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Antigens (20):
- Antigens, Heterophile
- Antigens, Bacterial
- Antigens, Archaeal
- Superantigens
- Antigens, Viral
- Antigens, Surface
- Antigens, Nuclear
- Antigen-Antibody Complex
- Antigens, Plant
- Antigens, T-Independent
- Antigens, Fungal
- Antigens, Protozoan
- Antigens, Helminth
- Vaccines, Synthetic
- Autoantigens
- Epitopes
- Antigens, Neoplasm
- Antigens, Dermatophagoides
- Allergens
- Isoantigens
Recent article
Antigens
Brain research (1410) 2011
Abstract
We attempted to characterize protein expression profiles in P301S tau-Tg mouse by using two-dimensional differential in-gel electrophoresis (2D-DIGE) coupled by peptide mass fingerprinting (PMF). As a result, we identified four upregulated proteins; heat shock protein 27 (Hsp27), peroxiredoxin 6 (Pr...
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PMID: 21803337
PDF is available here.
PDF is available here.
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New Microbiologica (34)3 2011
Abstract
We successfully generated a mouse monoclonal antibody fragment from a phage display library directed against protein E7 of HPV18 avoiding antigen purification as for immunizing mice as for antibody library selection. Our work demonstrates the feasibility of phage antibody selections on antigens tran...
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PMID: 21811748
PDF is available here.
PDF is available here.
Abstract
Adult bone marrow-derived mesenchymal stem cells (MSC) possess potent immune modulatory effects which support their possible use as a therapy for immune-mediated disease. MSC induce regulatory T cells (T(reg)) in vitro although the in vivo relevance of this is not clear....
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PMID: 21091718
PDF is available here.
PDF is available here.
Biology Direct (6)1 2011
Abstract
We examined the specificity of several commercially available anti-phosphorylated GSK-3 antibodies. We show that antibodies raised to peptides containing the phosphorylated Ser21/9 epitope crossreact with unidentified antigens that are highly expressed by mitotic cells and that mainly localise to sp...
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PMID: 21261990
PDF is available here.
PDF is available here.
Abstract
We propose a critical review of the latest findings in the field of NG2 cell physiology--discussing how they inform us on the possible function(s) of NG2 cells in the brain--and we present some personal views on new directions the field could benefit from in order to achieve lasting significance....
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PMID: 21288204
PDF is available here.
PDF is available here.
Abstract
We show that porcine sialoadhesin-specific antibodies and F(ab')₂ fragments trigger sialoadhesin internalization, both in primary porcine macrophages and in cells expressing recombinant porcine sialoadhesin. Using chemical inhibitors, double immunofluorescence stainings and dominant-negative const...
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PMID: 21359217
PDF is available here.
PDF is available here.
Abstract
We generated >240 hybridoma cell lines from native mitochondrial proteins after cell fusion, screening, and cloning. Antibodies that recognized mitochondrial proteins were identified by screening human liver cDNA expression libraries. In this study, we identified 6 major antigens that were recognize...
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PMID: 21253866
PDF is available here.
PDF is available here.
Abstract
Cross-presentation is the key process in stimulation of cytotoxic T lymphocyte (CTL) immune response in eliminating many infectious diseases and tumors. Previous studies have shown that surface modification of poly(D,L-lactic-co-glycolic acid) (PLGA) particles with polycations enhanc...
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PMID: 21058278
PDF is available here.
PDF is available here.
Abstract
We have previously shown that transgenic (tg) mice that have been created to overexpress bovine FcRn (bFcRn) demonstrate increased half-life of mouse IgG, significantly increased antigen-specific IgG in serum and augmented expansion of antigen-specific B cells and plasma cells after immunization. On...
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PMID: 21239891
PDF is available here.
PDF is available here.
Abstract
A new technology has been developed that allows human antibodies to be quickly generated against virtually any antigen. Using a novel process, naïve human B cells are isolated from tonsil tissue and transformed with efficiency up to 85%, thus utilizing a large portion of the human V...
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PMID: 21285537
PDF is available here.
PDF is available here.
Abstract
Evidence has been accumulated to show that the forkhead/winged-helix transcription factor Foxp3 is a good marker for specialized CD4+ T cells that regulate immune responses to self as well as to a variety of foreign antigens including infectious or tumor antigens, alloantigens, allergens, and commen...
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PMID: 20941599
PDF is available here.
PDF is available here.
Abstract
We have developed optimized methods that allow the rapid assembly of scFv libraries from chickens immunized with pools of immunogens. These methods allow the simplified generation of a single moderately sized library of single-chain Fv (scFv) and the subsequent isolation of diverse, high-affinity, a...
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PMID: 20978977
PDF is available here.
PDF is available here.
Arerugi = [Allergy] (60)1 2011
Abstract
We had searched a substance that inactivated sweat antigen adopting histamine release test. And we found that tannic acid which selected by screening various natural products inactivated sweat antigen....
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PMID: 21346405
PDF is available here.
PDF is available here.
Abstract
We critically consider the mechanistic bases for this specificity/degeneracy enigma and also compare and contrast Ag recognition by Abs and TCRs....
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PMID: 21173256
PDF is available here.
PDF is available here.
Lab On a Chip (10)23 2010
Abstract
This communication describes a simple method for printing aqueous solutions with millimeter-scale patterns on a variety of substrates using an easily fabricated, paper-based microfluidic device (a paper-based "stamp") as a contact printing device. The device is made from inexpensive materials, and i...
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PMID: 20949218
PDF is available here.
PDF is available here.
Abstract
We established in the present study a novel mouse model of passive IgG-mediated systemic anaphylaxis to a native protein antigen, ovalbumin (OVA), rather than artificially haptenated protein antigens used in previous studies. Passive sensitization of mice with a cocktail of but not individual IgG1 m...
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PMID: 21029722
PDF is available here.
PDF is available here.
Lab On a Chip (10)22 2010
Abstract
We have demonstrated that 0.4 and 1 μm beads conjugated with antibodies can be rapidly assembled into the microwells by applying a pulsed electric field across the chamber. By assembling step-wise a mixture of fluorescently labeled antibody-conjugated microbeads, we incorporated both spatial and fl...
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PMID: 20820631
PDF is available here.
PDF is available here.
Abstract
We are developing a specific antibody filter (SAF) device to selectively remove ABO blood group antibodies from the whole blood by utilizing immunoaffinity adsorption. The device consists of ultrafiltration hollow fiber membranes with synthetic antigens specific to bind blood group antibodies immobi...
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PMID: 20878917
PDF is available here.
PDF is available here.
Abstract
We foresee that this increased knowledge will permit us to design vaccines that will reprogram the immune system to intervene therapeutically in cancer, allergy, and autoimmunity.
Copyright © 2010 Elsevier Inc. All rights reserved....
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PMID: 21029958
PDF is available here.
PDF is available here.
Abstract
We have explored the role of recipient antigen expression by nonhematopoietic cells in the failure to sustain effective CTL immunity. Using clinically relevant models, we found that nonhematopoietic antigen severely disrupts the formation of donor CD8+ T cell memory at 2 distinct levels that operate...
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PMID: 20978352
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (152)41 2010
Abstract
Abstract
Analyses of microvascular networks with traditional tracer filling techniques suggest that the blood and lymphatic systems are distinct without direct communications, yet involvement of common growth factors during angiogenesis and lymphangiogenesis suggest that interactions at the c...
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PMID: 20648570
PDF is available here.
PDF is available here.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology (26)10 2010
Abstract
to isolate novel breast cancer antigen for developing cancer marker and vaccine, a phage display peptide library was screened with serum antibody from breast cancer patients.
a phage display peptide library was screened with serum IgG from six breast cancer patients, and then identified the positive...
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PMID: 20937226
PDF is available here.
PDF is available here.
Abstract
We can identify Th epitopes by predicting MHC-II binding peptides. Recently, instead of differentiating the peptides as binder or non-binder, researchers are more interested in predicting binding affinities between MHC-II molecules and peptides.
Motivated by the collective search strategy of the par...
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PMID: 20541921
PDF is available here.
PDF is available here.
Kidney International (78)10 2010
Abstract
Clinical Immunology (136)3 2010
Abstract
We immunized 9 HIV-negative subjects and 29 HIV-infected patients with CD4>/=450 cells/microL and undetectable HIV RNA levels with 2 doses of diphtheria/tetanus toxoid (TT) and KLH, a presumed neoantigen. We quantified the response by lymphoproliferative assay, delayed-type hypersensitivity (DTH), a...
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PMID: 20472504
PDF is available here.
PDF is available here.
Proteomics (10)17 2010
Abstract
We hypothesized that macrophages treated with M. tuberculosis culture filtrate proteins (CFPs) would release exosomes containing mycobacterial proteins. We found 29 M. tuberculosis proteins in exosomes released from CFP-treated J774 cells, the majority of which were also present in exosomes isolated...
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PMID: 20662102
PDF is available here.
PDF is available here.
Abstract
The hallmark of adaptive immunity is its ability to recognise a wide range of antigens and technologies that capture this diversity are therefore of substantial interest. New methods have recently been developed that allow the parallel analysis of T cell reactivity against vast numbe...
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PMID: 20177676
PDF is available here.
PDF is available here.
Developmental Biology (344)2 2010
Abstract
Tightly regulated crosstalk between endothelial cells and pericytes is required for formation and maintenance of functional blood vessels. When the NG2 proteoglycan is absent from pericyte surfaces, vascularization of syngeneic tumors growing in the C57Bl/6 mouse brain is aberrant in several respect...
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PMID: 20599895
PDF is available here.
PDF is available here.
Abstract
We evaluated the frequencies of irregular erythrocyte antibodies (Abs) by gender and history of transfusion or pregnancy. In total, data from 248,785 patients were analyzed, from whom 4222 irregular erythrocyte Abs were detected in 3554 cases (1.43%). Abs frequencies in these 4222 cases were as foll...
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PMID: 20675192
PDF is available here.
PDF is available here.
Biomarkers (15)5 2010
Abstract
We hypothesized that a collecting duct-specific lectin could be used in combination with a collecting duct-specific antibody to negate the need for two different antibodies. The collecting duct specificity of selected antibodies (NiCa II 13C2, Pap XI 3C7, HuPaP VII 2B11 and aquaporin 2), was verifie...
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PMID: 20491521
PDF is available here.
PDF is available here.
Abstract
Trypsin digestion for 90 min revealed the alpha(5) chain of type IV collagen along the glomerular basement membrane and Bowman's capsule in paraffin-embedded renal sections of controls. In the 9 patients with the ultrastructures suggestive of Alport syndrome (AS), 8 patients were classified as X-lin...
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PMID: 20594039
PDF is available here.
PDF is available here.
Immunology (130)4 2010
Abstract
We and others previously showed that ribosomal proteins, targeted in autoimmune disease, are also targets of anti-tumour T-cell responses. We asked whether particular properties of ribosomal proteins such as incorporation into RNP complexes or sub-cellular localization enhance ribosomal protein pres...
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PMID: 20331471
PDF is available here.
PDF is available here.
Chemical Communications (46)28 2010
Abstract
Efficient electrochemiluminescence (ECL) quenching was achieved by functionalized CdTe quantum dots (QDs) through ECL energy scavenging, based on which ultrasensitive antigen detection could be realized.
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PMID: 20559593
PDF is available here.
PDF is available here.
Abstract
We showed that repetitive antigen stimulations induced accumulation of memory CD8(+) T cells with uniform effector memory characteristics. However, genome-wide microarray analyses revealed that each additional antigen challenge resulted in the differential regulation of several hundred new genes in...
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PMID: 20619696
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (90)26 2010
Abstract
To evaluate the effect of calcium ionophore (CI) A23187 and human recombinant granulocyte/macrophage colony stimulating factor (rhGM-CSF) on the cultivation of dendritic cell (DC) from healthy human peripheral blood mononuclear cell (PBMC) and to evaluate the in vitro effect of DC stimulated by K562...
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PMID: 20979834
PDF is available here.
PDF is available here.
Pharmaceutical Biology (48)7 2010
Abstract
I (40 mg/kg) significantly increased the humoral response to the extent of 33.33 and 35.12%, respectively. The results of this study confirm the cellular and humoral immunostimulant properties of M. citrifolia fruits and justify its usage in traditional medicine....
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PMID: 20645768
PDF is available here.
PDF is available here.
Clinical Immunology (136)1 2010
Abstract
According to hygiene hypothesis, a lower exposure to infection is associated with increased prevalence of allergic diseases. This study aimed to investigate the association between atopy and Toxoplasma gondii (Tg) infection by analyzing the antibody and cytokine responses to house dust mite allergen...
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PMID: 20359954
PDF is available here.
PDF is available here.
Abstract
We demonstrate that cysteine protease-induced T(H)2 responses occur via 'cooperation' between migratory dermal dendritic cells (DCs) and basophils positive for interleukin 4 (IL-4). Subcutaneous immunization with papain plus antigen induced reactive oxygen species (ROS) in lymph node DCs and in derm...
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PMID: 20495560
PDF is available here.
PDF is available here.
Abstract
Antigen uptake has been shown to occur in the teleost intestine, but so far, limited information is available on the distribution and nature of cells involved in the process, and M cells, known for their antigen-sampling abilities in mammals, have not been identified. Here, different intestinal segm...
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PMID: 20178814
PDF is available here.
PDF is available here.
Abstract
We demonstrate that toll-like receptor (TLR) ligands influence the TI-2 antibody response not only by enhancing the overall magnitude but also by skewing this response to one that is dominated by IgG isotypes. Importantly, TLR ligands facilitate this response by inducing type I interferon (IFN), whi...
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PMID: 20566717
PDF is available here.
PDF is available here.
Abstract
We report the detection of plasma cells in lymphoid organs of OS patients, in which circulating B cells are undetectable. Hypomorphic Rag2(R229Q) knock-in mice, which recapitulate OS, revealed, beyond severe B cell developmental arrest, a normal or even enlarged compartment of immunoglobulin-secreti...
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PMID: 20547828
PDF is available here.
PDF is available here.
Abstract
We further showed that tyrosine sulfation plays a role in binding and neutralization. An N-linked glycan modification is observed in the variable light chain, but not required for antigen recognition. Further, the crystal structure of the PG9 light chain at 3.0 A facilitated homology modeling to sup...
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PMID: 20534513
PDF is available here.
PDF is available here.
Journal of Cell Biology (189)6 2010
Abstract
Pattern recognition receptors detect microbial components and induce innate immune responses, the first line of host defense against infectious agents. However, aberrant activation of immune responses often causes massive inflammation, leading to the development of autoimmune diseases. Therefore, bo...
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PMID: 20548099
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)23 2010
Abstract
We again measured conduction through the VLF using electrical stimulation while recording the resulting volley and synaptic potentials in target motoneurons. We found that intraspinal injection of chondroitinase-ABC, known to digest chondroitin sulfate proteoglycans (CSPGs), prevented the decline of...
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PMID: 20534825
PDF is available here.
PDF is available here.
Abstract
We revisit the antigen-based therapies used in the treatment of myelin-specific CD4+ T cells in the context of the functional avidity and the strength of signal of the encephalitogenic CD4+ T cell repertoire. In light of differences in activation thresholds, we propose that autoreactive T cells are...
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PMID: 19904613
PDF is available here.
PDF is available here.
Bioanalysis (2)6 2010
Abstract
Most therapeutic monoclonal antibodies are designed to bind a specific antigen to elicit pharmacological effects. Accurate quantification of a therapeutic monoclonal antibody in biological matrices is essential for assessing its pharmacokinetics and selecting an effective dosing regi...
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PMID: 21083212
PDF is available here.
PDF is available here.
Abstract
Majority of infectious microorganism make their gateway to the host through mucosal surfaces, such as gastrointestinal tract, nasal and vaginal tract. Mucosal immune response structured as sIgA can effectively prevent the attachment and invasion of the microorganism from mucosal surface and thereby...
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PMID: 20380624
PDF is available here.
PDF is available here.
Abstract
I will discuss the potential benefits and efficacy of the employed vaccine strategy that may be feasible for various studies in the field....
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PMID: 20353394
PDF is available here.
PDF is available here.
Abstract
The conjugation between nanotubes, coated with different doses of polyethylene imine (PEI) and hepatitis A virus (HAV) was investigated by scanning electron microscopy, Z-potential, thermogravimetric and differential thermal analysis, transmission electron microscopy, energy dispersive x-ray diffrac...
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PMID: 20404402
PDF is available here.
PDF is available here.
Abstract
We demonstrate that ovalbumin induces OX40 expression in CD4+ lymphocytes. Further stimulation of OX40 by OX40 activating antibody up-regulates CCL20 production. Both NF-kappaB dependent and independent signaling pathways are implicated in the induction of CCL20 by OX40. Finally, we primed the DO11....
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PMID: 20400327
PDF is available here.
PDF is available here.
Schizophrenia Research (119)1-3 2010
Abstract
These results suggest that HAL treatment activates adult OPCs, which divide infrequently under normal conditions but respond to a variety of insulting factors by proliferation and differentiation. However, our further observations showed no changes in the number of mature OLs and the amount of myeli...
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PMID: 20346631
PDF is available here.
PDF is available here.
Abstract
We used mAb 2E2 amino acid sequence information to create a homology model for the 3-D structure of its Fv fragment. Subsequent computational docking studies revealed the intermolecular interactions potentially responsible for mAb 2E2's cocaine binding properties. The driving force of cocaine bindin...
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PMID: 20185210
PDF is available here.
PDF is available here.
Abstract
Abstract
Feeding long-chain polyunsaturated fatty acids (LCP) influences immunity in adults; however, less is known about their effect during development. The aim of the study was to determine the effect of feeding LCP on immunity in healthy infants during the first 4 months of life.
Formula-fed infants were...
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PMID: 20386325
PDF is available here.
PDF is available here.
Experimental Neurology (223)2 2010
Abstract
The purpose of this study was to determine the fate and the effects of undifferentiated embryonic stem cells (ESCs) in mice after contusive lesion of the spinal cord (SCI). Reproducible traumatic lesion to the cord was performed at T8 level by means of the Infinite Horizon Device, and was followed b...
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PMID: 20100476
PDF is available here.
PDF is available here.
Abstract
We show, unexpectedly, that CD4 cells are also required to assist primed CD8 effector T cells in rejection of skin expressing human growth hormone, a neo-self-antigen, in keratinocytes. The requirement for CD4 cells can be substituted by CD40 costimulation. Rejection of skin expressing ovalbumin (OV...
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PMID: 20147961
PDF is available here.
PDF is available here.
Abstract
We modified the GLP-1 analog of exendin-4 using two fatty acids (FA) either lauric acid (LUA, C12) or palmitic acid (PAA, C16) at its two lysine residues, to produce; Lys(12)-FA-Exendin-4 (FA-M2), Lys(27)-FA-Exendin-4 (FA-M1), or Lys(12,27)-diBA-Exendin-4 (FA-Di). The structural, biological, and pha...
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PMID: 20093159
PDF is available here.
PDF is available here.
Abstract
This study evaluated a biodegradable drug delivery system for local cancer radiotherapy consisting of a thermally sensitive elastin-like polypeptide (ELP) conjugated to a therapeutic radionuclide. Two ELPs (49 kDa) were synthesized using genetic engineering to test the hypothesis that injectable bio...
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PMID: 20117157
PDF is available here.
PDF is available here.
Abstract
Despite its unlikely occurrence, post-mortem animal depredation is not unknown to forensic pathologists. In the case at issue, the corpse of a dead woman presented extensive facial wounds, which were then traced back to the dog she owned. A small specimen of injured tissue was subjected to species d...
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PMID: 20382359
PDF is available here.
PDF is available here.