Abstract
The results of this study do not support the notion of the persistence of cognitive effects of toluene after elimination of the solvent from blood....
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PMID: 11401021
PDF is available here.
Abstract
The relationships between cognitive and affective attitudes toward the body, body experiences (dissociation, insensitivity, and lack of control), and suicidal tendencies were examined as a derivative of the hypothesis that bodily attitudes and experiences may facilitate suicidal acting out. Three gr...
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PMID: 11577910
PDF is available here.
Abstract
This is a review of the literature on the effect of aluminum (Al) and its compounds on the nervous system. The role of aluminum in etiology of some degenerative diseases of the nervous system, e.g. Alzheimer disease, amyotrophic lateral sclerosis or dementia, is presented. The special attention was...
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PMID: 11928679
PDF is available here.
Abstract
Sixteen HIV-1 seropositive individuals participated in a single-blind, placebo-controlled, crossover-design study of the effectiveness of 30 mg/ day of methylphenidate (MPH) in the treatment of HIV-associated cognitive slowing. Regression analyses revealed that participants who entered the study wit...
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PMID: 11449032
PDF is available here.
Abstract
Parkinson's disease affects various neurotransmitter systems. Using SPECT, the authors measured [(123)I]beta-CIT binding ratios of the caudate, putamen, medial thalamus, and dorsal midbrain over cerebellum in 16 patients with Parkinson's disease, and examined correlations with clinical ratings. Wher...
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PMID: 11449029
PDF is available here.
Abstract
The optimal management of opioid-related side effects is hampered by a lack of comparative studies of management strategies. The prevalence of such side effects is influenced by the extent of disease, the patient's age, the presence of coexistent renal and hepatic disease, pulmonary disease, and cog...
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PMID: 11271983
PDF is available here.
Abstract
We analyzed the total phospholipid, phosphatidylcholine (PC), phosphatidylethanolamine (PE), and lysophosphatidylcholine (lysoPC) fractions of plasma from patients diagnosed with AD, OD, or CIND and compared them with a group of elderly control subjects with normal cognitive functioning. Plasma phos...
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PMID: 11201991
PDF is available here.
Abstract
We used unbiased stereological counting procedures to determine whether these changes extend to individuals with mild cognitive impairment (MCI) without dementia from a cohort of people enrolled in the Religious Orders Study. Thirty people (average age 84.7 years) came to autopsy. All individuals we...
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PMID: 11042589
PDF is available here.
Abstract
Nevertheless, between personal exposure and biomonitoring, linear correlation was found. Methylformate exposure correlated with methanol and formic acid concentration in the urine, and isopropanol exposure with its concentration in the urine. With the neurobehavioural tests used, no solvent effect i...
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PMID: 11100947
PDF is available here.
Abstract
The 1990 Clean Air Act mandated oxygenation of gasoline in regions where carbon monoxide standards were not met. To achieve this standard, methyl tertiary butyl ether (MTBE) was increased to 15% by volume during winter months in many locations. Subsequent to the increase of MTBE in gasoline, commute...
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PMID: 10964796
PDF is available here.
Abstract
A scale to assess patients and monitor cognitive recovery after severe head injury has been developed. While individual patients will show some departures from the sequence identified, the scale helps to make explicit the earliest stages of natural recovery patterns after head injury....
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PMID: 10945425
PDF is available here.
Abstract
These results suggest that there may be at least two functional disturbances in ADHD, one specific neurodevelopmentally determined disturbance of the frontal lobes, especially of the right hemisphere, related to behaviour deviance, and another disturbance of the integration of the temporal lobes, th...
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PMID: 10943967
PDF is available here.
V V Mittoux,
J M JM Joseph,
F F Conde,
S S Palfi,
C C Dautry,
T T Poyot,
J J Bloch,
N N Deglon,
S S Ouary,
E A EA Nimchinsky,
E E Brouillet,
P R PR Hof,
M M Peschanski,
P P Aebischer and
P P Hantraye
Abstract
We tested the therapeutic effects of direct intrastriatal infusion of ciliary neurotrophic factor (CNTF). To achieve a continuous delivery of CNTF over the full period of evaluation, we took advantage of the macroencapsulation technique. Baby hamster kidney (BHK) cells previously engineered to produ...
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PMID: 10834619
PDF is available here.
Abstract
We evaluated outcome and the clinical value of cognitive impairment in systemic lupus erythematosus (SLE). Fifty-one consecutive SLE subjects with or without overt nervous system involvement received two comprehensive neuropsychiatric and neuropsychological assessments, including the Mental Deterior...
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PMID: 10836619
PDF is available here.
Abstract
There were 34 patients who required hospitalization for care relating to TBI. Of these, nine family members took part in the questionnaire study. Three carers reported fairly high levels of stress and another three carers were considered to be at risk of anxiety and depression. There was a tendency...
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PMID: 10763794
PDF is available here.
Abstract
Cognitive factors hypothesised to influence the development and maintenance of PTSD were investigated. 92 assault victims completed questionnaires assessing a range of cognitive variables. Factors relating to onset of PTSD were investigated by comparing victims who did and who did not suffer PTSD. F...
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PMID: 10458046
PDF is available here.
Abstract
The conceptualization and treatment of oppositional defiant disorder (ODD) has been characterized by surprising homogeneity. In this paper evidence is presented to underscore the heterogeneity within ODD, including research demonstrating (a) the distinction between reactive and proactive forms of ag...
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PMID: 11227071
PDF is available here.
Abstract
Subcomponents of the N200 component of the event-related brain potential believed to be differentially sensitive to involuntary and voluntary cognitive processes were examined. Nonpatients (N = 131) identified initially by the Chapman and Depue research scales and classified later on the basis of di...
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PMID: 10432801
PDF is available here.
Abstract
We previously reported that IQ was significantly lowered in a group of toddler-aged children randomly assigned to receive phenobarbital or placebo for febrile seizures and there was no difference in the febrile seizure recurrence rate. We retested these children 3-5 years later, after they had enter...
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PMID: 10416094
PDF is available here.
C C CC Dickey,
R W RW McCarley,
M M MM Voglmaier,
M A MA Niznikiewicz,
L J LJ Seidman,
Y Y Hirayasu,
I I Fischer,
E K EK Teh,
R R Van Rhoads,
M M Jakab,
R R Kikinis,
F A FA Jolesz and
M E ME Shenton
Abstract
These abnormalities strengthen the hypothesis of a temporal lobe abnormality in SPD, and the similarity of STG findings in schizophrenia and SPD suggest that STG abnormalities may be part of the spectrum "endophenotype." It is also possible that presence of medial temporal lobe abnormalities may hel...
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PMID: 10356620
PDF is available here.
Abstract
Impaired verbal and figural fluency has been shown to be associated with frontal lobe dysfunction. Jones-Gotman and Milner (1977) demonstrated a double dissociation between verbal and nonverbal fluency in a small sample of patients with frontal lesions of the left or right hemisphere. The present st...
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PMID: 10425519
PDF is available here.
Abstract
We also present a study of 135 patients with cognitive deficits, 29 females and 106 males, mean age 48. Data from neuropsychological assessments are compared to scores on the Mini Mental State Examination and to results from the open-road tests. We recommend that patients with Mini Mental State scor...
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PMID: 10210956
PDF is available here.
Abstract
OTC deficiency should be suspected in term infants who have early signs of encephalopathy, particularly after the first 24 hours; a respiratory alkalosis is pathognomic of urea cycle disorders. Severe developmental delay is the usual outcome of OTC deficiency....
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PMID: 10064660
PDF is available here.
Abstract
We have examined neuroanatomical, biochemical and endocrine parameters and spatial learning in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor (nAChR) during ageing. Aged beta2(-/-) mutant mice showed region-specific alterations in cortical regions, including neocortical hypot...
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PMID: 10064590
PDF is available here.
Abstract
All patients had disturbances of affect, 95% of behavior and 71% of motivation, while 52% and 29% had delusions and hallucinations, respectively. Delusions, but not hallucinations, were correlated with verbal and physical aggressiveness. Factor analysis extracted three complex variables which accoun...
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PMID: 10226300
PDF is available here.
Abstract
We report the case of NG, a 43-year old woman with myotonic dystrophy (MYD) who has shown a slow decline in both motor and cognitive abilities since her referral to us at age 32. MYD is an autosomal dominant disorder characterised by weakening and wasting of the muscles together with impaired muscle...
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PMID: 10213538
PDF is available here.
Abstract
Lesions of the prefrontal cortex result in a wide variety of neuropsychological disorders. Despite recent advances, the executive processes and their functional architecture remain poorly specified. This study assessed control processes operating in novel, conflicting and combined tasks in patients...
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PMID: 10213531
PDF is available here.
Abstract
Schizophrenia has the quality of a 'top-down' disorder with perturbation of self, and malattuned appraisal of basic experience of the outside world, and of intentionality. There is dissonance between the faculties of consciousness. The neuronal cortical network displays distributed activation of the...
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PMID: 10225336
PDF is available here.
Abstract
There is evidence from the literature of phenomenological overlap between hypochondriasis and several anxiety disorders, including specific phobia, panic disorder with agoraphobia, generalized anxiety disorder, and obsessive-compulsive disorder. Even though the boundaries of these disorders are spec...
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PMID: 10068915
PDF is available here.
Abstract
The heterogeneity within schizophrenia or the group of schizophrenias remains a vexing and limiting problem. An alternative to the "classic" explanatory construct of a schizophrenic unitary psychosis is the current concept of a positive/negative dichotomy with or without mixed type. However, the val...
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PMID: 9924871
PDF is available here.
Abstract
The electrically elicited blink reflex consists of three components (R1, R2, R3). In humans the excitability of these components is influenced by attentional states. In particular, distraction from the stimulus leads to facilitation of the bilateral R2 and R3. The present study was performed in orde...
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PMID: 10072663
PDF is available here.
Abstract
This study examined the neurobehavioral effects of closed head injury (CHI) in older adults according to their significant others. Informants of 17 mild and moderate CHI patients > or = 50 years old when injured completed the Geriatric Evaluation of Relative's Rating Instrument, a questionnaire inqu...
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PMID: 9990554
PDF is available here.
Abstract
Our results demonstrate that psychotic states affect the ANS, suggesting a relationship between cerebral cognitive and peripheral ANS activities, and that this is presumably mediated through the parasympathetic nervous system. These findings are discussed in comparison with previous reports on the C...
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PMID: 9987060
PDF is available here.
Abstract
Considerable familiarity with the symptoms of whiplash injury and a knowledge of the risk factors contributing to delayed recovery are requirements for the professionals who write expert reports. In addition, good skills in evaluating the factors influencing pain and illness behavior are necessary,...
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PMID: 9894240
PDF is available here.
Abstract
In intention-to-treat analyses at 1 year, each active treatment demonstrated a marked, statistically significant, protective effect against vasomotor symptoms compared with placebo (odds ratios [ORs] 0.17-0.28); there was no additional benefit of estrogen-progestin over estrogen alone. Only progesti...
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PMID: 9840563
PDF is available here.
Abstract
Cognitive features in dementia of the Alzheimer's type (DAT) appear highly heterogeneous. Neuropsychological models seem useful to characterize the cognitive decline. Functional imaging may identify anatomoclinical correlations. Memory impairment is the major symptom in DAT, associated with cortical...
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PMID: 9854391
PDF is available here.
Abstract
Investigators have recently identified a two-factor structure underlying posttraumatic stress symptoms through the use of exploratory factor analysis. [Taylor et al. (1988). The structure of posttraumatic stress symptoms. Journal of Abnormal Psychology, 107, 154-160]. These two factors, which were l...
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PMID: 9737061
PDF is available here.
Abstract
At 21 months correct age (SD: 4.9), neuromotor and cognitive abnormalities were observed, respectively, in 25.7% and 20.3% of the infants evaluated. The neonatal neurological assessment was found to be more sensitive than those specific for neuromotor (sensibility: 77.7%, specificity: 57.6%) and cog...
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PMID: 10030058
PDF is available here.
Abstract
We investigated the neurological outcome of 57 (24 male, 33 female) patients with phenylketonuria (diet onset < 3 months) at a mean age of 23.6 (17-33) years in comparison to control subjects. Methods used were a clinical-neurological examination, tests for fine motor abilities, IQ test (WAIS-R), a...
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PMID: 9809823
PDF is available here.
Abstract
The findings suggest that excessive focus on pain sensations may be one of the mechanisms by which catastrophizing leads to increased pain. The clinical challenges will be to develop cost- and time-effective means of identifying individuals who catastrophize and to implement interventions to reduce...
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PMID: 9792127
PDF is available here.
Abstract
INTRODUCTION: Epilepsy is one of the most common neurological disorders, affecting about one percent of the world population. Pharmacological treatment fails in one-third of these patients. Surgical intervention has become an accepted treatment option for those patients with seizure disorders that a...
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PMID: 9803510
PDF is available here.
Abstract
Cognitive deterioration does not affect depressive symptoms, nor does depression affect cognitive function....
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PMID: 9803499
PDF is available here.
Abstract
We hospitalize younger patients, with a worse clinical condition and overall hemorrhagic stroke. The percentage of admissions among TIA patients is low. On the other hand, date, time and physicians-team features do not affect the percentage of admissions....
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PMID: 9803519
PDF is available here.
Abstract
In carefully selected children, as well as adults, intractable seizures may be eliminated or greatly reduced by cortical resection or hemispherectomy. Critical features of surgical candidacy include intractable disabling epilepsy, a localized epileptogenic zone, and a low risk of new postoperative d...
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PMID: 9806134
PDF is available here.
Abstract
The nocturnal worsening of asthma is a common event in asthma patients. Some studies have shown the prevalence of nocturnal asthma to be as high as 75% of patients. It is important to understand this phenomenon as nocturnal asthma is associated with decreased daytime cognitive function and increased...
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PMID: 9756189
PDF is available here.
Abstract
The use of linguistic context in positively thought-disordered (TD) schizophrenics was investigated through examination of their performance on an on-line word-monitoring task. Controls and non-TD schizophrenics took longer to recognize words preceded by linguistic anomalies compared with words in n...
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PMID: 9715577
PDF is available here.
Abstract
These results suggest that DSM-IV ADHD subtypes can be thought of as existing on separate continua of inattention, hyperactivity-impulsivity, and combined type problems. Membership in any of there severe ADHD latent classes did not preclude academic excellence, but it was associated with different t...
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PMID: 9695447
PDF is available here.
Abstract
In neuropsychological studies of Parkinson's disease, cognitive deficits are frequently reported, but the nature of these deficits is not clear. As far as cognitive deficits are manifest in parkinsonian patients at an early stage of the disease, many studies tend to describe them as fitting a fronta...
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PMID: 9746934
PDF is available here.
Abstract
Suicidal ideation and/or the 'wish to die' is self-reported in 4% of dementia patients attending a memory disorders clinic and is associated with comorbid depressive symptoms, particularly in Alzheimer's disease....
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PMID: 9884008
PDF is available here.
Abstract
Endogenous estrogens are not associated consistently with cognitive performance or risk of cognitive decline on a selected battery of cognitive tests in older community-dwelling women. Worse performance on two cognitive tests among women with higher estrone levels was surprising and warrants further...
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PMID: 9670866
PDF is available here.
Abstract
While the findings of this study are reassuring, they do not guarantee that all drivers with cognitive and visual impairments are limiting their driving exposure appropriately, and geriatricians and other health professionals should be encouraged to evaluate their patients' cognitive and visual fitn...
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PMID: 9670872
PDF is available here.