Abstract
We report that, in the rat hippocampus, learning leads to a significant increase in extracellular lactate levels that derive from glycogen, an energy reserve selectively localized in astrocytes. Astrocytic glycogen breakdown and lactate release are essential for long-term but not short-term memory f...
|
PMID: 21376239
PDF is available here.
Abstract
We describe techniques for measuring the amount and activity of Rubisco in higher plants. To accommodate a range of experimental capabilities, we describe basic radioisotopic methods as well as non-radioactive techniques. The required calculations are included. We discuss problems that commonly aris...
|
PMID: 20960142
PDF is available here.
Abstract
Metabolite profiling of Cheonggukjang inoculated with different Bacillus strains including Bacillus amyloliqueciens CH86-1, Bacillus licheniformis 58, and Bacillus licheniformis 67 during fermentation, was performed using gas chromatography-time of flight-mass spectrometry after derivatization, comb...
|
PMID: 20834151
PDF is available here.
Abstract
I (basket method). The results demonstrated that, besides the ratio of the coating polymers (ERS/ERL), the release mechanism was also influenced by the type of starter core used. Sugar- and isomalt-type pellet cores demonstrated similar drug release profiles....
|
PMID: 20237965
PDF is available here.
Abstract
Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) has been demonstrated to exhibit anticariogenic activity in randomized, controlled clinical trials of sugar-free gum and a tooth cream. Two randomized, double-blind, crossover studies were conducted to investigate the potential of CPP-ACP a...
|
PMID: 20090326
PDF is available here.
Abstract
The polyol isomalt (Palatinit) is a very low glycaemic sugar replacer. The effect of food supplemented with isomalt instead of higher glycaemic ingredients like sucrose and/or starch hydrolysates on metabolic control in patients with type 2 diabetes was examined in this open study. Thirty-three pati...
|
PMID: 19701877
PDF is available here.
Abstract
TMG-chitotriomycin, a potent and selective inhibitor of the beta-N-acetylglucosaminidases that possesses an unique N,N,N-trimethyl-d-glucosamine (TMG) residue, is revised to be the TMG-beta-(1-->4)-chitotriose instead of the originally proposed alpha-anomer via its total synthesis, for which a highl...
|
PMID: 19663423
PDF is available here.
Abstract
Apatite cement containing porogen can be a useful material for the fabrication of biporous (macro- and microporous) apatite, which has gained much attention as a bone substitute material because of its large surface area and that it improves cell penetration. In the present study, the effects of add...
|
PMID: 19822995
PDF is available here.
Abstract
Our present study provides evidence that interaction of CD24 with the cell adhesion molecule L1 is mediated by O-linked glycans carrying alpha2,3-linked sialic acid. Furthermore, de-N-glycosylated CD24 was shown to promote or inhibit neurite outgrowth of cerebellar neurons or dorsal root ganglion ne...
|
PMID: 19284289
PDF is available here.
Abstract
Alditol bearing chitosans have shown the ability to reduce silver ions in mild conditions and without addition of exogenous reducing agents. The ion reduction induces the formation of a lactone moiety on the polysaccharide (Fetizon reaction) without causing C-C bond cleavage on the p...
|
PMID: 19140690
PDF is available here.
Abstract
Alditol bearing chitosans have shown the ability to reduce silver ions in mild conditions and without addition of exogenous reducing agents. The ion reduction induces the formation of a lactone moiety on the polysaccharide (Fetizon reaction) without causing C-C bond cleavage on the p...
|
PMID: 19140690
PDF is available here.
Abstract
Alditol bearing chitosans have shown the ability to reduce silver ions in mild conditions and without addition of exogenous reducing agents. The ion reduction induces the formation of a lactone moiety on the polysaccharide (Fetizon reaction) without causing C-C bond cleavage on the p...
|
PMID: 19140690
PDF is available here.
Abstract
Alditol bearing chitosans have shown the ability to reduce silver ions in mild conditions and without addition of exogenous reducing agents. The ion reduction induces the formation of a lactone moiety on the polysaccharide (Fetizon reaction) without causing C-C bond cleavage on the p...
|
PMID: 19140690
PDF is available here.
Abstract
Alditol bearing chitosans have shown the ability to reduce silver ions in mild conditions and without addition of exogenous reducing agents. The ion reduction induces the formation of a lactone moiety on the polysaccharide (Fetizon reaction) without causing C-C bond cleavage on the p...
|
PMID: 19140690
PDF is available here.
Abstract
Alditol bearing chitosans have shown the ability to reduce silver ions in mild conditions and without addition of exogenous reducing agents. The ion reduction induces the formation of a lactone moiety on the polysaccharide (Fetizon reaction) without causing C-C bond cleavage on the p...
|
PMID: 19140690
PDF is available here.
Abstract
Alditol bearing chitosans have shown the ability to reduce silver ions in mild conditions and without addition of exogenous reducing agents. The ion reduction induces the formation of a lactone moiety on the polysaccharide (Fetizon reaction) without causing C-C bond cleavage on the p...
|
PMID: 19140690
PDF is available here.
Abstract
Alditol bearing chitosans have shown the ability to reduce silver ions in mild conditions and without addition of exogenous reducing agents. The ion reduction induces the formation of a lactone moiety on the polysaccharide (Fetizon reaction) without causing C-C bond cleavage on the p...
|
PMID: 19140690
PDF is available here.
Abstract
Alditol bearing chitosans have shown the ability to reduce silver ions in mild conditions and without addition of exogenous reducing agents. The ion reduction induces the formation of a lactone moiety on the polysaccharide (Fetizon reaction) without causing C-C bond cleavage on the p...
|
PMID: 19140690
PDF is available here.
Abstract
Alditol bearing chitosans have shown the ability to reduce silver ions in mild conditions and without addition of exogenous reducing agents. The ion reduction induces the formation of a lactone moiety on the polysaccharide (Fetizon reaction) without causing C-C bond cleavage on the p...
|
PMID: 19140690
PDF is available here.
Abstract
Alditol bearing chitosans have shown the ability to reduce silver ions in mild conditions and without addition of exogenous reducing agents. The ion reduction induces the formation of a lactone moiety on the polysaccharide (Fetizon reaction) without causing C-C bond cleavage on the p...
|
PMID: 19140690
PDF is available here.
Abstract
We describe a simple experimental method for evaluating the intrinsic hydration capacity of model surface coating functional groups based on the partial molal volume at infinite dilution. In order to evaluate a range of hydration capacity and nonfouling performance, solutes were selected from three...
|
PMID: 19072165
PDF is available here.
Abstract
The structural diversity of mucin-type O-glycans (O-GalNAc core-based) exceeds that of N-linked glycans by far. Structural analysis of this type of protein modification is hampered, however, by the unavailability of specific endo-acetylgalactosaminidases that would cleave the intact oligosaccharide...
|
PMID: 19277532
PDF is available here.
Abstract
The aim of the present study was to evaluate the effect of two chewing gums on the production of volatile sulfur-containing compounds (VSC) in vivo. Fourteen periodontally healthy participants (20-35 years old) were included in the test panel. Test gum 1 (TG1) contained sucrose and Test gum 2 (TG2)...
|
PMID: 19601490
PDF is available here.
Abstract
The results of 19 articles with data from 14 study populations showed that the use of xylitol, xylitol-sorbitol blend and sorbitol were associated with mean PF (95 percent confidence interval) of 58.66 percent (35.42-81.90), 52.82 percent (39.64-66.00) and 20.01 percent (12.74-27.27), respectively....
|
PMID: 19047666
PDF is available here.
Abstract
We discuss the idea that excess glucose overloads the electron transport chain, leading to the production of superoxides and subsequent mitochondrial and cytosolic oxidative stress. Defects in metabolic and vascular pathways intersect with oxidative stress to produce the onset and progression of ner...
|
PMID: 18709457
PDF is available here.
Abstract
No fungicidal effect was observed with sugar alcohols without BTC. The fungicidal effect of erythritol-containing BTC increased with the erythritol concentration. Further, the level of enhancement of erythritol was the highest in three sugar alcohols. CONCLUSION: Sugar alcohols, especially erythrito...
|
PMID: 18778883
PDF is available here.
Abstract
The aim of the study was to investigate the effects of supplementation of a microencapsulated blend of tributyrin and lactitol (TL) to a standard European (EU) diet without antibiotic growth promoters on intestinal metabolism and mucosa development of weaned piglets and to compare it with a standard...
|
PMID: 18502885
PDF is available here.
Abstract
Sugar alcohols find applications in pharmaceuticals, oral and personal care products, and as intermediates in chemical synthesis. While industrial-scale production of these compounds has generally involved catalytic hydrogenation of sugars, microbial-based processes receive increasing attention. The...
|
PMID: 18760354
PDF is available here.
Abstract
The synthesis of new seven-carbon, chain-extended sulfonium salts of 1,4-anhydro-4-thio- d-arabinitol, analogues of the naturally occurring glycosidase inhibitor salacinol, are described. These compounds were designed on the basis of the structure activity data of chain-extended analogues of salacin...
|
PMID: 18651773
PDF is available here.
Abstract
We focused on the highly conserved bce gene cluster thought to be involved in cepacian biosynthesis. We demonstrated induction of the bce gene cluster by mannitol, and found a clear correlation between the inability of representatives of the Burkholderia cenocepacia ET12 lineage to produce EPS and t...
|
PMID: 18667584
PDF is available here.
Abstract
We aimed to determine whether metabolites could be identified in placental cultures with acceptable experimental variability and to determine whether altered O2 tension affects the composition of the placental metabolome. In this study we used gas-chromatography-mass spectroscopy to determine the pr...
|
PMID: 18573524
PDF is available here.
Abstract
Nonglucose carbohydrates such as galactose, mannose, and inositol play a clinically important role in fetal and neonatal nutrition, though little is known about their metabolism in the neonate. The aim of this study was to determine whether postprandial changes in plasma carbohydrate and sugar alcoh...
|
PMID: 18391836
PDF is available here.
Abstract
These results indicate that a more hydrophilic surface might be attained by heating the talc. Consequently, talc was demonstrated to be the most desirable lubricant for the preparation of OD tablets based on the principle of the phase transition of sugar alcohol....
|
PMID: 18396020
PDF is available here.
Abstract
We determined that osmotic diarrhea caused by maltitol ingestion was suppressed by the addition of not only soluble but also insoluble dietary fiber in healthy humans. We then clarified that cellulose delayed gastric emptying in rats. Twenty-seven healthy volunteers ingested maltitol step-wise at do...
|
PMID: 18797153
PDF is available here.
Abstract
A novel alpha-galactosidase gene (aga2) was cloned from Bifidobacterium breve 203. It contained an ORF of 2226-bp nucleotides encoding 741 amino acids with a calculated molecular mass of 81.5 kDa. The recombinant enzyme Aga2 was heterogeneously expressed, purified and characterized. Regarding substr...
|
PMID: 18564335
PDF is available here.
Abstract
We also report the synthesis of the parent nitrogen heterocycles, N-Boc-1,2,4-trideoxy-2-amino-1,4-imino-D-arabinitol, and 1,2,4-trideoxy-2-acetamido-1,4-imino-D-arabinitol and its corresponding N-Boc protected compound. The 2-substituted analogues and the parent iminoalditol showed marginal activit...
|
PMID: 18358456
PDF is available here.
Abstract
Twenty-four hour integrated filter samples of fine particulate matter (PM2.5) were collected from May 2004 to April 2005 at one rural site and three urban sites located in the southeastern United States. Filters were extracted and analyzed for both biogenic secondary organic aerosol (SOA) tracers vi...
|
PMID: 18754365
PDF is available here.
Abstract
OBJECTIVE: To study the active constituents of Dendrobium aphyllum. METHOD: Various chromatographic techniques were used to isolate and purify the constituents, their physico-chemical properties and spectral data are determinated to elucidate the structure. RESULT: Eight compounds were isolated and...
|
PMID: 18841768
PDF is available here.
Abstract
The gum TW produced significantly greater remineralization (18.4 +/- 0.9%) than Orbit (8.9 +/- 0.5%) and Orbit Professional (10.5 +/- 0.9%). CONCLUSION: The superior remineralization activity of the TW gum in situ was attributed to the presence of casein phosphopeptide-amorphous calcium phosphate na...
|
PMID: 18435723
PDF is available here.
Abstract
Isomalt is a non-cariogenic sweetener, which is widely used in sugar-free candy and chewing gum. Little is known about the effects of Isomalt on de- and remineralization. Binding between calcium and Isomalt has been reported, which could affect the mineral balance. The objective of this study was to...
|
PMID: 18157558
PDF is available here.
Abstract
A polyhydroxylated cyclic 13-membered sulfoxide (1) was isolated from an aqueous extract of Kothala-himbutu ( Salacia reticulata WIGHT). The structure of compound 1 was elucidated by 1D and 2D NMR and APCI-MS methods. The alpha-glucosidase inhibitory activity of compound 1 (IC 50: maltase, 0.227 mic...
|
PMID: 18547114
PDF is available here.
Abstract
We report the identification and characterization of beta-fructofuranosidase genes (BmSuc1 and BmSuc2) from B. mori. The BmSuc1 gene was highly expressed in the midgut and silk gland, whereas the expression of BmSuc2 gene was not detected. BmSuc1 encodes a functional beta-fructofuranosidase, whose e...
|
PMID: 18397891
PDF is available here.
Jonathan D JD Silk,
Mariolina M Salio,
B Gopal BG Reddy,
Dawn D Shepherd,
Uzi U Gileadi,
James J Brown,
S Hajar SH Masri,
Paolo P Polzella,
Gerd G Ritter,
Gurdyal S GS Besra,
E Yvonne EY Jones,
Richard R RR Schmidt and
Vincenzo V Cerundolo
Abstract
We demonstrate that the nonglycosidic compound threitolceramide efficiently activates iNKT cells, resulting in dendritic cell (DC) maturation and the priming of Ag-specific T and B cells. Threitolceramide-pulsed DCs are more resistant to iNKT cell-dependent lysis than alpha-galactosylceramide-pulsed...
|
PMID: 18453560
PDF is available here.
Abstract
Chewing gum is being used as a delivery vehicle for substances such as calcium, bicarbonate, carbamide, chlorhexidine, fluoride and xylitol to improve oral health and reduce caries. These substances exhibit properties that are protective of the oral environment and mediate common oral diseases. The...
|
PMID: 18451371
PDF is available here.
Abstract
We have developed poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate)s, a new class of synthetic, biodegradable elastomeric poly(ester amide)s composed of crosslinked networks based on an amino alcohol. These crosslinked networks feature tensile Young's modulus on the order of 1MPa and reversable...
|
PMID: 18295329
PDF is available here.
Abstract
The pharmacological properties of 1,4-dideoxy-1,4-imino-d-arabinitol (DAB), a potent inhibitor of glycogen phosphorylase and synthase activity in liver preparations, were characterized in different brain tissue preparations as a prerequisite for using it as a tool to investigate brain glycogen metab...
|
PMID: 18221367
PDF is available here.
Abstract
2-Deoxy-2-fluorosalacinol and a 1,2-ene derivative of the naturally occurring glycosidase inhibitor salacinol were synthesized for structure activity studies with human maltase glucoamylase (MGA). 2-Deoxy-2-fluorosalacinol was synthesized through the coupling reaction of 2-deoxy-2-fluoro-3,5-di-O-p-...
|
PMID: 18295754
PDF is available here.
Abstract
We developed a method for the direct identification and quantification of carbohydrates in raw vegetable extracts using (13)C NMR spectroscopy without any preliminary step of precipitation or reduction of the components. This method has been validated (accuracy, precision and response linearity) usi...
|
PMID: 18299126
PDF is available here.
Abstract
This work reports the development and application of a negative ion mode online LC-ESI-MS method for studying the effect of water deficit on the carbohydrate content of Lupinus albus stems, using a porous graphitic carbon (PGC) stationary phase and an ion trap mass spectrometer. Using this method, s...
|
PMID: 18304562
PDF is available here.
Abstract
These results suggest that the (GlcNAc)3 unit positioned at the reducing end of 1 is essential for its enzyme inhibitory activity. The unique inhibitory spectrum of 1 will be useful to study chitinolytic systems and to develop selective fungicides or pesticides....
|
PMID: 18307344
PDF is available here.
Abstract
The inhibition of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) with dithiothreitol, 2-mercaptoethanol, tris(carboxyethyl)phosphine (reducing agent frequently added to enzyme assay buffers) and threitol has been investigated. The agents were very weak inhibitors of isozymes CA II and CA IX,...
|
PMID: 18295485
PDF is available here.
Abstract
This study suggests that it is possible to induce thermotolerance in biocontrol yeasts such as C. sake. However, this does not improve survival of cells exposed to spray-drying sufficiently to consider this a suitable formulation method for this biocontrol agent. HSPs, sugars and sugar polyols were...
|
PMID: 17927743
PDF is available here.
Abstract
We used a top-down approach that first established the fly sweetener-response profile. We employed the fruit fly Drosophila melanogaster, an omnivorous human commensal, and determined its sensitivity to an extended set of stimuli that humans find sweet. Flies were tested with all sweeteners in 2 ass...
|
PMID: 18234713
PDF is available here.
Abstract
Six compounds were isolated and identified as stearic acid (1), 3beta-hydroxyerg-osta-5,7,22-triene (2), sotolon (3), lactarorufin A (4), rufuslactone (5) and D-allitol (6), respectively. CONCLUSION: Compound 5 is the main sesquiterpenoid of Lactarius rufus and has the potential for the further inve...
|
PMID: 18619269
PDF is available here.
Abstract
Electrokinetic probes based on the differential migration of ternary boronate ester complexes permit the selective analysis of micromolar levels of UV-transparent polyol stereoisomers in urine samples via dynamic complexation-capillary electrophoresis that is applicable to single-step screening of i...
|
PMID: 18399200
PDF is available here.
Abstract
Research of influence of prebiotic lactitol on growth and biological activity of probiotic cultures Bacillus subtilis--the basis of the preparation endosporinum and some strains of the indigenous microflora of the human intestinal tract was conducted. Lactitol is actively utilized by bacteria B. sub...
|
PMID: 19351047
PDF is available here.
Abstract
The discrepancies were found in some physiological properties of enterococcal strains isolated from gastrointestinal tract of long-livers in 1978-1981 years after long-term storage in lyophilized state. Different results of conventional tube tests obtained before and after long-term storage concerni...
|
PMID: 19140419
PDF is available here.
Abstract
In the article the estimation of change of lipoperoxidation parameters is lead (carried out) at introduction to a diet of rats synbiotic dairy foods and synbiotic bifidobacteria cultures. Changes in the oxidation products level, ceruloplasmin level, and also in the colon bifidobacteria concentration...
|
PMID: 18505097
PDF is available here.