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Methylglucosides (1):
Recent article
Methylglucosides
Abstract
Amide cis-trans isomerization (CTI) in methyl 2-deoxy-2-acylamido-d-glucopyranosides was investigated by (1)H and (13)C NMR spectroscopy. Singly (13)C-labeled methyl 2-deoxy-2-formamido-d-glucopyranoside (MeGlcNFm) anomers provided standard (1)H and (13)C chemical shifts and (1)H-(1)H and (13)C-(13)...
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PMID: 20225805
PDF is available here.
PDF is available here.
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Abstract
Our analysis identified nine of the 11 consensus sequence sites, and all were found to be glycosylated. This constitutes a remarkably high glycosylation density in the C-terminal domain averaging one site for each stretch of 30-40 residues. Each of the glycosylation sites observed was shown to be mo...
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PMID: 20936123
PDF is available here.
PDF is available here.
Biotechnology Letters (31)9 2009
Abstract
Alkyl glucosides were synthesized by the reaction of Leuconostoc mesenteroides dextransucrase with sucrose and various alcohols. Alkyl alpha-D-glucosides were obtained with a yield of 30% (mol/mol) with primary alcohols, but secondary alcohols or tertiary alcohols gave yields below 5%. The optimal y...
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PMID: 19458920
PDF is available here.
PDF is available here.
Abstract
Abstract
Fragmentation of lithium cation-attached alpha- and beta-O-methyl-glucopyranoside precursor ions, formed by electrospray ionization (ESI) and trapped in a Fourier transform ion cyclotron resonance (FTICR) mass spectrometer, was produced by infrared radiation from a tunable CO(2) laser. Irradiation o...
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PMID: 19125567
PDF is available here.
PDF is available here.
Abstract
The ion-trap technique is an experimental approach allowing measurement of changes in ionic concentrations within a restricted space (the trap) comprised of a large-diameter ion-selective electrode apposed to a voltage-clamped Xenopus laevis oocyte. The technique is demonstrated with oocytes express...
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PMID: 18829896
PDF is available here.
PDF is available here.
Abstract
Our new data suggest that behaviorally critical neurocircuits of the lateral hypothalamus contain glucose detectors that exhibit novel sugar selectivity and can operate independently of glucose metabolism....
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PMID: 18591392
PDF is available here.
PDF is available here.
Journal of Antibiotics (61)10 2008
Abstract
We have now discovered two compounds, KS-505a and alazopeptin, which exhibit moderate antitrypanosomal characteristics. We report here the in vitro and in vivo antitrypanosomal activities and cytotoxicities of KS-505a and alazopeptin, compared with some commonly-used antitrypanosomal drugs. This is...
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PMID: 19168977
PDF is available here.
PDF is available here.
Medical Physics (35)8 2008
Abstract
The authors developed a transmission-dispersion model to estimate dispersion in blood sampling systems and to calculate dispersion-free input functions needed for kinetic analysis. Transport of molecules through catheters was considered in two parts: a central part with convective transmission of mo...
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PMID: 18777907
PDF is available here.
PDF is available here.
Abstract
We utilized a catabolite repressor to improve the enzymatic activity of recombinant beta-galactosidase inclusion bodies (IBs) produced in Escherichia coli under the araBAD promoter system. Specifically, we employed methyl alpha-D: -glucopyranoside (alpha-MG) to lower the transcription rate of the be...
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PMID: 18317827
PDF is available here.
PDF is available here.
Abstract
We used cysteine-scanning mutagenesis and chemical modification by methanethiosulfonate (MTS) derivatives to test whether predicted transmembrane IV participates in sugar binding. Five charged and polar residues (K139, Q142, T156, K157, and D161) and two glucose/galactose malabsorption missense muta...
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PMID: 18448629
PDF is available here.
PDF is available here.
Biophysical Chemistry (134)3 2008
Abstract
These results may be generalized to other methylations in methanol-water systems, where methanol positively affects synthesis yields. Pressure had a small, negative effect on synthesis yields....
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PMID: 18329783
PDF is available here.
PDF is available here.
Journal of Membrane Biology (223)2 2008
Abstract
We have examined the underlying mechanism using, as a model system, glucose and indican (indoxyl-beta-D-glucopyranoside) transport by human Na+/glucose cotransporter (hSGLT1). Indican is transported by hSGLT1 at 10% of the rate for glucose but with a fivefold higher apparent affinity. We expressed w...
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PMID: 18592293
PDF is available here.
PDF is available here.
Abstract
Our results showed that when OV-16 was orally administered, free forms of OV-16, PCA, and HBA were not present in blood and the major metabolites were the glucuronides/sulfates of PCA and HBA sulfate. The serum metabolites of OV-16 exhibited free radical scavenging activity. When oregano decoction w...
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PMID: 18376843
PDF is available here.
PDF is available here.
Abstract
Duodenal biopsies accumulated 249.84+/-35.49 (SEM) picomoles AMG/microg DNA (n=12), gastric fundus biopsies 36.20+/-6.62 (n=12), normal esophagus 12.10+/-0.59 (n=3) and Barrett's metaplasia 29.79+/-5.77 (n=8). There was a statistical difference (P<0.01) between biopsies from duodenum and each other...
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PMID: 18322949
PDF is available here.
PDF is available here.
Journal of Bacteriology (190)3 2008
Abstract
RNA polymerase is a central macromolecular machine controlling the flow of information from genotype to phenotype, and insights into global transcriptional regulation can be gained by studying mutational perturbations in the enzyme. Mutations in the RNA polymerase beta subunit gene rpoB causing resi...
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PMID: 17644585
PDF is available here.
PDF is available here.
Carbohydrate Research (343)1 2008
Abstract
A concise synthesis of d-desosamine has been accomplished in five steps and in 15% overall yield from methyl alpha-d-glucopyranoside. Desosamine was then transformed into two known 2-thiopyrimidinyl donors (Woodward and Tatsuta donors), each in two steps. Finally, analogues of methyl desosaminide at...
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PMID: 17977522
PDF is available here.
PDF is available here.
Carbohydrate Research (342)18 2007
Abstract
We report the crystal structure of the bisdiolatoborate Na2[B(Me alpha-D-Glcp4,6H(-2))(Me alpha-D-Glcp3,4,6H(-3))].NaOH.8H2O (1) along with a combined 11B and 13C NMR spectroscopic studies of borate-pyranoside solutions at different concentrations and pH. It is shown that crystallisation of a bisdio...
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PMID: 17889842
PDF is available here.
PDF is available here.
Abstract
We cloned a KS505a biosynthetic gene cluster. First we searched for a gene encoding octaprenyl diphosphates, which yielded a C40 precursor by PCR, and four candidate genes were obtained. Among these, one was confirmed to have the expected enzyme activity by recombinant enzyme assay. On the basis of...
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PMID: 18071268
PDF is available here.
PDF is available here.
Carbohydrate Research (342)14 2007
Abstract
Methyl 4,6-O-benzylidene-2,3-di-O-propargyl-alpha-D-glucoside (2) has been prepared and its structure determined, including its X-ray structural analysis. For comparison the structure of the corresponding allyl derivative has also been determined by X-ray crystallography. Glucoside 2 is a versatile...
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PMID: 17553472
PDF is available here.
PDF is available here.
Abstract
Recent studies have shown that interleukin 6 (IL-6) acts on the cellular proliferation-activating transduction signals during cellular regeneration. Therefore, this study examined the effect of IL-6 on the activation of Na(+)/glucose cotransporters (SGLTs) and its related signaling pathways in prima...
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PMID: 17581928
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (282)39 2007
Abstract
We identified two tripeptides in human RS1 (Gln-Cys-Pro (QCP) and Gln-Ser-Pro (QSP)) that induce posttranscriptional down-regulation of SGLT1 at the TGN leading to 40-50% reduction of SGLT1 in plasma membrane. For effective intracellular concentrations IC(50) values of 2.0 nM (QCP) and 0.16 nm (QSP)...
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PMID: 17686765
PDF is available here.
PDF is available here.
Journal of Organic Chemistry (72)19 2007
Abstract
These results suggest that H-bonding between adjacent and/or remote residues may play a role in dictating preferred glycosidic bond conformation in simple and complex oligosaccharides in aqueous solution....
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PMID: 17316047
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (282)37 2007
Abstract
Mycobacteria produce two unusual polymethylated polysaccharides, the 6-O-methylglucosyl-containing lipopolysaccharides (MGLP) and the 3-O-methylmannose polysaccharides, which have been shown to regulate fatty acid biosynthesis in vitro. A cluster of genes dedicated to the synthesis of MGLP was ident...
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PMID: 17640872
PDF is available here.
PDF is available here.
Endocrinology (148)9 2007
Abstract
We determined whether exogenous IGFs altered placental gene expression, transport, and nutrient partitioning during treatment, which may then persist. Guinea pigs were infused with IGF-I, IGF-II (both 1 mg/kg x d) or vehicle sc from d 20-35 of pregnancy and killed on d 35 (term is 70 d) after admini...
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PMID: 17525121
PDF is available here.
PDF is available here.
Abstract
We here describe studies using Xenopus oocytes that express hSGLT1 and the two-electrode voltage clamp technique to determine the transport characteristics of a variety of flavonoids carrying glucose residues at different positions as well as of their aglycones (altogether 27 compounds). Neither que...
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PMID: 17495124
PDF is available here.
PDF is available here.
Abstract
We find that the sonochemically produced hydrogen peroxide yields from oxygen-saturated solutions of long chain (hexyl, octyl) n-alkyl glucopyranosides at 614 kHz and 1.057 MHz ultrasound increase with increasing n-alkyl glucopyranoside concentration but are independent of concentration for methyl-b...
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PMID: 17224298
PDF is available here.
PDF is available here.
Journal of Physical Chemistry B (111)19 2007
Abstract
Our IR data suggest that TFA molecules are present as cyclic dimers when they penetrate into crystalline cellulose regions, transforming crystalline cellulose to amorphous cellulose. On the other hand, the rate of TFA penetration into the cellulose matrix was greatly retarded at higher temperatures...
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PMID: 17447810
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1768)5 2007
Abstract
We quantified mRNA levels for both transporters using quantitative real-time PCR and found that SMIT1 was predominantly expressed in the medulla while SMIT2 was mainly in the cortex. This distribution of SMIT2 was confirmed on Western blots where an antibody raised against a SMIT2 epitope specifical...
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PMID: 17306760
PDF is available here.
PDF is available here.
Abstract
With the hope of mimicking the chemical and biological properties of natural 6-O-methyl-D-glucose-containing polysaccharides (MGPs), synthetic 6-O-methyl-D-glucose-containing polysaccharides (sMGPs) were designed and synthesized from alpha-, beta-, and gamma-cyclodextrins (CDs). The synthetic route...
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PMID: 17274656
PDF is available here.
PDF is available here.
Abstract
We have previously shown in the guinea pig that increasing maternal IGF abundance in early to midpregnancy enhances fetal growth and viability near term. We now show that this treatment promotes placental transport to the fetus, fetal substrate utilization, and nutrient partitioning near term. Pregn...
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PMID: 17062842
PDF is available here.
PDF is available here.
Abstract
The direct esterification of ibuprofen and methyl alpha-D-glucopyranoside in organic solvent by Novozym 435 was investigated in terms of the main variables controlling the process, including initial water activity (a(w), 0.05-0.75), incubation time, (0-168 h) and substrate concentration. The results...
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PMID: 17134980
PDF is available here.
PDF is available here.
Abstract
I was coexpressed and increased after stimulation of PKC. Inhibition remained unaltered when endocytosis was inhibited by chlorpromazine, imipramine, or filipin but was prevented when exocytosis was inhibited by botulinum toxin B or when the release of vesicles from the TGN and endosomes was inhibit...
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PMID: 16788146
PDF is available here.
PDF is available here.
Abstract
We have observed experimentally, that presteady-state currents are blocked by saturating sugar, but not the changes in fluorescence. Thus we have isolated an electroneutral conformational change that has not been previously described. This rate-limiting step at maximal inward Na(+)/sugar cotransport...
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PMID: 17130520
PDF is available here.
PDF is available here.
Carbohydrate Research (341)16 2006
Abstract
Aqueous solutions of D-glucaric acid and model polyols xylitol, methyl alpha-D-glucopyranoside or beta-cyclodextrin were freeze dried, then heated, and the product mixtures analyzed by instrumental methods that included GC-MS, electrospray ionization-mass spectrometry (ESIMS), and NMR. The thermal p...
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PMID: 16973136
PDF is available here.
PDF is available here.
Abstract
We investigated the mechanisms underlying glucose-triggered activity in glucose-excited neurons, using primary cultures of rat hypothalamic neurons monitored by fluorescence calcium imaging. We found that 35% (738 of 2,139) of the neurons were excited by increasing glucose from 3 to 15 mmol/l, but o...
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PMID: 17130483
PDF is available here.
PDF is available here.
Journal of Biotechnology (124)2 2006
Abstract
We identified three homologous series (S1-S3) of methyl alpha-D-glucooligosaccharides. Series S2 and S3 were characterized by the presence of alpha(1-->2) linkages, in combination with alpha(1-->6) bonds. Two parameters, sucrose to acceptor concentration ratio (S/A) and the total sugar concentration...
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PMID: 16513200
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (281)26 2006
Abstract
We conclude that AglA, AglB, and IIA(Glc) are necessary and sufficient for growth of E. coli K12 on methyl-alpha-D-glucoside and related alpha-D-glucopyranosides....
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PMID: 16636060
PDF is available here.
PDF is available here.
Biochemistry (Washington) (45)14 2006
Abstract
We embarked on a more detailed investigation of Q170E using the two-microelectrode voltage clamping in Xenopus oocytes. Compared to wild-type (wt) rSGLT1, Q170E exhibits (i) a 2-fold decrease in methyl alpha-D-glucopyranoside affinity (-150 to -90 mV), (ii) a 5-fold increase in Na+ affinity (-150 to...
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PMID: 16584200
PDF is available here.
PDF is available here.
ChemBioChem (7)2 2006
Abstract
We have applied an enzyme microarray screening system for the identification of new acceptor specificities of the glycosyltransferase R (GTFR) from Streptococcus oralis (E.C. 2.4.1.5), which was able to effect the synthesis of sugar motifs in short times and with low amounts of substrate. These obse...
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PMID: 16416490
PDF is available here.
PDF is available here.
Abstract
A gas-liquid chromatographic-mass spectrometric (GLC-MS) method was applied to the detection of 3-deoxy-d-manno-2-octulosonic acid (Kdo), a constituent of bacterial lipopolysaccharide (LPS, endotoxin). Samples containing LPS were dried, methanolyzed with 2 M HCl in methanol at 60 degrees C for 1 h a...
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PMID: 15932775
PDF is available here.
PDF is available here.
FEMS Microbiology Letters (164)1 2006
Abstract
The time course production of xylanolytic enzymes by the rumen anaerobic fungus Neocallimastix frontalis was studied during growth on different carbon sources and revealed using isoelectric focusing and immunoblotting. A constant low level of endoxylanase expression was observed in glucose medium. A...
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PMID: 9675850
PDF is available here.
PDF is available here.
Abstract
We investigated effects of two glucose analogs, 2-Deoxy-D-glucose (2DG) and Methyl-D-glucoside (MG), on biofilm formation, expression of related gene and changes of surface protein in S. epidermidis 97-337 with high biofilm formation capability and pathogenicity. The effect of MG on biofilm formatio...
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PMID: 16496706
PDF is available here.
PDF is available here.
Analytical Sciences (21)11 2005
Abstract
Layered thin films composed of concanavalin A (Con A) and sugar-bearing polymers were prepared by a layer-by-layer deposition of Con A and the polymer on a solid surface. The sugar-induced disintegration was studied. Con A-polymer layered films could be successfully prepared using a maltose-bearing...
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PMID: 16317909
PDF is available here.
PDF is available here.
Abstract
Extracellular ATP plays an important role in the regulation of renal function. However, the effect of ATP on the Na(+)-glucose cotransporters (SGLTs) has not been elucidated in proximal tubule cells (PTCs). Therefore, this study was performed to examine the action of ATP on SGLTs and their related s...
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PMID: 16014705
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1751)2 2005
Abstract
Our results provide basic information for the enzymatic preparation of high-maltose syrup....
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PMID: 15975859
PDF is available here.
PDF is available here.
Regulatory Peptides (129)1-3 2005
Abstract
We decided to investigate the effect of these peptides on intestinal sugar absorption using everted rings from Wistar rat intestine. PAMP increases alpha-methylglucoside (MG) uptake at concentrations ranging from 10(-12) to 10(-7) M. AM shows a dual effect inhibiting sugar absorption at low concentr...
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PMID: 15927710
PDF is available here.
PDF is available here.
Abstract
The regioselective deacetylation of purified cellulose acetate esterase from Neisseria sicca SB was investigated on methyl 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside and 2,3,4,6-tetra-O-acetyl-beta-D-galactopyranoside. The substrates were used as model compounds of cellulose acetate in order to e...
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PMID: 16041133
PDF is available here.
PDF is available here.
Abstract
We cloned P2Ox cDNA by RACE-PCR from a cDNA library derived from the basidiomycete Peniophora gigantea. The P2Ox gene was expressed in Escherichia coli BL21(DE3), yielding an intracellular and enzymatically active P2OxB with a volumetric yield of 500 units/l. Site-directed mutagenesis was employed t...
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PMID: 15660220
PDF is available here.
PDF is available here.
Abstract
Cadmium (Cd2+) poisoning causes severe renal disorders manifested by defects in reabsorptive transport of various compounds. It is reported here that the renal brush-border membrane Na+/glucose co-transporter-1 (SGLT1) is a molecular target for Cd2+ toxicity. In micromolar concentrations, Cd2+ acted...
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PMID: 15829715
PDF is available here.
PDF is available here.
Abstract
We investigate the mechanisms responsible for the H2O2 production that occurs as the consequence of hyperglycemia and the effect of H2O2 on the activity of the Na+/glucose cotransport system (SGLT) in primary cultures of renal proximal tubule cells (PTCs). When primary PTCs were cultured in the pres...
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PMID: 15598843
PDF is available here.
PDF is available here.
Abstract
A model of the specific acid-catalyzed glycosidic bond formation in liquid water at ambient conditions is studied based on constrained Car-Parrinello ab initio molecular dynamics. Specifically the reaction of alpha-D-glucopyranose and methanol is found to proceed by a D(N)A(N) mechanism. The D(N) st...
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PMID: 15729673
PDF is available here.
PDF is available here.
Carbohydrate Research (340)5 2005
Abstract
We call B0 and B1, were found. For the manno configuration, a 4H3 and 3E almost isoenergetic pair were found, whereas for the gluco-configuration a 4H3 and 5S1 pair favouring 4H3 were calculated. These results corroborate earlier results and suggest that this two or more conformer hypothesis is gene...
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PMID: 15780250
PDF is available here.
PDF is available here.
Abstract
Both oxidative stress and epidermal growth factor (EGF) contribute to the initiation and progression of renal proximal tubular dysfunction under pathophysiologic conditions. Thus, this study was performed (1) to examine both the individual, and the combined effects of H2O2 and EGF on alpha-methyl-D-...
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PMID: 15368538
PDF is available here.
PDF is available here.
Abstract
We demonstrate that (i) the major mechanism for Bt toxin resistance in Caenorhabditis elegans entails a loss of glycolipid carbohydrates; (ii) Bt toxin directly and specifically binds glycolipids; and (iii) this binding is carbohydrate-dependent and relevant for toxin action in vivo. These carbohydr...
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PMID: 15705852
PDF is available here.
PDF is available here.
Toxicology In Vitro (19)1 2005
Abstract
TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) is a highly toxic environmental toxicant that alters cell proliferation and function. Estrogens are noted for their ability to stimulate cell proliferation in various tissues. However, little is known about any interaction between TCDD and estradiol-17beta...
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PMID: 15582352
PDF is available here.
PDF is available here.
Abstract
A Systematic investigation of the effect of pH on concanavalin A in the presence of specific and non-specific sugars is made using CD (circular dichroism) and fluorescence. The specific and non-specific sugars for concanavalin A were methyl alpha-D-glucopyranoside and methyl alpha-D-galactopyranosid...
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PMID: 15809680
PDF is available here.
PDF is available here.
Abstract
A growing body of evidence implicates albumin has an important regulatory function in renal proximal tubule cells (PTCs). In present study, the effect of bovine serum albumin (BSA) on 14C-alpha-methyl-D-glucopyranoside (alpha-MG) uptake and its related signal molecules were examined in the primary c...
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PMID: 15389529
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1703)1 2004
Abstract
The solvent kinetic isotope effects (SKIE) on the yeast alpha-glucosidase-catalyzed hydrolysis of p-nitrophenyl and methyl-d-glucopyranoside were measured at 25 degrees C. With p-nitrophenyl-D-glucopyranoside (pNPG), the dependence of k(cat)/K(m) on pH (pD) revealed an unusually large (for glycohydr...
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PMID: 15588703
PDF is available here.
PDF is available here.
Biochemistry (Washington) (43)41 2004
Abstract
We have previously proposed that SGLT1 contains separate Na(+)- and glucose-binding domains, that A166 (in the Na(+) domain) is close to D454 (in the sugar domain), and that interactions between these residues influence sugar specificity and transport. We have now expressed the mutant D454C in Xenop...
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PMID: 15476411
PDF is available here.
PDF is available here.