Lionel Le Bourhis,
Emmanuel Martin,
Isabelle Péguillet,
Amélie Guihot,
Nathalie Froux,
Maxime Coré,
Eva Lévy,
Mathilde Dusseaux,
Vanina Meyssonnier,
Virginie Premel,
Charlotte Ngo,
Béatrice Riteau,
Livine Duban,
Delphine Robert,
Shouxiong Huang,
Martin Rottman,
Claire Soudais and
Olivier Lantz
Abstract
We show that MAIT cells were activated by cells infected with various strains of bacteria and yeast, but not cells infected with virus, in both humans and mice. This activation required cognate interaction between the invariant TCR and MR1, which can present a bacteria-derived ligand. In humans, we...
|
PMID: 20581831
PDF is available here.
Abstract
Although the involvement of common childhood infections in the aetiology of acute appendicitis has long been conjectured, supporting evidence is largely restricted to a disparate set of clinical case reports. A systematic population-based analysis of the implied comorbid associations is lacking in t...
|
PMID: 20003616
PDF is available here.
Abstract
We use cystic fibrosis (CF) lower airway infections as a model system to examine how conceptual and technological advances can address two clinical questions that are central to improved management of CF respiratory disease. Firstly, can markers of the microbial community be identified that predict...
|
PMID: 20554204
PDF is available here.
Abstract
Co-trimoxazole is infrequently prescribed in the UK due to concerns regarding adverse events. However, it has a low association with Clostridium difficile-associated disease (CDAD) and may represent an alternative to higher-risk agents. This retrospective study examines the efficacy and safety of in...
|
PMID: 20685632
PDF is available here.
Abstract
Three major trends in antibiotic use in US hospitals have emerged over the last few years: antibiotics as quality metrics, persistent use of different measures of antibiotic consumption and the emergence of antibiotic stewardship programs. Compared with Europe, where approaches are heterogeneous but...
|
PMID: 20695745
PDF is available here.
Abstract
The aim of this study was to determine the economic impact on hospital budget expenditure for two different prescribing practices: use of tigecycline in second or first-line therapy (when appropriate). This empirical study was carried out at the Intensive Care Unit (ICU) (Chief, Dr. Alberto Costanti...
|
PMID: 21030933
PDF is available here.
Abstract
Sialidases are very common in biological systems. They are found particularly in diverse virus families and bacteria, but also in protozoa, some invertebrates and mammalian. The enzymes differ in their biochemical properties, e.g., kinetics, binding affinity or substrate preference. Nevertheless, th...
|
PMID: 20824954
PDF is available here.
Abstract
To analyze risk factors for serious bacterial illness (SBI) in children less than 2 years of age admitted with fever without source.
Children under 2 years admitted at the Pediatric Service of Sanatorio Mater Dei from May 2004 to December 2005.
Observational, prospective and longitudinal study.
Inde...
|
PMID: 21046713
PDF is available here.
Abstract
We (1) compared the frequency of positive cultures with synovial fluid inoculated in blood culture flasks (SF) with those of periprosthetic tissues or swabs in traditional cultures from patients with acute and chronic prosthetic joint infections (PJI) and (2) determined the sensitivity, specificity,...
|
PMID: 20162386
PDF is available here.
Abstract
We therefore determined the rate of each failure mode and the survivorship of revision THAs.
We retrospectively reviewed the charts of 1366 revision THAs performed between 2000 and 2007. There were 609 (44.5%) men and 757 (55.5%) women with a mean age of 66 years. The indications for...
|
PMID: 20195808
PDF is available here.
Abstract
We developed a new approach for treating acute periprosthetic total joint infections: initial débridement with prosthesis retention and placement of antibiotic-impregnated cement beads followed by a second débridement within 7 days, at which time the beads are removed and new modular parts inserte...
|
PMID: 20224958
PDF is available here.
Abstract
We determined the rate at which irrigation and débridement and prosthesis retention would control acute periprosthetic infections.
We retrospectively reviewed the medical records of 18 patients with acute periprosthetic infections occurring within 28 days after 13 THAs and 5 TKAs. T...
|
PMID: 20224960
PDF is available here.
Abstract
We have previously described a unique gene expression signature exhibited by synovial fluid leukocytes in response to bacterial infection, identifying a number of potential biomarkers for infection. However, the diagnostic performance of these potential biomarkers in an immunoassay format is unknown...
|
PMID: 20300901
PDF is available here.
Abstract
We do not know the exact incidence of infection after revision TKA.
We determined the incidence of infection after revision, the type of microorganisms involved and TKA, and the potential risk factors for this infection.
We retrospectively reviewed 475 patients (476 k...
|
PMID: 20309657
PDF is available here.
Abstract
We therefore determined whether prior use of antimicrobial therapy, prior PJI, and postoperative wound healing complications were associated with CN PJI.
We performed a retrospective case-control study of 135 patients with CN PJI treated between January 1, 1985, and December 31, 2000...
|
PMID: 20401555
PDF is available here.
Abstract
Our study suggests that CAZ measurement is needed in ICUs to achieve adequate CAZ concentrations to avoid treatment toxicity and to achieve efficacy as rapidly as possible, particularly in strains having limited susceptibility to antibiotics....
|
PMID: 20571462
PDF is available here.
Abstract
Expression of four reference genes of grass carp, including beta-actin (ACTB), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), 18S rRNA (18S) and elongation factor-1 alpha (EF1alpha), was studied in tissues of normal individuals and bacteria-infected individuals. EF1alpha had the most stable expre...
|
PMID: 20361234
PDF is available here.
Abstract
Dry socket is one of the most studied complications in dentistry, and a great number of studies have searched for an effective and safe method for its prevention and treatment. One of the great clinical challenges since the first case was reported has been the inconsistency and differences in the va...
|
PMID: 20537783
PDF is available here.
Abstract
We prospectively assessed all data from RA patients who underwent in-patient treatment for septic complications in the 3-year period from 01.01.2006 to 31.12.2009. All disease- and infection-specific data were gathered and analysed.
Of the 36 cases in total, infection was localized in the rheumatoid...
|
PMID: 20632179
PDF is available here.
Abstract
Viral and microbial infections often elicit programmed cell death as part of the host defense system or as a component of the survival strategy of the pathogen. It is thus not surprising that pathogens have evolved an array of toxins and virulence factors to modulate host cell death...
|
PMID: 20638641
PDF is available here.
Abstract
The gastrointestinal epithelium deploys multiple innate defense mechanisms to fight microbial intruders, including epithelial integrity, rapid epithelial cell turnover, quick expulsion of infected cells, autophagy, and innate immune responses. Nevertheless, many bacterial pathogens a...
|
PMID: 20638639
PDF is available here.
Abstract
The activation of inflammasomes containing NBD-LRR (NLRs) or non-NLRs is critical for effective host defense against microbial pathogens. Recent discoveries have uncovered a plethora of pathogenic strategies to inhibit inflammasome-mediated processing of IL-1beta and IL-18. We review...
|
PMID: 20638636
PDF is available here.