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Biological Factors (10)
Articles on Biological Factors
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Role of EDHF in type 2 diabetes-induced endothelial dysfunction.
Am J Physiol Heart Circ Physiol 295(5):H1982-8 (2008) PMID 18790831
We assessed the mechanisms of EDHF-induced vasodilation in wild-type (WT, normal), db/db (advanced type 2 diabetic) mice, and db/db mice null for TNF (dbTNF-/dbTNF-). In db/db mice, EDHF-induced vasodilation [ACh-induced vasodilation in the presence of N(G)-nitro-L-arginine methyl ester (L-NAME, 10... -
Affinity assays for detection of cellular communication and biomarkers.
Analyst 133(11):1481-5 (2008) PMID 18936823
The biological events occurring in the body are complex and challenging to decode. The expression, production, secretion and interaction of proteins, peptides and small molecules often occur in a fast manner and at low concentrations. Methods used to quantify these events must be rapid, selective, s... -
Current Directions in IBD Therapy: What Goals Are Feasible With Biological Modifiers?
Gastroenterology 135(5):6 (2008) PMID 18848556
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Hydrogen peroxide potentiates the EDHF phenomenon by promoting endothelial Ca2+ mobilization.
Arterioscler Thromb Vasc Biol 28(10):1774-81 (2008) PMID 18669883
H(2)O(2) can enhance EDHF-type relaxations by potentiating Ca(2+) release from endothelial stores, probably via redox modification of the InsP(3) receptor, leading to the opening of hyperpolarizing endothelial K(Ca) channels and an electrotonically-mediated relaxant response.... -
Endothelial H2O2: a bad guy turning good?
Arterioscler Thromb Vasc Biol 28(10):1691-3 (2008) PMID 18799797
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Physiological role of inward rectifier K(+) channels in vascular smooth muscle cells.
Pflugers Arch 457(1):137-47 (2008) PMID 18437413
We review the characteristics and regulation of Kir2 channels in vascular arterial smooth muscle. Current knowledge of the predominant Kir2 channel subtype is Kir2.1, not Kir2.2 and 2.3. Electrophysiological measurements to determine the current-voltage relationship in arterial smooth muscle reveale... -
Characterization of the inhibitory effect of vascular endothelium on agonist-induced vasoconstriction in rat mesenteric resistance arteries.
J Pharmacol Sci 108(1):95-103 (2008) PMID 18787304
We performed this study to characterize the inhibitory effect of the endothelium on vasoconstrictor stimuli in rat mesenteric vascular beds. Changes in perfusion pressure induced by continuous perfusion of Krebs solution containing methoxamine (alpha(1)-adrenoceptor agonist) or high KCl were measure... -
In vivo regulation of endothelium-dependent vasodilation in the rat renal circulation and the effect of streptozotocin-induced diabetes.
Am J Physiol Regul Integr Comp Physiol 295(3):R829-39 (2008) PMID 18635451
We assessed the relative contributions of endothelium-derived relaxing factors to renal vasodilation in vivo and determined whether these are altered in established streptozotocin-induced diabetes. In nondiabetic rats, stimulation of the endothelium by locally administered ACh or bradykinin-induced... -
Hypertension and the absence of EDHF-mediated responses favour endothelium-dependent contractions in renal arteries of the rat.
Br J Pharmacol 155(2):217-26 (2008) PMID 18574459
ACh evoked relaxations in preparations contracted with phenylephrine. L-NAME (inhibitor of NOS) attenuated (WKY) or abolished (SHR) these relaxations. TRAM-34 plus UCL 1684 (inhibitors of EDHF-mediated responses) did not decrease the relaxation, except in rings of WKY when L-NAME was also present. H... -
Participation of K+ channels in the endothelium-dependent and endothelium-independent components of the relaxant effect of rosuvastatin in r...
J Cardiovasc Pharmacol Ther 13(3):207-13 (2008) PMID 18635753
Rosuvastatin was tested on rat aortic rings in the presence and absence of K(+) channel blockers, mevalonic acid, and inhibitors of nitric oxide, prostaglandins, or endothelial-derived hyperpolarizing factor synthesis. The direct vascular effects of rosuvastatin were then evaluated by obtaining dose...
