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Biological Factors (10)
Articles on Biological Factors
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Payers begin to make plans for coming wave of biosimilars.
Manag Care 19(6):7-8, 10 (2010) PMID 20608402
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[Therapeutic target for endothelium-derived hyperpolarizing factor signaling in diabetic vascular complication]
Yakugaku Zasshi 130(6):777-84 (2010) PMID 20519855
Vascular tone is tightly regulated by endothelium-derived factors. These include relaxing factors (EDRFs) such as nitric oxide (NO), hyperpolarizing factors (EDHFs), and contracting factors (EDCFs). Although EDHF is a prominent vasodilator, particularly in smaller arteries, little attention has been... -
Biomaterials: Intelligent glue.
Nature 465(7296):298-9 (2010) PMID 20485421
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Connexins and gap junctions in the EDHF phenomenon and conducted vasomotor responses.
Audio, Transactions of the IRE Professi... 459(6):897-914 (2010) PMID 20379740
It is becoming increasingly evident that electrical signaling via gap junctions plays a central role in the physiological control of vascular tone via two related mechanisms (1) the endothelium-derived hyperpolarizing factor (EDHF) phenomenon, in which radial transmission of hyperpolarization from t... -
Epoxyeicosatrienoic acids and endothelium-dependent responses.
Pflugers Arch 459(6):881-95 (2010) PMID 20224870 PMCID PMC3373596
Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid that are produced by the vascular endothelium in response to agonists such as bradykinin and acetylcholine or physical stimuli such as shear stress or cyclic stretch. In the vasculature, the EETs have biological act... -
Nutritional improvement of the endothelial control of vascular tone by polyphenols: role of NO and EDHF.
Audio, Transactions of the IRE Professio... 459(6):853-62 (2010) PMID 20224869
Numerous studies indicate that regular intake of polyphenol-rich beverages (red wine and tea) and foods (chocolate, fruit, and vegetables) is associated with a protective effect on the cardiovascular system in humans and animals. Beyond the well-known antioxidant properties of polyphenols, several o... -
Endothelial dysfunction in diabetes: multiple targets for treatment.
Audio, Transactions of the IRE Professio... 459(6):977-94 (2010) PMID 20238124
We discuss the mechanisms whereby hyperglycaemia, oxidative stress and dyslipidaemia can alter endothelial function and highlight their effects on endothelial nitric oxide synthase (eNOS), the endothelium-dependent hyperpolarising factor (EDHF) pathway(s), as well as on the role of endothelium-deriv... -
Endothelium-derived hyperpolarising factors and associated pathways: a synopsis.
Pflugers Arch 459(6):863-79 (2010) PMID 20383718
The term endothelium-derived hyperpolarising factor (EDHF) was introduced in 1987 to describe the hypothetical factor responsible for myocyte hyperpolarisations not associated with nitric oxide (EDRF) or prostacyclin. Two broad categories of EDHF response exist. The classical EDHF pathway is blocked... -
Total synthesis of (-)-anominine.
Audio, Transactions of the IRE Professi... 132(17):5966-7 (2010) PMID 20384301
The first total synthesis of anominine has been achieved, and the absolute configuration of the product has been determined. The key features include the development of a new, highly efficient organocatalyzed method for the asymmetric synthesis of Wieland-Miescher ketone building blocks, an unusual... -
Endothelial dysfunction and blood pressure alterations in K+-channel transgenic mice.
Pflugers Arch 459(6):969-76 (2010) PMID 20349244
We summarize the cardiovascular phenotypes in murine models of genetic K(+)-channel deficiency and focus, in particular, on defective vasoregulation in mice deficient of endothelial Ca(2+)-activated K(+) channels, IK (KCa3.1) and SK (KCa2.3), and smooth muscle Ca(2+)-activated K(+) channels, BK (KCa...
