Giselle Guerra,
Gaetano Ciancio,
Jeffrey J Gaynor,
Alberto Zarak,
Randolph Brown,
Lois Hanson,
Junichiro Sageshima,
David Roth,
Linda Chen,
Warren Kupin,
Lissett Tueros,
Phillip Ruiz,
Alan S Livingstone and
George W Burke
Abstract
We conducted a randomized trial involving 150 kidney transplant recipients to compare tacrolimus/sirolimus, tacrolimus/mycophenolate mofetil (MMF), and cyclosporine/sirolimus. All patients received daclizumab induction and maintenance corticosteroids. Median follow-up was 8 yr post-transplant. Acute...
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PMID: 21807891
PDF is available here.
Abstract
The purpose of this study was to assess the characteristics of paranasal sinus mucoceles with ophthalmologic manifestations with a focus on optic neuropathy.
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PMID: 21819766
PDF is available here.
Abstract
Recent investigations of regulatory myeloid cell mobilization and amplification in response to cancer and chronic inflammation associated with infectious disease and autoimmunity have provided numerous insights into the suppressive mechanisms, pathobiology and potential pharmaceutica...
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PMID: 21315784
PDF is available here.
Abstract
In order to facilitate public health response and to achieve early control of infectious disease epidemics, an adjustable epidemiologic information system (AEIS) was established in the Taiwan public health network in February 2006.
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PMID: 21298043
PDF is available here.
Abstract
Unbalanced Th1/Th2 T-cell responses in the liver are a characteristic of hepatic inflammation and subsequent liver fibrosis. The recently discovered Th17 cells, a subtype of CD4(+) T-helper cells mainly producing IL-17 and IL-22, have initially been linked to host defense against inf...
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PMID: 21197451
PDF is available here.
Abstract
Combined radiation and burn injuries are likely to occur after nuclear events, such as a meltdown accident at a nuclear energy plant or a nuclear attack. Little is known about the mechanisms by which combined injuries result in higher mortality than by either insult alone, and few an...
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PMID: 21233728
PDF is available here.
Abstract
The hygiene hypothesis was proposed more than two decades ago, but its mechanism remains unclear. This review focuses on recent advances in the field, especially on the role played by dendritic cells (DCs) and their modulating effects on various infections and allergic diseases, incl...
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PMID: 21200379
PDF is available here.
Abstract
We argue that the dynamics of within-host evolution has implications at the within-host and at the between-host levels. We first show that epidemiologists should consider within-host evolution, notably because it affects the genotype of the pathogen that is transmitted. We then present studies that...
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PMID: 21055948
PDF is available here.
Abstract
The diabetic foot ulcer presents a therapeutic challenge with a high rate of limb infection and extremity amputation. Adequate debridement and stable coverage of exposed structures are paramount to preserving limb length. The authors reviewed their use of a collagen bilayer matrix in the diabetic po...
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PMID: 20938372
PDF is available here.
Abstract
We critically consider the mechanistic bases for this specificity/degeneracy enigma and also compare and contrast Ag recognition by Abs and TCRs....
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PMID: 21173256
PDF is available here.
Abstract
We review the published evidence with respect to the involvement of inflammation and infection in prostate cancer. We also present an overarching hypothesis that chronic inflammation associated with aging and infection may play an important role in the etiology and progression of prostate cancer. As...
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PMID: 21589950
PDF is available here.
Abstract
We suggest here that life-threatening infectious diseases in childhood, occurring in the course of primary infection, result mostly from individually rare but collectively diverse single-gene variations of variable clinical penetrance, whereas the genetic component of predisposition to secondary or...
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PMID: 21091717
PDF is available here.
Abstract
Neutrophils are the first line of innate immune defense against infectious diseases. However, since their discovery by Elie Metchnikoff, they have always been considered tissue-destructive cells responsible for inflammatory tissue damage occurring during acute infections. Now, extens...
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PMID: 20828640
PDF is available here.
Abstract
We identify the need for future studies that compare purified forms of β-glucans from different sources to further the understanding of the mechanisms of action and aid in the development of clinical studies.
β-Glucans appear to be effective at enhancing immune function and reducing susceptibility...
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PMID: 20842027
PDF is available here.
Abstract
Therapeutic hypothermia (TH) is very effective for the treatment of acute experimental brain injury. In contrast to other neuroprotective methods or pharmacological agents, TH represents the only clinically proven neuroprotective therapy. TH led to a decreased mortality rate and improved functional...
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PMID: 21082528
PDF is available here.
Abstract
The recent application of concepts of evolution to human disease is proving useful to understand certain pathophysiological mechanisms of different entities that span genomic alterations of immunity, respiratory and hormone function, and the circulatory and neural systems. However, e...
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PMID: 20675202
PDF is available here.
Abstract
Information on the medical problems and diseases encountered by practicing Internists in the hospital environment is lacking. The aim of this study is to assess the prevalence of various diagnostic categories that present to internists in the hospital setting in Europe.
A pan-European study used the...
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PMID: 20816603
PDF is available here.
Abstract
We studied 23 patients with PIFS and 25 healthy matched control subjects. A heartbeat discrimination task and a pressure pain threshold test were used to assess interoceptive sensitivity. Cardiac response was assessed over a 4-min Stroop task. PIFS was associated with higher accuracy in heartbeat di...
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PMID: 20678991
PDF is available here.
Abstract
To evaluate the incidence of microbial keratitis associated with the use of the Menicon Z rigid gas-permeable (RGP) contact lenses (CLs) for up to 30 days continuous wear (CW). For this study, CW was defined as wearing CLs in an extended-wear modality with an average wearing time of...
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PMID: 20724849
PDF is available here.
W Miehsler,
G Novacek,
H Wenzl,
H Vogelsang,
P Knoflach,
A Kaser,
C Dejaco,
W Petritsch,
M Kapitan,
H Maier,
W Graninger,
H Tilg,
W Reinisch and
Austrian Society of Gastroenterology and Hepatology
Abstract
Infliximab (IFX) has tremendously enriched the therapy of inflammatory bowel diseases (IBD) and other immune mediated diseases. Although the efficacy of IFX was undoubtedly proven during the last decade numerous publications have also caused various safety concerns. To summarize the...
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PMID: 21122513
PDF is available here.
Abstract
We quantitatively determined the relationship of fundamental demographic variables (age, race and gender) to infection and rejection. These analyses were conducted with respect to date of transplant and age at the time of transplantation. The patient group consisted of all primary heart transplants...
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PMID: 20580261
PDF is available here.
Abstract
Home SCIG therapy was safe and led to improved perceptions of general health, higher serum IgG levels, and very low rates of infections and days missed from work/school....
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PMID: 20689467
PDF is available here.
Gil Y Melmed,
Brennan M Spiegel,
Brian Bressler,
Adam S Cheifetz,
Shane M Devlin,
Laura E Harrell,
Peter M Irving,
Jennifer Jones,
Gilaad G Kaplan,
Patricia L Kozuch,
Fernando S Velayos,
Leonard Baidoo,
Miles P Sparrow and
Corey A Siegel
Abstract
We applied the RAND/University of California Los Angeles Appropriateness Method toward establishing appropriateness of concomitant immunomodulators and anti-TNF therapies for Crohn's disease.
A literature review was conducted regarding efficacy and safety of concomitant immunomodulat...
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PMID: 20451665
PDF is available here.
Abstract
We summarize immune responses participating in the evolution of atherosclerotic plaques and poststroke local immune responses in the injured CNS as well as in the systemic circulation. Ischemic injury of the CNS alters the balanced neuroimmune modulation resulting in CIDS, the central nervous system...
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PMID: 20812451
PDF is available here.
Abstract
We enrolled 100 diabetic HD patients and followed them up prospectively for 3 years. Data on demographics, as well as biochemical and clinical data, including hospitalizations and infections, were recorded. The mean age was 63 years. In all 54% were women and the majority were African Americans (72%...
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PMID: 20671744
PDF is available here.
Abstract
During the last few decades, scientific evidence has confirmed a wide range of health benefits related to regular physical activity. How physical activity affects the immune function and infection risk is, however, still under debate. Commonly, intensive exercise suppresses the activity and levels o...
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PMID: 20569522
PDF is available here.
Abstract
Social acceptance of drinking involves social and cultural roles and has important implications for public health. Since extensive evidence indicates that alcohol possesses immunomodulatory properties, scientists have recently debated the influence of alcohol consumption on the immune response, part...
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PMID: 20598197
PDF is available here.
Abstract
Probiotics, defined as living micro-organisms that provide a health benefit to the host when ingested in adequate amounts, have been used traditionally as food components to help the body to recover from diarrhoea. They are commonly ingested as part of fermented foods, mostly in fresh fermented dair...
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PMID: 20540822
PDF is available here.
Abstract
We were interested in the scientific and societal background which is necessary to declare an infectious disease being a reportable disease which needs to be eradicated. Results of this study have shown that the time interval between the first recognition of an infectious disease and the implementat...
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PMID: 20683824
PDF is available here.
Abstract
We report here the 10-year follow-up of 86 patients who underwent allogeneic stem cell transplantation (ASCT) for myelodysplastic syndrome (MDS). All patients received the busulfan, cytosine arabinoside, and cyclophosphamide (BAC) preparative regimen which consisted of busulfan 16 mg/kg, cytosine ar...
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PMID: 20578198
PDF is available here.
Abstract
A falciform ligament abscess is a rare type of intra-abdominal abscess. A 2-yr-old male, who had omphalitis two months previously, presented with a fever and right upper quadrant abdominal pain. The ultrasound and CT scan showed an abdominal wall abscess located anterior to the liver, which was refr...
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PMID: 20592906
PDF is available here.
Abstract
The development of type 1 diabetes involves a complex interaction between pancreatic beta-cells and cells of both the innate and adaptive immune systems. Analyses of the interactions between natural killer (NK) cells, NKT cells, different dendritic cell populations and T cells have highlighted how t...
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PMID: 20577267
PDF is available here.
Abstract
We review recent observations revealing the ability of gammadelta T cells to rapidly produce cytokines that regulate pathogen clearance, inflammation and tissue homeostasis in response to tissue stress. These studies provide insights into how they acquire these properties, through both developmental...
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PMID: 20539306
PDF is available here.
Abstract
We explore the many innate immune cell populations that are an early source of IL-17 in response to stress, injury or pathogens. These early sources have been shown to have a central role in the initiation of IL-17-dependent immune responses, even before the first CD4(+)T cell sees its cognate antig...
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PMID: 20559326
PDF is available here.
Abstract
The identification of chemokines in blood platelets has strengthened our view of these cells as participants in immune host defense. Platelet chemokines representing prestored and rapidly releasable proteins may play a major role as first-line inflammatory mediators. This is evident from their capab...
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PMID: 20213276
PDF is available here.
Abstract
The CRP range was between 1 and 530.3 mg/l. The results confirm the association between a rise in CRP and progressive intensity of toxic granulation in neutrophils in peripheral blood. Kruskal-Wallis equality of populations rank test showed a statistically significant difference between the graded c...
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PMID: 20822591
PDF is available here.
Abstract
Findings from this review demonstrate an association of nurse staffing in the intensive care unit with patient outcomes and are consistent with findings in studies of the general acute care population. A better understanding of nurse staffing needs for intensive care unit patients is important to ke...
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PMID: 20473146
PDF is available here.
Abstract
Of 8,661,227 non-childbirth-related discharges, 2,261,857 were associated with an infection, and of these, 381,787 (16.8%) had severe sepsis. Black patients had a 67% higher age- and sex-standardized severe sepsis rate than did white patients (9.4; 95% confidence interval [CI], 9.3-9.5 vs 5.6; 95% C...
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PMID: 20571016
PDF is available here.
Abstract
We looked at lymphocyte proliferation, reactive oxygen species (ROS), production by neutrophils and monocytes and cytokine production. The soluble beta-glucans Laminarin and Sleroglucan did not activate ROS-production of monocytes and neutrophils while the particulate beta-glucans (beta-glucan from...
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PMID: 20034677
PDF is available here.
Abstract
To investigate the curative effect of treating infected nonunion with debridement and granulated cancellous bone autografting in a one-stage procedure.
Between 1999 and 2005, 38 cases of infected nonunion were treated with immediate granulated cancellous bone autografting after debridement.
At a mea...
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PMID: 20979747
PDF is available here.
Abstract
We argue that in the case of Streptococcus pneumoniae there has been persistent coexistence of drug-sensitive and drug-resistant strains, with neither approaching 100 per cent prevalence. We have previously proposed that models seeking to understand the origins of coexistence should not incorporate...
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PMID: 19940002
PDF is available here.
Abstract
We examined the relationship between capacity of IFN-alpha production and metabolic parameters including fasting plasma glucose (FPG), lipids, uric acid, body mass index (BMI), and blood pressure in 575 healthy subjects. Linear regression analysis showed that log(IFN-alpha production) was positively...
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PMID: 20235627
PDF is available here.