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Chloralose (0):
Recent article
Chloralose
Abstract
Inhibition of the commissural nucleus of the solitary tract (commNTS) induces a fall in sympathetic nerve activity and blood pressure in spontaneously hypertensive rats (SHR), which suggests that this subnucleus of the NTS is a source of sympathoexcitation. Exercise training reduces sympathetic acti...
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PMID: 20410480
PDF is available here.
PDF is available here.
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Abstract
We observed that the diameter of the major cerebral artery was approximately 100 microm under isoflurane, but approximately 75 microm under alpha-chloralose. The capillary diameter was observed to be larger under alpha-chloralose than isoflurane: 5.1 +/- 1.2 microm vs. 4.8 +/- 1.1 microm, respective...
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PMID: 20204771
PDF is available here.
PDF is available here.
Abstract
These results suggest a strong advantage for using isoflurane, as opposed to alpha-chloralose, when studying anesthetized rats for in vivo effects of psychostimulants....
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PMID: 19467261
PDF is available here.
PDF is available here.
Abstract
We investigated effects of H(2)O(2) alone or combined with the glutamatergic antagonist kynurenate into the NTS on mean arterial pressure (MAP) and heart rate (HR). Conscious or anesthetized (urethane and alpha-chloralose) male Holtzman rats (280-320 g) were used. Injections of H(2)O(2) (125 to 1500...
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PMID: 19515983
PDF is available here.
PDF is available here.
Neuroscience Letters (441)1 2008
Abstract
We performed electrophysiological recordings to examine the effects of alpha-chloralose on synaptic transmission, tetanic stimulation-induced gamma oscillations (30-80 Hz) and neuronal receptor function in rat hippocampal slices and dissociated hippocampal CA1 pyramidal neurons. The results demonstr...
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PMID: 18597935
PDF is available here.
PDF is available here.
Abstract
We aimed to examine the role of central 5-HT on normoxic and acute hypoxic ventilatory depression (AHVD) in peripheral chemoreceptors denervated rabbits. All experiments were performed in peripherally chemodenervated rabbits anesthetized with intravenous injection of urethane (400 mg/kg) and alpha-c...
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PMID: 18935908
PDF is available here.
PDF is available here.
Experimental Neurology (212)1 2008
Abstract
We systematically studied CSD susceptibility comparing commonly used experimental anesthetics (isoflurane, alpha-chloralose, and urethane) with or without N(2)O or normobaric hyperoxia (100% O(2) inhalation). The frequency of evoked CSDs, and their propagation speed, duration, and amplitude were rec...
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PMID: 18501348
PDF is available here.
PDF is available here.
Neuroscience Letters (433)1 2008
Abstract
We employed multiscale entropy (MSE) measurement to assess the long-range temporal correlation (LRTC) of multifibre renal sympathetic nerve activity (RSNA) signals in conscious and anaesthetized Wistar rats. It was found that both groups presented more complex MSE profiles than an uncorrelated proce...
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PMID: 18206307
PDF is available here.
PDF is available here.
Brain Research (1191) 2008
Abstract
alpha-Chloralose is widely used as an anesthetic in studies of the cerebrovasculature because it provides robust metabolic and hemodynamic responses to functional stimulation. However, there have been no controlled studies of focal ischemia in the rat under alpha-chloralose anesthesia. Artificially...
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PMID: 18096143
PDF is available here.
PDF is available here.
NeuroImage (39)2 2008
Abstract
Understanding the link between the hemodynamic response and the underlying neuronal activity is important for interpreting functional magnetic resonance (fMRI) signals in human and animal studies. Simultaneous electrophysiological and functional imaging measurements provide a knowledge of informatio...
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PMID: 17964186
PDF is available here.
PDF is available here.
Abstract
Patterns of neuronal activity in the spinal cord using functional magnetic resonance imaging during noxious (48 degrees C) and innocuous (40 degrees C) thermal stimulation of the rat forepaw were examined. The patterns of functional activity elicited by thermal stimuli were compared in alpha-chloral...
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PMID: 17587529
PDF is available here.
PDF is available here.
Abstract
Pentobarbital considerably reduced, whereas propofol did not significantly affect the incidence of dofetilide-induced torsades de pointes (TdP) as compared with the results with alpha-chloralose (40% (P=0.011) and 70% (P=0.211) vs 100%, respectively). In additional experiments, neither doubling of t...
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PMID: 17965737
PDF is available here.
PDF is available here.
Abstract
Two adult and 1 juvenile free-flying greater sandhill cranes (Grus canadensis tabida) were diagnosed with capture myopathy after alpha-chloralose baiting and physical capture during a banding and feeding ecologic study. Blood samples were collected for serum biochemical analysis at the time of captu...
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PMID: 18351009
PDF is available here.
PDF is available here.
Experimental Physiology (92)6 2007
Abstract
Cardiac vagal preganglionic neurones (CVPNs) show respiratory modulation in the nucleus ambiguus but not in the dorsal vagal nucleus. Both types of neurones can be activated by pulmonary C fibre afferents. Another brainstem area that has been identified as containing CVPNs is the intermediate zone b...
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PMID: 17644702
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of GAL on SP-induced or VIP-induced evoked tongue jerks (ETJ) in response to noxious tooth pulp stimulation during perfusion of the cerebral ventricles with SP or VIP solutions. The experiments were carried out on rats under chloralose anesthesia. It was shown that both, S...
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PMID: 17928644
PDF is available here.
PDF is available here.
Abstract
We studied the effects of ketamine and memantine, administered intravenously or intrathecally. Rats were maintained under alpha-chloralose plus xylazine or pentobarbitone anaesthesia; VMR and jejunal motility were measured. Under alpha-chloralose/xylazine anaesthesia, i.v. ketamine inhibited VMRs at...
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PMID: 17539896
PDF is available here.
PDF is available here.
Abstract
The cerebrovascular coupling under neuronal nitric oxide synthase (nNOS) inhibition was investigated in alpha-chloralose anesthetized rats. Cerebral blood flow (CBF), cerebral blood volume (CBV), and blood oxygenation level dependent (BOLD) responses to electrical stimulation of the forepaw were mea...
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PMID: 16883353
PDF is available here.
PDF is available here.
NeuroImage (34)4 2007
Abstract
We therefore suggest that halothane may be used as an anesthetic agent for chronic fMRI studies of the spinal cord....
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PMID: 17204434
PDF is available here.
PDF is available here.
Abstract
Cerebellar granule cell sensory responses are highly sensitive to ethanol inhibition. A rapid development of acute tolerance appears to be a major factor contributing to the dynamic and nonlinear relationship among ethanol dosage, CSF ethanol concentration, and granule cell responses. It is likely t...
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PMID: 17250627
PDF is available here.
PDF is available here.
Abstract
We recorded the renal sympathetic nerve responses to static contraction before and after injection of gadolinium into the arterial supply of the statically contracting triceps surae muscles of decerebrate unanesthetized and chloralose-anesthetized cats. Gadolinium has been shown to be a selective bl...
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PMID: 17012352
PDF is available here.
PDF is available here.
Abstract
Intravenous injection of cannabinoids dissolved in cremophore EL:ethanol:NaCl mixture and water-soluble emulsion of the same cannabinoids caused identical negative chronotropic effects in chloralose-narcotized rats. Selective CB1 and CB2 receptor antagonist HU-210 also induced a negative chronotropi...
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PMID: 17415434
PDF is available here.
PDF is available here.
NeuroImage (32)3 2006
Abstract
The significance of changes in cerebral oxygen consumption in focally activated brain tissue is still controversial. Since the rate of cerebral oxygen consumption is tightly coupled to that of tricarboxylic acid cycle which can be measured from the turnover kinetics of [4-(13)C]glutamate using in vi...
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PMID: 16797191
PDF is available here.
PDF is available here.
Abstract
Although anaesthetics are widely used to alleviate stress in endotoxaemic animals, these drugs themselves may interfere with the effects of lipopolysaccharide (LPS). The effects of LPS on serum glucose, biochemical markers of hepatic, renal and pancreatic exocrine function, and lung myeloperoxidase...
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PMID: 16867022
PDF is available here.
PDF is available here.
Veterinary Journal (172)1 2006
Abstract
Alpha-chloralose (AC) is an anaesthetic compound also used as a rodenticide, and has dose-dependent central nervous system mixed effects of excitation and depression. The objectives of this study were to detail the clinical and clinicopathological characteristics, as well as the treatment and progno...
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PMID: 16772135
PDF is available here.
PDF is available here.
Archives de Pédiatrie (13)4 2006
Abstract
We report a case of an accidental intoxication in a 20-month-old boy resulting from the ingestion of a rodenticide containing alpha-chloralose. CASE REPORT: Three hours after initial admission to the pediatric emergency department for wheezing bronchitis, this patient was readmitted with a clinical...
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PMID: 16531025
PDF is available here.
PDF is available here.
Inorganic Chemistry (45)7 2006
Abstract
Carbohydrate-based phosphoranes were synthesized by reacting 2,2'-ethylidenebis(4,6-di-tert-butylphenyl)fluorophosphite with 1,2-O-isopropylidene-alpha-D-glucofuranose, beta-chloralose, and 1,2-isopropylidene-alpha-D-xylofuranose to form the monocyclic biophosphoranes 1-3, respectively, in the prese...
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PMID: 16562968
PDF is available here.
PDF is available here.
NeuroImage (29)4 2006
Abstract
We therefore developed a new, totally noninvasive fMRI protocol, using sedation with the alpha2-adrenoreceptor agonist medetomidine in combination with transcutaneous monitoring of blood gases. The continuous subcutaneous administration of medetomidine resulted in stable physiological conditions ove...
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PMID: 16223588
PDF is available here.
PDF is available here.
Abstract
We investigated transient and steady state cardiovascular changes by combining the tilt technique with cardiovascular telemetry. Normotensive and NO-deprived hypertensive Wistar rats were used to analyze responses of mean arterial blood pressure, heart rate, contractility, spontaneous baroreflex sen...
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PMID: 16495768
PDF is available here.
PDF is available here.
Abstract
We implemented multimodal measurements of these parameters into a compartmental model of oxygen transport and metabolism (i.e., hemoglobin-bound oxygen, oxygen dissolved in plasma and tissue spaces, oxygen metabolized in the mitochondria). In the alpha-chloralose anesthetized rat brain, we used magn...
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PMID: 15973353
PDF is available here.
PDF is available here.
Neuroscience (137)2 2006
Abstract
We sought to gain insight into the neural actions of ABT-594, in vivo, by conducting functional magnetic resonance imaging in awake and anesthetized rats. Using T(2)*-weighted gradient echo imaging and an ultrasmall superparamagnetic iron oxide contrast agent, functional imaging was conducted on a 4...
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PMID: 16289887
PDF is available here.
PDF is available here.
Abstract
Evoked neural activity (ensemble single-unit activity and evoked field potential) and functional magnetic resonance imaging (fMRI) changes of the primary somatosensory cortex in response to electrical stimulation of the hind paw were studied in rats under anesthesia. The effects of stimulation frequ...
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PMID: 16548422
PDF is available here.
PDF is available here.
NeuroImage (28)2 2005
Abstract
We report metabolic responses of rat somatosensory cortex to forepaw stimulation in alpha-chloralose-anesthetized rats. The phosphocreatine/creatine ratio was found to be significantly decreased by 15.1 +/- 4.6% (mean +/- SEM, P < 0.01). Lactate remained very low (approximately <0.3 micromol/g w/w)...
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PMID: 16182571
PDF is available here.
PDF is available here.
Abstract
Eight types of peaks were revealed in the cardiac rhythm spectrum during acute experiments on vagotomized cats. Some peaks had no physiological nature and resulted from specificity of ECG processing by Fourier analysis, while others reflected myogenic reaction of the sinoatrial node (length-dependen...
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PMID: 16671555
PDF is available here.
PDF is available here.
Abstract
We demonstrate an in vivo multiple sampling microdialysis system coupled with liquid chromatography for cocaine assay and verified by tandem mass spectrometry. Three microdialysis probes were concurrently inserted into the jugular vein, bile duct and brain striatum of each anesthetized rat. After a...
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PMID: 15651094
PDF is available here.
PDF is available here.
Abstract
We used normotensive and hypertensive Wistar rats to analyze responses and diurnal variations of arterial blood pressure, heart rate, temperature, and locomotor activity by telemetry. Orthostatic tests were carried out during 45 degrees head-up tilt (R, repeated 3 times for 5 minutes; or S, sustaine...
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PMID: 15772525
PDF is available here.
PDF is available here.
NeuroImage (24)1 2005
Abstract
We have used a rat model of direct cortical stimulation to investigate the effects of anesthesia in rodent fMRI. Specifically, we have sought to answer two questions (i) what is the relationship between baseline neuronal activity and the BOLD response to stimulation under halothane anesthesia? And (...
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PMID: 15588600
PDF is available here.
PDF is available here.
Journal of Anesthesia (19)2 2005
Abstract
In normal myocardium, intracoronary infusion of propofol at doses of 1.2 and 2.4 mg x kg(-1) x h(-1) caused slight decreases in %SS to 83% +/- 8% and 80% +/- 10%, respectively. In ischemic myocardium, propofol caused greater decreases in %SS (59% +/- 18% and 35% +/- 20%, respectively). The changes i...
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PMID: 15875131
PDF is available here.
PDF is available here.
Journal of Neuroscience Research (79)1-2 2005
Abstract
We found that: (1) the ratio between the enrichment of alanine C3 and that of glutamate C4, gamma-aminobutyric acid (GABA) C2, glutamine C4, or aspartate C3 decreased from pentobarbital to alphachloralose and morphine whatever the labeled precursor, indicating a link between metabolic and cerebral a...
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PMID: 15558748
PDF is available here.
PDF is available here.
Abstract
Esmolol and dexmedetomidine decreased two haemodynamic indices of overall myocardial oxygen demand to a similar extent but neither drug decreased directly measured myocardial oxygen consumption in the territory of the left anterior descending artery....
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PMID: 15719859
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (279)46 2004
Abstract
Brain metabolism of glucose and lactate was analyzed by ex vivo NMR spectroscopy in rats presenting different cerebral activities induced after the administration of pentobarbital, alpha-chloralose, or morphine. The animals were infused with a solution of either [1-(13)C]glucose plus lactate or gluc...
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PMID: 15361523
PDF is available here.
PDF is available here.
Abstract
Mice that lack or over-express a gene of interest are important tools for unraveling gene function. The determination of single nephron function by micropuncture or precise determination of glomerular filtration rate (GFR) by inulin clearance method require experiments under anesthesia. A good anest...
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PMID: 15549274
PDF is available here.
PDF is available here.
Abstract
Chloralose poisoning especially leads to consciousness failure and hyperexcitability with typical myoclonic jerks. In an observation of chloralose poisoning by ingestion of synthetic substance against moles, curarization by cistracurium besylate was proposed to contribute in the symptomatic treatmen...
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PMID: 15120781
PDF is available here.
PDF is available here.
Abstract
Electrical discharges in the cervical sympathetic trunk and arterial blood pressure were recorded in chloralose-anaesthetized Wistar rats. Some experiments were performed in rats with impaired baroreceptor reflex. The efferent electrical activity was analysed in amplitude and frequency domain. It ha...
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PMID: 15296064
PDF is available here.
PDF is available here.
Journal of Physiology (555)Pt 2 2004
Abstract
Non-noxious cooling stimuli were delivered to the shaved back of urethane-chloralose-anaesthetized, artificially ventilated rats using a plastic bag containing water at 24-40 degrees C. Cooling of the skin by 2-6 degrees C increased the rate of whole body oxygen consumption (.V(O(2)) and triggered e...
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PMID: 14578483
PDF is available here.
PDF is available here.
Abstract
The proarrhythmic effects of fluoroquinolone antibacterial agents, sitafloxacin, gatifloxacin and moxifloxacin, were compared using three in vivo models. In the halothane-anesthetized dogs (n=5), intravenous 10-min infusion of gatifloxacin and moxifloxacin (1-3 mg/kg) prolonged the ventricular effec...
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PMID: 14975708
PDF is available here.
PDF is available here.
Abstract
We studied the forces produced at the cat's hindpaw by microstimulation of the ipsi- and contralateral lumbar spinal cord in spinal intact alpha-chloralose anesthetized (n = 3) or decerebrate (n = 3) animals. Isometric force and EMG responses were measured at 9-12 limb configurations, with the paw a...
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PMID: 14523079
PDF is available here.
PDF is available here.
Abstract
We made 188 successful captures of 166 different greater sandhill cranes (Grus canadensis tabida) through experimental use of alpha-chloralose (AC). Most captures took place during September (72.3%; n = 136), followed by August (14.9%; n = 28), and October (12.8%; n = 24). Territorial pairs were cap...
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PMID: 14733281
PDF is available here.
PDF is available here.
Neuropharmacology (45)3 2003
Abstract
We have now investigated this question by comparing the antinociceptive effects of i.v. NCX-701 and paracetamol in monoarthritic rats under alpha-chloralose anesthesia. The influence of spinalization on the effects of NCX-701 was also studied. NCX-701 and paracetamol were equipotent in reducing sing...
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PMID: 12871658
PDF is available here.
PDF is available here.
Abstract
Abstract
I investigated whether muscular contraction evokes cardiorespiratory increases (exercise pressor reflex) in alpha-chloralose- and chloral hydrate-anesthetized and precollicular, midcollicular, and postcollicular decerebrated rats. Mean arterial pressure (MAP), heart rate (HR), and minute ventilation...
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PMID: 12543631
PDF is available here.
PDF is available here.
Abstract
We tested the hypothesis that intracerebroventricular (lateral ventricle) administration of interleukin-1beta (IL-1beta) antibody increases the level of sympathetic nerve discharge (SND) in alpha-chloralose-anesthetized rats. Mean arterial pressure (MAP), heart rate (HR), and SND (splenic and renal)...
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PMID: 12531724
PDF is available here.
PDF is available here.
Abstract
Alpha-chloralose, a compound widely used as a rodenticide and in the control of bird pests, is readily available. Two cases of intentional poisoning are reported. Both patients became comatose and presented hypersialorrhea and myoclonal crises in the legs. They were discharged from hospital after se...
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PMID: 12731657
PDF is available here.
PDF is available here.
Cardiovascular Research (55)1 2002
Abstract
Compared to the controls, NA markedly reduced the severity of ventricular arrhythmias resulted from coronary artery occlusion and increased survival (to 40%) following reperfusion; there were no survivors in the control group. Noradrenaline released endogenously following guanethidine administration...
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PMID: 12062708
PDF is available here.
PDF is available here.
Abstract
Our aim was to characterize the autonomic modulation before and after cardiac autonomic blockade and during baroreflex function tests. The instantaneous power of decomposed low-frequency (LF) and high-frequency (HF) components was used for a time-variant spectral analysis. Our results suggested that...
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PMID: 12083299
PDF is available here.
PDF is available here.
Brain Research (939)1-2 2002
Abstract
These results suggest that i.c.v. administered SIN-1 activates central noradrenergic neurons innervating the PVN by prostaglandin-mediated mechanisms. Released noradrenaline in the PVN elevates plasma levels of corticosterone via an activation of the central alpha-adrenoreceptors in rats....
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PMID: 12020848
PDF is available here.
PDF is available here.
Abstract
We studied the dose-effects of thoracic epidural and intravenous clonidine (1 to 8 microg/kg) on cardiac sympathetic nerve activity (CSNA), hemodynamics and intracardiac conduction in cats anesthetized with alpha-chloralose. Mean arterial pressure was decreased with epidural clonidine doses above 2...
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PMID: 12375697
PDF is available here.
PDF is available here.
Cephalalgia (22)5 2002
Abstract
I and II of the entire brain stem from the area postrema to C2 level, being maximum at the decussatio pyramidum level. The area postrema, solitary tract, medullary and lateral reticular nuclei were also labelled. The 5-hydroxytryptamine(1B/1D/1F) receptor agonist sumatriptan (0.01, 0.1, 1 and 10 mg/...
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PMID: 12110114
PDF is available here.
PDF is available here.
Abstract
We compared two commonly used anesthetic treatments, urethane alpha-chloralose (U-alphaCh; 968 mg U and 65 mg alphaCh/kg) and 2,2,2-tribromoethanol (TBE; 435 mg/kg) and fentanyl fluanisone midazolam (FFM; 3.313 mg fentanyl, 104.8 mg fluanisone, and 52.42 mg midazolam/kg) with respect to mean arteria...
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PMID: 12051657
PDF is available here.
PDF is available here.
Abstract
These results demonstrate that GLP-1-(9-36) amide neither stimulates insulin secretion nor antagonizes the insulinotropic effect of GLP-1-(7-36) amide in vivo. Moreover, the metabolite itself possesses anti-hyperglycemic effects, supporting the hypothesis that selective DPP IV action is important in...
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PMID: 11882507
PDF is available here.
PDF is available here.
Abstract
Our purpose was to determine the role of N-methyl-D-aspartate (NMDA) receptors in modulating early R1 responses (at 9 ms) and/or later more prolonged R2 responses (at 36 ms) during electrical stimulation of the laryngeal afferent fibers contained in the internal branch of the superior laryngeal nerv...
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PMID: 11877499
PDF is available here.
PDF is available here.