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Intercellular Signaling Peptides and Proteins (24)
- Agouti Signaling Protein
- Agouti-Related Protein
- Angiogenic Proteins
- CCN Intercellular Signaling Proteins
- Endothelial Growth Factors
- Epidermal Growth Factor
- Fibroblast Growth Factors
- Hedgehog Proteins
Articles on Intercellular Signaling Peptides and Proteins
Role of adipokines in cardiovascular disease.
The discovery of leptin in 1994 sparked dramatic new interest in the study of white adipose tissue. It is now recognised to be a metabolically active endocrine organ, producing important chemical messengers - adipokines and cytokines (adipocytokines). The search for new adipocytokine...
Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin.
Adipose tissue is an active endocrine organ, and our knowledge of this secretory tissue, in recent years, has led us to completely rethink how our body functions and becomes dysregulated with weight gain. Human adipose tissue appears to act as a multifunctional secretory organ with t...
Matrix Rigidity Activates Wnt Signaling through Down-regulation of Dickkopf-1 Protein.
I gels led to a dramatic down-regulation of the Wnt signaling inhibitor dickkopf-1 with a concomitant increase in nuclear β-catenin and enhanced β-catenin/Tcf/Lef transcriptional activity. Increased three-dimensional collagen gel invasion was accompanied by transcriptional up-regulation of the mem...
Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and...
We will discuss the role of (i) growth factors, cytokines, chemokines and bioactive lipids and (ii) microvesicles (MVs) released from cells employed as cellular therapeutics in regenerative medicine. In particular, stem cells are a rich source of these soluble factors and MVs released from their sur...
Effects of Wnt/β-catenin signalling on proliferation and differentiation of apical papilla stem cells.
Our results suggest that canonical Wnt/β-catenin signalling promotes proliferation and odonto/osteogenic differentiation of SCAP. © 2012 Blackwell Publishing Ltd....
The clinical and pathological phenotype of C9ORF72 hexanucleotide repeat expansions.
There is increasing evidence that frontotemporal dementia and amyotrophic lateral sclerosis are part of a disease continuum. Recently, a hexanucleotide repeat expansion in C9orf72 was identified as a major cause of both sporadic and familial frontotemporal dementia and amyotrophic la...
Effects of administration of hormone therapy or raloxifene on the immune system and on biochemical markers of bone remodeling.
We analyzed the effects of treatments on immune system parameters such as serum levels of interleukin (IL)-6, tumor necrosis factor α, and IL-1β; lymphocyte subpopulations; cell proliferation by peripheral blood mononuclear cells (PBMCs); in vitro production of IL-1β by PBMCs; and the expression...
Modulation of gap junction channels and hemichannels by growth factors.
Gap junction hemichannels and cell-cell channels have roles in coordinating numerous cellular processes, due to their permeability to extra and intracellular signaling molecules. Another mechanism of cellular coordination is provided by a vast array of growth factors that interact wi...
MicroRNA-132 targets HB-EGF upon IgE-mediated activation in murine and human mast cells.
Our data provide a novel example for negative regulation of a growth factor by an upregulated miRNA. © Springer Basel AG 2011...
BMP activated Smad signaling strongly promotes migration and invasion of hepatocellular carcinoma cells.
We performed RT-PCR analysis and revealed enhanced expression levels of several BMPs (BMP4, 6, 7, 8, 9, 10, 11, 13 and 15) in HCC. Thus, we treated HCC cells with the general BMP inhibitors chordin and noggin to determine the functional relevance of BMP overexpression and observed decreased migratio...