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Mycoses (17):
Recent article
Mycoses
Abstract
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Abstract
Oxidative stress disturbs organism's homeostasis and leads to excessive reactive oxygen species (ROS) production. Researchers are still focused on antioxidants that help to reduce oxidative stress level and are helpful in treatment of diseases were ROS overproduction is observed. Amo...
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PMID: 21991851
PDF is available here.
PDF is available here.
Abstract
Our results showed that T. stromaticum spores prevented the expression and production of inflammatory mediators in macrophages stimulated with interferon (IFN)-γ plus lipopolysaccharide (LPS) and neutrophils stimulated with phorbol myristate 13-acetate (PMA). Quantitative polymerase chain reaction...
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PMID: 21623538
PDF is available here.
PDF is available here.
Abstract
Abstract
These results indicate that HRT II-RCM can be used to diagnose FK and to monitor the effect of therapy on FK....
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PMID: 20847667
PDF is available here.
PDF is available here.
Abstract
The pathogenic mechanisms of fungal infection during human keratomycosis were investigated in an ex vivo corneal model that used strains of Fusarium oxysporum differing in the production of a fungal transcription factor.
A pacC loss-of-function mutant and a pacC dominant-activating mutant were const...
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PMID: 20856109
PDF is available here.
PDF is available here.
Abstract
To report trends in fungal keratitis from a single institution between 1999 and 2008.
Retrospective chart review of the patients presenting to the cornea service with fungal keratitis from April 1999 to December 2008.
Seventy-eight eyes of 76 patients were identified. The most common predisposing fa...
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PMID: 20847685
PDF is available here.
PDF is available here.
Medical Mycology (48 Suppl 1) 2010
Abstract
Abstract
The hypothesis that fungus causes most, if not all, cases of chronic rhinosinusitis (CRS) has been debated for over a decade. Many opinions and interpretations have been rendered, but it is the objective data that speaks the loudest. The debate simply boils down to a core tenet of the scientific met...
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PMID: 20974327
PDF is available here.
PDF is available here.
Abstract
We report a case of hyalohyphomycosis morphologically suggestive of an Aspergillus spp. in a 22-year-old patient with aplastic anaemia, treated with multiple transfusions and broad spectrum antibiotics....
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PMID: 20950704
PDF is available here.
PDF is available here.
Abstract
Anidulafungin is one of three available intravenous echinocandins that plays an important role in the treatment of serious fungal infections. Currently, anidulafungin is approved for the treatment of esophageal candidiasis, candidemia and other invasive Candida infections including intra-abdominal a...
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PMID: 20822479
PDF is available here.
PDF is available here.
Abstract
A series of novel 1H-dibenzo[a,c]carbazole derivatives were synthesized in good yield through reaction of methyl 7-oxo-dehydroabietate with a variety of substituted phenylhydrazines. The structures of the newly synthesized compounds were confirmed by IR, (1)H NMR, MS spectral studies and elemental a...
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PMID: 20702006
PDF is available here.
PDF is available here.
Abstract
A series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols (1a-v, 2a-w), which are analogues of fluconazole, have been designed and synthesized as the potential antifungal agents by the click reaction. Click reaction approach toward the synthesis of two sets of novel 1,2,...
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PMID: 20675019
PDF is available here.
PDF is available here.
Abstract
A series of novel sulfanilamide-derived 1,2,3-triazole compounds were synthesized in excellent yields via 1,3-dipolar cycloaddition and confirmed by MS, IR and NMR spectra as well as elemental analyses. All the compounds were screened in vitro for their antibacterial and antifungal activities. Preli...
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PMID: 20708826
PDF is available here.
PDF is available here.
Abstract
We demonstrate a temperature-independent and likely immunological mechanism for the clearance of Bd in a resistant amphibian species. Future studies are needed to determine the generality of this mechanism among amphibians and to describe the immune factors affecting different outcomes of Bd exposur...
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PMID: 20890631
PDF is available here.
PDF is available here.
Abstract
We characterized epidemiologic, clinical, and laboratory features of invasive fungal disease (IFD) in children with cancer and FN with the aim to identify risk factors for IFD that can aid in better selecting children who require antifungal treatment.
In a prospective, multicenter study, children ad...
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PMID: 20616763
PDF is available here.
PDF is available here.
Abstract
The order Passeriformes comprises the largest number of families and species of birds of any avian order. Brazil is rich in passerine birds, which are a common victim of wildlife trafficking in Brazil. Annually, many birds die as a consequence of illegal trade. To investigate the occurrence of the p...
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PMID: 21046940
PDF is available here.
PDF is available here.
Abstract
Untreated infection may cause stillbirth by several mechanisms, including direct fetal infection, placental damage, and severe maternal illness. Many bacteria, viruses, and protozoa have been associated with stillbirth. In developed countries, up to 24% of stillbirths have been attributed to infecti...
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PMID: 20661048
PDF is available here.
PDF is available here.
Journal de Radiologie (91)9 Pt 2 2010
Abstract
While the imaging features of established spondylodiscitis are well known, other presentations may be misleading. The purpose of this article is to review the typical imaging features of spondylodiscitis as well as some more atypical and unusual imaging features (early spondylodiscitis, sceptic spon...
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PMID: 20814395
PDF is available here.
PDF is available here.
Abstract
We found that the THF ring is crucial for the remarkably selective activity of aureothin analogues against certain pathogenic fungi....
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PMID: 20662518
PDF is available here.
PDF is available here.
Abstract
Abstract
Journal of Chemotherapy (22)4 2010
Abstract
Abstract
A defective mucociliary clearance facilitates colonization with bacteria and fungal spores in cystic fibrosis patients. Yeasts and molds are cultured from the cystic fibrosis respiratory tract and often their clinical relevance is unknown. Candida spp. are the most commonly isolated yeasts, whereas...
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PMID: 20695750
PDF is available here.
PDF is available here.
Journal of wound care (19)8 2010
Abstract
We searched the IMS Disease Analyzer database, which stores representative information on approximately 4.2 million patients. All documented diagnoses of diabetes mellitus in 2008, based on either ICD-10 (international classification of diseases) codes or free text comments from doctors, were analys...
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PMID: 20852505
PDF is available here.
PDF is available here.
Abstract
A recent pharmacoepidemiological study has found a more than five-fold incidence ratio in the adjusted rate of sudden death from cardiac diseases among those patients who were given simultaneously inhibitors of cytochrome P450 (CYP) enzymes and their substrates. Although new triazole antifungals are...
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PMID: 20610983
PDF is available here.
PDF is available here.
Abstract
Patients with corneal blindness secondary to autoimmune disease often fare poorly with available surgical treatments. Study of existing literature on prosthetic device complications in autoimmune diseases may help uncover common mechanisms of tissue destruction to establish perioperative immunomodul...
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PMID: 20662659
PDF is available here.
PDF is available here.
Journal of Medical Microbiology (59)Pt 7 2010
Abstract
We report what we believe to be the first confirmed Neosartorya hiratsukae CAPD-related peritonitis case in Europe. The patient died, despite early removal of the peritoneal catheter and antifungal therapy. This report highlights the impact of emerging fungal pathogens and the importance of early di...
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PMID: 20395379
PDF is available here.
PDF is available here.
Abstract
Despite the impressive advances in pathology and microbiology of recent years, the morphologic recognition of an organism remains a major component in rendering a specific diagnosis of an infectious process, or at minimum, a trigger in the process of identifying an infectious agent. Artifacts and mi...
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PMID: 20574173
PDF is available here.
PDF is available here.
Abstract
We describe a patient with native aortic valve endocarditis and aortic pseudoaneurysm caused by this agent who required multiple cardiac procedures.
Copyright 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved....
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PMID: 20609735
PDF is available here.
PDF is available here.
Journal of Infection (61)1 2010
Abstract
We report the first known case of CAPD peritonitis due to Fusarum dimerum successfully treated with antifungals and catheter removal.
Copyright (c) 2010 The British Infection Society. Published by Elsevier Ltd. All rights reserved....
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PMID: 20359497
PDF is available here.
PDF is available here.
Abstract
Our primary objective was to analyze the results of antifungal susceptibility testing of Candida species performed at Niigata University Medical and Dental Hospital and usage of antifungal agents. Antifungal susceptibility testing was performed by the CLSI M27-A2 method. Yeast-like fungi were isolat...
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PMID: 20715508
PDF is available here.
PDF is available here.
Chemosphere (80)6 2010
Abstract
White-nose syndrome (WNS) is a condition associated with white fungal growth on ears, wings, and nose of hibernating bats; this condition has recently resulted in high bat mortality in the northeastern United States. Nevertheless, the pathogenesis of morbidity and mortality are still unknown. Elevat...
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PMID: 20493513
PDF is available here.
PDF is available here.
Journal of Bacteriology (192)12 2010
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Abstract
Abstract
We present two new cases of K. ohmeri fungemia. We investigated the nature and treatment of K. ohmeri infections using minimum inhibitory concentrations of antifungal agents and by comparing the two cases with those described in the literature.
From March 1998 to December 2008, a tot...
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PMID: 21291847
PDF is available here.
PDF is available here.
Journal of Parasitology (96)3 2010
Abstract
We use high-speed (500 frames/sec) videography to study how Bd-induced mouthpart deformities affect the feeding kinematics of Fowler's toad (Anaxyrus [= Bufo] fowleri ) and grey tree frog (Hyla chrysoscelis) tadpoles. We tested for species-specific patterns of Bd-induced mouthpart deformities to ass...
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PMID: 20557202
PDF is available here.
PDF is available here.
Abstract
To investigate the effects and related factors of itraconazole in the treatment of invasive fungal infection (IFI) in the patients with blood diseases (BD).
A total of 156 BD patients with IFI treated with itraconazole in General Hospital, Tianjin Medical University from 2005 to 2008, were retrospec...
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PMID: 20979739
PDF is available here.
PDF is available here.
Abstract
We cultured specimens from injured earthquake survivors in Wenchuan, China, 2008. Of 123 cultures, 46 (59%) grew only 1 type of pathogenic bacteria. Smear was more effective than culture for early diagnosis of gas gangrene. Early diagnosis and treatment of wounds are crucial....
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PMID: 20507749
PDF is available here.
PDF is available here.
Avian Diseases (54)2 2010
Abstract
A young, female black-eared kite was rescued from a small reservoir adjacent to a rice paddy in Nagano Prefecture, Japan. The bird was given a fluid diet through the esophagus and started to eat by herself from the fifth day. Her fecal samples were examined for parasites on the seventh day and fluke...
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PMID: 20608550
PDF is available here.
PDF is available here.
Abstract
Bacterial coinfections were identified in more than two thirds of patients with fungus balls and purulent secretions. This finding suggests that bacterial infection may influence the development and persistence of clinical symptoms in a substantial portion of fungus ball cases....
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PMID: 20583740
PDF is available here.
PDF is available here.
Archives of Ophthalmology (128)6 2010
Abstract
To conduct a therapeutic exploratory clinical trial comparing clinical outcomes of treatment with topical natamycin vs topical voriconazole for fungal keratitis.
The multicenter, double-masked, clinical trial included 120 patients with fungal keratitis at Aravind Eye...
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PMID: 20547942
PDF is available here.
PDF is available here.
Minerva Pediatrica (62)3 Suppl 1 2010
Abstract
Sepsis-related morbidity and mortality is an increasing concern in all neonatal intensive care units, with reported incidences that are dramatically high regardless of the improvements in the quality of neonatal assistance. Antimicrobial resistance is also becoming a global and regional threat to pu...
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PMID: 21089728
PDF is available here.
PDF is available here.
Abstract
Pharmacodynamic targets in adults and neonates with sepsis are likely similar; thus, extrapolations are possible. When using beta-lactams, the free-drug concentration should be maintained above the minimum inhibitory concentration (MIC) level for the entire dosing interval, but thus far clinical stu...
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PMID: 20179595
PDF is available here.
PDF is available here.
Abstract
We present results of a 5-year study showing that infected adult frogs in persistent populations have low fungal loads, are surviving between years, and frequently lose and regain the infection. Here we put forward the hypothesis that fungal load dynamics can explain the different population-level o...
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PMID: 20457916
PDF is available here.
PDF is available here.
Abstract
We use fine-scale spatiotemporal data to describe (i) the invasion and spread of Bd through three lake basins, each containing multiple populations of the mountain yellow-legged frog, and (ii) the accompanying host-pathogen dynamics. Despite intensive sampling, Bd was not detected on frogs in study...
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PMID: 20457913
PDF is available here.
PDF is available here.
Rinsho Ketsueki (51)5 2010
Abstract
We prospectively investigated the pharmacokinetics and promotion of treatment adherence in patients taking oral ITCZ solution mixed with a beverage. Compared with the responses of patients taking oral ITCZ solution with water, the taste of the agent was improved significantly when mixed with orange...
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PMID: 20534951
PDF is available here.
PDF is available here.
Abstract
We investigated the antifungal activity and mechanism of action of (+)-pinoresinol, a biphenolic compound isolated from the herb Sambucus williamsii,used in traditional medicine. (+)-Pinoresinol displays potent antifungal properties without hemolytic effects on human erythrocytes. To understand the...
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PMID: 20657496
PDF is available here.
PDF is available here.
Medical Mycology (48)3 2010
Abstract
Deep, respiratory tract and ear infections due to Microascaceae (Pseudallescheria, Scedosporium, Microascus or Scopulariopsis) were studied nationwide in Finland during 1993-2002. The data were based on 52,000 fungal cultures that represented about 50% of all such specimens in Finland and included a...
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PMID: 19672782
PDF is available here.
PDF is available here.
Abstract
The commercial technique Vitek 2 system for antifungal susceptibility testing of yeast species was evaluated. A collection of 154 clinical yeast isolates, including amphotericin B- and azole-resistant organisms, was tested. Results were compared with those obtained by the reference procedures of bot...
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PMID: 20220169
PDF is available here.
PDF is available here.
Abstract
Clinical specimens cultured on two selective fungal media, inhibitory mold agar (IMA) and Sabouraud dextrose agar (SDA), were compared with respect to recovery of fungi. Of the 840 fungal isolates recovered, 69.3% grew on both IMA and SDA; 24.9% grew only on IMA; and 5.8% grew only on SDA, showing t...
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PMID: 20220162
PDF is available here.
PDF is available here.
Abstract
Our data show that phenotypic methods were insufficient for correct identification (only 25%) and that most of the wrongly identified strains showed a resistant antifungal profile....
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PMID: 20237094
PDF is available here.
PDF is available here.
Journal of Infection (60)5 2010
Abstract
Fusariosis, although uncommon, continues to have poor prognosis in neutropenic leukemic patients who present with fungemia.
2010. Published by Elsevier Ltd....
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PMID: 20138081
PDF is available here.
PDF is available here.
Abstract
We prospectively analysed the microbiological isolates of all febrile/infectious episodes occurring at our haematology unit during 2 consecutive 18-month periods. Microbiologically documented infections (MDI) and antibiotic resistance were correlated with type and status of haematological disease, n...
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PMID: 20100118
PDF is available here.
PDF is available here.
Abstract
The autopsy rate in Germany has drastically diminished in the last decades and is below 10% nowadays. Possible reasons for this development are discussed. Pressure of cost is a quoted cause, although it is not so high. There is a large discrepancy between the clinically supposed cause of death and t...
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PMID: 20433656
PDF is available here.
PDF is available here.
Abstract
Trends in Microbiology (18)5 2010
Abstract
This article provides a perspective on the current status of drug therapy for invasive fungal diseases, together with priorities for the future development of novel compounds. Key opportunities for new drugs include production of orally bioavailable agents for the treatment of invasive aspergillosis...
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PMID: 20207544
PDF is available here.
PDF is available here.
Abstract
Abstract
We report 2 cases of Alternaria and 3 cases of Paecilomyces keratitis in patients wearing frequent replacement lenses and using multipurpose solutions diagnosed during 2008. We want to raise awareness of fungal keratitis caused by unusual organisms associated with SCL wear....
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PMID: 20335812
PDF is available here.
PDF is available here.
Abstract
A rapid turnaround is a prerequisite of therapeutic drug monitoring (TDM). For antifungals, this need is still unmet, since hardly any method has been established to simultaneously quantitate concentrations of different antifungal classes. A liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
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PMID: 20176892
PDF is available here.
PDF is available here.