: 3149973
PDF is available here.
PDF is available here.
Abstract
All three polyamines - putrescine, spermidine and spermine stimulated the activity of mycobacterial RNA polymerase in vitro although the concentration required for maximal stimulation was different for each of the amines. Spermidine and spermine showed a biphasic effect on the enzyme activity. Stimu...
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PMID: 2457796
PDF is available here.
PDF is available here.
Experientia. Basel (41)10 1985
Effect of testosterone on the kinetics of the development of suppressor cells in adjuvant arthritis.
Abstract
The induction of unresponsiveness to mycobacterial adjuvant took a longer time in male DA rats than in female rats. A shift in the induction time of unresponsiveness in males toward the female type was brought about by castration, but could be reverted to the male type by the application of testoste...
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PMID: 2931302
PDF is available here.
PDF is available here.
Acta leprologica (2)2-4 1984
Abstract
Doklady Akademii nauk SSSR (272)2 1983
Abstract
Abstract
An attempt to elucidate the taxonomic position of the genera Mycococcus has been made. For this purpose the full range of the taxonomically important properties were investigated among microbial cultures preliminary identified as Mycococci. As a result of comparison Mycococcus with Micrococcus the t...
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PMID: 6405816
PDF is available here.
PDF is available here.
Abstract