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All › Amino Acids, Peptides, and Proteins › Peptides › Intercellular Signaling Peptides and Proteins › Cytokines

Cytokines (15)

Articles on Cytokines

  1. Role of adipokines in cardiovascular disease.
    Harman S HS Mattu and Harpal S HS Randeva

    J Endocrinol 216(1):T17-36 (2013) PMID 23160967

    The discovery of leptin in 1994 sparked dramatic new interest in the study of white adipose tissue. It is now recognised to be a metabolically active endocrine organ, producing important chemical messengers - adipokines and cytokines (adipocytokines). The search for new adipocytokine...
  2. Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin.
    M K MK Piya, P G PG McTernan, and S S Kumar

    J Endocrinol 216(1):T1-T15 (2013) PMID 23160966

    Adipose tissue is an active endocrine organ, and our knowledge of this secretory tissue, in recent years, has led us to completely rethink how our body functions and becomes dysregulated with weight gain. Human adipose tissue appears to act as a multifunctional secretory organ with t...
  3. Biochemical and proteomic characterization of alkaptonuric chondrocytes.
    Daniela Braconi, Giulia Bernardini, ... Annalisa Santucci

    J Cell Physiol 227(9):3333-43 (2012) PMID 22213341

    We characterized biochemically chondrocytes isolated from the ochronotic cartilage of AKU patients. Based on the macroscopic appearance of the ochronotic cartilage, two sub-populations were identified: cells coming from the black portion of the cartilage were referred to as "black" AKU chondrocytes,...
  4. Biochemical and proteomic characterization of alkaptonuric chondrocytes.
    Daniela Braconi, Giulia Bernardini, ... Annalisa Santucci

    J Cell Physiol 227(9):3333-43 (2012) PMID 22213341

    We characterized biochemically chondrocytes isolated from the ochronotic cartilage of AKU patients. Based on the macroscopic appearance of the ochronotic cartilage, two sub-populations were identified: cells coming from the black portion of the cartilage were referred to as "black" AKU chondrocytes,...
  5. A role for sphingolipids in the pathophysiology of obesity-induced inflammation.
    Benjamin T BT Bikman

    Cell Mol Life Sci 69(13):2135-46 (2012) PMID 22294100

    Following the initial discovery that adipose tissue actively synthesizes and secretes cytokines, obesity-induced inflammation has been implicated in the etiology of a host of disease states related to obesity, including cardiovascular disease and type II diabetes. Interestingly, a gr...
  6. Phase II study of bevacizumab in patients with HIV-associated Kaposi's sarcoma receiving antiretroviral therapy.
    Thomas S TS Uldrick, Kathleen M KM Wyvill, ... Robert R Yarchoan

    J Clin Oncol 30(13):1476-83 (2012) PMID 22430271

    We evaluated the humanized anti-VEGF-A monoclonal antibody, bevacizumab, in patients with HIV-KS. Patients with HIV-KS who either experienced progression while receiving highly active antiretroviral therapy (HAART) for at least 1 month or did not regress despite HAART for at least 4...
  7. Serum titres of anti-glutamic acid decarboxylase-65 and anti-IA-2 autoantibodies are associated with different immunoregulatory milieu in ne...
    M Andrade Lima MA Gabbay, M N MN Sato, ... S A SA Dib

    Clin Exp Immunol 168(1):60-7 (2012) PMID 22385239

    We showed that peripheral sera cytokines [interleukin (IL)-12, IL-6, II-1β, tumour necrosis factor (TNF)-α, IL-10] and chemokines (CXCL10, CXCL8, CXCL9, CCL2) measured were significantly higher in newly diagnosed T1AD patients when compared to healthy controls (P < 0·001). Among T1AD, we foun...
  8. Midkine prevented hypoxic injury of mouse embryonic stem cells through activation of Akt and HIF-1α via low-density lipoprotein receptor-rel...
    Sang Hun SH Lee, Han Na HN Suh, ... Ho Jae HJ Han

    J Cell Physiol 227(4):1731-9 (2012) PMID 21688265

    Stem cell functions are dramatically altered by oxygen in tissue culture, which means the antioxidant/oxidant balance is critical for protection as well as toxicity. This study examined the effect of the heparin-binding growth factor midkine (MK) on hypoxia-induced apoptosis and rela...
  9. Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells.
    S-I SI Lee, K-H KH Park, ... E-C EC Kim

    Clin Exp Immunol 168(1):113-24 (2012) PMID 22385246

    These results suggest that MS activates human PDL cells to express immune/defence genes encoding cytokines, chemokines, defensins and TLRs via a SIRT1 pathway. © 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology....
  10. Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-@kB
    Fera Y FY Goh, Nadine N Upton, ... W S Fred WS Wong

    Eur J Pharmacol 679(1-3):8 (2012) PMID 22290391

    We hypothesized that fisetin may attenuate allergic asthma via negative regulation of the NF-κB activity. Female BALB/c mice sensitized and challenged with ovalbumin developed airway inflammation. Bronchoalveolar lavage fluid was assessed for total and differential cell counts, and cytokine and che...