Abstract
The purpose of this study is to compare the efficacy of olanzapine and risperidone for the acute treatment of first-episode schizophrenia patients with cannabis use disorders. This secondary analysis of a previously published study included 49 first-episode patients with a diagnosis...
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PMID: 21636134
PDF is available here.
Abstract
We conclude that CRT leads to measurable physiological adaptation associated with improved cognitive ability. Trial name: Cognitive Remediation Theraphy and Schizophrenia. http://clinicaltrials.gov/ct2/show/NCT01078129. Registration number: NCT01078129....
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PMID: 21543191
PDF is available here.
Michael F MF Green,
Nina R NR Schooler,
Robert S RS Kern,
Fred J FJ Frese,
Wendy W Granberry,
Philip D PD Harvey,
Craig N CN Karson,
Nancy N Peters,
Michelle M Stewart,
Larry J LJ Seidman,
John J Sonnenberg,
William S WS Stone,
David D Walling,
Ellen E Stover and
Stephen R SR Marder
Abstract
Because reduction of psychotic symptoms in schizophrenia does not result in adequate community functioning, efforts have shifted to other areas, such as cognitive impairment. The U.S. Food and Drug Administration requires that drugs for cognition enhancement in schizophrenia show improvement on two d...
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PMID: 21285142
PDF is available here.
Abstract
The authors conducted a randomized, placebo-controlled study of nicotine replacement therapy for the reduction of agitation and aggression in smokers with schizophrenia.
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PMID: 21245085
PDF is available here.
Abstract
The adequacy of the Positive and Negative Syndrome Scale (PANSS) items in measuring symptom severity in schizophrenia was examined using Item Response Theory (IRT). Baseline PANSS assessments were analyzed from two multi-center clinical trials of antipsychotic medication in chronic s...
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PMID: 21463902
PDF is available here.
Abstract
Several overlapping features have frequently been described between psychosis and the subjective experience of dreaming from the neurobiological to the phenomenological level, but whether this similarity reflects the cognitive organization of schizophrenic thought or rather that of p...
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PMID: 21435729
PDF is available here.
Abstract
This paper systematically reviews the existing evidence of the effects of physical activity on psychological well-being for those with schizophrenia. A search of 15 databases including for example, PsycINFO, SportDiscus, and Science Direct was conducted to identify studies investigating the effects o...
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PMID: 21332522
PDF is available here.
Abstract
Dissociation, though understood as a response to trauma, lacks a proven etiology. The assumption of a dose-response relationship between trauma, dissociation and Schneiderian symptoms led to the proposal of a dissociative subtype of schizophrenia characterized by severe child maltreatment, dissociati...
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PMID: 21295351
PDF is available here.
Abstract
This study examined the effect of medication nonadherence on the return of positive symptoms among recent-onset schizophrenia patients.
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PMID: 21205805
PDF is available here.
Abstract
Spectral characteristic of the alpha activity (frequency of the maximum spectral peak) were comparatively studied in schizophrenic patients with predominance of positive or negative symptoms and healthy subjects in the resting state and during cognitive task performance. In patients...
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PMID: 21961319
PDF is available here.
Abstract
The rate of smoking is known to be high in patients with schizophrenia. The purpose of this study was to quantitatively examine the relationship between smoking and family history of smoking in patients with schizophrenia.
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PMID: 21675350
PDF is available here.
Abstract
The aim of the current study was to investigate the levels of social and physical anhedonia, as measured with the Chapman Scales for social and physical anhedonia in groups of patients with schizophrenia spectrum psychosis (n = 91), their unaffected siblings (n = 105), and control subjects drawn fro...
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PMID: 21206244
PDF is available here.
Abstract
The aim of this study was a retrospective analysis of available data on patients who committed suicide after the first episode of schizophrenia with focus on risk factors for suicide. Seven of 162 patients consecutively hospitalized at the Department of Psychiatry in Brno with first-episode schizoph...
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PMID: 21206250
PDF is available here.
Abstract
Chronic exposure to adverse interpersonal environment in schizophrenia is associated with vulnerability to relapse. The construct of expressed emotion (EE) measures the quality of interpersonal environment, of which criticism is a main component. To use functional magnetic resonance imaging and to i...
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PMID: 21206243
PDF is available here.
Abstract
summary background Neurocognitive dysfunction is a core feature of schizophrenia and is related to the functional outcome of the illness. It has been suggested that the so-called atypical antipsychotics may have a more favo...
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PMID: 21319067
PDF is available here.
Abstract
We anthropologically elucidated a temporality of schizophrenia concerning the delusional perception without concrete abnormal meanings. In considering the distinguishing feature of delusion, we paid attention to the exclusion of chance. Generally speaking, a chance encounter between person A and per...
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PMID: 21404628
PDF is available here.
Abstract
A principal component analysis on the Psychosocial Impairment Rating Schedule produced two factors (interactive skills; withdrawal from interactions). Patients with FRS showed greater impairments in the domain linked to 'interactive skills', which remained 2 years after the first experience of...
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PMID: 21166784
PDF is available here.
Abstract
The physical health of people with schizophrenia is poor, and the challenges in finding effective treatment and optimizing health outcomes are significant. However, it is likely that people diagnosed with schizophrenia can be partners in the treatment of their physical health problems. Research sugg...
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PMID: 20971339
PDF is available here.
Abstract
The present investigation examined the validity of a new cognitive test intended to assess organizational skills. Participants were 180 middle-aged or older participants with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnosis of schizophrenia or schizoaffective disorde...
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PMID: 21135646
PDF is available here.
Abstract
We examined whether murderers with schizophrenia would demonstrate birth order anomalies, distinguishing them from both nonviolent schizophrenia patients and murderers without schizophrenia. Self-report birth order, psychosocial history data (i.e., maternal birth age, family size, parental criminali...
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PMID: 21135637
PDF is available here.
M R Broome,
P Fusar-Poli,
P Matthiasson,
J B Woolley,
L Valmaggia,
L C Johns,
P Tabraham,
E Bramon,
S C R Williams,
M J Brammer,
X Chitnis,
F Zelaya and
P K McGuire
Abstract
We used functional magnetic resonance imaging (fMRI) to examine the neural substrate of SWM in the ARMS and in patients who had just developed schizophrenia.
FMRI was used to study 17 patients with an ARMS, 10 patients with a first episode of psychosis and 15 age-matched healthy comparison subjects....
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PMID: 20214840
PDF is available here.
Abstract
Encoding and maintenance of information in working memory, followed by internal manipulation of that information for planning adaptive behavior, are two key components of working-memory systems. Both processes have been reported to be impaired in schizophrenia, but few studies have directly compared...
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PMID: 20214839
PDF is available here.
Abstract
Nonadherence with medication treatment is common but difficult to detect in patients with schizoaffective disorder and schizophrenia, almost half of whom take less than 70% of prescribed doses. Like patients in all areas of medicine, patients with schizoaffective disorder weigh the perceived benefit...
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PMID: 21190649
PDF is available here.
Abstract
Psychobiologic evidence and psychosocial functioning in patients with schizoaffective disorder suggest that the disease may be a distinct disorder, a variant of schizophrenia or affective disorders, the comorbidity of schizophrenia and a mood disorder, or an intermediate disorder on a spectrum that...
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PMID: 21190647
PDF is available here.
Abstract
We view schizophrenia in 2030? Schizophrenia today is a chronic, frequently disabling mental disorder that affects about one per cent of the world's population. After a century of studying schizophrenia, the cause of the disorder remains unknown. Treatments, especially pharmacological treatments, ha...
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PMID: 21068826
PDF is available here.
Abstract
Several studies have researched the attentional functioning of schizophrenic patients by means of the Attentional Network Test. The present work reviews these studies and assesses the clinical relevance of their results. Both the reviewed data and our own results suggest that the Attentional Network...
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PMID: 21044495
PDF is available here.
Abstract
These results suggest that "need for care" is characterized by distress and personalizing appraisals, but not by a higher incidence of trauma. The role of interpersonal trauma, specifically, may be to predispose to a "paranoid" world view....
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PMID: 21048472
PDF is available here.
Abstract
We sought to examine the prevalence of FRS in a representative sample of first episode psychosis patients and compare those with and without FRS clinically and in terms of duration of untreated illness. Information was gathered from 158 consecutive cases of first episode psychosis presenting in a de...
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PMID: 21048473
PDF is available here.
Abstract
These results suggest that the patients displayed inadequate levels of augmentations in eye gaze during negative emotional situations. These deficits should be considered in the treatment and social skills training for patients with schizophrenia....
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PMID: 21048475
PDF is available here.
Abstract
Numerous studies have documented high rates of functional impairment in patients with schizophrenia and bipolar disorder. However, this impairment appears early in the course of the illness. The purpose of the present study was to validate the Functioning Assessment Short Test (FAST) by comparing it...
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PMID: 21048476
PDF is available here.
Abstract
Childhood-onset schizophrenia is a rare variant of adult-onset schizophrenia. Patients with early-onset schizophrenia typically have a more chronic course of illness, greater cognitive impairment, increased negative symptoms, and more severe social consequences than patients with adult-onset schizop...
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PMID: 21114942
PDF is available here.
Abstract
We have evaluated the degree of deviation in brain structure in Kraepelinian patients with respect to controls and non-Kraepelinian schizophrenia patients. We used voxel-brain morphometry (VBM) to assess the differences in gray matter volume across the brain in the Kraepelinian group with respect to...
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PMID: 20832256
PDF is available here.
Abstract
The aim of this study was to compare patients' preference for olanzapine orodispersible tablet (ODT) with oral conventional tablet (OCT).
A 12-week randomized, crossover, multinational, open-label study was conducted to estimate the proportion of patients preferring O...
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PMID: 20653494
PDF is available here.
Abstract
We argue that psychiatric professionals should discuss the risks of treatment and of non-treatment with patients (or with their substitute decision-makers) and should maintain a duty to warn about the consequences of not having treatment. However, assessment of risk of harm should not form the basis...
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PMID: 20863176
PDF is available here.
Abstract
Changes in emotional and social behavior are considered to be amongst the most common and debilitating consequences of schizophrenia. However, little is known of the effects of schizophrenia on alexithymia, which refers to impairment in aspects of understanding emotions. In the current study, partic...
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PMID: 20373195
PDF is available here.
Abstract
The n-back task is frequently used as an experimental paradigm in imaging studies of working memory. This study aimed to investigate whether the Bergen 2-back task is suitable for use in desktop assessment of patients with schizophrenia. Looking at the psychometric properties of the task, including...
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PMID: 20383801
PDF is available here.
Abstract
We provide the rationale, design, and preliminary data from 3 ongoing clinical trials of mobile interventions developed for bipolar disorder or schizophrenia. Project 1 used a personal digital assistant to prompt engagement in personalized self-management behaviors based on real-time data. Project 2...
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PMID: 20921861
PDF is available here.
Abstract
Cognitive impairment is considered to be a core characteristic of schizophrenia. The relationship between psychosis and cognitive deterioration, however, remains unclear. This longitudinal study investigated the neuropsychological functioning of patients before and after their first psychotic episod...
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PMID: 20132582
PDF is available here.
Abstract
Schizophrenia out-patients have deficits in affective theory of mind (ToM) but also on more basal levels of social cognition, such as the processing of neutral and emotional expressions. These deficits are associated with changes in brain activation in the amygdala and the superior temporal sulcus (...
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PMID: 20056024
PDF is available here.
Abstract
The effects of cannabis use on neuropsychological indices that show characteristic disturbances in schizophrenia are unclear. The effect of cannabis use on these cognitive functions is of particular interest given the hypothesized association between cannabis use and schizophrenia. Therefore, this s...
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PMID: 20018124
PDF is available here.
Abstract
For individuals with mental illness, others' perceptions of mental illness often limit integration into communities. Perceptions of mental illness manifest as social stigma in the form of social distance and may depend on individuals' attributions of the origins of mental illness. 180 university stu...
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PMID: 21117481
PDF is available here.
Abstract
The Trialog project offers patients with early-onset schizophrenia (EOS) a two-year programme of residential outpatient care following discharge from a clinic. The programme aims to support their further recovery and independence and encompasses interactive and psycho-educational multifamily care, c...
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PMID: 20809472
PDF is available here.
Abstract
We conducted a 24-week, rater-blinded, flexible-dose study. Sixty patients with DSM-IV schizophrenia (n = 58) or schizoaffective disorder (n = 2) met the DSM-IV research criteria for neuroleptic-induced tardive dyskinesia and were randomly assigned to a risperidone or olanzapine group. The p...
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PMID: 20441726
PDF is available here.
Abstract
We examined the blood oxygen level-dependent (BOLD) changes induced by experimental pain-tolerance (endure) hot stimuli vs. non-painful stimuli during an acute psychotic episode in 12 drug-free patients with schizophrenia and in 13 gender- and age-matched healthy controls. The analyses revealed that...
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PMID: 20609569
PDF is available here.
Abstract
Verbal memory deficits commonly observed among patients with schizophrenia include the tendency to commit intrusion errors (i.e., the incorrect recall of task-irrelevant material). Intrusion errors have been linked to deficits in self-monitoring, increased positive and disorganized symptoms, and poo...
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PMID: 20638729
PDF is available here.
Abstract
These results provide cross-sectional evidence suggest that positive self-appraisals may buffer individuals with psychosis against the pernicious impact of a well known clinical risk factor, hopelessness. Accounting for positive self-appraisals may improve identification of individuals at high risk...
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PMID: 20538264
PDF is available here.
Abstract
This study examined the neural pathophysiology of the theory of mind network by eliciting self-referential processing during an idea of reference evocating situation in patients with schizophrenia.
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PMID: 20712827
PDF is available here.
Abstract
We assessed the degree of intersensory facilitation for a sample of 20 patients compared to 20 non-psychiatric individuals using a very simple target detection task. RTs were recorded for participants to detect targets that were either unimodal (auditory alone, A; visual alone, V) or bimodal (audito...
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PMID: 20600181
PDF is available here.
Abstract
We conducted a randomized controlled trial with 183 older adults with SMI (58% schizophrenia spectrum) age 50 and older at 3 sites who were assigned to HOPES or treatment as usual with blinded follow-up assessments at baseline and 1- and 2-year follow-up.
Retention in the HOPES program was high (80%...
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PMID: 20658812
PDF is available here.
Abstract
Schizophrenia is a persistent, lifelong illness such that enduring functional improvements may only occur over the course of years [corrected].This post hoc analysis in stable outpatients with schizophrenia investigated the negative symptom efficacy and treatment outcomes of ziprasidone (80-160 mg/d...
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PMID: 20571437
PDF is available here.
Abstract
These results indicate the heightened sensitivity of magnocellular pathways in unmedicated first-episode schizophrenia, which may contribute to anomalous perceptual experiences and sensory overloading.
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PMID: 20677847
PDF is available here.