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Amygdalin (0):
Recent article
Amygdalin
Abstract
To study the influence of processing on metabolism of the main component of bitter almond-amygdalin in rat.
The blood was collected at different times after amygdalin given by injection and oral, bitter almond and its processed production given by oral respectively, and then detected by both HPLC an...
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PMID: 21246818
PDF is available here.
PDF is available here.
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Abstract
A reference method (higher accuracy) and a routine method (higher throughput) were developed for the extraction of cyanogenic glycosides from flaxseed. Conditions of (essentially) complete extraction were identified by comparing grinding methods and extraction solvent composition, and optimizing sol...
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PMID: 20480892
PDF is available here.
PDF is available here.
Abstract
Small molecules that inhibit the activation of T lymphocytes, leukocyte trafficking, leukotriene activity/production and angiogenesis, and promote apoptosis have been patented. Small molecules that have been patented for the treatment of other autoimmune diseases and could be used for treating psori...
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PMID: 19566378
PDF is available here.
PDF is available here.
Abstract
We evaluated the antiinflammatory and analgesic activities of amygdalin, using an in vitro lipopolysaccharide (LPS)-induced cell line and a rat model with carrageenan-induced ankle arthritis. One mM amygdalin significantly inhibited the expression of TNF-alpha and IL-1beta mRNAs in LPS-treated RAW 2...
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PMID: 18955812
PDF is available here.
PDF is available here.
Journal of Food Protection (71)10 2008
Abstract
We generated recombinant antibodies against amygdalin from a phage display of a combinatorial rabbit/human chimeric antibody library and used it in a sensitive competition enzyme immunoassay system to detect amygdalin in extracts of pits and nuts. The detection limit was determined to be 1 x 10(-9)...
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PMID: 18939751
PDF is available here.
PDF is available here.
Antinociceptive effect of amygdalin isolated from Prunus armeniaca on formalin-induced pain in rats.
Abstract
We induced pain in rats through intraplantar injection of formalin, and evaluated the antinociceptive effect of amygdalin at doses of 0.1, 0.5, 1.0, and 10.0 mg/kg-body weight by observing nociceptive behavior such as licking, biting and shaking, the number of Fos-immunoreactive neurons in the spina...
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PMID: 18670089
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To investigate the factors influencing on the ephedrine contents in different compositions of Maxingshigan decoction. METHOD: Adopt mixed uniform design to dismantle recipes, employ the stepping regression analysis to deal with experimental statistics, use the partial correlational analys...
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PMID: 18338596
PDF is available here.
PDF is available here.
Abstract
The content of amygdalin in traditional decoction of Maxingshigan Decoction was 17.74 mg/g and 24.80 mg/g in granular one. CONCLUSION: The content of glycyrrhizic acid in traditional decoction of Maxingshigan decoction is obviously higher than that in granular one....
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PMID: 18236758
PDF is available here.
PDF is available here.
Abstract
Simple and accurate HPLC methods were developed for the determination of oleanolic acid (OA), ursolic acid (UA) and amygdalin in loquat (Eriobotrya japonica Lindl.) flower, which is commonly used for the treatment of various diseases as a traditional Chinese medicine. HPLC assay was performed on a r...
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PMID: 17385800
PDF is available here.
PDF is available here.
Supportive Care Cancer (15)6 2007
Abstract
Thirty six reports met our inclusion criteria. No controlled clinical trials were found. Three articles were nonconsecutive case series, 2 were consecutive case series, 6 were best case series, and 25 were case reports. None of these publications proved the effectiveness of laetrile. CONCLUSION: The...
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PMID: 17106659
PDF is available here.
PDF is available here.
Abstract
In full formula remove Glycyrrhiza uralensis group, the contents of L-ephedrine, d-pseudephedrine and the amygdaloside cut down significantly. In full formula remove armeniacae semen group, the content of glycyrrhetic acid cut down significantly. Four chemical composition in full formula group had h...
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PMID: 17727071
PDF is available here.
PDF is available here.
Abstract
The development of well-characterized rapid methodology for the extraction and gas chromatographic analysis of the cyanogenic glycosides linustatin and neolinustatin from flaxseed (Linum usitatissimum L.) is reported. Two quantitation methods using phenyl-beta-D-glucopyranoside as an internal standa...
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PMID: 17373446
PDF is available here.
PDF is available here.
Neurological Research (29 Suppl 1) 2007
Abstract
The present results showed that amygdalin suppressed the prostaglandin E(2) synthesis and the nitric oxide production by inhibiting the LPS-stimulated mRNA expressions of COX-2 and iNOS in the mouse BV2 cells. CONCLUSION: These results show that amygdalin exerts anti-inflammatory and analgesic effec...
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PMID: 17359643
PDF is available here.
PDF is available here.
Abstract
Armeniacae Semen not only contains amygdalin, but emulsin also, which is an enzyme that hydrolyzes amygdalin. The extraction yield of amygdalin from Armeniacae Semen was low, due to the presence of emulsin, when extracted with water. When Schizandrae Fructus solution was used as the extractant; howe...
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PMID: 17225457
PDF is available here.
PDF is available here.
Abstract
We prepared the aqueous extract of the amygdalin from Armeniacae semen and investigated whether this extract induces apoptotic cell death in human DU145 and LNCaP prostate cancer cells. In the present results, DU145 and LNCaP cells treated with amygdalin exhibited several morphological characteristi...
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PMID: 16880611
PDF is available here.
PDF is available here.
Abstract
We report a novel approach for the controlled delivery of an antiinflammatory, chemopreventive drug by an enzyme-triggered drug release mechanism via the degradation of encapsulated hydrogels. The hydro- and organogelators are synthesized in high yields from renewable resources by using regioselecti...
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PMID: 16819889
PDF is available here.
PDF is available here.
Molecules and Cells (21)2 2006
Abstract
We immunized New Zealand White rabbits with an amygdalin-KLH (keyhole limpet hemocyanin) conjugate and succeeded in raising anti-sera reactive to amygdalin, proving that amygdalin can behave as a hapten in rabbits. Using this polyclonal antibody, we developed a competition enzyme immunoassay for det...
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PMID: 16682828
PDF is available here.
PDF is available here.
Journal of Chromatography A (1112)1-2 2006
Abstract
The application of analytical and semi-preparative columns in reversed-phase liquid chromatography-solid-phase extraction-nuclear magnetic resonance (HPLC-SPE-NMR) was compared. The work was aiming at separating a higher sample amount in a single run and in this way to reduce the necessary NMR measu...
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PMID: 16364345
PDF is available here.
PDF is available here.
Abstract
The genome of Streptococcus mutans UA159 contains two phospho-beta-glucosidase genes, bglA and celA, which occur in operon-like arrangements along with genes for components of phosphotransferase transport systems and a third phospho-beta-glucosidase encoded by the arb gene, which does not have its o...
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PMID: 16390337
PDF is available here.
PDF is available here.
Abstract
Abstract
The claim that Laetrile has beneficial effects for cancer patients is not supported by data from controlled clinical trials. This systematic review has clearly identified the need for randomised or controlled clinical trials assessing the effectiveness of Laetrile or amygdalin for cancer treatment....
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PMID: 16625640
PDF is available here.
PDF is available here.
Abstract
High-performance liquid chromatography with evaporative light-scattering detection (HPLC-ELSD) was employed for determination of amygdalin content in Semen Armeniacae Amarum. The detection was performed with the column of Hypersil-ODS (4.6 mm x 250 mm, 5 microm) and column temperature of 25 degrees...
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PMID: 16361161
PDF is available here.
PDF is available here.
Experimental Dermatology (14)11 2005
Abstract
We synthesized analogues lacking the cyanide group. Human keratinocytes were treated with PT or with three different peptidomimetics of PT. To study its effects on the expression of HSP-70, TGF-beta, alpha-v integrin, ICAM-1 and cytokines, we analysed the protein levels by Western blot and ELISA. Ou...
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PMID: 16232308
PDF is available here.
PDF is available here.
Abstract
We describe a case of severe cyanide poisoning arising from amygdalin, a putative vitamin supplement. A 32-year-old woman arrived in the emergency department by ambulance unresponsive, shocked and with fixed dilated pupils. She was hypothermic and tachycardic but was breathing spontaneously. Despite...
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PMID: 16175068
PDF is available here.
PDF is available here.
Abstract
Microarray showed that amygdalin downregulated especially genes belonging to cell cycle category: exonuclease 1 (EXO1), ATP-binding cassette, sub-family F, member 2 (ABCF2), MRE11 meiotic recombination 11 homolog A (MRE11A), topoisomerase (DNA) I (TOP1), and FK506 binding protein 12-rapamycin-associ...
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PMID: 16127745
PDF is available here.
PDF is available here.
Abstract
A suitable method for extraction of amygdalin from hawthorn has been established. At first, the lipophilic components were removed with petroleum ether by ultrasonic extraction. The amygdalin was then extracted by methanol in a Soxhlet's apparatus. For quantitation, a high performance liquid chromat...
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PMID: 16350793
PDF is available here.
PDF is available here.
Abstract
This case highlights the fact that CAMs can produce life-threatening toxicity. This case also adds a further note of caution, namely, the potential for serious interactions between CAMs, particularly where there is no tradition of concomitant use....
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PMID: 16014371
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To establish an HPLC method for the simultaneous determination of three major bioactive components in Jingzhi Guizhi Fuling capsules namely laetrile, paeoniflorin and paeonol. METHOD: A LiChrospher C18 column (4.6 mm x 250 mm, 5 microm) was used. The chromatography was carried out with a...
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PMID: 16245901
PDF is available here.
PDF is available here.
Abstract
Apricot-kernel and Prunus Tomentosa Thunb. are traditional Chinese herb medicines that contain amygdalin as their major effective ingredient. In this report, three methods for the extraction of amygdalin from the medicinal materials are compared: ultrasonic extraction by methanol, Soxhlet extraction...
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PMID: 16176653
PDF is available here.
PDF is available here.
Current Biology (15)14 2005
Abstract
We examined evidence for natural selection on the human receptor TAS2R16 by sequencing the entire coding region, as well as part of the 5' and 3' UTRs, in 997 individuals from 60 human populations. We detected signatures of positive selection, indicated by an excess of evolutionarily derived alleles...
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PMID: 16051168
PDF is available here.
PDF is available here.
Journal of Chromatography A (1074)1-2 2005
Abstract
Salicin in the bark extract of Salix alba and amygdalin in the fruit extract of Semen armeniacae were each separated by slow rotary counter-current chromatography (SRCCC). The apparatus was equipped with a 40-L column made of 17 mm i.d. convoluted Teflon tubing. A 500g amount of crude extract contai...
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PMID: 15941037
PDF is available here.
PDF is available here.
Abstract
Peptide T (ASTTTNYT) is a promising molecule to prevent the neuropsychometric symptoms of patients suffering AIDS and for the treatment of psoriasis. In order to fully prove its therapeutic benefits, efforts were put forward to design peptidomimetics of the peptide. In this direction, in a recent co...
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PMID: 15713414
PDF is available here.
PDF is available here.
Abstract
Crabapple trees belong to the Malus genus (Rosaceae) and bear fruits that are sparingly consumed and used in the preparation of fruit beverages. Cyclooxygenase (COX) enzyme inhibitory and antioxidant bioassay-guided fractionation of the aqueous and methanol extracts of Malus x kornicensis and Malus...
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PMID: 12643656
PDF is available here.
PDF is available here.
Abstract
We used newly developed simple acid boiling method in preparation of Persicae Semen extract. HPLC analysis revealed most of amygdalin in Persicae Semen extract was active D-form. Persicae Semen extract was used to analyze its effect on cell proliferation and induction of apoptosis in human promyeloc...
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PMID: 12643594
PDF is available here.
PDF is available here.
Abstract
Evidence is accumulating that glucose-conjugated compounds may be carried across the gut mucosa via the epithelial sodium-dependent monosaccharide transporter SGLT1. A modification of the everted intestinal sac technique was utilized to study the transport of the cyanogenic glycoside amygdalin (D-ma...
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PMID: 12975776
PDF is available here.
PDF is available here.
Abstract
The determination of cyanogenic compounds in plants is often performed by HPLC. However, in this analysis, interferences due to compounds in the matrix, such as tannins and other pigments, are encountered, especially in roots and leaves. A new method is proposed for determining the cyanogenic glycos...
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PMID: 12428943
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To systematically evaluate the quality of Semen Armeniacae Amarum. METHOD: The amygdalin content in the samples of Semen Armeniacae Amarum from different markets was analysed by HPLC. Some physical and chemical tests were done to investigate their quality. RESULT: Some significant differe...
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PMID: 12776549
PDF is available here.
PDF is available here.
Abstract
We establish methods for simple HPLC analysis and the inhibition of D-amygdalin conversion. D-Amygdalin and its conversion product, neoamygdalin, were clearly separated on reverse-phase column chromatography by an optimized eluent of 10 mM sodium phosphate buffer (pH 3.8) containing 6% acetonitrile....
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PMID: 12372866
PDF is available here.
PDF is available here.
Abstract
Tonin(Persicae Semen) is the herb medicine that contains amygdalin as a major ingredient. Amygdalin in water is decomposed into benzaldehyde, HCN, and glucose by emulsin, a hydrolysis enzyme in tonin. A useful and practical method for the optimum extraction condition of amygdalin without enzymatic h...
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PMID: 12214855
PDF is available here.
PDF is available here.
Abstract
There are many important considerations in the interactions among the herbal constituents in a prescription of traditional Chinese medicine (TCM). Ephedra Herb [Chinese characters: see text] (Eph) is described a warm and acrid agent in TCM. The combination of Eph and Gypsum [Chinese characters: see...
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PMID: 12132660
PDF is available here.
PDF is available here.
Abstract
Abstract
The relationship between the levels of cyanogenic compounds (amygdalin and prunasin) in kernels, leaves, and roots of 5 sweet-, 5 slightly bitter-, and 5 bitter-kernelled almond trees was determined. Variability was observed among the genotypes for these compounds. Prunasin was found only in the veg...
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PMID: 11902971
PDF is available here.
PDF is available here.
Diabetes self-management (19)4 2002
Abstract
Abstract
Results are presented that explore the possibility of organocyanide compounds in wastewater contributing to elevated cyanide levels in the chlorinated effluents of publicly owned treatment works. Four model compounds, acetonitrile, amygdalin, cyanocobalamin, and 2-acetoxy-3-butenenitrile, were selec...
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PMID: 11995867
PDF is available here.
PDF is available here.
Abstract
Randomized controlled trials are generally regarded as the standard of study designs to determine potential causality. The inclusion of a placebo group in these trials, when appropriate, is generally needed to access the efficacy of a drug or dietary supplement. The recent increasing use of dietary...
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PMID: 11769876
PDF is available here.
PDF is available here.
Journal of Chromatography A (923)1-2 2001
Abstract
A new capillary electrophoresis method was developed for the quantitative determination of the amygdalin epimers, amygdalin and neoamygdalin, which are biologically significant constituents in the crude drugs, namely Persicae Semen and Armeniacae Semen. The effects of surfactants, additives and othe...
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PMID: 11510547
PDF is available here.
PDF is available here.
FDA Consumer (35)2 2001
Abstract
Abstract
The separation of amygdalin, prunasin and their isomers neoamygdalin and sambunigrin could be achieved with micellar capillary electrophoresis (MEKC). The two isomers were obtained in alkaline conditions and were produced in less than 15 min at pH 11.0. The developed methods showed a good selectivit...
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PMID: 10744317
PDF is available here.
PDF is available here.
Abstract
Peptide T (pepT) is a segment of the human immunodeficiency virus (HIV) envelope protein gp120. The peptide competitively binds to the CD4 receptor of a subset of peripheral T lymphocytes and inhibits binding of gp120. Previous studies of this laboratory allowed the assessment of a bioactive form of...
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PMID: 10698109
PDF is available here.
PDF is available here.
Journal of Chromatography A (866)2 2000
Abstract
We have developed a simple, rapid and reproducible method for the determination of D-amygdalin and its epimer by using micellar electrokinetic chromatography (MEKC). Separation of D-amygdalin was performed in a 20 mM sodium borate buffer (pH 8.5) containing 300 mM sodium dodecyl sulfate using a bare...
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PMID: 10670815
PDF is available here.
PDF is available here.
Abstract
Strains of Lactobacillus plantarum, Leuconostoc mesenteroides, Candida tropicalis and Penicillium sclerotiorum were screened for 19 enzymatic activities using the commercial kit API zym (Bio Mérieux). This activity was compared to the ability of degrading the toxic cyanogenic glycosides amygdalin,...
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PMID: 10634708
PDF is available here.
PDF is available here.
Journal of Biochemistry (126)2 1999
Abstract
A DNA polymerase beta (pol. beta) inhibitor has been isolated independently from two organisms; a red perilla, Perilla frutescens, and a mugwort, Artemisia vulgaris. These molecules were determined by spectroscopic analyses to be the cyanogenic glucoside, D-mandelonitrile-beta-D-glucoside, prunasin....
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PMID: 10423540
PDF is available here.
PDF is available here.
Abstract
Effects of ephedrine, amygdalin, glycyrrhizin, gypsum and their combinations on body temperature and body fluid were studied in rats using the method developed in our previous reports. Ephedrine significantly increased respiratory evaporative water loss and heat loss in response to a marked elevatio...
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PMID: 10077436
PDF is available here.
PDF is available here.
Abstract
We describe a novel version of antibody-directed enzyme prodrug therapy (ADEPT), with the use of amygdalin as prodrug. Amygdalin is a naturally occurring cyanogenic glycoside, which can be cleaved by sweet almond beta-glucosidase to yield free cyanide. If amygdalin could be activated specifically at...
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PMID: 9833764
PDF is available here.
PDF is available here.
Abstract
We examined the induction of xenobiotic-metabolizing P450s by 12 plant toxins in rats, using hepatic activity for testosterone metabolism as the index. The compounds tested were aconitine, morphine, tubocurarine, physostigmine, pilocarpine, muscarine, cocaine, atropine, amygdalin, digitonin, nicotin...
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PMID: 9922942
PDF is available here.
PDF is available here.
Abstract
It is commonly accepted that bronchial asthma or rhinitis accompanies disorders in body fluids and body temperature. The effects of ephedrine and the traditional antiasthmatics "Makyo-kanseki-to" and "Goko-to" were therefore studied on such constitutional predispositions as insensible perspiration a...
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PMID: 9853407
PDF is available here.
PDF is available here.
Abstract
The geometrical features of the proposed bioactive conformation of peptide T assessed by computational methods in a previous study, together with available structure-activity studies on peptide T, led us to propose a pharmacophore for the CD4-peptide T interaction. Subsequent, data base searching pe...
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PMID: 9871541
PDF is available here.
PDF is available here.
Archives of Microbiology (169)2 1998
Abstract
Mucor circinelloides LU M40 and Penicillium aurantiogriseum P 35 produce extracellular beta-glycosidases that are active on the cyanogenic glycoside amygdalin. From the culture broths of M. circinelloides, only one beta-glycosidase could be identified, while two different enzymes - both having amygd...
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PMID: 9446681
PDF is available here.
PDF is available here.
Abstract
In our previous studies, the yeast Endomyces fibuliger LU677 was found to degrade amygdalin in bitter apricot seeds. The present investigation shows that E. fibuliger LU677 produces extracellular beta-glycosidase activity when grown in malt extract broth (MEB). Growth was very good at 25 degrees C a...
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PMID: 9534258
PDF is available here.
PDF is available here.
Abstract
The hydrophobicity values of hydrolyzable tannins were evaluated by measuring the distribution of the compounds between n-octanol and water. Of 8 gallotannins and 13 ellagitannins examined, pentagalloylglucose (7), the major polyphenol of Paeoniae Radix, showed the largest partition coefficient valu...
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PMID: 9433758
PDF is available here.
PDF is available here.