Stephane Ciocchi,
Cyril Herry,
François Grenier,
Steffen B E Wolff,
Johannes J Letzkus,
Ioannis Vlachos,
Ingrid Ehrlich,
Rolf Sprengel,
Karl Deisseroth,
Michael B Stadler,
Christian Müller and
Andreas Lüthi
Abstract
We show that neuronal activity in the lateral subdivision of the central amygdala (CEl) is required for fear acquisition, whereas conditioned fear responses are driven by output neurons in the medial subdivision (CEm). Functional circuit analysis revealed that inhibitory CEA microcircuits are highly...
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PMID: 21068837
PDF is available here.
Abstract
We have used two genetic lines of quail divergently selected on tonic immobility duration, a behavioural index of fear. These two lines differ in their behavioural response to some, but not all, fear-inducing situations. In the present study, we investigated the contribution of human intervention in...
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PMID: 20553824
PDF is available here.
Abstract
We tested 2 main hypotheses: first, that an early self-concept along with self-other differentiation is a universal precursor of prosocial behavior in 19-month-olds, and second, that the importance attached to relational socialization goals (SGs) concerning interpersonal responsiveness (obedience, p...
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PMID: 20604610
PDF is available here.
Abstract
These results show that the size of recovery is proportional to the size of the depression produced by CS-alone exposures regardless of whether they occurred before, after, or both before and after conditioning. The results are discussed in terms of some contemporary models of recovery and of the in...
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PMID: 20658866
PDF is available here.
Abstract
We studied the learning produced by simple exposures to a stimulus. Exposures depressed orienting and subsequent conditioned freezing in rats. A remotely preexposed conditioned stimulus (CS) conditioned better and overshadowed a novel CS more than a recently preexposed CS. Additional preexposures re...
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PMID: 20658867
PDF is available here.
Abstract
I compared intra-individual variation in an immobile aposematic behavior of the newt Cynops pyrrhogaster under different thermal gradients, using 40 animals from four populations. I found a negative relationship between ambient temperature and the frequency of performing this behavior, independent o...
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PMID: 20608843
PDF is available here.
Abstract
We examined whether rat strain influences the effects of IL lesions on extinction. In Experiment 1, Sprague-Dawley (SD) or Long-Evans (LE) rats received a standard auditory fear conditioning procedure, which was followed by an extinction session; freezing served as the index of conditional fear. Our...
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PMID: 20528083
PDF is available here.
Abstract
We found that OFC lesions concomitantly alter BI and metabolism in the bed nucleus of stria terminalis (BNST) region and that individual differences in BNST activity predict BI. Thus it appears that an important function of the OFC in response to threat is to modulate the BNST, which may more direct...
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PMID: 20484644
PDF is available here.
Abstract
We compared sleep in animals trained with IS to that in animals trained with escapable shock (ES), a controllable stressor, in a paradigm in which animals always received shock but could terminate it by their actions....
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PMID: 20469804
PDF is available here.
Abstract
We then showed that the reduction in freezing resulting from either US habituation or CS extinction was context-specific (i.e., a change in context led to a renewal of the learned fear response; Experiment 2) and, furthermore, was attenuated when a pre-test shock was given (i.e., reinstatement of fe...
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PMID: 20074653
PDF is available here.
Abstract
We show that short-term memory is, unlike long-term memory, not context specific. During this short period after learning, behavioral memory can be updated in order to incorporate new contextual information. We found that, during this period, the cycloheximide retrograde amnesic effect can be revert...
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PMID: 20188846
PDF is available here.
Abstract
We investigated the role of these thalamic targets in both unconditioned (i.e., fear responses to predatory threat) and conditioned (i.e., contextual responses to predator-related cues) defensive behaviors. During cat exposure, all experimental groups exhibited intense defensive responses with the a...
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PMID: 20096798
PDF is available here.
Abstract
We investigated whether spermidine and polyamine antagonists that selectively block the NR2B subunit at the NMDAr alter the extinction of contextual conditioned fear in male Wistar rats. The bilateral intra-hippocampal administration of exogenous spermidine (2 nmol/site) immediately after, but not 6...
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PMID: 20206278
PDF is available here.
Abstract
We tested the hypothesis that CRF(2) contributes to isolation rearing effects on emotional memory. At weaning, mice were housed either in groups of three or individually in standard mouse cages. In adulthood, isolation-reared mice exhibited significant reductions in context-specific, but not cue-spe...
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PMID: 20097235
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
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PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
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PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
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PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
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PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
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PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
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PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
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PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
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PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
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PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
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PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
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PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
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PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
|
PMID: 19938174
PDF is available here.
Abstract
We evaluated whether the need to avoid sudden obstacles on a treadmill can provoke FOG. We included 21 PD patients (15 with self-reported off-period FOG). Patients were tested in the off-state. FOG during overground walking was assessed using a standardized gait trajectory and axial 360 degrees turn...
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PMID: 19938174
PDF is available here.
Abstract
We investigated the relationship between pain sensitivity in two pain tests (the 'tail-flick' and 'flinch-jump' tests) and a conditioned, fear-evoked, freezing response in rats. The results show that there was no correlation between: (1) the conditioned (associative) and the novelty-evoked (non-spec...
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PMID: 20407487
PDF is available here.
Abstract
We studied responses in renal and lumbar sympathetic nerve activity and cardiovascular function during freezing behaviour in conscious rats, which was induced by exposure to loud white noise. Freezing behaviour was associated with regionally specific alterations in sympathetic nerve activity, in tha...
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PMID: 19700516
PDF is available here.
Abstract
Despite intense scrutiny over the past 20 years, the reasons for the high addictive liability of nicotine and extreme rates of relapse in smokers have remained elusive. One factor that contributes to the development and maintenance of nicotine addiction is the ability of nicotine to produce long-las...
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PMID: 19776730
PDF is available here.
Abstract
The neural circuits for unconditioned fear to predator odors (e.g., cat fur odor, trimethylthiazoline, TMT) are not well delineated. A putative neural circuit for predator odor fear, the medial hypothalamic defensive circuit (MHDC), consisting of the anterior hypothalamic (AHN), ventromedial hypotha...
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PMID: 19559688
PDF is available here.
Abstract
We assessed the effects of chronic administration of a subanesthetic dose of ketamine on contextual fear conditioning, detection of pitch deviants and auditory gating. After four, but not two, weeks of daily ketamine injections, mice exhibited decreased freezing in the fear conditioning paradigm. Ga...
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PMID: 19467327
PDF is available here.
Abstract
Our observation that male rat's innate fear response differed with hormonal status, as well as the higher prevalence of fear and anxiety disorders in human females led to the current investigation of the impact of phases of the estrus cycle on innate fear responding. Female rats in different phases...
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PMID: 19428610
PDF is available here.
Abstract
Damage to rat perirhinal cortex (PR) profoundly impairs fear conditioning to 22kHz ultrasonic vocalizations (USVs), but has no effect on fear conditioning to continuous tones. The most obvious difference between these two sounds is that continuous tones have no internal temporal structure, whereas U...
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PMID: 19185613
PDF is available here.
Abstract
We investigated the effects of long- versus short-term E(2)-replacement by examining cognitive (object placement task), anxiety (open field, mirror maze, light-dark transition task), and depression (forced swim task) behavior of female rats that were ovariectomized (OVX) at middle-age (14 months) or...
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PMID: 19216030
PDF is available here.
Abstract
Schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD) present abnormalities in emotion processing. A previous study showed that the spontaneously hypertensive rats (SHR), a putative animal model of ADHD, present reduced contextual fear conditioning (CFC). The aim of th...
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PMID: 18281713
PDF is available here.
Abstract
We employed the CA3-TeTX transgenic mouse, in which CA3 output can be specifically and inducibly controlled. We found that posttraining blockade of CA3 output for up to 4 weeks impairs the consolidation of contextual fear memory. Moreover, in vivo hippocampal recordings revealed a reduced intrinsic...
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PMID: 19555647
PDF is available here.
Abstract
We investigated the effectiveness of a new rehabilitation strategy based on treadmill training associated with auditory and visual cues. Forty Parkinsonian patients with freezing were randomly assigned to two groups: Group 1 underwent a rehabilitation program based on treadmill training associated w...
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PMID: 19370729
PDF is available here.
Abstract
It has been proposed that the hippocampus and subcortical structures interact during the processing of fear and anxiety-related information. It has been demonstrated that the subcortical efferents from CA3 and CA1 can be selectively disrupted without concomitant disruption to the afferents. The pres...
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PMID: 19485569
PDF is available here.