Abstract
A randomised, double blind, parallel groups, placebo controlled clinical trial was conducted to assess the efficacy and safety profile of 250 mg ascorbic acid (Vit. C, Vagi C) in women with bacterial vaginosis (BV). Overall, 277 out-patients with at least three of the following signs (white discharge...
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PMID: 21650086
PDF is available here.
Abstract
The increased use of screening tests has led to the identification of large numbers of women with human immunodeficiency virus (HIV). Consequently, there is an increased role for obstetrician-gynecologists in caring for infected women. Women infected with HIV are living longer, healthier lives and,...
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PMID: 21099636
PDF is available here.
Abstract
To assess the accuracy of a sign of bacterial vaginosis and a sign of cervical insufficiency in predicting preterm labor (PTL, occurring in the 37th week or earlier) and early PTL (occurring in the 34th week or earlier) in a low-risk cohort of 316 pregnant women.
Vaginal pH was assessed using test g...
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PMID: 20615503
PDF is available here.
Zhong-ming Zeng,
Qin-pin Liao,
Chen Yao,
Li Geng,
Li-hua Feng,
Hui-rong Shi,
Xiao-yan Xin,
Ping Li,
Hui-lan Wang,
Yi-cun Pang,
Shu-wen Liu and
Shi-bo Jiang
Abstract
Bacterial vaginosis (BV) is one of the most common infectious diseases among sexually active women and is associated with the increased acquisition of a variety of sexually transmitted diseases. This study aimed to compare the efficacy of a non-antibiotic sucrose gel against an antibiotic metronidaz...
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PMID: 20819541
PDF is available here.
Abstract
Antagonistic and synergistic substances are important for interactions between micro-organisms associated with human body surfaces, either in healthy or in diseased conditions. In the present study, such compounds produced by Gardnerella vaginalis strains isolated from women with bacterial vaginosis...
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PMID: 20466841
PDF is available here.
Abstract
Mycoplasma hominis, the first mycoplasma of human origin to be isolated, has been associated with several diseases, notably bacterial vaginosis, pelvic inflammatory disease, prematurity and puerperal fever. The mouse model does not mimic closely these features of human disease, but has some notable...
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PMID: 20448062
PDF is available here.
Michael S Kramer,
John Lydon,
Louise Séguin,
Lise Goulet,
Susan R Kahn,
Helen McNamara,
Jacques Genest,
Shakti Sharma,
Michael J Meaney,
Michael Libman,
Mourad Dahhou and
Robert W Platt
Abstract
We carried out a case-control study nested within a large, multicentre prospective cohort of pregnant women to examine potential 'upstream' factors associated with maternal CRH concentration measured at 24-26 weeks of gestation. The predictors studied included maternal age, parity, birthplace (as a...
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PMID: 20618729
PDF is available here.
Abstract
Bacterial vaginosis (BV) is a common cause of abnormal vaginal discharge. It is characterised by an overgrowth of predominantly anaerobic organisms (Gardnerella vaginalis, Prevotella spp., Peptostreptocci, Mobiluncus spp.) in the vagina leading to a replacement of lactobacilli and an increase in vag...
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PMID: 20723268
PDF is available here.
Abstract
Women in the Otago region undergoing preterm labour were approximately twice as likely to have a bacterial vaginosis type vaginal microflora as controls. In preterm labour, the incidence of bacterial vaginosis was comparable with that found elsewhere, suggesting that current guidelines for treatment...
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PMID: 20618238
PDF is available here.
Abstract
The present study supports the use of pH measurement for sensitive, objective, and simple therapy follow-up in women with BV and shows that long-term administration of vaginal tablets containing Lactobacillus rhamnosus represents an effective and safe treatment for restoring the physiological vagina...
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PMID: 20012637
PDF is available here.
Abstract
Pre-pubertal girls with inflammatory chronic vulval disease excluding lichen sclerosus are often described as having 'non-specific vulvovaginitis'. The aim of this retrospective case series was to determine the aetiology of chronic vulvovaginitis in pre-pubertal (Tanner Stage 1) girls, with particul...
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PMID: 20546218
PDF is available here.
Abstract
We have been using the Roche GS-FLX sequencing platform to produce tens of thousands of sequencing reads from samples of both bacterial communities (microbiome) and fungal communities (mycobiome) of stool, gut mucosa, vaginal washes, and oral washes from a large number of subjects. This vast volume...
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PMID: 20491067
PDF is available here.
Abstract
We developed quantitative real-time PCR (qPCR) assays to facilitate assessments of bacterial abundance in vaginal specimens and evaluated the utility of these assays by measuring species abundance in patients whose vaginal floras were clinically described as normal, intermediate, or bacterial vagino...
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PMID: 20305015
PDF is available here.
Abstract
BV is associated with practices that efficiently transmit vaginal fluid and with use of vaginal lubricant; since these are correlated, assessing independent effects will require further analysis. More research is required to understand relationships between role of transmission of BV-associated bact...
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PMID: 20429087
PDF is available here.
Abstract
Vaginal ecosystem study with the detection of pathogens is a key instrument in the prevention of preterm delivery, pPROM, chorioamnionitis, neonatal, puerperal and maternal-fetal infections....
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PMID: 19967381
PDF is available here.
Abstract
Lactobacilli isolated from the vaginal tract of women with and without bacterial vaginosis (BV) were identified and characterized for the production of antagonists. Bacterial samples were isolated from healthy women (N = 16), from patients with clinical complaints but without BV (N = 30), and from p...
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PMID: 20209377
PDF is available here.
Abstract
Most cervical cancers begin where the endocervix and ectocervix meet. Pap tests (also called Pap smears) are vital in the early detection of cervical cancer. Ecto-endocervical Pap-tests from 230 patients with verified bacterial vaginosis (BV) were studied. Endometrial biopsy was also used in the eva...
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PMID: 20495228
PDF is available here.
Abstract
BV occurred in 12.8% of 906 sexually active intervals to white women-24.8% of intervals when the woman reported a black partner and 10.7% when all partners were white. Among white women, there was a 2-fold increased risk for BV incidence with a black, compared with a white partner (risk ratio [RR] 2...
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PMID: 19959972
PDF is available here.
Abstract
We investigated the effects of glycerol monolaurate (GML) on Lactobacillus, Candida, and Gardnerella vaginalis human vaginal microflora. Our previous work demonstrated that 6 months of GML treatment vaginally does not alter lactobacillus counts in monkeys. Candida and G. vaginalis are commonly assoc...
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PMID: 20008774
PDF is available here.
Abstract
Vaginal douching is consistently associated with bacterial vaginosis (BV), but whether it is a cause or result of BV remains unknown. The association between BV and other feminine hygienic behaviors is less studied; if BV symptoms caused behavior change then all hygiene behaviors might be more commo...
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PMID: 19823112
PDF is available here.
Abstract
the results of the present study did not differ from the literature regarding the symptoms reported by the women, the clinical criteria most frequently observed in the diagnosis, or the bacterial species detected in cultures of vaginal content. These findings indicate the need for further studies th...
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PMID: 20305946
PDF is available here.
Abstract
We utilized in vitro assays to compare three virulence properties of G. vaginalis relative to other BV-associated anaerobes. We designed a viable assay to analyse bacterial adherence to vaginal epithelial cells, we compared biofilm-producing capacities, and we assessed cytotoxic activity. Of the BV-...
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PMID: 19910411
PDF is available here.
Abstract
Bacterial vaginosis (BV) is the most frequent diagnosis made in women with lower genital tract symptoms. It has recently been observed that 90 % of subjects with BV show the growth of bacteria in the form of biofilms as against only 10% without BV, and that Gardnerella vaginalis was the predominant...
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PMID: 21175040
PDF is available here.
Abstract
The aim of the study was to evaluate the impact of early, second trimester bacterial vaginosis [BV] on the number of threatened preterm deliveries. Group A consisted of 52 pregnant women in whom BV was diagnosed in the beginning of the 2nd trimester of pregnancy. Group A patients were treated with a...
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PMID: 20557012
PDF is available here.
Abstract
Among multiple possible predisposing factors, only African American ethnicity (p < 0.001) and > 1 male sex partner in the previous 2 years (p = 0.007) were strongly associated with RBV. Abnormal uterine bleeding, frequent intercourse without a condom or withdrawal, anal intercourse, menstrual hygien...
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PMID: 20337209
PDF is available here.
Abstract
Deployed military women have an increased risk for development of vaginitis due to extreme temperatures, primitive sanitation, hygiene and laundry facilities, and unavailable or unacceptable healthcare resources. The Women in the Military Self-Diagnosis (WMSD) and treatment kit was developed as a fi...
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PMID: 20010039
PDF is available here.
Abstract
Nugent scoring system appears to be a reliable and convenient method for laboratory evaluation of cases of bacterial vaginosis. At the same time, one must be aware of the factors that might lead to discrepant results....
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PMID: 20167979
PDF is available here.
Abstract
The results of research on changes in the level of apoptosis among the spleen cells during the development of intravaginal staphylococcal infection in experimental models of different genetic mice lines are given in the paper. Intravaginal injection of Staphylococcus aureus resulted in an increased...
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PMID: 20455439
PDF is available here.
Abstract
The American Academy of Pediatrics (AAP) male circumcision policy states that while there are potential medical benefits of newborn male circumcision, the data are insufficient to recommend routine neonatal circumcision. Since 2005, however, 3 randomized trials have evaluated male circumcision for p...
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PMID: 20048246
PDF is available here.
Abstract
We evaluated cervical and rectal Chlamydia trachomatis OmpA genotypes isolated from 22 women in Birmingham, AL, who were infected at both sites. Two women had mixed infection at one site. Of 20 women infected with a single OmpA genotype at each site, four (20%) had discordant genotypes at these site...
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PMID: 19734824
PDF is available here.
Abstract
Bacterial vaginosis is a widely spread health problem with multiple connotations. It has been the subject of many studies and work during decades and it still remains a polemic entity, with contradictory finding. The polymicrobian etiology, unsolved epidemiology, obstetrico-gynecological complicatio...
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PMID: 19447450
PDF is available here.
Abstract
Few data exist regarding management strategies for women with early treatment failure for bacterial vaginosis. Cure rates after re-treatment were compared for two topical agents. The overall cure rate was 62%; rates between medications were comparable. Re-treatment with the same topical medication f...
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PMID: 19652628
PDF is available here.
Abstract
Fifty-eight women were treated for a total of 77 episodes of RBV. Sixty episodes of BV were available for a follow-up evaluation 4 to 12 weeks after enrollment, having completed both nitroimidazole and BA therapy and before initiating vaginal metronidazole gel. Cure after nitroimidazole and BA thera...
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PMID: 19704395
PDF is available here.
Abstract
Bacterial vaginosis is the most common cause of vaginal complaints. Bacterial vaginosis is further associated with a sizeable burden of infectious complications. Diagnosis relies on standardized clinical criteria or on scoring bacterial cell morphotypes on a Gram-stained vaginal smear. A few point-o...
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PMID: 19883331
PDF is available here.
Abstract
One thousand twenty-eight respondents (67.5% weighted) agreed to provide a vaginal specimen; 99.1% were successful. The specimen adequacy rates were BV and VC, 94.1%; HR-HPV, 99.7%; and cytology, 85.5%. The most common recorded reason for nonparticipation was a physical or health problem (38% of non...
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PMID: 19204072
PDF is available here.
Abstract
The cervico-vaginal IL-6 level was higher in the study group (458 pg/mL vs 123 pg/mL; p < 0.05). A significant reduction of cervico-vaginal IL-6 level was observed after two days of tocolytic treatment. CONCLUSION: A bedside, quantitative spectrofotometric method allows for a quick and repeatable as...
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PMID: 19886241
PDF is available here.
Abstract
Out of 55 patients, 17 (31%) had negative findings, benign findings were reported in 34 patients (62%), and 4 (7%) patients were subjected to mammographically guided breast biopsy. All the biopsies were done on the basis of abnormal findings on mammograms. All of the 4 patients had no evidence of ca...
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PMID: 19750852
PDF is available here.
Abstract
A diagnosis of bacterial vaginosis was made in 21% of the patients by the Amsels criteria. However, culture report suggested bacterial vaginosis in 18% of cases with most of the cases (56%) having normal flora. Overall, incidence of infection was 44% in patients with preterm labour. CONCLUSION: The...
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PMID: 19750853
PDF is available here.
Abstract
All 12 participants took 5 doses and completed study follow-up.Overall, 45 adverse events (AEs) occurred, of which 31 (69%) were genitourinary (GU) AEs. GU AEs appeared evenly distributed between the 3 treatment blocks and between LACTIN-V and placebo arms. The most common GU AEs were vaginal discha...
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PMID: 19543144
PDF is available here.
Abstract
To estimate the prevalence of sexually transmitted infections (STI) and lower reproductive tract infections (RTI) and determine risk factors for STI among rural women in Sichuan Province, China, a cross-sectional, community-based cluster sample of 2,000 rural, married women were interviewed, examine...
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PMID: 19842387
PDF is available here.
Abstract
Women with BV rated potential protection features of a vaginal microbicide higher than side effects. A product's personal hygiene aspects were rated equally or more important than the product's ability to prevent HIV/STD infections. Younger women may respond to different factors that influence produ...
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PMID: 19630538
PDF is available here.
Abstract
Contrary to the commonly posited hypothesis that vaginal Lactobacillus colonization has a protective effect, we found that such colonization was associated with a nearly 4-fold increase in the likelihood of symptomatic VVC....
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PMID: 19456235
PDF is available here.
Abstract
The predominant species isolated were L. reuteri present in 26 (32.5%) women, L. fermentum in 20 (25%), and L. salivarius in 13 (16.25%) women. Sequencing of 16S rDNA of 20 isolates showed that except for two isolates of L. plantarum, sequences of the remaining agreed well with PCR identification. N...
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PMID: 19692744
PDF is available here.
Abstract
This study aimed to determine changes in fertility intentions of HIV-1 infected and uninfected reproductive age women in Blantyre, Malawi. Participants were asked about their fertility intentions at baseline and at 3-month visits for 1 year. Time-to-event statistical models were used to determine fa...
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PMID: 19308718
PDF is available here.
Abstract
We report the results of a systematic review to determine the efficacy of probiotics for prevention or treatment of three major urogenital infections: bacterial vaginosis, vulvovaginal candidiasis, and urinary tract infection. Using multiple computerized databases, we extracted data from clinical tr...
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PMID: 19567343
PDF is available here.
Abstract
These data suggest that the factors that predict failure to become colonized by probiotic lactobacilli include exposure to semen, vaginal intercourse, and the presence of lactobacilli of the same species at enrollment....
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PMID: 19331578
PDF is available here.
Abstract
Of 201 women, 117 were diagnosed with vulvodynia and 84 had other diagnoses. Of the women diagnosed with vulvodynia in the vulvar clinic, 88.9% were correctly diagnosed before referral. The women with vulvodynia were more likely to report dyspareunia (chi2 = 7.89, p = 0.005) and stinging pain (chi2...
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PMID: 19517691
PDF is available here.
Abstract
Generalized periodontal disease and its association with ascending bacterial infection are related to preterm delivery and placental markers of bacterial ascending infection....
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PMID: 19623416
PDF is available here.
Abstract
Samples by Nugent's criteria were positive for 32 women out of a sample size of 193 (16.6%). There were no significant differences in chief complaints between women with and without BV. Significantly more women with BV reported odor, but there were no other significant differences in symptoms betwee...
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PMID: 18758800
PDF is available here.
Abstract
The mean prevalence of syphilis was 17.7% (95% CI: 15.1-20.3%). Genital gonorrhoea was found among 0.8-12.3% of subjects with mean of 4.5% (95% CI: 0.8-5.2%). Genital chlamydia was seen in 0.2-11% individuals with mean of 2.6% (95% CI: 2.1-3.1%). Trichomonas was present in 19.3% FSWs of Lahore and 5...
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PMID: 19356337
PDF is available here.
Abstract
A 41-year old multisectio patient got a life-threatening postoperative infection with Gardnerella vaginalis and Peptostreptococcus spp. Perioperative treatment with cefuroxime and metronidazol is recommended.
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PMID: 19284925
PDF is available here.
Abstract
One hundred and ten patients presenting with vaginal discharge were investigated for microbiological spectrum of vaginitis and outcome of treatment. Laboratory-documented disorder could be ascertained in 86 patients (78%). Bacterial vaginosis was the commonest aetiology (43.6%), followed by candidia...
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PMID: 19810384
PDF is available here.
Abstract
Further identification of the individual attributable risk for separate BV-associated bacteria may be most useful in developing successful treatments to prevent SPTB among BV positive women....
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PMID: 18999913
PDF is available here.
Abstract
The real-time polymerase chain reaction (PCR) quantification of several vaginal bacterial groups in healthy women and patients developing asymptomatic bacterial vaginosis (BV) and candidiasis (CA) was performed. Statistical analysis revealed that the BV condition is characterised by a great variabil...
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PMID: 18762999
PDF is available here.