Abstract
Anthocyanins are polyphenol antioxidants that have been shown to prevent many chronic diseases. The compounds are not stable, so they tend to be decolorized or degraded during processing and storage. In this study, the spectral characteristics alteration and degradation products of cyanidin-3-glucos...
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PMID: 20163112
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Abstract
Novel C-aryl glucoside SGLT2 inhibitors containing 1,3,4-thiadiazole moieties were designed and synthesized. Among the compounds tested, biaryl-type compounds containing pyrazine 59, 2-furan 61, and 3-thiophene 71 showed the best in vitro inhibitory activities to date (IC(50) = 3.51-7.03 nM) against...
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PMID: 20181486
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Abstract
The kidney plays a major role in glucose homeostasis because of its role in gluconeogenesis and the glomerular filtration and reabsorption of glucose in the proximal convoluted tubules. Approximately 180 g of glucose is filtered daily in the glomeruli of a normal healthy adult. Typically, all of thi...
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PMID: 20205482
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M Obermeier,
M Yao,
A Khanna,
B Koplowitz,
M Zhu,
W Li,
B Komoroski,
S Kasichayanula,
L Discenza,
W Washburn,
W Meng,
B A Ellsworth,
J M Whaley and
W G Humphreys
Abstract
(2S,3R,4R,5S,6R)-2-(3-(4-Ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyl-tetrahydro-2H-pyran-3,4,5-triol (dapagliflozin; BMS-512148) is a potent sodium-glucose cotransporter type II inhibitor in animals and humans and is currently under development for the treatment of type 2 diabetes. The preclinical...
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PMID: 19996149
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Vichai Reutrakul,
Natthinee Anantachoke,
Manat Pohmakotr,
Thaworn Jaipetch,
Chalobon Yoosook,
Jittra Kasisit,
Chanita Napaswa,
Ampai Panthong,
Thawatchai Santisuk,
Samran Prabpai,
Palangpon Kongsaeree and
Patoomratana Tuchinda
Abstract
Two new lupanes, 2 alpha-acetoxy-3 beta-hydroxy-19 beta-hydrogen-lup-20(29)-en-28-oic acid (2-acetoxyalphitolic acid) ( 1) and 2 alpha-hydroxy-3 beta-acetoxy-19 beta-hydrogen-lup-20(29)-en-28-oic acid (3-acetoxyalphitolic acid) ( 2), together with the known betulinic acid ( 3), betulin ( 4), and sti...
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PMID: 19830655
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Abstract
Three new phenolic glycosides, scolochinenosides C-E ( 1- 3), and a new triterpenoid, scolopianate A ( 4), were isolated from the stems of SCOLOPIA CHINENSIS, along with 15 known compounds. The structures of the new compounds were elucidated by means of extensive spectroscopic and chemical methods....
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PMID: 19790034
PDF is available here.
Abstract
No phytochemical investigation regarding Scrophularia striata Boiss. (Scrophulariaceae) has been performed, although several reports about other Scrophularia species have been published. The inhibitory effects of aerial parts of S. striata on matrix metalloproteinase expression elaborate a new appro...
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PMID: 20645822
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Abstract
I (1) together with eugeniin (2) and casuarictin (3) as the potent HCV invasion inhibitors. Furthermore, structure-activity relationship analysis of some relative tannins including the synthesized analogs elucidated the partial structures crucial for potent activity of 1.
Copyright 2010 Elsevier Lt...
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PMID: 20144544
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Abstract
Lactobacillus sp. FTDC 2113, L. acidophilus FTDC 8033, L. acidophilus ATCC 4356, L. casei ATCC 393, Bifidobacterium FTDC 8943 and B. longum FTDC 8643 were incorporated into soymilk supplemented with fructooligosaccharides (FOS), inulin, mannitol, maltodextrin and pectin. The objective of the present...
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PMID: 20085504
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Abstract
The current work compared the relative efficacies of six commercial formulations of H. procumbens. Each formulation was assayed for the content of harpagoside (1), harpagide (2), verbascoside (3) and 8-O-p-coumaroyl harpagide (4) and, based on the recommended dosages, the total daily...
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PMID: 19610038
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Abstract
In the present investigation 16 phytoconstituents, which are active moieties found in several medicinal herbs, have been evaluated for their P-glycoprotein (P-gp) stimulation/inhibition profiles using a P-gp-dependent ATPase assay in rat jejunal membrane (in vitro). Acteoside, agnusi...
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PMID: 19653312
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Abstract
OBJECTIVE:To establish a HPLC-PDA method for the determination of baicalin, wogonoside, baicalein, wogonin and glycyrrhizic acid in Xiaochaihu Tang. METHOD: A Symmetry Shield RP18 (4.6 mm x 250 mm, 5.0 microm) was used with a mobile phase of acetonitrile-0.01% H3PO4 in gradient elution. The detectio...
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PMID: 20545192
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Abstract
OBJECTIVE: To investigate the chemical constituents of the flowers of Chrysanthemum indicum. METHOD: The chemical constituents were isolated by various column chromatographic methods. The structures were identified by spectral data. RESULT: Twelve compounds were isolated and identified as acacetin (...
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PMID: 20545195
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Abstract
The cells were injured when treated with 25 mL/L alcohol for 36 h. Compared with the control group , the ROS level in cells markedly increased while mitochondrial membrane potential and ATP content in cells significantly decreased (P<0.01). Gastrodine obviously inhibited cell damage, reduced ROS lev...
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PMID: 20230681
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Abstract
TGP (12.5, 62.5, and 312.5 microg/ml) resulted in a dose-dependent reduction in the proliferation of endothelial cells. This inhibition effect began 6h after treatment and lasted at least 24h. Fluorescence-activated cell sorting analysis data showed an accumulation of cells in the G0/G1 phase of the...
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PMID: 19914370
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Abstract
We used ventricular myocardium from 61 end-stage failing human hearts (ischaemic cardiomyopathy, ICM and dilated cardiomyopathy, DCM) and 13 non-failing donor hearts. The effect of insulin on isometric twitch force was examined with or without blocking of PI3-kinase, GLUT4-translocation, or SGLT-1....
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PMID: 20083620
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Abstract
We examined the protein concentration and pH dependence of TJL activity in the presence or absence of 500 mM NaCl. TJL activity was suppressed at the high protein concentration. And the optimum pH of TJL activity was decreased in the absence of NaCl. These dependencies confirm the presence of electr...
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PMID: 19807675
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Abstract
A new flavonoid, isorhamnetin-3-O-[-alpha-l-rhamnopyranosyl-(1 --> 3)]-beta-D-glucopyranoside (1), along with two known flavonoids 3'-O-methylorobol (2) and quercetin 3-O-beta-d-glucopyranoside (3), was isolated from Alhagi maurorum. Their structures were established with the help of mass spectromet...
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PMID: 20390757
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Abstract
OBJECTIVE: To investigate chemical constituents of Iodes cirrhosa. METHOD: Constituents were isolated by using a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, and C-18, as well as reversed-phase HPLC. Structures of the isolates wer...
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PMID: 20450044
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Abstract
We use cultured chicory (Cichorium intybus) explants as a model to investigate cell reactivation and somatic embryogenesis and have produced 2 chicory genotypes (K59, C15) sharing a similar genetic background. K59 is a responsive genotype (embryogenic) capable of undergoing complete cell reactivatio...
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PMID: 20565992
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Abstract
We have previously demonstrated that ethanol increased the migration/invasion of breast cancer cells expressing high levels of ErbB2. Amplification of ErbB2 is found in 20-30% of breast cancer patients and is associated with poor prognosis. We sought to identify agents that can prevent or ameliorate...
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PMID: 21034468
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Abstract
From a 1-BuOH-soluble fraction of an extract of the leaves of Elaeocarpus japonicus, six megastigmane glucosides (1-6) were isolated. Five were known compounds (2-6), i.e. amelopsisionoside, citroside A, roseoside, alangionoside A and turpinionoside A, respectively. The structure of...
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PMID: 20091243
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Abstract
We established an animal model of cerebral infarct by occluding both the common carotid arteries and the right middle cerebral artery for 90 min, followed by reperfusion of 24 hours. The ratios of cerebral infarction area to total brain area, and neuro-deficit score were used as an index to observe...
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PMID: 20128044
PDF is available here.