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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Biological Factors (10):
Recent article
Biological Factors
Abstract
Evidence from both clinical and experimental studies indicates that Di-peptidyl peptidase-IV (DPP-4) inhibition may mediate favorable effects on the cardiovascular system. The objective of this study was to examine the acute effects of DPP-4 inhibition on vascular responses and to st...
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PMID: 21397040
PDF is available here.
PDF is available here.
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Cancer Science (101)11 2010
Abstract
We aim to investigate its inhibitory effect on both MCF-7 and MDA-MB-231 cells, and explore the possible mechanisms of its anticancer effect. Cell viability and motility were measured by MTT and invasive assays, migration and scratch assays in vitro, respectively. The distribution of cell cycle, PI-...
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PMID: 20718753
PDF is available here.
PDF is available here.
Abstract
Abstract
This study is to investigate the putative effect of an extract of the oyster mushroom, Pleurotus ostreatus, on reduced glutathione (GSH) and its metabolic enzymes in major organs of male albino rats. A significant (P < .05) decrease in the level of GSH was observed in liver, kidneys, heart, and brai...
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PMID: 20673055
PDF is available here.
PDF is available here.
Abstract
As a potent anticoagulant, leech a traditional Chinese medicine, has become increasing topics. Hirudin, which is the primary effective component in leech, is a specific and efficient inhibitor of thrombin, mainly used in prevention and treatment of thrombus on the clinic practice. However, there is...
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PMID: 20931853
PDF is available here.
PDF is available here.
Medicina Clínica (135)6 2010
Abstract
Journal of Chromatography A (1217)25 2010
Abstract
The primary objective of this review is to discuss recent technological developments in the field of solid-phase microextraction that have enhanced the utility of this sample preparation technique in the field of bioanalysis. These developments include introduction of various new biocompatible coati...
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PMID: 20031143
PDF is available here.
PDF is available here.
Abstract
Microbial secondary metabolites have a wide range of biological activities due to their structural diversity and have been proved a major source for drug lead compounds. However,the traditional method of a single culture restricts the metabolic pathways of microorganisms and as a result many metabol...
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PMID: 20687332
PDF is available here.
PDF is available here.
YAKUGAKU ZASSHI (130)6 2010
Abstract
Vascular tone is tightly regulated by endothelium-derived factors. These include relaxing factors (EDRFs) such as nitric oxide (NO), hyperpolarizing factors (EDHFs), and contracting factors (EDCFs). Although EDHF is a prominent vasodilator, particularly in smaller arteries, little attention has been...
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PMID: 20519855
PDF is available here.
PDF is available here.
Abstract
Abstract
The first total synthesis of anominine has been achieved, and the absolute configuration of the product has been determined. The key features include the development of a new, highly efficient organocatalyzed method for the asymmetric synthesis of Wieland-Miescher ketone building blocks, an unusual...
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PMID: 20384301
PDF is available here.
PDF is available here.
Abstract
Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid that are produced by the vascular endothelium in response to agonists such as bradykinin and acetylcholine or physical stimuli such as shear stress or cyclic stretch. In the vasculature, the EETs have biological act...
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PMID: 20224870
PDF is available here.
PDF is available here.
Abstract
The term endothelium-derived hyperpolarising factor (EDHF) was introduced in 1987 to describe the hypothetical factor responsible for myocyte hyperpolarisations not associated with nitric oxide (EDRF) or prostacyclin. Two broad categories of EDHF response exist. The classical EDHF pathway is blocked...
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PMID: 20383718
PDF is available here.
PDF is available here.
Abstract
We summarize the cardiovascular phenotypes in murine models of genetic K(+)-channel deficiency and focus, in particular, on defective vasoregulation in mice deficient of endothelial Ca(2+)-activated K(+) channels, IK (KCa3.1) and SK (KCa2.3), and smooth muscle Ca(2+)-activated K(+) channels, BK (KCa...
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PMID: 20349244
PDF is available here.
PDF is available here.
Abstract
We have demonstrated that endothelium-derived hydrogen peroxide (H(2)O(2)) is an EDHF in animals and humans. For the synthesis of H(2)O(2)/EDHF, endothelial NO synthase system that is functionally coupled with Cu,Zn-superoxide dismutase plays a crucial role. Importantly, endothelium-derived H(2)O(2)...
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PMID: 20140449
PDF is available here.
PDF is available here.
Abstract
We will first focus on the current understanding of the caveolin/eNOS paradigm and will then detail the most recent findings on the role of caveolae in driving EDHF-signaling pathways....
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PMID: 20339866
PDF is available here.
PDF is available here.
Abstract
We discuss the mechanisms whereby hyperglycaemia, oxidative stress and dyslipidaemia can alter endothelial function and highlight their effects on endothelial nitric oxide synthase (eNOS), the endothelium-dependent hyperpolarising factor (EDHF) pathway(s), as well as on the role of endothelium-deriv...
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PMID: 20238124
PDF is available here.
PDF is available here.
Abstract
It is becoming increasingly evident that electrical signaling via gap junctions plays a central role in the physiological control of vascular tone via two related mechanisms (1) the endothelium-derived hyperpolarizing factor (EDHF) phenomenon, in which radial transmission of hyperpolarization from t...
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PMID: 20379740
PDF is available here.
PDF is available here.
Abstract
Since the detection of nitric oxide two and a half decades ago, there has been an incredible boost in endothelial function research, which is fascinating the research community. Physiologically, endothelial cells synthesize a number of vasoactive substances. In particular, several endothelium-derive...
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PMID: 20383717
PDF is available here.
PDF is available here.
Abstract
Numerous studies indicate that regular intake of polyphenol-rich beverages (red wine and tea) and foods (chocolate, fruit, and vegetables) is associated with a protective effect on the cardiovascular system in humans and animals. Beyond the well-known antioxidant properties of polyphenols, several o...
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PMID: 20224869
PDF is available here.
PDF is available here.
Microbiology (156)Pt 5 2010
Abstract
Signal-mediated interactions between the human opportunistic pathogens Pseudomonas aeruginosa and Candida albicans affect virulence traits in both organisms. Phenotypic studies revealed that bacterial supernatant from four P. aeruginosa strains strongly reduced the ability of C. albicans to form bio...
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PMID: 20150241
PDF is available here.
PDF is available here.
Southern Medical Journal (103)4 2010
Abstract
A 49-year-old female was started on efalizumab for severe psoriasis. Three weeks later, she developed rapidly progressive inflammatory polyarthritis associated with high titers of both rheumatoid factor (RF) and anticyclic citrullinated peptide (anti-CCP) antibody. To our knowledge, this is the firs...
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PMID: 20224509
PDF is available here.
PDF is available here.
Abstract
Ionic liquids (ILs) have been applied in different areas of separation, such as ionic liquid supported membranes, as mobile phase additives and surface-bonded stationary phases in chromatography separations and as the extraction solvent in sample preparations, because they can be composed from vario...
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PMID: 20428052
PDF is available here.
PDF is available here.
Abstract
We have demonstrated that endothelium-derived hydrogen peroxide(H2(0)2) is an EDHF in mouse and human mesenteric arteries and porcine coronary microvessels, which was subsequently confirmed by other investigators in human and canine coronary microvessels. We have also demonstrated that endothelial n...
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PMID: 20387553
PDF is available here.
PDF is available here.
Abstract
Abstract
Circulation Journal (74)4 2010
Abstract
OLM + AZL may improve the severely impaired EDHF-mediated responses in diabetic ApoE(-/-) mice, in which activation of the endothelial Akt - eNOS pathway may be involved....
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PMID: 20154404
PDF is available here.
PDF is available here.
European Journal of Pharmacology (630)1-3 2010
Abstract
We have examined the relative contribution of EDHF/NO to the attenuated endothelium-dependent relaxation of pulmonary artery in sepsis, and the role of inducible nitric oxide synthase (iNOS)-derived NO in this mechanism. Sepsis was induced in male adult Wistar rats by caecal ligation and puncture. A...
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PMID: 20035746
PDF is available here.
PDF is available here.
Abstract
A series of phenolic acids and phenol natural products, such as p-hydroxybenzoic acid, p-coumaric acid, caffeic acid, ferulic acid, gallic acid, syringic acid, quercetin, and ellagic acid, were investigated for their inhibitory effects against the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). A...
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PMID: 20185318
PDF is available here.
PDF is available here.
Abstract
Abstract
At 6 months, significant improvements in all SF-36 subscale scores were found, with the greatest percentage improvement from baseline related to physical role (113.8%; 95% confidence interval [95% CI] 102.6, 125.0). The percent improvement for the physical component scale was 53.2% (95% CI 44.5, 61....
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PMID: 20391480
PDF is available here.
PDF is available here.
Abstract
To examine changes in utilization and expenditures for infliximab in rheumatoid arthritis (RA) patients associated with the 2 changes implemented by the Medicare Prescription Drug Improvement and Modernization Act (MMA) of 2003, specifically 1) reductions in physician reimbursement for Part B drugs...
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PMID: 20391481
PDF is available here.
PDF is available here.
Abstract
Anesthesiology (112)3 2010
Abstract
In diabetes, vascular responses to acetylcholine, norepinephrine, and volatile anesthetics are altered in mesenteric resistance arteries, presumably reflecting endothelial dysfunction and possibly underlying circulatory instability during administration of either anesthetic. Some endothelial mechani...
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PMID: 20124980
PDF is available here.
PDF is available here.
Abstract
We studied myogenic constriction and endothelium-mediated dilatory responses in two inbred Fawn-Hooded (FH) rat strains, one of which spontaneously develops hypertension, proteinuria, and glomerulosclerosis (FHH), whereas the other (FHL) does not. Small renal, mesenteric resistance arteries and thor...
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PMID: 20007352
PDF is available here.
PDF is available here.
Circulation Journal (74)2 2010
Abstract
Increases in the diameter of small resistance arteries and arterioles occur secondary to processes that can be dependent or independent of changes in membrane potential. Hyperpolarization reduces the opening of voltage-gated calcium channels and thereby the stimulus for contraction of these resistan...
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PMID: 20065608
PDF is available here.
PDF is available here.
Abstract
Zhonghua Yixue Zazhi (90)3 2010
Abstract
Abstract
Aseptic loosening resulting from periprosthetic osteolysis continues to be an important cause of hip implant failure. Wear particles from the bearing surfaces play a major role in initiating periprosthetic osteolysis, which is also potentiated by mechanical factors such as increased synovial fluid p...
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PMID: 20415362
PDF is available here.
PDF is available here.
Abstract
Four compounds were isolated from the broth culture of Volvariella bombycina and they were identified as ergosta-4,6,8(14),22-tetraene-3-one (1), ergosterol peroxide (2), indole-3-carboxaldehyde (3) and indazole (4) by interpretation of spectroscopic data. Among them, compound 2 exhibited melanogene...
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PMID: 20134236
PDF is available here.
PDF is available here.
Abstract
Cyanobacteria are a simple, but primitive and diverse group of microorganisms, with characteristics in common to both bacteria and algae. Their success as a group in a wide range of habitats has been attributed to their unique physiological characters and high adaptive ability under a wide range of...
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PMID: 20391755
PDF is available here.
PDF is available here.
Srpski arhiv za celokupno lekarstvo (138 Suppl 1) 2010
Abstract
Patients with absent PF-activity did not differ concerning age, height, weight, body mass index, waist circumference and different lipid and lipoprotein parameters. Mean Lp(a) in patients with absent PF-activity was 18 vs. 94 mg/dl (p < 0.001). Laboratory parameters such as C-reactive protein, fibri...
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PMID: 20229675
PDF is available here.
PDF is available here.
Abstract
We attempted to purify this substance. One thousand g of dried silkworm pupae was subjected to methanol extraction, followed by methanolysis, two different solvent partitions, and three different column chromatographies. A total of 12.4 mg of substance was obtained in the active fraction. The substa...
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PMID: 20208348
PDF is available here.
PDF is available here.
Abstract
We report a patient with stiff-person syndrome and insulin-dependent diabetes mellitus with anti-glutamic acid decarboxylase (GAD) antibody, who suddenly complained of diplopia due to dysthyroid ophthalmopathy. Therapeutic efficacy of plasmapheresis and high-dose intravenous immunoglobulin was trans...
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PMID: 20118602
PDF is available here.
PDF is available here.
Abstract
We have identified a novel stress-responsive gene called BRE which interacts with TNF-receptor-1 and blocks the apoptotic effect of TNF-alpha. BRE enhances tumor growth in vivo and is up-regulated in hepatocellular and esophageal carcinomas. BRE also regulates the ubiquitination of the DNA repair co...
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PMID: 19757177
PDF is available here.
PDF is available here.
Abstract
We summarized chemerin-proteases interactions, chemerin receptors, and their importance in normal and pathologic conditions....
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PMID: 20011981
PDF is available here.
PDF is available here.
Abstract
Psoriatic arthritis (PsA) is a chronic inflammatory musculoskeletal disorder associated with a heterogeneous disease presentation, varied disease expression and an unpredictable but often chronically destructive clinical course. Joint damage can occur early in the disease; indeed, several imaging mo...
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PMID: 19806150
PDF is available here.
PDF is available here.
Abstract
The first total synthesis of euplectin, a rare metabolite with a chromone annulated indenone motif, has been accomplished in 17 steps. This has been possible through interplay among three key reactions: a Hauser sulfoxide annulation, a new chromone formation and a late-stage retro-Diels-Alder reacti...
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PMID: 19736910
PDF is available here.
PDF is available here.
Journal of Physiology and Pharmacology (60 Suppl 4) 2009
Abstract
Endothelium plays a crucial role in the regulation of cardiovascular homeostasis through the release of vasoactive factors. Nitric oxide (NO) and endothelium-derived hyperpolarizing factors (EDHF) are the two major actors controlling the vasomotor tone. The endothelial nitric oxide synthase (eNOS) w...
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PMID: 20083858
PDF is available here.
PDF is available here.
Journal of Organic Chemistry (74)19 2009
Abstract
A highly selective convergent coupling reaction is described between alkynes for the synthesis of stereodefined trisubstituted (E,E)-1,3-dienes-structural motifs commonly found embedded in the skeletons of bioactive polyketide-derived natural products. While numerous multistep processes for the synt...
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PMID: 19722544
PDF is available here.
PDF is available here.
Journal of Organic Chemistry (74)19 2009
Abstract
The enantioselective synthesis of the R-enantiomer of the marine natural product (S)-ypaoamide (5) is reported. The synthesis features both a flexible racemization-free approach to the 5-substituted 3-pyrrolin-2-one segment, and a lipase (CCL)-promoted deacetylation reaction to reach the orthogonal...
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PMID: 19746925
PDF is available here.
PDF is available here.
Journal of Organic Chemistry (74)19 2009
Abstract
The first total syntheses of (+)-villatamines A and B have been realized in six and five steps, respectively. The stereogenic center present in these two naturally occurring alkaloids should have an (S)-configuration based on our results.
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PMID: 19778083
PDF is available here.
PDF is available here.
Abstract
Chronic infections are commonly associated with biofilms formed by bacteria such as Staphylococcus epidermidis. With the increase in antibiotic resistant bacteria, maggot debridement therapy has been reintroduced for the treatment of chronic wounds. Studies have shown that the excretion/ secretions...
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PMID: 19856274
PDF is available here.
PDF is available here.
Journal of Organic Chemistry (74)15 2009
Abstract
We were able to intercept a key intermediate in our first synthesis with better selectivity and greater convergence than had previously been the case....
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PMID: 19537725
PDF is available here.
PDF is available here.
Journal of Organic Chemistry (74)15 2009
Abstract
The natural product tetrahydrolathyrine has been synthesized through an iminoiodane-mediated aziridination of a (2S)-allylglycinol derivative, which provided a 2:3 mixture of diastereoisomers. One of these diastereoisomers was converted to the natural product and the other to its C-4 epimer. The C-4...
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PMID: 19572523
PDF is available here.
PDF is available here.
Abstract
Psoriatic arthritis (PsA) is a seronegative spondyloarthropathy (SpA) occurring in up to 30% of patients with psoriasis. It has a wide variation of annual incidence (median 6.4, range 0.1-3.1 per 10(5) people), based on analysis of 13 incidence and prevalence reviews published between 1987 and Decem...
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PMID: 19661546
PDF is available here.
PDF is available here.
Abstract
We applied in vivo forward chemical genetics to identify novel compounds and biologic mechanisms involved in (lymph)angiogenesis in Xenopus tadpoles. A novel 2-step screening strategy involving a simple phenotypic read-out (edema formation or larval lethality) followed by semiautomated in situ hybri...
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PMID: 19478043
PDF is available here.
PDF is available here.
Abstract
Biotransformations are useful methods for producing medicinal and agricultural chemicals from both active and inactive natural products with the introduction of chemical functions into remote sites of the molecules. Research on microbial biotransformations of commonly available sesquiterpenoids into...
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PMID: 19769003
PDF is available here.
PDF is available here.
Abstract
We investigated whether similar mechanisms occurred in smaller mesenteric resistance arteries from aged Wistar-Kyoto (WKY) rats, spontaneously hypertensive rats (SHRs), and SHRs treated with the angiotensin-converting enzyme inhibitor, enalapril, using immunohistochemistry, serial-section electron m...
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PMID: 19411610
PDF is available here.
PDF is available here.
Abstract
Psoriasis is a common chronic inflammatory skin disease that may lead to disability and significant effects on patients' quality of life. A challenge in psoriasis management is to use an effective therapy early in the disease course in order to achieve a safe and well tolerated maintenance of remiss...
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PMID: 19661545
PDF is available here.
PDF is available here.