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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Etoposide (0):
Recent article
Etoposide
Abstract
The prognosis for patients with extensive-stage small cell lung cancer remains poor. This trial was designed to evaluate the efficacy and toxicity of maintenance sunitinib after platinum-etoposide chemotherapy.
Patients who demonstrated objective tumor response or sta...
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PMID: 21512407
PDF is available here.
PDF is available here.
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Acta clinica Belgica (66)4 2011
Abstract
Our study suggests that long-term survival can be obtained by means of HDCT for metastatic germ cell tumours, even in patients with bad prognostic features at diagnosis. The question of whether to use 1 or 2 cycles of HDCT still remains unanswered....
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PMID: 21938979
PDF is available here.
PDF is available here.
Abstract
Our patient underwent a rigorous chemotherapeutic regimen followed by peripheral blood stem cell transplant, and as of August 2010, (17 months after initial diagnosis), the patient has had no recurrence....
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PMID: 21117517
PDF is available here.
PDF is available here.
Abstract
I on genetic testing. Chest CT revealed a mediastinal mass 4 cm in maximum dimension, and an atypical carcinoid was diagnosed according to mediastinal biopsy findings. Bone metastasis was detected and he was given cisplatin and etoposide. The tumor decreased in size by 30%, and was evaluated as show...
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PMID: 21141066
PDF is available here.
PDF is available here.
Anti-Cancer Drugs (21)10 2010
Abstract
I trial was carried out to determine the recommended duration of oral etoposide in combination with a fixed dose of carboplatin. Nineteen patients with varied solid tumors, who were not candidates for standard chemotherapy, were administered an escalating duration (6, 9 or 12 consecutive days) of or...
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PMID: 20856105
PDF is available here.
PDF is available here.
Neurological Surgery (38)11 2010
Abstract
The adverse effects of combination chemotherapy of ifosfamide, cisplatin, and etoposide (ICE) were evaluated in the treatment of various intracranial brain tumors.
108 cases were retrospectively reviewed. The histological diagnosis was newly diagnosed or recurrent germ cell tumor in 45 cases, medull...
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PMID: 21081811
PDF is available here.
PDF is available here.
New England Journal of Medicine (363)14 2010
Abstract
A very high rate of survival among patients with intermediate-risk neuroblastoma was achieved with a biologically based treatment assignment involving a substantially reduced duration of chemotherapy and reduced doses of chemotherapeutic agents as compared with the regimens used in earlier trials. T...
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PMID: 20879880
PDF is available here.
PDF is available here.
European Journal of Cancer (46)15 2010
Abstract
We have examined the contribution of epigenetic modulation of gene expression in the potentiation of etoposide-mediated cytotoxicity in neuroblastoma cells. Specifically, we studied the effects of histone deacetylase inhibition with valproic acid on topoisomerase II gene expression and apoptosis in...
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PMID: 20886683
PDF is available here.
PDF is available here.
Anticancer Research (30)10 2010
Abstract
Platinum-based chemotherapy represents the standard of care for advanced non-small cell lung cancer (NSCLC) while non-platinum-based regimens are frequently administered in patients with relapse. A retrospective analysis of the sequence administration of these regimens in the first- and second-line...
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PMID: 21036760
PDF is available here.
PDF is available here.
Anticancer Research (30)10 2010
Abstract
We investigated 147 patients suffering from Hodgkin's disease after a follow-up of at least 5 years from the completion of CT-RT. Seventy-eight patients were submitted to ABVD-RT, 36 to VEBEP-RT and 33 to MOPP-ABVD-RT. Patients underwent spirometry, 2D-doppler echocardiography at rest, cardiopulmona...
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PMID: 21036768
PDF is available here.
PDF is available here.
Abstract
Abstract
Of 73 patients, 26 received CY/E/TBI and 47 received BEAM. The median follow-up for the CY/E/TBI group was 12.0 years and for the BEAM group was 7.3 years. After PBSCT, no differences in acute toxicity were seen between the two groups. The 5-year disease relapse-free survival rate was 50.0% and 50.7...
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PMID: 20137862
PDF is available here.
PDF is available here.
Abstract
We here observed that nuclear translocation of TPPII was dependent on signaling by MAP kinases, including p38MAPK. Further, this was caused by several types of DNA-damaging drugs, a DNA cross-linker (cisplatinum), an inhibitor of topoisomerase II (etoposide), and to some extent also by nucleoside-an...
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PMID: 20643100
PDF is available here.
PDF is available here.
Abstract
We investigated how the combinatorial effect of the location of injection and procedural differences affected xenograft characteristics. Patient-derived breast cancer cells were injected into mouse abdominal or thoracic mammary glands +/- estrogen and/or etoposide pretreatment. Abdominal xenografts...
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PMID: 20578247
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
The p53 tumor suppressor is negatively regulated by murine double minute 2 (MDM2), which binds to p53 and promotes p53 ubiquitination and degradation. MDM2 inhibitor-219 (MI-219), a small molecule MDM2 inhibitor, was recently reported to disrupt p53-MDM2 binding, leading to p53 activation and suppre...
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PMID: 20944104
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
Between 2003 and 2009, 61 patients were enrolled. In terms of PSA levels, >70% of patients showed a >50% reduction (complete response [CR] 51%, partial response 23%) and >90% showed a clinical response. Of 58 patients with measurable lesions, 24% (14/58) showed a CR, and most of these patients (13/1...
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PMID: 20944163
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
The expression of P-gp was clearly inhibited by verapamil in all four cell lines. Following pretreatment with verapamil, NCI-H-446 was more sensitive to cisplatin, while SPCA-1, NCI-H-460 and NCI-H-446 were more sensitive to VP-16 compared to the control. CONCLUSION: Down-regulation of P-gp is assoc...
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PMID: 20944142
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
Desmoplastic small round cell tumour (DSRCT) is a rare tumour, usually arising in the abdominal cavity. DSRCT remains an aggressive malignancy, with a poor prognosis despite multi-modality treatments. In the published literature, there has been no patient who lived for three years or more without su...
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PMID: 20944167
PDF is available here.
PDF is available here.
Infection and Immunity (78)8 2010
Abstract
We have shown that E. coli penetration into the brain requires E. coli invasion of human brain microvascular endothelial cells (HBMEC), which constitute the blood-brain barrier. E. coli invasion of HBMEC involves its interaction with HBMEC receptors, such as E. coli cytotoxic necrotizing factor 1 (C...
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PMID: 20515928
PDF is available here.
PDF is available here.
Nutrition and Cancer (62)6 2010
Abstract
We concluded that genistein-based therapy may have antagonistic effects when combined with mitotic poisons. The proposed therapeutic strategy allows protection of p53 wild type cells from taxol and selectively increases apoptosis in p53-deficient cells. This strategy exploits the naturally occurring...
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PMID: 20661829
PDF is available here.
PDF is available here.
Biotechnology Letters (32)8 2010
Abstract
We assessed the pulse width of the propidium iodide fluorescence signal. The anti-cancer drug etoposide is reportedly cytostatic, can induce a strong G2/M arrest, and results in nuclear enlargement. Based on these characteristics, we used etoposide-treated HCT116 cells as our experimental model syst...
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PMID: 20429026
PDF is available here.
PDF is available here.
Cancer Letters (294)1 2010
Abstract
We have found that KG-135 potentates cytotoxicity of etoposide by modulating apoptotic signaling. Co-treatment of etoposide and KG-135 markedly elevated the expression and phosphorylation at the serine 15 residue of p53 as well as the cellular levels of Bax and p21(Waf1/Cip1). The increased accumula...
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PMID: 20226587
PDF is available here.
PDF is available here.
Cancer Letters (295)1 2010
Abstract
We investigate the activation of the NF-kappaB and Akt pathways by two frontline anticancer drugs cisplatin and etopside in a variety of cancer cell lines. The effects of blocking these two survival pathways individually or concurrently on cisplatin- or etopside-induced cytotoxicity were detected. T...
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PMID: 20207071
PDF is available here.
PDF is available here.
Journal of Urology (184)1 2010
Abstract
Management for unresectable late relapse germ cell tumors remains controversial. High dose chemotherapy followed by resection of all residual lesions can result in long-term remission in individuals.
Copyright (c) 2010 American Urological Association Education and Research, Inc. Published by Elsevie...
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PMID: 20483152
PDF is available here.
PDF is available here.
Abstract
This experience confirms that a subset of young AT/RT patients may achieve long-term survival with intensive and high-dose chemotherapy. The role of radiotherapy is still unclear. However, evidence of neuro-cognitive impairment even in the absence of radiotherapy in this young population suggests th...
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PMID: 20495479
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
We hypothesized that single-dose pegfilgrastim would mimic multiple daily doses of filgrastim, resulting in an equivalent shortening of post-PBSCT neutropenia.
Patients who were eligible for PBSCT and aged >or= 18 years were identified before high-dose chemotherapy, after the harvest...
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PMID: 20511163
PDF is available here.
PDF is available here.
Cancer/Radiothérapie (14)3 2010
Abstract
We report the case of a 66-year-old patient with a pilomatrix carcinoma from the right submandibular region with pulmonary and cerebral metastases. The histological confirmation of the diagnosis has been based on the biopsy of the submandibular tumefaction which was rapidly growing. We tried at firs...
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PMID: 20434933
PDF is available here.
PDF is available here.
Nucleic Acids Research (38)11 2010
Abstract
We report that excess Prep1 increases the sensitivity of cells to genotoxic stress and the extent of the apoptosis directly correlates with the level of Prep1. The apoptotic response of Prep1-overexpressing cells is mediated by the pro-apoptotic p53 protein that we show is a direct target of Prep1,...
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PMID: 20110257
PDF is available here.
PDF is available here.
Anticancer Research (30)6 2010
Abstract
There was no significant difference between NMT-1 cells and NMT-1R cells in sensitivity to high-LET heavy-ion irradiation. The RBE of carbon beam was larger in mutant-type p53 cells than in wild-type p53 cells. Etoposide showed a supra-additive effect in combination with carbon beam irradiation in N...
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PMID: 20651340
PDF is available here.
PDF is available here.
Abstract
We retrospectively evaluated the safety and efficacy of the treatment in these 12 patients based on clinical imaging and laboratory data. The median age of patients was 82. 5 years(range: 80-89); PS 1/2/3/4, 6/3/1/2; Clinical stageIIIB/IV, 2/9; treatment with BSC/CE/Amurubicin, 5/6/1. All 6 patients...
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PMID: 20567104
PDF is available here.
PDF is available here.
Abstract
Our study assessed consolidation with either gemcitabine alone or with docetaxel after identical chemoradiation as used in Southwest Oncology Group 9504.
Patients with stage III non-small cell lung cancer and good performance status were included. Treatment consisted of concurrent ci...
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PMID: 20354453
PDF is available here.
PDF is available here.
Abstract
We report that stimulation of DAOY with HGF resulted in the protection of these cells against etoposide-induced apoptosis, this anti-apoptotic effect being correlated with an increase in the expression of tissue factor (TF), the initiator of the extrinsic pathway of coagulation. HGF-mediated protect...
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PMID: 19921488
PDF is available here.
PDF is available here.
Abstract
Median age was 49. All but three patients received prior treatment with doxorubicin and/or ifosfamide. One patient (4%) had partial response and 11 patients (42%) had stable disease for more than 24 weeks. The 6-month and the 1-year progression-free survival rates were 42% [95% CI: 23; 61] and 23% [...
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PMID: 20182726
PDF is available here.
PDF is available here.
Journal of Ethnopharmacology (128)3 2010
Abstract
We suggest that the flavonoids isolated from F I and II (vitexin, isovitexin, rhamnopyranosylvitexin and isoembigenin) contribute to the anti-MPO activity, as well as to their anti-Helicobacter pylori activity. These flavonoids may also be responsible for the important inhibition of H(+), K(+)-ATPas...
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PMID: 20152892
PDF is available here.
PDF is available here.
Abstract
Overall response rate (ORR) and complete response (CR) were similar among ESHAP and R-ESHAP (ORR, 33 patients [62%] and 28 patients [60%], respectively; CR, 20 patients [37%] and 18 patients [36%], respectively). Actuarial curves at 5 years showed that progression-free survival (PFS) and overall sur...
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PMID: 20371445
PDF is available here.
PDF is available here.
Seminars in Hematology (47)2 2010
Abstract
Several recent studies have reported the phenomenon of late-onset neutropenia occurring usually several months following the administration of rituximab or rituximab-based therapies. While it appears that late-onset neutropenia is usually not clinically significant and is self-limited, it is importa...
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PMID: 20350665
PDF is available here.
PDF is available here.
Abstract
We report a case with severe multiple liver metastases after surgery for right renal PNET. The patient was a 21-year-old man with a chief complaint of right abdominal pain. Hemorrhage in a right renal malignant tumor was diagnosed, and radical nephrectomy was performed. Histopathology showed bare nu...
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PMID: 20186557
PDF is available here.
PDF is available here.
Abstract
We planned a bone marrow transplantation (BMT) from an HLA-haploidentical sibling donor. He was moved to the Department of Hematology, Hyogo Medical College, to receive this BMT as part of a clinical trial. During the conditioning procedure for the transplantation, however, he died of septicemia. Si...
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PMID: 20217452
PDF is available here.
PDF is available here.
Abstract
We performed a detailed documentation of the pedigree of an LFS family with a comprehensive analysis of genotype-phenotype correlations. We sequenced the TP53 gene and verified that the proband carries a germline nonsense mutation in codon 146 in one allele, the TP53Arg72Pro polymorphism in the seco...
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PMID: 20198344
PDF is available here.
PDF is available here.
Leukemia & Lymphoma (51)4 2010
Abstract
Abstract
We investigated the anti-cancer effects of downregulating survivin by shRNA vector pSUPER-sh in combination with chemotherapeutic drugs on human osteosarcoma cells.
Expression of survivin was detected by Western blot. The effects of pSUPER-sh and chemotherapeutic drugs on osteosarcoma cell lines Sao...
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PMID: 20682173
PDF is available here.
PDF is available here.
Annals of Oncology (21)4 2010
Abstract
The PET weekly regimen significantly improves both DMFS and OS in LABC patients, compared with the triweekly ET combination. The therapeutic advantage is limited to patients with highly aggressive tumours....
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PMID: 19815652
PDF is available here.
PDF is available here.
Bulletin du cancer (97)4 2010
Abstract
We distinguish four groups: group 1 (0 factor and age < 70 years), group 2 (1-3 factors and age < or = 60 years), group 3 (1-3 factors and age between 61 and 70 years) and group 4 (1-3 factors and age > 70 years). The patients of group 1 (N = 47) received 3 courses of CHOP regimen followed by irradi...
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PMID: 20374978
PDF is available here.
PDF is available here.
Abstract
Abstract
We reviewed the cases in our database from October 1995 to January 2009 and retrospectively examined the clinical data of patients, with unresectable or recurrent poorly differentiated neuroendocrine carcinoma arising from the hepatobiliary tract and pancreas, who received combination chemotherapy w...
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PMID: 20047862
PDF is available here.
PDF is available here.
Abstract
Inter-occasion variability in MTT was significant for all the investigated datasets, except for topotecan, and was of similar magnitude (8-16 CV%). IOV in slope was significant for docetaxel, topotecan, and etoposide (19-39 CV%). For all six investigated datasets, the IOV in myelosuppression paramet...
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PMID: 19680655
PDF is available here.
PDF is available here.
Abstract
We describe a series of 13 patients treated with intensive chemotherapy, defined as the intention to include high-dose chemotherapy with autologous hematopoietic stem cell rescue.
Induction chemotherapy generally included vincristine, cisplatin or carboplatin, cyclophosphamide, and e...
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PMID: 19908299
PDF is available here.
PDF is available here.
Abstract
Our results indicate that, at the present time, standard treatment for CNS GCT continues to include irradiation either alone or combined with chemotherapy for pure germinomas and with chemotherapy for those with MMGCT.
Copyright 2009 Wiley-Liss, Inc....
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PMID: 20063410
PDF is available here.
PDF is available here.
Abstract
We use mass spectrometry-based proteomics to provide an unbiased, quantitative, and high throughput approach for measuring the subcellular distribution of the proteome, termed "spatial proteomics." The spatial proteomics method analyzes a whole cell extract created by recombining differentially labe...
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PMID: 20026476
PDF is available here.
PDF is available here.
Abstract
We previously showed that nicotine enhances growth and proliferation in lung cancer. However, the effects of nicotine, a tobacco carcinogen that inhibits apoptosis, have not been studied before in nasal epithelial carcinoma (NC). In this study, we sought to determine the effects of nicotine on chemo...
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PMID: 20338106
PDF is available here.
PDF is available here.
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine (12)1 2010
Abstract
We describe a 44-year-old man who developed toxic shock syndrome caused by hospitalacquired methicillin-resistant Staphylococcus aureus while pancytopenic after chemotherapy. He died of multiorgan failure despite high-level intensive care support and treatment with appropriate antibiotics and intrav...
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PMID: 20196714
PDF is available here.
PDF is available here.
Abstract
We retrospectively analyzed our therapeutic results of advanced male germ cell tumors in terms of efficacy and feasibility of our treatment strategy.
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PMID: 20387513
PDF is available here.
PDF is available here.
Abstract
A 37-year-old man with the chief complaints of lumbago and fever is presented. Laboratory data showed the extreme elevation of alfa feto-protein (AFP), human chorionic gonadotropin (hCG) and lactate dehydorgenase (LDH). Computed tomography (CT) scan revealed a huge retroperitoneal tumor with multiple...
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PMID: 20387517
PDF is available here.
PDF is available here.
Abstract
A 29-year-old man was admitted to our hospital due to bilateral testicular tumors. The bilateral testicular tumors were palpated and visualized by ultrasound and magnetic resonance imaging (right 8 cm, left 6 cm in diameter). Bilateral high orchiectomies were performed after frozen storage of the spe...
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PMID: 20387519
PDF is available here.
PDF is available here.
Abstract
We report two highly refractory patients with HL who successfully responded to a combination of thalidomide, cyclophosphamide and dexamethasone (ThaCyDex). Despite the use of a very large number of different drugs (>5 different schemes) including high-dose therapy and autologous and allogeneic stem...
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PMID: 19912314
PDF is available here.
PDF is available here.
Abstract
Abstract
Journal of Chemotherapy (22)1 2010
Abstract
We introduced the modified R-ESHAP regimen in which cisplatin was switched to carboplatin. we evaluated the safety and effectiveness of this modified regimen by reviewing the records of 35 patients who had been administered R-ESHAP. Our cohort included 21 patients with diffuse large b cell lymphoma...
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PMID: 20227994
PDF is available here.
PDF is available here.